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Phenotypic Abnormality (PA): Abnormality of the vertebral column

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the skeletal system [HP:0000924] <7>(88|98) (93|55|34)
+ + 2:   Abnormality of skeletal morphology [HP:0011842] <17>(86|89) (90|52|33)
+ 1:   Abnormal axial skeleton morphology [HP:0009121] <6>(47|61) (51|30|26)
0:   Abnormality of the vertebral column [HP:0000925] <20>(22|27) (25|11|10)
- 1:   Abnormal vertebral morphology [HP:0003468] <16>(7|6) (8|1|2)
- 1:   Abnormality of the cervical spine [HP:0003319] <14>(3|4) (4|2|1)
- 1:   Abnormal sacrum morphology [HP:0005107] <9>(0|1) (1|0|0)
- 1:   Abnormality of the curvature of the vertebral column [HP:0010674] <6>(13|16) (13|7|4)
- 1:   Aplasia/Hypoplasia involving the vertebral column [HP:0008518] <6>(2|0) (2|0|0)
- 1:   Abnormality of the intervertebral disk [HP:0005108] <5>(1|1) (1|0|0)
- 1:   Abnormality of the coccyx [HP:0008519] <4>(0|0) (0|0|0)
- 1:   Abnormality of the odontoid process [HP:0003310] <4>(2|0) (2|0|0)
- 1:   Abnormality of the lumbar spine [HP:0100712] <3>(0|0) (0|0|0)
- 1:   Spinal canal stenosis [HP:0003416] <3>(0|0) (0|0|0)
- 1:   Abnormality of the thoracic spine [HP:0100711] <2>(2|2) (2|1|0)
- 1:   Atlantoaxial abnormality [HP:0003413] <2>(0|0) (0|0|0)
- 1:   Back pain [HP:0003418] <2>(0|0) (0|0|0)
- 1:   Spinal instability [HP:0005881] <1>(0|0) (0|0|0)
- 1:   Spondylolisthesis [HP:0003302] <1>(1|1) (1|0|0)
- 1:   Reversed usual vertebral column curves [HP:0008433](0|0) (0|0|0)
- 1:   Spinal deformities [HP:0008443](0|0) (0|0|0)
- 1:   Spinal dysplasia [HP:0008423](0|0) (0|0|0)
- 1:   Spinal rigidity [HP:0003306](0|1) (0|1|0)
- 1:   Spondylolysis [HP:0003304](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
C-terminal, gelsolin-like domain of Sec23/240Direct
Restriction endonuclease-like0Direct
RuvA domain 2-like0Direct
Helical domain of Sec23/240Direct
Smc hinge domain0Direct
Zn-finger domain of Sec23/240Direct
beta-sandwich domain of Sec23/240.0005998Direct
Alkaline phosphatase-like0.003413Inherited
HMG-box0.01618Inherited
Galactose-binding domain-like0.02035Inherited
Cystine-knot cytokines0.04361Inherited
Nucleotide-diphospho-sugar transferases0.1345Inherited
WD40 repeat-like0.1836Inherited
MIR domain0.2168Inherited
Notch domain0.2245Inherited
FKBP-like0.2245Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.398Inherited
Nicotinic receptor ligand binding domain-like0.398Inherited
GST C-terminal domain-like0.4315Inherited
ARID-like0.4315Inherited
(Trans)glycosidases0.5885Inherited
Homeodomain-like0.9066Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
Myotubularin-like phosphatases0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Helical domain of Sec23/240Direct
Glycosyl transferases group 10Direct
Smc hinge domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Histone deacetylase, HDAC0Direct
Exostosin0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
beta-sandwich domain of Sec23/240Direct
Trunk domain of Sec23/240Direct
Regulator of chromosome condensation RCC10.002852Inherited
HMG-box0.01101Inherited
Transforming growth factor (TGF)-beta0.01209Inherited
beta-glycanases0.02323Inherited
Arylsulfatase0.02355Inherited
Integrin A (or I) domain0.08296Inherited
MIR domain0.1796Inherited
Notch domain0.192Inherited
FKBP immunophilin/proline isomerase0.192Inherited
Bromodomain0.253Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.345Inherited
Nicotinic receptor ligand binding domain-like0.345Inherited
Actin/HSP700.3538Inherited
ARID domain0.3923Inherited
Homeodomain0.8068Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Smc hinge domain0Direct
Restriction endonuclease-like0Direct
RuvA domain 2-like0Direct
Helical domain of Sec23/240Direct
Zn-finger domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
beta-sandwich domain of Sec23/240.0003069Direct
Alkaline phosphatase-like0.002005Inherited
GroEL equatorial domain-like0.008714Inherited
HMG-box0.01082Inherited
Galactose-binding domain-like0.01387Inherited
Cystine-knot cytokines0.03163Inherited
Nucleotide-diphospho-sugar transferases0.1087Inherited
WD40 repeat-like0.1521Inherited
MIR domain0.1827Inherited
Notch domain0.1898Inherited
FKBP-like0.1898Inherited
Bromodomain0.2512Inherited
Concanavalin A-like lectins/glucanases0.301Inherited
Nicotinic receptor ligand binding domain-like0.3546Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3546Inherited
GST C-terminal domain-like0.3876Inherited
ARID-like0.3876Inherited
(Trans)glycosidases0.5456Inherited
Homeodomain-like0.878Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.06475Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1879Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.3546Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.401Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2845Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.494Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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