Phenotypic Abnormality (PA): Palmoplantar hyperkeratosis

---

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children)	HP term [HP ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + + + + 6:	Abnormality of the integument [HP:0001574] <4>	(48|69)	(59|37|15)
+ + + + + + 6:	Phenotypic abnormality [HP:0000118] <25>
+ + + + + 5:	Abnormality of limbs [HP:0040064] <8>	(58|66)	(63|33|25)
+ + + + + 5:	Abnormality of the upper limb [HP:0002817] <20>	(29|35)	(35|17|16)
+ + + + + 5:	Abnormality of the skin [HP:0000951] <4>	(34|55)	(45|36|12)
+ + + + 4:	Abnormality of the hand [HP:0001155] <26>	(22|27)	(27|15|14)
+ + + + 4:	Abnormality of skin morphology [HP:0011121] <22>	(29|49)	(40|31|11)
+ + + + 4:	Thickened skin [HP:0001072] <4>	(3|6)	(3|6|2)
+ + + + 4:	Abnormality of the lower limb [HP:0002814] <17>	(31|34)	(35|15|13)
+ + + 3:	Abnormality of the palm [HP:0100871] <6>	(6|7)	(7|2|1)
+ + + 3:	Abnormality of the foot [HP:0001760] <30>	(20|24)	(21|13|10)
+ + + 3:	Regional abnormality of skin [HP:0011356] <11>	(6|9)	(8|5|1)
+ + + 3:	Epidermal thickening [HP:0011368] <9>	(3|6)	(3|6|2)
+ + 2:	Hyperkeratosis [HP:0000962] <21>	(2|5)	(2|6|2)
+ + 2:	Abnormality of the skin of the palm [HP:0040211] <9>	(4|5)	(5|2|1)
+ + 2:	Abnormality of the plantar skin of foot [HP:0100872] <13>	(2|2)	(2|3|0)
+ 1:	Palmar hyperkeratosis [HP:0010765] <2>	(2|2)	(2|1|0)
+ 1:	Plantar hyperkeratosis [HP:0007556] <1>	(1|2)	(2|2|0)
0:	Palmoplantar hyperkeratosis [HP:0000972] <7>	(1|1)	(1|1|0)
- 1:	Congenital palmoplantar keratosis [HP:0007545]	(0|0)	(0|0|0)
- 1:	Congenital symmetrical palmoplantar keratosis [HP:0007553]	(0|0)	(0|0|0)
- 1:	Diffuse palmoplantar hyperkeratosis [HP:0007447]	(0|0)	(0|0|0)
- 1:	Focal friction-related palmoplantar hyperkeratosis [HP:0007497]	(0|0)	(0|0|0)
- 1:	Palmoplantar keratosis with erythema and scale [HP:0007548]	(0|0)	(0|0|0)
- 1:	Punctate palmoplantar hyperkeratosis [HP:0007530]	(0|0)	(0|0|0)
- 1:	Spinous keratoses of palms and soles [HP:0007613]	(0|0)	(0|0|0)

---

Superfamily

Superfamily domains annotated to this HP term (Not in SDHP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Prefoldin	0.000009284	DIRECT

---

Family

Family domains annotated to this HP term (Not in SDHP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Tyrosine-dependent oxidoreductases	0.0001727	DIRECT

---

Supra-domain (including individual superfamily)

Supra-domains annotated to this HP term (Not in SPHO)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Prefoldin	0.000003891	DIRECT

Supra-domains annotated to this HP term (Not in SPHO)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
46579,64593 46579 - Prefoldin 64593 - Intermediate filament protein, coiled coil region	0.00000006209	DIRECT