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Phenotypic Abnormality (PA): Generalized hypotonia

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Phenotypic abnormality [HP:0000118] <25>
+ + + + 4:   Abnormality of the musculature [HP:0003011] <3>(64|83) (70|33|9)
+ + + 3:   Abnormal muscle physiology [HP:0011804] <12>(44|59) (51|22|5)
+ + 2:   Abnormal muscle tone [HP:0003808] <3>(23|37) (27|15|5)
+ 1:   Muscular hypotonia [HP:0001252] <9>(15|27) (18|9|4)
0:   Generalized hypotonia [HP:0001290] <2>(4|9) (5|3|0)
- 1:   Episodic generalized hypotonia [HP:0006852](0|0) (0|0|0)
- 1:   Generalized hypotonia due to defect at the neuromuscular junction [HP:0003397](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
TK C-terminal domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
NTF2-like0Direct
CCCH zinc finger0Direct


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
CCCH zinc finger0Direct
Ferredoxin domains from multidomain proteins0Direct
Protein serine/threonine phosphatase0Direct
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
IF2B-like0Direct
ValRS/IleRS/LeuRS editing domain0.0006506Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
TK C-terminal domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
CCCH zinc finger0Direct
NTF2-like0Direct
ValRS/IleRS/LeuRS editing domain0.0008248Direct

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0.0008248Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)