Phenotypic Abnormality (PA): Abnormality of the lower limb

(show info)

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: Phenotypic abnormality [HP:0000118] <25>

+ 1: Abnormality of limbs [HP:0040064] <8> (58|66) (63|33|25)

0: Abnormality of the lower limb [HP:0002814] <17> (31|34) (35|15|13)

- 1: Abnormality of the foot [HP:0001760] <30> (20|24) (21|13|10)

- 1: Abnormal lower limb bone morphology [HP:0040069] <10> (11|9) (12|5|6)

- 1: Abnormality of the musculature of the lower limbs [HP:0001437] <6> (3|3) (5|2|2)

- 1: Abnormality of lower limb joint [HP:0100491] <5> (10|13) (11|2|1)

- 1: Abnormality of lower limb epiphysis morphology [HP:0006500] <4> (2|1) (2|0|0)

- 1: Abnormality of the calf [HP:0002981] <3> (1|0) (1|1|1)

- 1: Abnormality of lower-limb metaphyses [HP:0006490] <2> (0|0) (0|0|0)

- 1: Areflexia of lower limbs [HP:0002522] <2> (1|0) (1|0|0)

- 1: Distal lower limb muscle weakness [HP:0009053] <2> (1|0) (1|0|0)

- 1: Hyporeflexia of lower limbs [HP:0002600] <2> (1|0) (1|0|0)

- 1: Lower limb asymmetry [HP:0100559] <2> (0|0) (0|0|0)

- 1: Externally rotated/abducted legs [HP:0003783] <1> (0|0) (0|0|0)

- 1: Hypertrophy of the lower limb [HP:0010496] <1> (0|0) (0|0|0)

- 1: Pedal edema [HP:0010741] <1> (0|0) (0|0|0)

- 1: Amniotic constriction rings of legs [HP:0010495] (0|0) (0|0|0)

- 1: Rickets of the lower limbs [HP:0006463] (0|0) (0|0|0)

- 1: Sirenomelia [HP:0010497] (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Rhodanese/Cell cycle control phosphatase	0	Direct
Hedgehog/intein (Hint) domain	0	Direct
CalX-like	0	Direct
RuvA domain 2-like	0	Direct
Hedgehog/DD-peptidase	0	Direct
Plakin repeat	0	Direct
BRK domain-like	0	Direct
Nucleotide-diphospho-sugar transferases	0.0205	Inherited
Spectrin repeat	0.04286	Inherited
Arginase/deacetylase	0.04577	Inherited
Restriction endonuclease-like	0.04577	Inherited
HMG-box	0.04918	Inherited
ARID-like	0.05619	Inherited
Calponin-homology domain, CH-domain	0.07389	Inherited
SNARE fusion complex	0.1109	Inherited
Bromodomain	0.1119	Inherited
Concanavalin A-like lectins/glucanases	0.132	Inherited
Prefoldin	0.1674	Inherited
SET domain	0.231	Inherited
MIR domain	0.2739	Inherited
Intermediate filament protein, coiled coil region	0.2903	Inherited
FnI-like domain	0.3675	Inherited
Class II aaRS and biotin synthetases	0.3675	Inherited
Tropomyosin	0.3727	Inherited
HSP20-like chaperones	0.3727	Inherited
S15/NS1 RNA-binding domain	0.456	Inherited
Immunoglobulin	0.6992	Inherited
WD40 repeat-like	0.8577	Inherited
Cystine-knot cytokines	0.8885	Inherited
vWA-like	0.9213	Inherited
Voltage-gated potassium channels	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
CalX-beta domain	0	Direct
Myotubularin-like phosphatases	0	Direct
Filamin repeat (rod domain)	0	Direct
BRK domain-like	0	Direct
XPF/Rad1/Mus81 nuclease	0	Direct
Histone deacetylase, HDAC	0	Direct
Plakin repeat	0	Direct
Hedgehog (development protein), N-terminal signaling domain	0	Direct
Exostosin	0	Direct
Inositol polyphosphate 5-phosphatase (IPP5)	0	Direct
Hedgehog C-terminal (Hog) autoprocessing domain	0	Direct
Histone lysine methyltransferases	0.009842	Inherited
VWC domain	0.01924	Inherited
Spectrin repeat	0.03078	Inherited
ZZ domain	0.03382	Inherited
HMG-box	0.03589	Inherited
RecA protein-like (ATPase-domain)	0.04132	Inherited
ARID domain	0.04225	Inherited
Calponin-homology domain, CH-domain	0.06642	Inherited
SNARE fusion complex	0.08849	Inherited
Bromodomain	0.1006	Inherited
MIR domain	0.2357	Inherited
Intermediate filament protein, coiled coil region	0.2484	Inherited
Hemopexin-like domain	0.2848	Inherited
TSP-1 type 1 repeat	0.301	Inherited
Tyrosine-dependent oxidoreductases	0.3048	Inherited
Tropomyosin	0.351	Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0.3523	Inherited
LIM domain	0.409	Inherited
a tRNA synthase domain	0.4328	Inherited
Clathrin adaptor core protein	0.4328	Inherited
I set domains	0.4494	Inherited
Myosin rod fragments	0.4755	Inherited
Integrin A (or I) domain	0.8283	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
BRK domain-like	0	Direct
CalX-like	0	Direct
Plakin repeat	0	Direct
RuvA domain 2-like	0	Direct
Hedgehog/intein (Hint) domain	0	Direct
Hedgehog/DD-peptidase	0	Direct
Rhodanese/Cell cycle control phosphatase	0	Direct
Nucleotide-diphospho-sugar transferases	0.01399	Inherited
Spectrin repeat	0.03101	Inherited
Restriction endonuclease-like	0.03339	Inherited
Arginase/deacetylase	0.03339	Inherited
Cysteine proteinases	0.03581	Inherited
HMG-box	0.03616	Inherited
ARID-like	0.04191	Inherited
Calponin-homology domain, CH-domain	0.05652	Inherited
SNARE fusion complex	0.08753	Inherited
Bromodomain	0.08836	Inherited
Concanavalin A-like lectins/glucanases	0.1064	Inherited
Prefoldin	0.1376	Inherited
SET domain	0.1957	Inherited
MIR domain	0.2357	Inherited
Intermediate filament protein, coiled coil region	0.251	Inherited
Hemopexin-like domain	0.2654	Inherited
FnI-like domain	0.3249	Inherited
Class II aaRS and biotin synthetases	0.3249	Inherited
Tropomyosin	0.3298	Inherited
HSP20-like chaperones	0.3298	Inherited
S15/NS1 RNA-binding domain	0.4121	Inherited
Myosin rod fragments	0.4465	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.6527	Inherited
Immunoglobulin	0.6604	Inherited
WD40 repeat-like	0.8258	Inherited
Cystine-knot cytokines	0.8586	Inherited
vWA-like	0.8936	Inherited
Voltage-gated potassium channels	0.9998	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
75399,75399 75399 - Plakin repeat 75399 - Plakin repeat	0	Direct
55166,51294 55166 - Hedgehog/DD-peptidase 51294 - Hedgehog/intein (Hint) domain	0	Direct
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	Direct
141072,141072 141072 - CalX-like 141072 - CalX-like	0	Direct
57184,57581 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	Direct
57581,57184 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	Direct
81296,81296 81296 - E set domains 81296 - E set domains	0.00531	Inherited
46579,64593 46579 - Prefoldin 64593 - Intermediate filament protein, coiled coil region	0.03339	Inherited
53300,53300 53300 - vWA-like 53300 - vWA-like	0.08753	Inherited
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.08995	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.3166	Inherited
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.5185	Inherited
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region	0.5526	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.5865	Inherited
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.7981	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57184,57581,57196 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0	Direct
141072,141072,141072 141072 - CalX-like 141072 - CalX-like 141072 - CalX-like	0	Direct
57184,57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	Direct
57184,57184,57581 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	Direct
57184,57581,57184 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	Direct
57581,57184,57581 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	Direct
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains	0.00531	Inherited
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.1376	Inherited
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0.1454	Inherited
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.1701	Inherited
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0.4121	Inherited
57184,57196,57184 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.4121	Inherited
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.8512	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Phenotypic Abnormality (PA): Abnormality of the lower limb

Superfamily

Family

Supra-domain (including individual superfamily)