Phenotypic Abnormality (PA): Abnormality of the upper limb

---

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children)	HP term [HP ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + 2:	Phenotypic abnormality [HP:0000118] <25>
+ 1:	Abnormality of limbs [HP:0040064] <8>	(58|66)	(63|33|25)
0:	Abnormality of the upper limb [HP:0002817] <20>	(29|35)	(35|17|16)
- 1:	Abnormality of the hand [HP:0001155] <26>	(22|27)	(27|15|14)
- 1:	Abnormality of upper limb epiphysis morphology [HP:0003839] <12>	(0|0)	(0|0|0)
- 1:	Abnormality of upper limb metaphysis [HP:0009809] <12>	(0|0)	(0|0|0)
- 1:	Abnormality of the musculature of the upper limbs [HP:0001446] <8>	(6|7)	(7|2|1)
- 1:	Aplasia/hypoplasia involving bones of the upper limbs [HP:0006496] <8>	(3|8)	(6|2|4)
- 1:	Abnormality of the forearm [HP:0002973] <7>	(4|4)	(5|2|1)
- 1:	Anomaly of the upper limb diaphyses [HP:0009808] <7>	(0|0)	(0|0|0)
- 1:	Abnormal upper limb bone morphology [HP:0040070] <5>	(5|4)	(6|2|1)
- 1:	Abnormality of upper limb joint [HP:0009810] <4>	(4|5)	(4|4|2)
- 1:	Abnormal arm span [HP:0012769] <2>	(0|0)	(0|0|0)
- 1:	Abnormality of the upper arm [HP:0001454] <2>	(0|0)	(0|0|0)
- 1:	Bowing of the arm [HP:0006488] <2>	(0|1)	(0|0|0)
- 1:	Upper limb asymmetry [HP:0100560] <2>	(0|0)	(0|0|0)
- 1:	Duplication of bones involving the upper extremities [HP:0009142] <1>	(2|1)	(2|1|0)
- 1:	Hypertrophy of the upper limb [HP:0010484] <1>	(0|0)	(0|0|0)
- 1:	Amniotic constriction rings of arms [HP:0010483]	(0|0)	(0|0|0)
- 1:	Areflexia of upper limbs [HP:0012046]	(0|0)	(0|0|0)
- 1:	Distal upper limb muscle weakness [HP:0008959]	(0|0)	(0|0|0)
- 1:	Edema of the upper limbs [HP:0010742]	(0|0)	(0|0|0)
- 1:	Hyporeflexia of upper limbs [HP:0012391]	(0|0)	(0|0|0)

---

Superfamily

Superfamily domains annotated to this HP term (SDHP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
RuvA domain 2-like	0	DIRECT
Plakin repeat	0	DIRECT
Smc hinge domain	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.002745	INHERITED FROM: Finger swelling
Arginase/deacetylase	0.04175	INHERITED FROM: Abnormality of the palm
Restriction endonuclease-like	0.04175	INHERITED FROM: Abnormal thumb morphology || Abnormality of the radius || Abnormality of forearm bone || Abnormality of the forearm
Insulin-like	0.04175	INHERITED FROM: Deviation of the hand or of fingers of the hand || Deviation of finger
EGF/Laminin	0.04682	INHERITED FROM: Palmar hyperhidrosis
ARID-like	0.05024	INHERITED FROM: Bilateral single transverse palmar creases || Abnormal 5th finger phalanx morphology || Aplasia/Hypoplasia of the distal phalanges of the hand || Aplasia/Hypoplasia of the phalanges of the hand || Abnormal distal phalanx morphology of finger || Elbow dislocation || Aplasia/hypoplasia involving bones of the hand || Aplasia/Hypoplasia of fingers || Abnormality of the palm || Abnormal hand morphology || Single transverse palmar crease || Abnormality of the distal phalanx of the 5th finger || Short finger || Abnormal palmar dermatoglyphics || Short distal phalanx of finger || Aplasia/Hypoplasia of the distal phalanx of the 5th finger || Abnormality of the palmar creases || Short phalanx of finger
Tropomyosin	0.05065	INHERITED FROM: Abnormality of the shoulder girdle musculature || Elbow flexion contracture || Scapular winging
SET domain	0.0544	INHERITED FROM: Radioulnar synostosis
Calponin-homology domain, CH-domain	0.0544	INHERITED FROM: Scapular winging
Multidrug efflux transporter AcrB transmembrane domain	0.1018	INHERITED FROM: Aplasia/Hypoplasia of the distal phalanges of the hand || Aplasia/Hypoplasia of the phalanges of the hand || Abnormal distal phalanx morphology of finger || Short finger || Short distal phalanx of finger || Short phalanx of finger
HLH, helix-loop-helix DNA-binding domain	0.1172	INHERITED FROM: Abnormality of the phalanges of the 2nd finger
WD40 repeat-like	0.1433	INHERITED FROM: Hand polydactyly
Prefoldin	0.1528	INHERITED FROM: Palmoplantar hyperkeratosis || Palmar hyperkeratosis
Myosin rod fragments	0.1712	INHERITED FROM: Scapular winging
Intermediate filament protein, coiled coil region	0.2502	INHERITED FROM: Abnormality of the palm || Palmar hyperkeratosis
HMG-box	0.2626	INHERITED FROM: Abnormality of the distal phalanx of the 5th finger || Aplasia/Hypoplasia of the distal phalanx of the 5th finger
Metalloproteases ("zincins"), catalytic domain	0.2847	INHERITED FROM: Broad metacarpals
Cystine-knot cytokines	0.2847	INHERITED FROM: Abnormality of the middle phalanx of the 5th finger || Abnormal middle phalanx morphology of the hand || Aplasia/Hypoplasia of the middle phalanges of the hand
GroEL equatorial domain-like	0.3329	INHERITED FROM: Hand polydactyly || Postaxial hand polydactyly || Duplication of phalanx of hand
p53-like transcription factors	0.4031	INHERITED FROM: Absent hand
Histone-fold	0.4159	INHERITED FROM: Abnormality of the ulna || Abnormality of the radius || Synostosis involving bones of the upper limbs
BRK domain-like	0.4159	INHERITED FROM: Abnormality of the palm
UDP-Glycosyltransferase/glycogen phosphorylase	0.4223	INHERITED FROM: Scapular winging
vWA-like	0.5394	INHERITED FROM: Increased laxity of fingers || Finger joint hypermobility || Abnormality of hand joint mobility
Neurotransmitter-gated ion-channel transmembrane pore	0.8378	INHERITED FROM: Weakness of the intrinsic hand muscles || Weakness of long finger extensor muscles || Triceps weakness || Abnormality of the musculature of the hand || Hand muscle weakness || Shoulder girdle muscle weakness
Nicotinic receptor ligand binding domain-like	0.8378	INHERITED FROM: Weakness of the intrinsic hand muscles || Weakness of long finger extensor muscles || Triceps weakness || Abnormality of the musculature of the hand || Hand muscle weakness || Shoulder girdle muscle weakness

---

Family

Family domains annotated to this HP term (Not in SDHP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Proteasome subunits	0	DIRECT
Smc hinge domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Plakin repeat	0	DIRECT
Exostosin	0	DIRECT
Erythroid transcription factor GATA-1	0.001446	INHERITED FROM: Abnormality of finger || Clinodactyly of the 5th finger || Finger clinodactyly || Abnormality of the hand
Insulin-like	0.0288	INHERITED FROM: Deviation of the hand or of fingers of the hand || Deviation of finger
Tropomyosin	0.03523	INHERITED FROM: Abnormality of the shoulder girdle musculature || Elbow flexion contracture || Scapular winging
ARID domain	0.03525	INHERITED FROM: Aplasia/hypoplasia involving bones of the upper limbs || Bilateral single transverse palmar creases || Abnormal 5th finger phalanx morphology || Aplasia/Hypoplasia of the distal phalanges of the hand || Aplasia/Hypoplasia of the phalanges of the hand || Abnormal distal phalanx morphology of finger || Elbow dislocation || Aplasia/hypoplasia involving bones of the hand || Aplasia/Hypoplasia of fingers || Abnormality of the palm || Abnormal hand morphology || Single transverse palmar crease || Abnormality of the distal phalanx of the 5th finger || Short finger || Abnormal palmar dermatoglyphics || Short distal phalanx of finger || Aplasia/Hypoplasia of the distal phalanx of the 5th finger || Abnormality of upper limb joint || Abnormality of the palmar creases || Short phalanx of finger
Calponin-homology domain, CH-domain	0.04035	INHERITED FROM: Scapular winging
Transforming growth factor (TGF)-beta	0.06753	INHERITED FROM: Short middle phalanx of finger || Abnormal middle phalanx morphology of the hand || Aplasia/Hypoplasia of the middle phalanges of the hand
HLH, helix-loop-helix DNA-binding domain	0.08347	INHERITED FROM: Abnormality of the phalanges of the 2nd finger
Classic zinc finger, C2H2	0.08348	INHERITED FROM: Hand polydactyly || Duplication of bones involving the upper extremities
Integrin A (or I) domain	0.08601	INHERITED FROM: Increased laxity of fingers || Adducted thumb || Finger joint hypermobility || Interphalangeal joint contracture of finger || Abnormality of hand joint mobility || Flexion contracture of finger || Abnormal phalangeal joint morphology of the hand
Growth factor receptor domain	0.1247	INHERITED FROM: Bowing of the arm
Laminin-type module	0.1406	INHERITED FROM: Palmar hyperhidrosis || Mitten deformity
Myosin rod fragments	0.1406	INHERITED FROM: Abnormality of the shoulder girdle musculature || Scapular winging
Actin/HSP70	0.1406	INHERITED FROM: Abnormality of finger
Intermediate filament protein, coiled coil region	0.1953	INHERITED FROM: Abnormality of the palm || Palmar hyperkeratosis
MIR domain	0.2106	INHERITED FROM: Abnormality of the musculature of the upper limbs
HMG-box	0.2245	INHERITED FROM: Abnormality of the distal phalanx of the 5th finger || Aplasia/Hypoplasia of the distal phalanx of the 5th finger
RecA protein-like (ATPase-domain)	0.2286	INHERITED FROM: Aplasia/Hypoplasia of the ulna || Hypoplasia of the ulna || Aplasia/Hypoplasia of the radius || Forearm undergrowth || Abnormality of thumb phalanx || Abnormal morphology of ulna || Triphalangeal thumb || Triangular shaped phalanges of the hand || Abnormal forearm bone morphology
I set domains	0.2714	INHERITED FROM: Aplasia of the phalanges of the hand || Aplasia involving bones of the upper limbs
VWC domain	0.2924	INHERITED FROM: Slender finger || Long fingers
TB module/8-cys domain	0.2924	INHERITED FROM: Abnormal thumb morphology
Filamin repeat (rod domain)	0.3741	INHERITED FROM: Abnormality of the musculature of the upper limbs
BRK domain-like	0.3741	INHERITED FROM: Aplasia/hypoplasia involving bones of the hand || Abnormality of the palm
Notch domain	0.3741	INHERITED FROM: Aplasia/hypoplasia involving bones of the hand
PHD domain	0.3864	INHERITED FROM: Radioulnar synostosis
Tyrosine-dependent oxidoreductases	0.4142	INHERITED FROM: Palmoplantar hyperkeratosis
Homeodomain	0.4516	INHERITED FROM: Aplasia/Hypoplasia of the 2nd finger
Bromodomain	0.453	INHERITED FROM: Single transverse palmar crease
Neurotransmitter-gated ion-channel transmembrane pore	0.8108	INHERITED FROM: Weakness of the intrinsic hand muscles || Proximal muscle weakness in upper limbs || Weakness of long finger extensor muscles || Triceps weakness || Abnormality of the musculature of the hand || Hand muscle weakness || Shoulder girdle muscle weakness
Nicotinic receptor ligand binding domain-like	0.8108	INHERITED FROM: Weakness of the intrinsic hand muscles || Proximal muscle weakness in upper limbs || Weakness of long finger extensor muscles || Triceps weakness || Abnormality of the musculature of the hand || Hand muscle weakness || Shoulder girdle muscle weakness

---

Supra-domain (including individual superfamily)

Supra-domains annotated to this HP term (Not in SPHO)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Smc hinge domain	0	DIRECT
Plakin repeat	0	DIRECT
RuvA domain 2-like	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.00158	INHERITED FROM: Finger swelling
Insulin-like	0.03011	INHERITED FROM: Deviation of the hand or of fingers of the hand || Deviation of finger
Restriction endonuclease-like	0.03011	INHERITED FROM: Abnormality of forearm bone || Abnormality of the forearm || Abnormality of the radius || Abnormal thumb morphology || Abnormal upper limb bone morphology
Arginase/deacetylase	0.03011	INHERITED FROM: Abnormality of the palm || Aplasia/hypoplasia involving bones of the hand
EGF/Laminin	0.03422	INHERITED FROM: Palmar hyperhidrosis
ARID-like	0.03702	INHERITED FROM: Short distal phalanx of finger || Elbow dislocation || Abnormality of the palmar creases || Abnormal palmar dermatoglyphics || Abnormality of upper limb joint || Aplasia/Hypoplasia of the distal phalanges of the hand || Bilateral single transverse palmar creases || Abnormal 5th finger phalanx morphology || Abnormality of the palm || Abnormal distal phalanx morphology of finger || Aplasia/Hypoplasia of fingers || Abnormal hand morphology || Short phalanx of finger || Aplasia/Hypoplasia of the distal phalanx of the 5th finger || Aplasia/Hypoplasia of the phalanges of the hand || Abnormality of the distal phalanx of the 5th finger || Aplasia/hypoplasia involving bones of the hand || Single transverse palmar crease || Short finger || Aplasia/hypoplasia involving bones of the upper limbs
Tropomyosin	0.03737	INHERITED FROM: Scapular winging || Abnormality of the shoulder girdle musculature || Elbow flexion contracture
Calponin-homology domain, CH-domain	0.0404	INHERITED FROM: Scapular winging
SET domain	0.0404	INHERITED FROM: Abnormality of the hand || Radioulnar synostosis
Nucleotide-diphospho-sugar transferases	0.0435	INHERITED FROM: Abnormality of the radius
Multidrug efflux transporter AcrB transmembrane domain	0.08007	INHERITED FROM: Short distal phalanx of finger || Aplasia/Hypoplasia of the distal phalanges of the hand || Abnormal distal phalanx morphology of finger || Aplasia/Hypoplasia of fingers || Short phalanx of finger || Aplasia/Hypoplasia of the phalanges of the hand || Short finger
HLH, helix-loop-helix DNA-binding domain	0.09316	INHERITED FROM: Abnormality of the phalanges of the 2nd finger
WD40 repeat-like	0.1165	INHERITED FROM: Duplication of bones involving the upper extremities || Hand polydactyly
Prefoldin	0.1248	INHERITED FROM: Palmar hyperkeratosis || Palmoplantar hyperkeratosis
Myosin rod fragments	0.141	INHERITED FROM: Scapular winging || Abnormality of the shoulder girdle musculature
Actin-like ATPase domain	0.1521	INHERITED FROM: Abnormality of the hand
Intermediate filament protein, coiled coil region	0.2135	INHERITED FROM: Abnormality of the palm || Palmar hyperkeratosis
MIR domain	0.2175	INHERITED FROM: Abnormality of the musculature of the upper limbs
HMG-box	0.2249	INHERITED FROM: Aplasia/Hypoplasia of the distal phalanx of the 5th finger || Abnormality of the distal phalanx of the 5th finger
Metalloproteases ("zincins"), catalytic domain	0.2459	INHERITED FROM: Broad metacarpals
Cystine-knot cytokines	0.2459	INHERITED FROM: Abnormal 5th finger phalanx morphology || Aplasia/Hypoplasia of the middle phalanges of the hand || Abnormality of the middle phalanx of the 5th finger || Abnormal middle phalanx morphology of the hand
TB module/8-cys domain	0.2916	INHERITED FROM: Abnormal thumb morphology
GroEL equatorial domain-like	0.2916	INHERITED FROM: Duplication of phalanx of hand || Postaxial hand polydactyly || Hand polydactyly
p53-like transcription factors	0.3597	INHERITED FROM: Absent hand
BRK domain-like	0.3722	INHERITED FROM: Abnormality of the palm || Aplasia/hypoplasia involving bones of the hand
Histone-fold	0.3722	INHERITED FROM: Abnormality of forearm bone || Abnormality of the ulna || Abnormality of the forearm || Abnormality of the radius || Synostosis involving bones of the upper limbs
Notch domain	0.3722	INHERITED FROM: Aplasia/hypoplasia involving bones of the hand
UDP-Glycosyltransferase/glycogen phosphorylase	0.3785	INHERITED FROM: Scapular winging
Bromodomain	0.4519	INHERITED FROM: Single transverse palmar crease
vWA-like	0.4954	INHERITED FROM: Increased laxity of fingers || Slender finger || Finger joint hypermobility || Abnormality of hand joint mobility
Nicotinic receptor ligand binding domain-like	0.8046	INHERITED FROM: Weakness of long finger extensor muscles || Weakness of the intrinsic hand muscles || Abnormality of the shoulder girdle musculature || Abnormality of the musculature of the hand || Shoulder girdle muscle weakness || Hand muscle weakness || Triceps weakness || Proximal muscle weakness in upper limbs
Neurotransmitter-gated ion-channel transmembrane pore	0.8046	INHERITED FROM: Weakness of long finger extensor muscles || Weakness of the intrinsic hand muscles || Abnormality of the shoulder girdle musculature || Abnormality of the musculature of the hand || Shoulder girdle muscle weakness || Hand muscle weakness || Triceps weakness || Proximal muscle weakness in upper limbs

Supra-domains annotated to this HP term (Not in SPHO)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
75399,75399 75399 - Plakin repeat 75399 - Plakin repeat	0	DIRECT
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	DIRECT
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP	0	DIRECT
57581,57184 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	DIRECT
46579,64593 46579 - Prefoldin 64593 - Intermediate filament protein, coiled coil region	0.03011	INHERITED FROM: Abnormality of the skin of the palm || Abnormality of the palm || Palmar hyperkeratosis || Palmoplantar hyperkeratosis
53300,53300 53300 - vWA-like 53300 - vWA-like	0.08007	INHERITED FROM: Increased laxity of fingers || Abnormality of the elbow || Interphalangeal joint contracture of finger || Elbow flexion contracture || Adducted thumb || Slender finger || Joint contracture of the hand || Finger joint hypermobility || Abnormal thumb morphology || Abnormality of hand joint mobility || Limited elbow movement || Abnormal phalangeal joint morphology of the hand || Camptodactyly of finger || Flexion contracture of finger
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.08573	INHERITED FROM: Short phalanx of finger || Short finger
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.1001	INHERITED FROM: Interphalangeal joint contracture of finger || Mitten deformity || Palmar hyperhidrosis
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.1494	INHERITED FROM: Elbow ankylosis
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.2587	INHERITED FROM: Duplication of bones involving the upper extremities || Hand polydactyly
57581,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0.2916	INHERITED FROM: Abnormal thumb morphology
57196,57581 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.2916	INHERITED FROM: Abnormal thumb morphology
81296,81296 81296 - E set domains 81296 - E set domains	0.2916	INHERITED FROM: Abnormality of forearm bone || Abnormality of the ulna || Abnormality of the radius || Aplasia/Hypoplasia involving the metacarpal bones || Abnormal metacarpal morphology || Abnormality of the musculature of the upper limbs
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0.3722	INHERITED FROM: Short phalanx of finger || Aplasia/Hypoplasia of the phalanges of the hand
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin	0.3722	INHERITED FROM: Abnormal thumb morphology
50729,50729 50729 - PH domain-like 50729 - PH domain-like	0.6425	INHERITED FROM: Interphalangeal joint contracture of finger || Camptodactyly of finger
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.8046	INHERITED FROM: Weakness of long finger extensor muscles || Weakness of the intrinsic hand muscles || Abnormality of the shoulder girdle musculature || Abnormality of the musculature of the hand || Shoulder girdle muscle weakness || Hand muscle weakness || Triceps weakness || Proximal muscle weakness in upper limbs

Supra-domains annotated to this HP term (Not in SPHO)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,57581,57196 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0	DIRECT
57196,57196,57581 57196 - EGF/Laminin 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0	DIRECT
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0	DIRECT
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	DIRECT
57184,57581,57184 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	DIRECT
57196,57581,57184 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	DIRECT
57581,57184,57581 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	DIRECT
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.03737	INHERITED FROM: Clubbing of fingers || Abnormal fingertip morphology
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.1107	INHERITED FROM: Short phalanx of finger || Short finger
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.1186	INHERITED FROM: Elbow ankylosis
57581,57196,57581 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.2916	INHERITED FROM: Abnormal thumb morphology
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains	0.2916	INHERITED FROM: Abnormality of forearm bone || Abnormality of the ulna || Abnormality of the radius || Aplasia/Hypoplasia involving the metacarpal bones || Abnormal metacarpal morphology || Abnormality of the musculature of the upper limbs
57581,57196,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0.2916	INHERITED FROM: Abnormal thumb morphology
57184,57196,57184 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.3722	INHERITED FROM: Abnormality of the elbow
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin	0.3722	INHERITED FROM: Abnormal thumb morphology
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.5181	INHERITED FROM: Mitten deformity || Palmar hyperhidrosis