Phenotypic Abnormality (PA): Abnormal circulating hormone level

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children)	HP term [HP ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + 2:	Phenotypic abnormality [HP:0000118] <25>
+ 1:	Abnormality of the endocrine system [HP:0000818] <16>	(28|35)	(35|13|5)
0:	Abnormal circulating hormone level [HP:0003117] <28>	(4|9)	(6|4|1)
- 1:	Abnormal calcium-phosphate regulating hormone level [HP:0100530] <4>	(0|0)	(0|0|0)
- 1:	Abnormal circulating androgen level [HP:0030347] <4>	(0|0)	(0|0|0)
- 1:	Abnormal circulating gonadotropin level [HP:0030338] <4>	(0|0)	(0|0|0)
- 1:	Abnormal circulating estrogen level [HP:0025132] <3>	(0|0)	(1|0|0)
- 1:	Abnormal circulating progesterone level [HP:0031212] <3>	(1|1)	(1|0|0)
- 1:	Abnormal thyroid hormone level [HP:0031508] <3>	(0|0)	(0|0|0)
- 1:	Abnormal adiponectin level [HP:0030684] <2>	(0|0)	(0|0|0)
- 1:	Abnormal antimullerian hormone level [HP:0031101] <2>	(0|0)	(0|0|0)
- 1:	Abnormal circulating osteocalcin level [HP:0031427] <2>	(0|0)	(0|0|0)
- 1:	Abnormal glucagon level [HP:0030687] <2>	(0|0)	(0|0|0)
- 1:	Abnormal growth hormone level [HP:0032367] <2>	(1|1)	(1|0|0)
- 1:	Abnormal pituitary glycoprotein hormone alpha subunit level [HP:0032481] <2>	(0|0)	(0|0|0)
- 1:	Abnormal serum insulin-like growth factor 1 level [HP:0030352] <2>	(0|0)	(0|0|0)
- 1:	Abnormality of circulating adrenocorticotropin level [HP:0011043] <2>	(2|2)	(2|0|0)
- 1:	Abnormality of circulating glucocorticoid level [HP:0012111] <2>	(0|0)	(1|0|0)
- 1:	Abnormality of circulating leptin level [HP:0004361] <2>	(0|0)	(0|0|0)
- 1:	Abnormality of gonadotropin-releasing hormone level [HP:0500012] <2>	(0|0)	(0|0|0)
- 1:	Abnormal circulating gastrin level [HP:0500166] <1>	(0|0)	(0|0|0)
- 1:	Abnormal circulating inhibin level [HP:0031099] <1>	(0|0)	(0|0|0)
- 1:	Abnormal insulin level [HP:0040214] <1>	(0|0)	(0|0|0)
- 1:	Abnormality of circulating catecholamine level [HP:0012099] <1>	(0|0)	(0|0|0)
- 1:	Abnormality of circulating pregnenolone level [HP:0031187]	(0|0)	(0|0|0)
- 1:	Decreased circulating dehydroepiandrosterone level [HP:0031214]	(0|0)	(0|0|0)
- 1:	Decreased circulating dehydroepiandrosterone-sulfate level [HP:0031215]	(0|0)	(0|0|0)
- 1:	Elevated vascular endothelial growth factor level [HP:0031052]	(0|0)	(0|0|0)
- 1:	Fasting hypoglycemia [HP:0003162]	(0|0)	(0|0|0)
- 1:	Increased serum 1,25-dihydroxyvitamin D3 [HP:0003152]	(0|0)	(0|0|0)
- 1:	Increased serum serotonin [HP:0003144]	(0|0)	(0|0|0)

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Superfamily

Superfamily domains annotated to this HP term (Not in SDHP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Nuclear receptor ligand-binding domain	0.0006122	DIRECT
NagB/RpiA/CoA transferase-like	0.0583	INHERITED FROM: Abnormal circulating progesterone level
Cytochrome P450	0.07878	INHERITED FROM: Increased circulating ACTH level
Homeodomain-like	0.1751	INHERITED FROM: Decreased circulating ACTH level || Pituitary dwarfism

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Family

Family domains annotated to this HP term (SDHP level: Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
IF2B-like	0	DIRECT
Acetylcholinesterase-like	0.00008508	DIRECT
PDEase	0.000171	DIRECT
Nuclear receptor ligand-binding domain	0.0003603	DIRECT
GAF domain	0.0007176	DIRECT
Hypoxia-inducible factor Hif2a, C-terminal domain	0.0007176	DIRECT
Nuclear receptor	0.0008326	DIRECT
Cytochrome P450	0.05948	INHERITED FROM: Increased circulating ACTH level
Homeodomain	0.1358	INHERITED FROM: Decreased circulating ACTH level || Pituitary dwarfism

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Supra-domain (including individual superfamily)

Supra-domains annotated to this HP term (SPHO level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nuclear receptor ligand-binding domain	0.0003135	DIRECT
GAF domain-like	0.0006068	DIRECT
NagB/RpiA/CoA transferase-like	0.04361	INHERITED FROM: Abnormal circulating progesterone level
Cytochrome P450	0.06057	INHERITED FROM: Abnormality of circulating cortisol level || Increased circulating ACTH level
Homeodomain-like	0.1444	INHERITED FROM: Abnormal growth hormone level || Decreased circulating ACTH level || Pituitary dwarfism
Cystine-knot cytokines	0.2542	INHERITED FROM: Decreased serum estradiol

Supra-domains annotated to this HP term (SPHO level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.000497	DIRECT
55781,109604 55781 - GAF domain-like 109604 - HD-domain/PDEase-like	0.0006068	DIRECT
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain)	0.0006068	DIRECT
55781,55781 55781 - GAF domain-like 55781 - GAF domain-like	0.0006068	DIRECT

Supra-domains annotated to this HP term (SPHO level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
55781,55781,109604 55781 - GAF domain-like 55781 - GAF domain-like 109604 - HD-domain/PDEase-like	0.0006068	DIRECT