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Phenotypic Abnormality (PA): Elevated serum creatine kinase

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Phenotypic abnormality [HP:0000118] <25>
+ + + + + 5:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(75|82) (79|40|16)
+ + + + 4:   Abnormal circulating metabolite concentration [HP:0032180] <12>(30|31) (31|14|4)
+ + + 3:   Abnormal circulating protein level [HP:0010876] <41>(3|9) (4|5|2)
+ + 2:   Abnormality of circulating enzyme level [HP:0011021] <1>(1|7) (1|3|2)
+ 1:   Abnormal circulating creatine kinase concentration [HP:0040081] <4>(1|7) (1|3|2)
0:   Elevated serum creatine kinase [HP:0003236] <4>(1|7) (1|3|2)
- 1:   Elevated creatine kinase after exercise [HP:0008331](0|0) (0|0|0)
- 1:   Extremely elevated creatine kinase [HP:0030235](0|0) (0|0|0)
- 1:   Highly elevated creatine kinase [HP:0030234](0|0) (0|0|0)
- 1:   Mildly elevated creatine kinase [HP:0008180](0|0) (0|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Tropomyosin0.0006906Direct


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
LIM domain0.00001781Direct
Tropomyosin0.0003315Direct
FAD/NAD-linked reductases, N-terminal and central domains0.0005435Direct
Inositol polyphosphate 5-phosphatase (IPP5)0.0005435Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0006514Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0006514Direct
Canonical RBD0.0008646Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Tropomyosin0.0003562Direct

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.00003737Direct
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.0005728Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0007786Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0000002693Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0004986Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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