Phenotypic Abnormality (PA): Abnormality of mitochondrial metabolism

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children)	HP term [HP ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + + 4:	Phenotypic abnormality [HP:0000118] <25>
+ + + 3:	Abnormal cellular phenotype [HP:0025354] <3>	(10|10)	(13|3|0)
+ + + 3:	Abnormality of metabolism/homeostasis [HP:0001939] <16>	(75|82)	(79|40|16)
+ + 2:	Abnormal cellular physiology [HP:0011017] <16>	(10|10)	(13|3|0)
+ 1:	Abnormality of the mitochondrion [HP:0012103] <2>	(5|3)	(7|1|0)
0:	Abnormality of mitochondrial metabolism [HP:0003287] <14>	(5|3)	(7|1|0)
- 1:	Abnormal activity of mitochondrial respiratory chain [HP:0011922] <2>	(0|0)	(0|0|0)
- 1:	Decreased plasma carnitine [HP:0003234] <2>	(2|2)	(2|1|0)
- 1:	3-Methylglutaconic aciduria [HP:0003535] <1>	(0|0)	(0|0|0)
- 1:	Abnormal iron deposition in mitochondria [HP:0008306]	(0|0)	(0|0|0)
- 1:	Abnormal mitochondria in muscle tissue [HP:0008316]	(0|0)	(0|0|0)
- 1:	Decreased activity of 3-hydroxyacyl-CoA dehydrogenase [HP:0100950]	(0|0)	(0|0|0)
- 1:	Decreased activity of the pyruvate dehydrogenase complex [HP:0002928]	(0|0)	(0|0|0)
- 1:	Deficiency or absence of cytochrome b(-245) [HP:0003514]	(0|0)	(0|0|0)
- 1:	Electron transfer flavoprotein-ubiquinone oxidoreductase defect [HP:0003647]	(0|0)	(0|0|0)
- 1:	Mitochondrial depletion [HP:0030059]	(0|0)	(0|0|0)
- 1:	Mitochondrial lysine transport defect [HP:0008265]	(0|0)	(0|0|0)
- 1:	Mitochondrial malic enzyme reduced [HP:0003232]	(0|0)	(0|0|0)
- 1:	Mitochondrial propionyl-CoA carboxylase defect [HP:0003288]	(0|0)	(0|0|0)
- 1:	Mitochondrial respiratory chain defects [HP:0200125]	(0|0)	(0|0|0)

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Superfamily

Superfamily domains annotated to this HP term (Not in SDHP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Acyl-CoA dehydrogenase C-terminal domain-like	0.000004691	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0.000004691	DIRECT
4Fe-4S ferredoxins	0.00001544	DIRECT
ClpP/crotonase	0.0002091	DIRECT
Adenine nucleotide alpha hydrolases-like	0.000359	DIRECT

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Family

Family domains annotated to this HP term (SDHP level: Highly Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0.0000003674	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0.0000003674	DIRECT
Crotonase-like	0.00008135	DIRECT

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Supra-domain (including individual superfamily)

Supra-domains annotated to this HP term (SPHO level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Acyl-CoA dehydrogenase NM domain-like	0.00000193	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0.00000193	DIRECT
4Fe-4S ferredoxins	0.000006619	DIRECT
ClpP/crotonase	0.0001007	DIRECT
Adenine nucleotide alpha hydrolases-like	0.0001782	DIRECT
CoA-dependent acyltransferases	0.0005481	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0.0009927	DIRECT

Supra-domains annotated to this HP term (SPHO level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0.00000193	DIRECT