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Phenotypic Abnormality (PA): Aplasia/Hypoplasia of the cerebrum

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Phenotypic abnormality [HP:0000118] <25>
+ + + + 4:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
+ + + 3:   Abnormality of nervous system morphology [HP:0012639] <5>(69|97) (79|52|16)
+ + + 3:   Abnormality of brain morphology [HP:0012443] <13>(43|63) (53|34|15)
+ + 2:   Morphological abnormality of the central nervous system [HP:0002011] <17>(60|85) (69|44|16)
+ + 2:   Abnormality of forebrain morphology [HP:0100547] <6>(26|32) (30|18|5)
+ 1:   Aplasia/Hypoplasia involving the central nervous system [HP:0002977] <13>(19|26) (23|13|3)
+ 1:   Abnormality of the cerebrum [HP:0002060] <16>(25|31) (29|18|5)
0:   Aplasia/Hypoplasia of the cerebrum [HP:0007364] <5>(13|19) (14|7|1)
- 1:   Anencephaly [HP:0002323] <2>(0|1) (0|0|0)
- 1:   Aplasia/Hypoplasia of the corpus callosum [HP:0007370] <2>(5|6) (5|2|0)
- 1:   Cerebral hypoplasia [HP:0006872] <2>(0|0) (0|0|0)
- 1:   Microcephaly [HP:0000252] <2>(7|12) (8|5|1)
- 1:   Aprosencephaly [HP:0007268](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Restriction endonuclease-like0Direct
Pseudouridine synthase0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
ARID-like0.004562Inherited
Periplasmic binding protein-like II0.00734Inherited
Ribonuclease H-like0.04568Inherited
Nucleotidylyl transferase0.2008Inherited
Class II aaRS and biotin synthetases0.2324Inherited
Homeodomain-like0.2545Inherited
NagB/RpiA/CoA transferase-like0.4031Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin domains from multidomain proteins0Direct
N-acetyl transferase, NAT0Direct
Clathrin adaptor core protein0Direct
SWIRM domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
Exostosin0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
IF2B-like0Direct
Phosphate binding protein-like0.00113Inherited
ARID domain0.002226Inherited
Bromodomain0.002594Inherited
Ypt/Rab-GAP domain of gyp1p0.02Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.07554Inherited
PHD domain0.1449Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.1725Inherited
Elongation factors0.1787Inherited
T-box0.2208Inherited
Homeodomain0.3325Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Acyl-CoA N-acyltransferases (Nat)0Direct
Pseudouridine synthase0Direct
Restriction endonuclease-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
ARID-like0.002752Inherited
Bromodomain0.003719Inherited
Periplasmic binding protein-like II0.004615Inherited
Ribonuclease H-like0.03332Inherited
Nucleotidylyl transferase0.168Inherited
Class II aaRS and biotin synthetases0.197Inherited
Homeodomain-like0.2173Inherited
NagB/RpiA/CoA transferase-like0.3597Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.02282Inherited
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.05559Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.1962Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)