Phenotypic Abnormality (PA): Abnormality of skin morphology

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + 3: Phenotypic abnormality [HP:0000118] <25>

+ + 2: Abnormality of the integument [HP:0001574] <4> (48|69) (59|37|15)

+ 1: Abnormality of the skin [HP:0000951] <4> (34|55) (45|36|12)

0: Abnormality of skin morphology [HP:0011121] <22> (29|49) (40|31|11)

- 1: Localized skin lesion [HP:0011355] <29> (12|20) (18|10|6)

- 1: Abnormality of skin pigmentation [HP:0001000] <17> (2|8) (4|2|0)

- 1: Generalized abnormality of skin [HP:0011354] <12> (8|12) (12|4|1)

- 1: Regional abnormality of skin [HP:0011356] <11> (6|9) (8|5|1)

- 1: Abnormality of epidermal morphology [HP:0011124] <5> (1|1) (1|0|0)

- 1: Abnormal blistering of the skin [HP:0008066] <4> (3|2) (3|3|1)

- 1: Abnormal cutaneous elastic fiber morphology [HP:0025082] <4> (0|0) (0|0|0)

- 1: Abnormal dermoepidermal junction morphology [HP:0031538] <4> (0|0) (0|0|0)

- 1: Thickened skin [HP:0001072] <4> (3|6) (3|6|2)

- 1: Abnormal elasticity of skin [HP:0010647] <3> (0|2) (0|1|0)

- 1: Abnormal cutaneous collagen fibril morphology [HP:0031512] <2> (0|0) (0|0|0)

- 1: Lichenification [HP:0100725] <1> (1|0) (1|0|0)

- 1: Pallor [HP:0000980] <1> (1|1) (1|0|0)

- 1: Dermal translucency [HP:0010648] (0|0) (0|0|0)

- 1: Dry skin [HP:0000958] (0|0) (0|0|0)

- 1: Elevated dermal desmosine content [HP:0025083] (0|0) (0|0|0)

- 1: Flaky paint dermatosis [HP:0032178] (0|0) (0|0|0)

- 1: Keratosis pilaris [HP:0032152] (1|1) (1|0|0)

- 1: Maceration [HP:0032007] (0|0) (0|0|0)

- 1: Ochronosis [HP:0030764] (0|0) (0|0|0)

- 1: Poikiloderma [HP:0001029] (0|0) (0|0|0)

- 1: Stiff skin [HP:0030053] (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Notch domain	0	Direct
Tricorn protease domain 2	0	Direct
DHS-like NAD/FAD-binding domain	0	Direct
RuvA domain 2-like	0	Direct
Plakin repeat	0	Direct
Isocitrate/Isopropylmalate dehydrogenase-like	0	Direct
Integrin beta tail domain	0	Direct
SAND domain-like	0	Direct
Apolipoprotein A-I	0	Direct
Zn-finger domain of Sec23/24	0	Direct
ABC transporter transmembrane region	0.002587	Inherited
Intermediate filament protein, coiled coil region	0.009743	Inherited
DNA/RNA polymerases	0.01182	Inherited
Integrin domains	0.02131	Inherited
Globin-like	0.02357	Inherited
Spectrin repeat	0.02377	Inherited
EGF/Laminin	0.03016	Inherited
ARID-like	0.1158	Inherited
Prefoldin	0.1295	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.1784	Inherited
Nicotinic receptor ligand binding domain-like	0.1784	Inherited
FnI-like domain	0.3326	Inherited
Complement control module/SCR domain	0.5623	Inherited
HMG-box	0.5623	Inherited
(Trans)glycosidases	0.5908	Inherited
RNI-like	0.6836	Inherited
alpha/beta-Hydrolases	0.9787	Inherited
Immunoglobulin	1	Inherited
DEATH domain	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Zn-finger domain of Sec23/24	0	Direct
Proteasome subunits	0	Direct
alpha-Amylases, C-terminal beta-sheet domain	0	Direct
Apolipoprotein A-I	0	Direct
Integrin beta EGF-like domains	0	Direct
ets domain	0	Direct
Notch domain	0	Direct
XPF/Rad1/Mus81 nuclease	0	Direct
Histone deacetylase, HDAC	0	Direct
Plakin repeat	0	Direct
Exostosin	0	Direct
Ferredoxin reductase FAD-binding domain-like	0	Direct
Dimeric isocitrate & isopropylmalate dehydrogenases	0	Direct
Integrin beta tail domain	0	Direct
Integrin A (or I) domain	0.0002324	Direct
Intermediate filament protein, coiled coil region	0.008429	Inherited
GLA-domain	0.008841	Inherited
Integrin domains	0.01691	Inherited
Globins	0.01837	Inherited
DnaQ-like 3'-5' exonuclease	0.01837	Inherited
Spectrin repeat	0.0197	Inherited
EGF-type module	0.03795	Inherited
C-terminal, gelsolin-like domain of Sec23/24	0.07295	Inherited
Helical domain of Sec23/24	0.07295	Inherited
beta-sandwich domain of Sec23/24	0.07295	Inherited
Trunk domain of Sec23/24	0.07295	Inherited
ARID domain	0.1003	Inherited
Ras-binding domain, RBD	0.1003	Inherited
Histone lysine methyltransferases	0.1214	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.166	Inherited
Nicotinic receptor ligand binding domain-like	0.166	Inherited
Laminin-type module	0.1815	Inherited
VWC domain	0.1834	Inherited
G proteins	0.2216	Inherited
RecA protein-like (ATPase-domain)	0.2673	Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.2777	Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)	0.404	Inherited
PHD domain	0.4954	Inherited
Tyrosine-dependent oxidoreductases	0.523	Inherited
Complement control module/SCR domain	0.523	Inherited
HMG-box	0.523	Inherited
Bromodomain	0.5825	Inherited
DEATH domain, DD	0.6502	Inherited
Erythroid transcription factor GATA-1	0.6874	Inherited
Ngr ectodomain-like	0.812	Inherited
MHC antigen-recognition domain	0.9121	Inherited
V set domains (antibody variable domain-like)	0.913	Inherited
TNF receptor-like	0.9517	Inherited
C1 set domains (antibody constant domain-like)	1	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
DHS-like NAD/FAD-binding domain	0	Direct
Notch domain	0	Direct
Plakin repeat	0	Direct
Isocitrate/Isopropylmalate dehydrogenase-like	0	Direct
Tricorn protease domain 2	0	Direct
RuvA domain 2-like	0	Direct
SAND domain-like	0	Direct
Apolipoprotein A-I	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Integrin beta tail domain	0	Direct
ABC transporter transmembrane region	0.00148	Inherited
Intermediate filament protein, coiled coil region	0.006255	Inherited
GLA-domain	0.007694	Inherited
DNA/RNA polymerases	0.007694	Inherited
Integrin domains	0.01457	Inherited
Globin-like	0.01626	Inherited
Spectrin repeat	0.01639	Inherited
EGF/Laminin	0.02116	Inherited
Helical domain of Sec23/24	0.06681	Inherited
C-terminal, gelsolin-like domain of Sec23/24	0.06681	Inherited
ARID-like	0.09182	Inherited
Prefoldin	0.1042	Inherited
Nicotinic receptor ligand binding domain-like	0.1474	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.1474	Inherited
4-helical cytokines	0.237	Inherited
FnI-like domain	0.2913	Inherited
Adenine nucleotide alpha hydrolases-like	0.3821	Inherited
Protein kinase-like (PK-like)	0.4458	Inherited
Nucleotide-diphospho-sugar transferases	0.4923	Inherited
HMG-box	0.5189	Inherited
Complement control module/SCR domain	0.5189	Inherited
(Trans)glycosidases	0.5479	Inherited
Bromodomain	0.5782	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.6158	Inherited
RNI-like	0.6443	Inherited
MHC antigen-recognition domain	0.901	Inherited
L domain-like	0.9402	Inherited
alpha/beta-Hydrolases	0.956	Inherited
Immunoglobulin	0.9898	Inherited
DEATH domain	0.998	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
75399,75399 75399 - Plakin repeat 75399 - Plakin repeat	0	Direct
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases	0	Direct
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	Direct
57424,50494 57424 - LDL receptor-like module 50494 - Trypsin-like serine proteases	0	Direct
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	Direct
103473,100895 103473 - MFS general substrate transporter 100895 - Kazal-type serine protease inhibitors	0	Direct
49265,53300 49265 - Fibronectin type III 53300 - vWA-like	0	Direct
64268,50044 64268 - PX domain 50044 - SH3-domain	0	Direct
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0	Direct
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0	Direct
53300,49265 53300 - vWA-like 49265 - Fibronectin type III	0	Direct
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain	0	Direct
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0	Direct
53300,69179 53300 - vWA-like 69179 - Integrin domains	0	Direct
57184,49899 57184 - Growth factor receptor domain 49899 - Concanavalin A-like lectins/glucanases	0	Direct
46579,64593 46579 - Prefoldin 64593 - Intermediate filament protein, coiled coil region	0	Direct
90123,52540 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.00148	Inherited
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region	0.02014	Inherited
53300,53300 53300 - vWA-like 53300 - vWA-like	0.03313	Inherited
47986,52540 47986 - DEATH domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.03313	Inherited
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.04489	Inherited
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0.06681	Inherited
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0.09182	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.1066	Inherited
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.112	Inherited
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.1474	Inherited
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.4424	Inherited
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.5479	Inherited
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.901	Inherited
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.9202	Inherited
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.989	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0	Direct
57424,57424,50494 57424 - LDL receptor-like module 57424 - LDL receptor-like module 50494 - Trypsin-like serine proteases	0	Direct
57196,57196,90193 57196 - EGF/Laminin 57196 - EGF/Laminin 90193 - Notch domain	0	Direct
49265,49265,53300 49265 - Fibronectin type III 49265 - Fibronectin type III 53300 - vWA-like	0	Direct
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0	Direct
57184,49899,49899 57184 - Growth factor receptor domain 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	Direct
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.003641	Inherited
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.03561	Inherited
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.1042	Inherited
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.1417	Inherited
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.2597	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Phenotypic Abnormality (PA): Abnormality of skin morphology

Superfamily

Family

Supra-domain (including individual superfamily)