Phenotypic Abnormality (PA): Abnormality of cranial sutures

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children)	HP term [HP ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + + + + 6:	Abnormality of the skeletal system [HP:0000924] <7>	(88|98)	(93|55|34)
+ + + + + + 6:	Phenotypic abnormality [HP:0000118] <25>
+ + + + + 5:	Abnormality of skeletal morphology [HP:0011842] <17>	(86|89)	(90|52|33)
+ + + + + 5:	Abnormality of head or neck [HP:0000152] <2>	(86|104)	(97|58|38)
+ + + + 4:	Abnormal axial skeleton morphology [HP:0009121] <6>	(47|61)	(51|30|26)
+ + + + 4:	Abnormality of the head [HP:0000234] <6>	(85|102)	(96|57|38)
+ + + 3:	Abnormal skull morphology [HP:0000929] <14>	(25|38)	(28|22|20)
+ + 2:	Abnormality of the calvaria [HP:0002683] <7>	(8|15)	(8|6|6)
+ 1:	Abnormality of the fontanelles or cranial sutures [HP:0000235] <2>	(6|6)	(6|2|1)
0:	Abnormality of cranial sutures [HP:0011329] <10>	(5|5)	(5|2|1)
- 1:	Craniosynostosis [HP:0001363] <5>	(0|0)	(0|0|0)
- 1:	Abnormality of the metopic suture [HP:0005556] <4>	(1|0)	(1|1|0)
- 1:	Delayed cranial suture closure [HP:0000270] <1>	(0|0)	(0|0|0)
- 1:	Wide cranial sutures [HP:0010537] <1>	(0|0)	(0|0|0)
- 1:	Accessory cranial suture [HP:0012800]	(0|0)	(0|0|0)
- 1:	Ridged cranial sutures [HP:0010823]	(0|0)	(0|0|0)
- 1:	Sclerotic cranial sutures [HP:0005441]	(0|0)	(0|0|0)
- 1:	Widely patent coronal suture [HP:0005442]	(0|0)	(0|0|0)
- 1:	Widely patent sagittal suture [HP:0005476]	(0|0)	(0|0|0)
- 1:	Wormian bones [HP:0002645]	(0|0)	(0|0|0)

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Superfamily

Superfamily domains annotated to this HP term (Not in SDHP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Notch domain	0.000282	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0.000282	DIRECT
Helical domain of Sec23/24	0.000282	DIRECT
beta-sandwich domain of Sec23/24	0.0006906	DIRECT
Actin-like ATPase domain	0.7728	INHERITED FROM: Prominent metopic ridge

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Family

Family domains annotated to this HP term (SDHP level: Highly Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
C-terminal, gelsolin-like domain of Sec23/24	0.0001513	DIRECT
Helical domain of Sec23/24	0.0001513	DIRECT
Notch domain	0.0001513	DIRECT
beta-sandwich domain of Sec23/24	0.0001513	DIRECT
Trunk domain of Sec23/24	0.0001513	DIRECT

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Supra-domain (including individual superfamily)

Supra-domains annotated to this HP term (SPHO level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Notch domain	0.0001383	DIRECT
Helical domain of Sec23/24	0.0001383	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0.0001383	DIRECT
beta-sandwich domain of Sec23/24	0.0003562	DIRECT
Actin-like ATPase domain	0.7361	INHERITED FROM: Prominent metopic ridge

Supra-domains annotated to this HP term (SPHO level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0.0001383	DIRECT
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.7361	INHERITED FROM: Prominent metopic ridge

Supra-domains annotated to this HP term (SPHO level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57184,57196,57184 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.0001383	DIRECT