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Phenotypic Abnormality (PA): Localized skin lesion

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the integument [HP:0001574] <4>(48|69) (59|37|15)
+ + 2:   Abnormality of the skin [HP:0000951] <4>(34|55) (45|36|12)
+ 1:   Abnormality of skin morphology [HP:0011121] <22>(29|49) (40|31|11)
0:   Localized skin lesion [HP:0011355] <29>(12|20) (18|10|6)
- 1:   Nevus [HP:0003764] <12>(0|2) (1|0|0)
- 1:   Papule [HP:0200034] <10>(2|0) (2|1|0)
- 1:   Aplasia/Hypoplasia of the skin [HP:0008065] <8>(4|4) (5|2|1)
- 1:   Skin nodule [HP:0200036] <8>(0|3) (2|2|0)
- 1:   Xanthomatosis [HP:0000991] <7>(2|1) (2|0|0)
- 1:   Capillary malformation [HP:0025104] <5>(0|0) (0|0|0)
- 1:   Skin dimple [HP:0010781] <5>(0|1) (1|0|0)
- 1:   Skin pit [HP:0100276] <5>(0|2) (0|1|0)
- 1:   Atypical scarring of skin [HP:0000987] <4>(1|2) (1|1|1)
- 1:   Cutaneous cyst [HP:0025245] <4>(1|1) (1|0|0)
- 1:   Macule [HP:0012733] <4>(0|1) (0|0|0)
- 1:   Skin plaque [HP:0200035] <4>(2|2) (2|0|0)
- 1:   Skin ulcer [HP:0200042] <4>(0|2) (2|1|0)
- 1:   Hypopigmented skin patches [HP:0001053] <3>(0|0) (0|0|0)
- 1:   Cafe-au-lait spot [HP:0000957] <2>(0|3) (0|0|0)
- 1:   Comedo [HP:0025249] <2>(0|0) (0|0|0)
- 1:   Skin tags [HP:0010609] <1>(0|0) (0|0|0)
- 1:   Skin vesicle [HP:0200037] <1>(0|0) (0|0|0)
- 1:   Anetoderma [HP:0032026](0|0) (0|0|0)
- 1:   Annular cutaneous lesion [HP:0025528](0|0) (0|0|0)
- 1:   Lichenoid skin lesion [HP:0031452](0|0) (0|0|0)
- 1:   Milia [HP:0001056](0|1) (0|1|1)
- 1:   Molluscoid pseudotumors [HP:0000993](0|0) (0|0|0)
- 1:   Perioral radial furrowing [HP:0032099](0|0) (0|0|0)
- 1:   Rope sign [HP:0031924](0|0) (0|0|0)
- 1:   Serpiginous cutaneous lesion [HP:0025527](0|0) (0|0|0)
- 1:   Skin detachment [HP:0032156](0|0) (0|0|0)
- 1:   Skin erosion [HP:0200041](0|1) (0|1|1)
- 1:   Skin fissure [HP:0031057](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Plakin repeat0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Apolipoprotein A-I0Direct
FnI-like domain0.05034Inherited
DEATH domain0.1292Inherited
EGF/Laminin0.1653Inherited
RNI-like0.1795Inherited
DNA/RNA polymerases0.2022Inherited
Immunoglobulin0.3466Inherited
Intermediate filament protein, coiled coil region0.4634Inherited
alpha/beta-Hydrolases0.71Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
alpha-Amylases, C-terminal beta-sheet domain0Direct
Apolipoprotein A-I0Direct
Notch domain0Direct
Plakin repeat0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
VWC domain0.01737Inherited
TNF receptor-like0.03361Inherited
G proteins0.05012Inherited
RecA protein-like (ATPase-domain)0.07499Inherited
C1 set domains (antibody constant domain-like)0.07749Inherited
MHC antigen-recognition domain0.1199Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1255Inherited
Ras-binding domain, RBD0.1255Inherited
PHD domain0.1271Inherited
Bromodomain0.1524Inherited
Erythroid transcription factor GATA-10.183Inherited
Laminin-type module0.3097Inherited
V set domains (antibody variable domain-like)0.3844Inherited
GLA-domain0.4293Inherited
Intermediate filament protein, coiled coil region0.457Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Notch domain0Direct
Plakin repeat0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Apolipoprotein A-I0Direct
FnI-like domain0.0371Inherited
4-helical cytokines0.04118Inherited
P-loop containing nucleoside triphosphate hydrolases0.07539Inherited
Protein kinase-like (PK-like)0.0834Inherited
DEATH domain0.1039Inherited
MHC antigen-recognition domain0.1093Inherited
EGF/Laminin0.1357Inherited
Bromodomain0.1386Inherited
RNI-like0.1484Inherited
DNA/RNA polymerases0.1693Inherited
Immunoglobulin0.3049Inherited
GLA-domain0.407Inherited
Intermediate filament protein, coiled coil region0.4193Inherited
alpha/beta-Hydrolases0.6713Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0001859Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.03873Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04316Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1093Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1169Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3414Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.777Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.000004297Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00273Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1169Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)