Phenotypic Abnormality (PA): Abnormality of higher mental function

(show info)

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + 3: Phenotypic abnormality [HP:0000118] <25>

+ + 2: Abnormality of the nervous system [HP:0000707] <4> (142|168) (156|103|45)

+ 1: Abnormality of nervous system physiology [HP:0012638] <26> (101|119) (112|81|39)

0: Abnormality of higher mental function [HP:0011446] <9> (38|45) (40|24|8)

- 1: Neurological speech impairment [HP:0002167] <20> (5|9) (5|4|1)

- 1: Reduced consciousness/confusion [HP:0004372] <11> (11|10) (13|3|1)

- 1: Apraxia [HP:0002186] <6> (0|0) (1|0|0)

- 1: Intellectual disability [HP:0001249] <6> (11|11) (11|5|2)

- 1: Agnosia [HP:0010524] <4> (2|3) (2|1|0)

- 1: Cognitive impairment [HP:0100543] <3> (4|5) (6|4|0)

- 1: Language impairment [HP:0002463] <1> (0|0) (0|0|0)

- 1: Micrographia [HP:0031908] (0|0) (0|0|0)

- 1: Optic ataxia [HP:0031868] (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Rhodanese/Cell cycle control phosphatase	0	Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	Direct
Methylglyoxal synthase-like	0	Direct
SNARE fusion complex	0	Direct
Aminoacid dehydrogenase-like, N-terminal domain	0	Direct
HIT-like	0	Direct
Lamin A/C globular tail domain	0	Direct
Arginase/deacetylase	0	Direct
ADC-like	0	Direct
CRAL/TRIO domain	0	Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
Pseudouridine synthase	0	Direct
L-aspartase-like	0	Direct
4Fe-4S ferredoxins	0	Direct
Proton glutamate symport protein	0	Direct
Multidrug efflux transporter AcrB transmembrane domain	0	Direct
PP2C-like	0	Direct
LuxS/MPP-like metallohydrolase	0	Direct
BRK domain-like	0	Direct
Single hybrid motif	0.01683	Inherited
Bromodomain	0.0501	Inherited
(Trans)glycosidases	0.06884	Inherited
S-adenosyl-L-methionine-dependent methyltransferases	0.1206	Inherited
NagB/RpiA/CoA transferase-like	0.1734	Inherited
PreATP-grasp domain	0.1853	Inherited
Glycosyl hydrolase domain	0.2292	Inherited
Thiamin diphosphate-binding fold (THDP-binding)	0.2835	Inherited
GST C-terminal domain-like	0.2835	Inherited
Acyl-CoA dehydrogenase C-terminal domain-like	0.2859	Inherited
Acyl-CoA dehydrogenase NM domain-like	0.2859	Inherited
ClpP/crotonase	0.3571	Inherited
Mitochondrial carrier	0.3595	Inherited
CoA-dependent acyltransferases	0.3949	Inherited
RNA-binding domain, RBD	0.5406	Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.6573	Inherited
Ribosomal protein S5 domain 2-like	0.6588	Inherited
Intermediate filament protein, coiled coil region	0.8485	Inherited
Adenine nucleotide alpha hydrolases-like	0.9517	Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Amylase, catalytic domain	0	Direct
Double-stranded RNA-binding domain (dsRBD)	0	Direct
Ferredoxin domains from multidomain proteins	0	Direct
Aminoacid dehydrogenase-like, C-terminal domain	0	Direct
Multidrug efflux transporter AcrB transmembrane domain	0	Direct
alpha-Amylases, C-terminal beta-sheet domain	0	Direct
Lamin A/C globular tail domain	0	Direct
Glycosyl transferases group 1	0	Direct
SNARE fusion complex	0	Direct
Phosphate binding protein-like	0	Direct
BRK domain-like	0	Direct
beta-glycanases	0	Direct
MPP-like	0	Direct
PP2C-like	0	Direct
CUT domain	0	Direct
Proton glutamate symport protein	0	Direct
CAT-like	0	Direct
Histone deacetylase, HDAC	0	Direct
L-aspartase/fumarase	0	Direct
C5 cytosine-specific DNA methylase, DCM	0	Direct
Ubiquitin carboxyl-terminal hydrolase, UCH	0	Direct
Exostosin	0	Direct
Histone lysine methyltransferases	0	Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	Direct
UBA domain	0	Direct
PWWP domain	0	Direct
IF2B-like	0	Direct
Extended AAA-ATPase domain	0.0004032	Direct
Biotinyl/lipoyl-carrier proteins and domains	0.011	Inherited
Bromodomain	0.03702	Inherited
L-arabinose binding protein-like	0.0411	Inherited
BC N-terminal domain-like	0.05282	Inherited
BC ATP-binding domain-like	0.05282	Inherited
DNA gyrase/MutL, second domain	0.087	Inherited
DNA gyrase/MutL, N-terminal domain	0.087	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.2856	Inherited
Nicotinic receptor ligand binding domain-like	0.2856	Inherited
Clathrin coat assembly domain	0.3095	Inherited
Mitochondrial carrier	0.316	Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0.3519	Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0.3519	Inherited
Canonical RBD	0.5426	Inherited
ABC transporter ATPase domain-like	0.7282	Inherited
Intermediate filament protein, coiled coil region	0.8146	Inherited
Complement control module/SCR domain	0.865	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

Plot tree as:

Download Newick format tree:

(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	Direct
LuxS/MPP-like metallohydrolase	0	Direct
BRK domain-like	0	Direct
Multidrug efflux transporter AcrB transmembrane domain	0	Direct
Pseudouridine synthase	0	Direct
Proton glutamate symport protein	0	Direct
L-aspartase-like	0	Direct
PP2C-like	0	Direct
CRAL/TRIO domain	0	Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
SNARE fusion complex	0	Direct
HIT-like	0	Direct
Arginase/deacetylase	0	Direct
Lamin A/C globular tail domain	0	Direct
4Fe-4S ferredoxins	0	Direct
Aminoacid dehydrogenase-like, N-terminal domain	0	Direct
Methylglyoxal synthase-like	0	Direct
ADC-like	0	Direct
Rhodanese/Cell cycle control phosphatase	0	Direct
Single hybrid motif	0.01129	Inherited
Bromodomain	0.03691	Inherited
(Trans)glycosidases	0.05236	Inherited
S-adenosyl-L-methionine-dependent methyltransferases	0.09616	Inherited
NagB/RpiA/CoA transferase-like	0.143	Inherited
PreATP-grasp domain	0.1536	Inherited
Glycosyl hydrolase domain	0.1941	Inherited
GST C-terminal domain-like	0.2448	Inherited
Thiamin diphosphate-binding fold (THDP-binding)	0.2448	Inherited
Acyl-CoA dehydrogenase NM domain-like	0.2471	Inherited
Acyl-CoA dehydrogenase C-terminal domain-like	0.2471	Inherited
Nicotinic receptor ligand binding domain-like	0.2865	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.2865	Inherited
ClpP/crotonase	0.3149	Inherited
Mitochondrial carrier	0.3172	Inherited
CoA-dependent acyltransferases	0.3516	Inherited
RNA-binding domain, RBD	0.4965	Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.6167	Inherited
Ribosomal protein S5 domain 2-like	0.6182	Inherited
Intermediate filament protein, coiled coil region	0.8158	Inherited
Adenine nucleotide alpha hydrolases-like	0.9264	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like	0	Direct
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains	0	Direct
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	Direct
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0	Direct
52096,52096 52096 - ClpP/crotonase 52096 - ClpP/crotonase	0	Direct
141072,141072 141072 - CalX-like 141072 - CalX-like	0	Direct
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
50447,-8 50447 - Translation proteins -8 - ECOD	0	Direct
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like	0	Direct
-8,54980 -8 - ECOD 54980 - EF-G C-terminal domain-like	0	Direct
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin	0	Direct
51905,55424 51905 - FAD/NAD(P)-binding domain 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	Direct
63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase	0	Direct
53822,53850 53822 - Periplasmic binding protein-like I 53850 - Periplasmic binding protein-like II	0	Direct
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier	0	Direct
55874,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like	0.0873	Inherited
51206,51206 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like	0.1428	Inherited
52440,56059 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	0.1941	Inherited
51445,51011 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain	0.1941	Inherited
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0.2471	Inherited
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.2865	Inherited
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.3516	Inherited
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.8228	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
49899,57196,49899 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	Direct
141072,141072,141072 141072 - CalX-like 141072 - CalX-like 141072 - CalX-like	0	Direct
50447,-8,54980 50447 - Translation proteins -8 - ECOD 54980 - EF-G C-terminal domain-like	0	Direct
54160,54160,52540 54160 - Chromo domain-like 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	Direct
54160,52540,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin	0	Direct
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.8753	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

Plot tree as:

Download Newick format tree:

(show help)

SEARCH

BROWSE

TOOLS

ABOUT

HELP

Phenotypic Abnormality (PA): Abnormality of higher mental function

Superfamily

Family

Supra-domain (including individual superfamily)