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Phenotypic Abnormality (PA): Abnormality of the digestive system
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this HP term (SDHP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| Double-stranded RNA-binding domain (dsRBD) | 0 | DIRECT |
| YicI catalytic domain-like | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
| N-acetyl transferase, NAT | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| Interleukin-1 (IL-1) | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Glycosyl transferases group 1 | 0 | DIRECT |
| beta-glycanases | 0 | DIRECT |
| MPP-like | 0 | DIRECT |
| FAD/NAD-linked reductases, N-terminal and central domains | 0 | DIRECT |
| P4 origin-binding domain-like | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Ribonuclease PH domain 1-like | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Putative glucosidase YicI, domain 3 | 0 | DIRECT |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | DIRECT |
| DIX domain | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| DNA polymerase I | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.01288 | INHERITED FROM: Hepatic steatosis || Decreased liver function |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0.02054 | INHERITED FROM: Hepatic steatosis || Vomiting |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0.02054 | INHERITED FROM: Hepatic steatosis || Vomiting |
| Actin/HSP70 | 0.02054 | INHERITED FROM: Abnormal peristalsis |
| Ran binding protein zinc finger-like | 0.03239 | INHERITED FROM: Abnormal gastrointestinal motility |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.041 | INHERITED FROM: Hepatic steatosis || Storage in hepatocytes |
| Transforming growth factor (TGF)-beta | 0.041 | INHERITED FROM: Intestinal obstruction |
| PX domain | 0.05067 | INHERITED FROM: Splenomegaly |
| 28-residue LRR | 0.06842 | INHERITED FROM: Abnormal large intestine morphology || Colitis || Splenomegaly |
| Histone lysine methyltransferases | 0.06842 | INHERITED FROM: Intestinal malrotation || Feeding difficulties |
| G proteins | 0.07044 | INHERITED FROM: Aplasia/Hypoplasia of the abdominal wall musculature |
| Extended AAA-ATPase domain | 0.07625 | INHERITED FROM: Abnormality of the stomach |
| Globins | 0.07845 | INHERITED FROM: Abnormal liver morphology || Abnormality of the spleen || Hepatomegaly || Abnormality of the liver || Abnormality of abdomen morphology || Splenomegaly || Visceromegaly || Abnormal spleen morphology |
| ValRS/IleRS/LeuRS editing domain | 0.07845 | INHERITED FROM: Decreased liver function |
| Ras-binding domain, RBD | 0.07845 | INHERITED FROM: Abnormality of the spleen |
| DnaQ-like 3'-5' exonuclease | 0.07845 | INHERITED FROM: Abnormal large intestine morphology |
| Tetratricopeptide repeat (TPR) | 0.09097 | INHERITED FROM: Aplasia/Hypoplasia of the spleen || Asplenia |
| Integrin domains | 0.09797 | INHERITED FROM: Melena || Bloody diarrhea |
| Eukaryotic proteases | 0.1078 | INHERITED FROM: Abdominal pain |
| CalX-beta domain | 0.1199 | INHERITED FROM: Abnormality of the anus || Anal stenosis || Omphalocele || Ectopic anus |
| DNA gyrase/MutL, second domain | 0.1199 | INHERITED FROM: Neoplasm of the large intestine || Abnormal large intestine morphology || Nausea and vomiting || Gastrointestinal hemorrhage || Neoplasm of the liver || Abnormality of the pancreas || Abnormal intestine morphology || Intestinal polyp || Neoplasm of the rectum || Colon cancer || Neoplasm of the pancreas || Malabsorption || Abdominal pain || Anorectal anomaly || Intestinal polyposis || Abnormality of the rectum || Pancreatic adenocarcinoma || Neoplasm of the gastrointestinal tract || Hepatocellular carcinoma || Neoplasm of the colon || Constipation |
| DNA gyrase/MutL, N-terminal domain | 0.1199 | INHERITED FROM: Neoplasm of the large intestine || Abnormal large intestine morphology || Nausea and vomiting || Gastrointestinal hemorrhage || Neoplasm of the liver || Abnormality of the pancreas || Abnormal intestine morphology || Intestinal polyp || Neoplasm of the rectum || Colon cancer || Neoplasm of the pancreas || Malabsorption || Abdominal pain || Anorectal anomaly || Intestinal polyposis || Abnormality of the rectum || Pancreatic adenocarcinoma || Neoplasm of the gastrointestinal tract || Hepatocellular carcinoma || Neoplasm of the colon || Constipation |
| Pyrin domain, PYD | 0.1199 | INHERITED FROM: Abnormality of the spleen || Abdominal pain || Abnormality of abdomen morphology || Splenomegaly || Visceromegaly || Abnormal spleen morphology |
| DEATH domain, DD | 0.1375 | INHERITED FROM: Splenomegaly |
| DNA repair protein MutS, domain III | 0.1829 | INHERITED FROM: Neoplasm of the large intestine || Abnormal large intestine morphology || Intestinal polyp || Neoplasm of the rectum || Colon cancer || Anorectal anomaly || Intestinal polyposis || Abnormality of the rectum || Neoplasm of the stomach || Neoplasm of the gastrointestinal tract || Neoplasm of the colon |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.1829 | INHERITED FROM: Neoplasm of the gastrointestinal tract |
| Complement control module/SCR domain | 0.183 | INHERITED FROM: Diarrhea |
| RecA protein-like (ATPase-domain) | 0.1912 | INHERITED FROM: Primary peritoneal carcinoma || Tracheoesophageal fistula || Duodenal stenosis || Anal atresia || Abnormality of the duodenum || Meckel diverticulum || Small intestinal stenosis || Abnormal ileum morphology |
| VWC domain | 0.196 | INHERITED FROM: Hernia of the abdominal wall || Abnormality of the abdominal wall || Abnormal morphology of the abdominal musculature || Abdominal wall defect || Inguinal hernia || Aplasia/Hypoplasia of the abdominal wall musculature |
| ABC transporter transmembrane region | 0.2348 | INHERITED FROM: Abnormal gallbladder morphology || Cholelithiasis |
| BC N-terminal domain-like | 0.2731 | INHERITED FROM: Vomiting |
| C1 set domains (antibody constant domain-like) | 0.2731 | INHERITED FROM: Abnormality of pancreas physiology || Abnormal intestine morphology || Abdominal pain |
| Nitrogenase iron protein-like | 0.2731 | INHERITED FROM: Vomiting |
| BC ATP-binding domain-like | 0.2731 | INHERITED FROM: Vomiting |
| MHC antigen-recognition domain | 0.3019 | INHERITED FROM: Abnormality of pancreas physiology || Nausea and vomiting || Abdominal pain |
| Laminin-type module | 0.3413 | INHERITED FROM: Esophageal stenosis || Esophageal stricture |
| EGF-type module | 0.3615 | INHERITED FROM: Hernia of the abdominal wall || Abnormality of the abdominal wall || Abdominal wall defect |
| SNARE fusion complex | 0.3766 | INHERITED FROM: Gastroesophageal reflux |
| Anti-sigma factor antagonist SpoIIaa | 0.3766 | INHERITED FROM: Abdominal distention |
| Fibrinogen C-terminal domain-like | 0.384 | INHERITED FROM: Splenic rupture |
| TNF receptor-like | 0.509 | INHERITED FROM: Splenomegaly || Abnormal spleen morphology |
| KRAB domain (Kruppel-associated box) | 0.5525 | INHERITED FROM: Abnormality of the small intestine |
| Laminin G-like module | 0.5563 | INHERITED FROM: Abnormality of the stomach |
| SH3-domain | 0.7389 | INHERITED FROM: Liver abscess |
| Intermediate filament protein, coiled coil region | 0.7855 | INHERITED FROM: Pseudobulbar paralysis |
| Homeodomain | 0.9658 | INHERITED FROM: Abnormal pancreas size || Aplasia/Hypoplasia of the pancreas |
| Cadherin | 0.9943 | INHERITED FROM: Anteriorly placed anus |
| Ngr ectodomain-like | 1 | INHERITED FROM: Hematemesis |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| Double-stranded RNA-binding domain (dsRBD) | 0 | Direct |
| YicI catalytic domain-like | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
| N-acetyl transferase, NAT | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| Interleukin-1 (IL-1) | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Glycosyl transferases group 1 | 0 | Direct |
| beta-glycanases | 0 | Direct |
| MPP-like | 0 | Direct |
| FAD/NAD-linked reductases, N-terminal and central domains | 0 | Direct |
| P4 origin-binding domain-like | 0 | Direct |
| Notch domain | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Ribonuclease PH domain 1-like | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Putative glucosidase YicI, domain 3 | 0 | Direct |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | Direct |
| DIX domain | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| DNA polymerase I | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.01288 | Inherited |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0.02054 | Inherited |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0.02054 | Inherited |
| Actin/HSP70 | 0.02054 | Inherited |
| Ran binding protein zinc finger-like | 0.03239 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.041 | Inherited |
| Transforming growth factor (TGF)-beta | 0.041 | Inherited |
| PX domain | 0.05067 | Inherited |
| 28-residue LRR | 0.06842 | Inherited |
| Histone lysine methyltransferases | 0.06842 | Inherited |
| G proteins | 0.07044 | Inherited |
| Extended AAA-ATPase domain | 0.07625 | Inherited |
| Globins | 0.07845 | Inherited |
| ValRS/IleRS/LeuRS editing domain | 0.07845 | Inherited |
| Ras-binding domain, RBD | 0.07845 | Inherited |
| DnaQ-like 3'-5' exonuclease | 0.07845 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.09097 | Inherited |
| Integrin domains | 0.09797 | Inherited |
| Eukaryotic proteases | 0.1078 | Inherited |
| CalX-beta domain | 0.1199 | Inherited |
| DNA gyrase/MutL, second domain | 0.1199 | Inherited |
| DNA gyrase/MutL, N-terminal domain | 0.1199 | Inherited |
| Pyrin domain, PYD | 0.1199 | Inherited |
| DEATH domain, DD | 0.1375 | Inherited |
| DNA repair protein MutS, domain III | 0.1829 | Inherited |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.1829 | Inherited |
| Complement control module/SCR domain | 0.183 | Inherited |
| RecA protein-like (ATPase-domain) | 0.1912 | Inherited |
| VWC domain | 0.196 | Inherited |
| ABC transporter transmembrane region | 0.2348 | Inherited |
| BC N-terminal domain-like | 0.2731 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.2731 | Inherited |
| Nitrogenase iron protein-like | 0.2731 | Inherited |
| BC ATP-binding domain-like | 0.2731 | Inherited |
| MHC antigen-recognition domain | 0.3019 | Inherited |
| Laminin-type module | 0.3413 | Inherited |
| EGF-type module | 0.3615 | Inherited |
| SNARE fusion complex | 0.3766 | Inherited |
| Anti-sigma factor antagonist SpoIIaa | 0.3766 | Inherited |
| Fibrinogen C-terminal domain-like | 0.384 | Inherited |
| TNF receptor-like | 0.509 | Inherited |
| KRAB domain (Kruppel-associated box) | 0.5525 | Inherited |
| Laminin G-like module | 0.5563 | Inherited |
| SH3-domain | 0.7389 | Inherited |
| Intermediate filament protein, coiled coil region | 0.7855 | Inherited |
| Homeodomain | 0.9658 | Inherited |
| Cadherin | 0.9943 | Inherited |
| Ngr ectodomain-like | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this HP term (SPHO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
51905,51905
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0 | DIRECT |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | DIRECT |
49854,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
64268,50044
64268 - PX domain
50044 - SH3-domain | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
57535,50494
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
54928,90209
54928 - RNA-binding domain, RBD
90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0 | DIRECT |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.001558 | INHERITED FROM: Abnormal peristalsis |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.007268 | INHERITED FROM: Vomiting || Hepatic steatosis || Storage in hepatocytes |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0.07348 | INHERITED FROM: Decreased liver function |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.09204 | INHERITED FROM: Diarrhea |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.09546 | INHERITED FROM: Jaundice || Cholelithiasis || Cholestasis |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0.1146 | INHERITED FROM: Abnormality of the pancreas || Neoplasm of the large intestine || Neoplasm of the pancreas || Abnormality of the rectum || Intestinal polyposis || Gastrointestinal hemorrhage || Anorectal anomaly || Neoplasm of the colon || Neoplasm of the rectum || Abdominal pain || Colon cancer || Constipation || Hepatocellular carcinoma || Intestinal polyp || Nausea and vomiting || Neoplasm of the liver || Neoplasm of the gastrointestinal tract || Pancreatic adenocarcinoma || Abnormal large intestine morphology || Malabsorption || Abnormal intestine morphology |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1146 | INHERITED FROM: Abnormality of the spleen || Abdominal pain || Abnormal spleen morphology || Visceromegaly || Splenomegaly || Abnormality of abdomen morphology |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.1758 | INHERITED FROM: Splenomegaly |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0.1758 | INHERITED FROM: Abnormality of the pancreas || Neoplasm of the gastrointestinal tract |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1758 | INHERITED FROM: Neoplasm of the large intestine || Abnormality of the rectum || Intestinal polyposis || Anorectal anomaly || Neoplasm of the colon || Neoplasm of the rectum || Colon cancer || Neoplasm of the stomach || Intestinal polyp || Neoplasm of the gastrointestinal tract || Abnormal large intestine morphology |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.1758 | INHERITED FROM: Neoplasm of the gastrointestinal tract |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.1806 | INHERITED FROM: Abnormal spleen morphology || Visceromegaly || Splenomegaly || Abnormality of abdomen morphology |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.2628 | INHERITED FROM: Intestinal malrotation |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.2882 | INHERITED FROM: Abnormality of pancreas physiology || Abdominal pain || Nausea and vomiting |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.2882 | INHERITED FROM: Chronic constipation |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3217 | INHERITED FROM: Esophageal stricture |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.4338 | INHERITED FROM: Abnormal umbilicus morphology || Inguinal hernia || Umbilical hernia |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.5162 | INHERITED FROM: Abnormality of the stomach |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.6897 | INHERITED FROM: Hepatic fibrosis |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.9772 | INHERITED FROM: Anteriorly placed anus |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
51905,51905
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0 | Direct |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | Direct |
49854,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
64268,50044
64268 - PX domain
50044 - SH3-domain | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | Direct |
57535,50494
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
54928,90209
54928 - RNA-binding domain, RBD
90209 - Ran binding protein zinc finger-like | 0 | Direct |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0 | Direct |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.001558 | Inherited |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.007268 | Inherited |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0.07348 | Inherited |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.09204 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.09546 | Inherited |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0.1146 | Inherited |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1146 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.1758 | Inherited |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0.1758 | Inherited |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1758 | Inherited |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.1758 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.1806 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.2628 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.2882 | Inherited |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.2882 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3217 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.4338 | Inherited |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.5162 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.6897 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.9772 | Inherited |
(show details)
Supra-domains annotated to this HP term (SPHO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57581,57196
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
57196,49854,57535
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
49854,57535,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
57184,57581,57184
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
57535,57535,50494
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.06302 | INHERITED FROM: Diarrhea |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.1758 | INHERITED FROM: Splenomegaly |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.1758 | INHERITED FROM: Abnormal umbilicus morphology || Hernia of the abdominal wall || Abnormality of the abdominal wall || Inguinal hernia || Abdominal wall defect || Umbilical hernia |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.2882 | INHERITED FROM: Abnormal umbilicus morphology || Inguinal hernia || Umbilical hernia |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.5663 | INHERITED FROM: Aplasia/Hypoplasia of the spleen || Asplenia |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.8439 | INHERITED FROM: Esophageal stricture |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.9772 | INHERITED FROM: Anteriorly placed anus |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57581,57196
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
57196,49854,57535
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
49854,57535,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
57184,57581,57184
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
57535,57535,50494
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | Direct |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.06302 | Inherited |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.1758 | Inherited |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.1758 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.2882 | Inherited |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.5663 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.8439 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.9772 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
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