SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from supfam.org. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormality of the lymphatic system

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the cardiovascular system [HP:0001626] <5>(60|88) (73|43|30)
+ 1:   Abnormality of the vasculature [HP:0002597] <13>(35|56) (45|27|18)
+ 1:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
0:   Abnormality of the lymphatic system [HP:0100763] <7>(9|19) (15|8|5)
- 1:   Abnormality of the lymph nodes [HP:0002733] <6>(3|9) (7|5|2)
- 1:   Abnormality of the tonsils [HP:0100765] <6>(0|0) (0|0|0)
- 1:   Abnormal lymphatic vessel morphology [HP:0100766] <5>(0|0) (0|0|0)
- 1:   Abnormality of the thymus [HP:0000777] <5>(0|1) (0|0|0)
- 1:   Abnormality of the spleen [HP:0001743] <2>(7|14) (9|4|3)
- 1:   Lymphangioma [HP:0100764] <2>(0|0) (0|0|0)
- 1:   Abnormal pulmonary lymphatics [HP:0006529] <1>(0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
DEATH domain0.000001818Direct
TNF receptor-like0.00001298Direct
Globin-like0.0001599Direct
Caspase-like0.004388Inherited
Notch domain0.03921Inherited
TNF-like0.07125Inherited
(Trans)glycosidases0.1173Inherited
Fibrinogen C-terminal domain-like0.2438Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Globins0.0001003Direct
TNF receptor-like0.0001996Direct
Pyrin domain, PYD0.0005787Direct
Transcription factor STAT-4 N-domain0.002353Inherited
STAT DNA-binding domain0.002353Inherited
STAT0.002353Inherited
Caspase recruitment domain, CARD0.01009Inherited
Ras-binding domain, RBD0.01193Inherited
28-residue LRR0.01656Inherited
DEATH domain, DD0.01764Inherited
beta-glycanases0.03038Inherited
Notch domain0.03038Inherited
PX domain0.03742Inherited
Tetratricopeptide repeat (TPR)0.0453Inherited
TNF-like0.06013Inherited
Fibrinogen C-terminal domain-like0.2184Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
DEATH domain0.0000007325Direct
TNF receptor-like0.000005503Direct
Globin-like0.0000754Direct
Transcription factor STAT-4 N-domain0.001998Inherited
STAT0.001998Inherited
Caspase-like0.002636Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01086Inherited
Notch domain0.02815Inherited
PX domain0.03422Inherited
TNF-like0.05435Inherited
RNI-like0.08341Inherited
(Trans)glycosidases0.09322Inherited
Fibrinogen C-terminal domain-like0.2076Inherited
SH3-domain0.3389Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000001919Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0004737Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001998Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001998Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.001998Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.002636Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.008993Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001998Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001998Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.002636Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05069Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)