Mammalian Phenotype (MP): abnormal leukocyte cell number

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + + 5: mammalian phenotype [MP:0000001] <29>

+ + + + 4: immune system phenotype [MP:0005387] <2> (76|114) (86|66|35)

+ + + + 4: hematopoietic system phenotype [MP:0005397] <2> (72|102) (78|63|30)

+ + + 3: abnormal hematopoietic system morphology/development [MP:0002396] <5> (58|86) (66|47|21)

+ + + 3: abnormal immune system morphology [MP:0000685] <3> (51|76) (60|35|18)

+ + 2: abnormal hematopoietic cell morphology [MP:0013656] <9> (49|77) (60|43|18)

+ + 2: abnormal immune system cell morphology [MP:0000716] <5> (38|63) (48|29|16)

+ 1: abnormal hematopoietic cell number [MP:0011180] <7> (34|57) (43|29|13)

+ 1: abnormal leukocyte morphology [MP:0008246] <4> (37|62) (47|29|15)

0: abnormal leukocyte cell number [MP:0000217] <8> (29|49) (37|25|12)

- 1: abnormal dendritic cell number [MP:0008125] <7> (2|4) (2|1|0)

- 1: abnormal granulocyte number [MP:0020201] <6> (3|7) (5|6|2)

- 1: abnormal lymphocyte cell number [MP:0000717] <6> (18|38) (25|21|9)

- 1: decreased leukocyte cell number [MP:0000221] <5> (17|28) (24|18|10)

- 1: increased leukocyte cell number [MP:0000218] <5> (9|23) (15|11|7)

- 1: abnormal monocyte cell number [MP:0012441] <4> (1|1) (1|1|0)

- 1: abnormal macrophage cell number [MP:0020202] <2> (5|7) (5|1|0)

- 1: abnormal plasmacytoid dendritic cell number [MP:0008123] <2> (1|2) (1|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
SPOC domain-like	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
PsbU/PolX domain-like	0	Direct
L30e-like	0.001251	Inherited
DNA polymerase beta, N-terminal domain-like	0.0037	Inherited
Flavoproteins	0.004064	Inherited
Toll/Interleukin receptor TIR domain	0.005322	Inherited
DEATH domain	0.006453	Inherited
Ran binding protein zinc finger-like	0.01103	Inherited
Triple coiled coil domain of C-type lectins	0.01272	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.014	Inherited
Bcl-2 inhibitors of programmed cell death	0.01963	Inherited
E2F-DP heterodimerization region	0.02709	Inherited
p53-like transcription factors	0.03942	Inherited
TIMP-like	0.05703	Inherited
SH2 domain	0.06559	Inherited
TNF receptor-like	0.08588	Inherited
Cysteine-rich domain	0.08588	Inherited
Integrin domains	0.1342	Inherited
DBL homology domain (DH-domain)	0.1477	Inherited
MHC antigen-recognition domain	0.1801	Inherited
Nuclear receptor ligand-binding domain	0.2017	Inherited
Integrin alpha N-terminal domain	0.2405	Inherited
Riboflavin synthase domain-like	0.3005	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.3005	Inherited
Calponin-homology domain, CH-domain	0.3625	Inherited
WWE domain	0.5744	Inherited
SMAD/FHA domain	0.6986	Inherited
Terpenoid cyclases/Protein prenyltransferases	0.7767	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Proteasome subunits	0	Direct
RUNT domain	0	Direct
DNA polymerase beta-like	0	Direct
BAFF receptor-like	0	Direct
Interleukin 17F, IL-17F	0	Direct
DNA polymerase beta-like, second domain	0	Direct
C1 set domains (antibody constant domain-like)	0.0000003148	Direct
Rel/Dorsal transcription factors, DNA-binding domain	0.00006258	Direct
Pyrin domain, PYD	0.0001677	Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.0004826	Direct
ets domain	0.001053	Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.001409	Inherited
Interleukin-1 (IL-1)	0.002483	Inherited
DNA polymerase beta, N-terminal domain-like	0.002483	Inherited
Pointed domain	0.002779	Inherited
Ran binding protein zinc finger-like	0.008183	Inherited
Toll/Interleukin receptor TIR domain	0.008562	Inherited
E2F dimerization segment	0.008972	Inherited
Tissue inhibitor of metalloproteinases, TIMP	0.009052	Inherited
Triple coiled coil domain of C-type lectins	0.009052	Inherited
Cytochrome p450 reductase N-terminal domain-like	0.009052	Inherited
Bcl-2 inhibitors of programmed cell death	0.01464	Inherited
Interferon regulatory factor	0.01464	Inherited
Phoshoinositide 3-kinase (PI3K) helical domain	0.02037	Inherited
NADPH-cytochrome p450 reductase-like	0.0269	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.0269	Inherited
Nuclear receptor coactivator interlocking domain	0.0269	Inherited
Pleckstrin-homology domain (PH domain)	0.03408	Inherited
SH2 domain	0.05026	Inherited
CCCH zinc finger	0.05863	Inherited
Cell cycle transcription factor e2f-dp	0.05937	Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain	0.08837	Inherited
Integrin domains	0.1087	Inherited
TNF receptor-like	0.1087	Inherited
DEATH domain, DD	0.1087	Inherited
MATH domain	0.1185	Inherited
PLC-like (P variant)	0.1276	Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0.1276	Inherited
DBL homology domain (DH-domain)	0.132	Inherited
SH3-domain	0.1355	Inherited
MHC antigen-recognition domain	0.1497	Inherited
Nuclear receptor ligand-binding domain	0.1704	Inherited
Nuclear receptor	0.1704	Inherited
V set domains (antibody variable domain-like)	0.2232	Inherited
Calponin-homology domain, CH-domain	0.3434	Inherited
Short-chain cytokines	0.4015	Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases	0.5026	Inherited
WWE domain	0.5354	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
SPOC domain-like	0	Direct
PsbU/PolX domain-like	0	Direct
L30e-like	0.0006925	Direct
DNA polymerase beta, N-terminal domain-like	0.002172	Inherited
Flavoproteins	0.002397	Inherited
Toll/Interleukin receptor TIR domain	0.0032	Inherited
DEATH domain	0.003931	Inherited
Ran binding protein zinc finger-like	0.006936	Inherited
Triple coiled coil domain of C-type lectins	0.008082	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.008969	Inherited
NAD kinase/diacylglycerol kinase-like	0.008969	Inherited
Bcl-2 inhibitors of programmed cell death	0.01285	Inherited
E2F-DP heterodimerization region	0.01822	Inherited
Nuclear receptor coactivator interlocking domain	0.0246	Inherited
p53-like transcription factors	0.0273	Inherited
TIMP-like	0.04083	Inherited
SH2 domain	0.04768	Inherited
CCCH zinc finger	0.05309	Inherited
beta-beta-alpha zinc fingers	0.05453	Inherited
TNF receptor-like	0.06385	Inherited
Cysteine-rich domain	0.06385	Inherited
Integrin domains	0.1049	Inherited
DBL homology domain (DH-domain)	0.1166	Inherited
SH3-domain	0.1307	Inherited
MHC antigen-recognition domain	0.1453	Inherited
Nuclear receptor ligand-binding domain	0.1648	Inherited
Integrin alpha N-terminal domain	0.2009	Inherited
Riboflavin synthase domain-like	0.2572	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.2572	Inherited
Calponin-homology domain, CH-domain	0.3168	Inherited
WWE domain	0.528	Inherited
Protein kinase-like (PK-like)	0.5564	Inherited
Acyl-CoA N-acyltransferases (Nat)	0.6563	Inherited
SMAD/FHA domain	0.6575	Inherited
C-type lectin-like	0.6583	Inherited
Terpenoid cyclases/Protein prenyltransferases	0.7402	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
47802,81585 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like	0	Direct
81585,81301 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase	0	Direct
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0	Direct
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain)	0	Direct
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.00003745	Direct
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.00004937	Direct
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0.0005597	Direct
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0.0006925	Direct
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.002053	Inherited
57944,56436 57944 - Triple coiled coil domain of C-type lectins 56436 - C-type lectin-like	0.008082	Inherited
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0.01822	Inherited
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0.01822	Inherited
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain	0.03363	Inherited
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.05412	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.0902	Inherited
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.1109	Inherited
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like	0.12	Inherited
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.1708	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.1747	Inherited
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.2357	Inherited
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.2357	Inherited
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.2418	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.4478	Inherited
50729,55550 50729 - PH domain-like 55550 - SH2 domain	0.4491	Inherited
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.524	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50729,50044,55550 50729 - PH domain-like 50044 - SH3-domain 55550 - SH2 domain	0	Direct
47802,81585,81301 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase	0	Direct
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain	0	Direct
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	Direct
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.001163	Inherited
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.01822	Inherited
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.03363	Inherited
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.2357	Inherited
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.3135	Inherited
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.5128	Inherited
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0.528	Inherited
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.528	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Mammalian Phenotype (MP): abnormal leukocyte cell number

Superfamily

Family

Supra-domain (including individual superfamily)