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Mammalian Phenotype (MP): abnormal homeostasis
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this MP term (SDMP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Ammonium transporter | 0 | DIRECT |
| Lipoxigenase | 0 | DIRECT |
| HMA, heavy metal-associated domain | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Hormone receptor domain | 0.0004016 | DIRECT |
| PLP-dependent transferases | 0.006067 | INHERITED FROM: abnormal circulating amino acid level || abnormal amino acid level |
| Acyl-CoA dehydrogenase NM domain-like | 0.006368 | INHERITED FROM: abnormal circulating carnitine level || abnormal adaptive thermogenesis || abnormal circulating amino acid level || abnormal amino acid level |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.006368 | INHERITED FROM: abnormal circulating carnitine level || abnormal adaptive thermogenesis || abnormal circulating amino acid level || abnormal amino acid level |
| MFS general substrate transporter | 0.007831 | INHERITED FROM: abnormal urine uric acid level |
| Aquaporin-like | 0.008046 | INHERITED FROM: abnormal blood osmolality || increased blood osmolality || abnormal urine homeostasis || abnormal circulating glycerol level || decreased urine osmolality || abnormal urine osmolality || abnormal glycerol level |
| Glycerol-3-phosphate (1)-acyltransferase | 0.008046 | INHERITED FROM: increased oxygen consumption |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.01163 | INHERITED FROM: abnormal circulating phospholipid level || abnormal circulating cholesterol level || abnormal cholesterol level |
| SMAD MH1 domain | 0.01189 | INHERITED FROM: abnormal circulating gonadotropin level || abnormal follicle stimulating hormone level |
| STAT | 0.02164 | INHERITED FROM: abnormal adaptive thermogenesis || increased circulating leptin level || abnormal cytokine level || increased circulating insulin level || abnormal circulating leptin level || abnormal protein level || abnormal interleukin level || increased triglyceride level || abnormal circulating interleukin level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || increased circulating triglyceride level || abnormal circulating interferon-gamma level || abnormal circulating insulin-like growth factor I level || abnormal circulating protein level || impaired adaptive thermogenesis || abnormal insulin-like growth factor I level |
| Transcription factor STAT-4 N-domain | 0.02164 | INHERITED FROM: abnormal adaptive thermogenesis || increased circulating leptin level || abnormal cytokine level || increased circulating insulin level || abnormal circulating leptin level || abnormal protein level || abnormal interleukin level || increased triglyceride level || abnormal circulating interleukin level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || increased circulating triglyceride level || abnormal circulating interferon-gamma level || abnormal circulating insulin-like growth factor I level || abnormal circulating protein level || impaired adaptive thermogenesis || abnormal insulin-like growth factor I level |
| Thioesterase/thiol ester dehydrase-isomerase | 0.0391 | INHERITED FROM: abnormal lipid homeostasis || abnormal fatty acid level || abnormal lipid level |
| KA1-like | 0.0391 | INHERITED FROM: abnormal circulating hormone level || abnormal hormone level || abnormal energy homeostasis || decreased circulating insulin level || abnormal energy expenditure || decreased susceptibility to diet-induced obesity || decreased circulating glucose level |
| DHS-like NAD/FAD-binding domain | 0.04028 | INHERITED FROM: increased liver triglyceride level |
| Insulin-like | 0.04028 | INHERITED FROM: hyperglycemia |
| C-type lectin-like | 0.04435 | INHERITED FROM: abnormal protein level || abnormal circulating protein level |
| SNF-like | 0.04554 | INHERITED FROM: abnormal amino acid level |
| Nuclear receptor ligand-binding domain | 0.05388 | INHERITED FROM: abnormal circulating gonadotropin level || increased circulating leptin level || abnormal lipid homeostasis || abnormal circulating testosterone level || abnormal circulating hormone level || abnormal hormone level || abnormal lipoprotein level || abnormal circulating androgen level || abnormal triiodothyronine level || abnormal circulating lipoprotein level || abnormal testosterone level || abnormal circulating lipid level || abnormal energy expenditure || increased bile salt level || abnormal circulating pituitary hormone level || decreased circulating progesterone level || decreased circulating insulin-like growth factor I level |
| Family A G protein-coupled receptor-like | 0.05643 | INHERITED FROM: abnormal circulating corticosterone level || abnormal circulating hormone level || abnormal hormone level || abnormal catecholamine level || abnormal energy homeostasis || abnormal circulating glucocorticoid level || abnormal corticosterone level || abnormal dopamine level || abnormal body temperature homeostasis || decreased response to stress-induced hyperthermia |
| Serum albumin-like | 0.06922 | INHERITED FROM: abnormal circulating cholesterol level |
| Nuclear receptor coactivator interlocking domain | 0.06922 | INHERITED FROM: increased circulating leptin level || abnormal circulating leptin level |
| FAD-binding/transporter-associated domain-like | 0.06922 | INHERITED FROM: abnormal lipid homeostasis || abnormal lipid level |
| Apolipoprotein A-I | 0.06922 | INHERITED FROM: abnormal lipid homeostasis || abnormal circulating triglyceride level || abnormal lipoprotein level || abnormal sterol level || decreased circulating HDL cholesterol level || abnormal cholesterol homeostasis || abnormal circulating cholesterol level || abnormal cholesterol level || abnormal circulating lipoprotein level || abnormal circulating lipid level || abnormal triglyceride level || abnormal lipid level |
| ACT-like | 0.06922 | INHERITED FROM: abnormal serotonin level || abnormal hormone level |
| Transducin (alpha subunit), insertion domain | 0.08003 | INHERITED FROM: abnormal circulating parathyroid hormone level || abnormal platelet aggregation || abnormal platelet physiology || decreased platelet aggregation || abnormal circulating calcium level || abnormal platelet activation || increased circulating parathyroid hormone level |
| Galactose mutarotase-like | 0.1069 | INHERITED FROM: abnormal glycogen homeostasis |
| SH2 domain | 0.1211 | INHERITED FROM: increased circulating interleukin-17 level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || abnormal circulating interferon-gamma level || increased circulating interleukin-12 level |
| Triple coiled coil domain of C-type lectins | 0.1212 | INHERITED FROM: abnormal cytokine level || abnormal intercellular signaling peptide or protein level |
| ClpP/crotonase | 0.1321 | INHERITED FROM: increased circulating insulin level || abnormal fatty acid level |
| Clathrin adaptor appendage domain | 0.1321 | INHERITED FROM: hypoglycemia |
| GAT-like domain | 0.1685 | INHERITED FROM: hypoglycemia |
| Cation efflux protein transmembrane domain-like | 0.1685 | INHERITED FROM: abnormal mineral homeostasis || abnormal zinc homeostasis |
| (Trans)glycosidases | 0.1887 | INHERITED FROM: abnormal brain glycogen level || increased skeletal muscle glycogen level || abnormal urine homeostasis || increased brain glycogen level || abnormal muscle glycogen level || abnormal skeletal muscle glycogen level || abnormal urine glycosaminoglycan level || abnormal glycosaminoglycan level |
| PYP-like sensor domain (PAS domain) | 0.1887 | INHERITED FROM: increased circulating leptin level || abnormal hormone level || decreased noradrenaline level || decreased circulating noradrenaline level || abnormal circulating estradiol level |
| p53-like transcription factors | 0.1983 | INHERITED FROM: abnormal fluid regulation || abnormal interleukin level || abnormal intercellular signaling peptide or protein level || abnormal circulating interferon-gamma level || abnormal circulating insulin-like growth factor I level || impaired adaptive thermogenesis || abnormal insulin-like growth factor I level |
| GroEL equatorial domain-like | 0.2594 | INHERITED FROM: increased circulating leptin level || abnormal circulating leptin level |
| Integrin domains | 0.2814 | INHERITED FROM: decreased platelet aggregation |
| Lipocalins | 0.2814 | INHERITED FROM: decreased triglyceride level || abnormal vitamin A level || abnormal vitamin homeostasis || abnormal vitamin level || abnormal fat-soluble vitamin level |
| Alkaline phosphatase-like | 0.3062 | INHERITED FROM: abnormal glycosaminoglycan level |
| 4-helical cytokines | 0.3094 | INHERITED FROM: abnormal protein level || decreased core body temperature || increased circulating interleukin-17 level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level |
| Cystine-knot cytokines | 0.3296 | INHERITED FROM: abnormal circulating gonadotropin level || abnormal follicle stimulating hormone level || abnormal circulating pituitary hormone level || decreased circulating follicle stimulating hormone level |
| Toll/Interleukin receptor TIR domain | 0.3316 | INHERITED FROM: decreased macrophage nitric oxide production || abnormal protein level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || decreased circulating interleukin-6 level || abnormal circulating protein level || abnormal circulating interferon-alpha level |
| E set domains | 0.3708 | INHERITED FROM: abnormal circulating amylase level |
| HMG-box | 0.3728 | INHERITED FROM: edema |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.3801 | INHERITED FROM: abnormal circulating gonadotropin level || decreased circulating testosterone level || abnormal circulating testosterone level || abnormal hormone level || abnormal pituitary hormone level || abnormal circulating pituitary hormone level |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.3965 | INHERITED FROM: abnormal glycogen level |
| Riboflavin synthase domain-like | 0.4219 | INHERITED FROM: abnormal blood osmolality || decreased urine sodium level || increased blood osmolality || abnormal nitric oxide homeostasis || increased circulating pituitary hormone level || increased circulating LDL cholesterol level || increased prostaglandin level || increased pituitary hormone level || decreased adiponectin level || abnormal amino acid level || abnormal sodium ion homeostasis || abnormal circulating LDL cholesterol level || abnormal urine sodium level || glomerular capillary thrombosis || abnormal thrombosis || decreased urine osmolality || abnormal circulating alkaline phosphatase level || increased blood urea nitrogen level || abnormal kidney thrombosis || increased circulating creatinine level || abnormal prostaglandin level || increased circulating alkaline phosphatase level |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.4219 | INHERITED FROM: abnormal blood osmolality || decreased urine sodium level || increased blood osmolality || abnormal nitric oxide homeostasis || increased circulating pituitary hormone level || increased circulating LDL cholesterol level || increased prostaglandin level || increased pituitary hormone level || decreased adiponectin level || abnormal amino acid level || abnormal sodium ion homeostasis || abnormal circulating LDL cholesterol level || abnormal urine sodium level || glomerular capillary thrombosis || abnormal thrombosis || decreased urine osmolality || abnormal circulating alkaline phosphatase level || increased blood urea nitrogen level || abnormal kidney thrombosis || increased circulating creatinine level || abnormal prostaglandin level || increased circulating alkaline phosphatase level |
| Bet v1-like | 0.4219 | INHERITED FROM: abnormal lipid homeostasis || abnormal cholesterol level |
| PH domain-like | 0.4449 | INHERITED FROM: abnormal platelet activation |
| CBS-domain pair | 0.4584 | INHERITED FROM: abnormal renal protein reabsorption |
| DEATH domain | 0.4618 | INHERITED FROM: abnormal circulating interleukin-18 level || abnormal protein level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || abnormal circulating interferon-gamma level || abnormal circulating protein level |
| Carbonic anhydrase | 0.4904 | INHERITED FROM: abnormal pH regulation |
| Phoshotransferase/anion transport protein | 0.5382 | INHERITED FROM: abnormal pH regulation || abnormal urine calcium level || decreased circulating bicarbonate level || decreased urine osmolality || abnormal circulating bicarbonate level |
| YWTD domain | 0.5382 | INHERITED FROM: abnormal sterol level || increased triglyceride level || increased circulating cholesterol level || increased cholesterol level || increased circulating triglyceride level || decreased susceptibility to diet-induced obesity || decreased liver triglyceride level |
| Glycosyl hydrolase domain | 0.5382 | INHERITED FROM: abnormal glycogen homeostasis |
| Actin-like ATPase domain | 0.5571 | INHERITED FROM: increased circulating ketone body level || abnormal circulating ketone body level |
| Flavoproteins | 0.5833 | INHERITED FROM: abnormal blood osmolality || abnormal circulating amino acid level || decreased urine sodium level || increased blood osmolality || abnormal nitric oxide homeostasis || abnormal circulating triglyceride level || increased circulating LDL cholesterol level || abnormal blood coagulation || increased prostaglandin level || decreased adiponectin level || abnormal amino acid level || abnormal sodium ion homeostasis || abnormal circulating LDL cholesterol level || abnormal cholesterol level || abnormal urine sodium level || glomerular capillary thrombosis || abnormal thrombosis || decreased urine osmolality || abnormal circulating alkaline phosphatase level || abnormal circulating enzyme level || increased blood urea nitrogen level || abnormal triglyceride level || abnormal kidney thrombosis || abnormal urine osmolality || abnormal lipid level || increased circulating creatinine level || abnormal prostaglandin level || increased circulating alkaline phosphatase level |
| Growth factor receptor domain | 0.6148 | INHERITED FROM: cyanosis |
| TNF receptor-like | 0.6203 | INHERITED FROM: abnormal body temperature homeostasis |
| Thioredoxin-like | 0.6213 | INHERITED FROM: increased circulating levels of thyroid hormone || increased thyroxine level || increased circulating thyroxine level |
| Clc chloride channel | 0.6323 | INHERITED FROM: abnormal renal protein reabsorption |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6323 | INHERITED FROM: decreased sterol level || decreased cholesterol level || abnormal sterol level || abnormal liver cholesterol level || abnormal cholesterol homeostasis || abnormal circulating LDL cholesterol level || abnormal cholesterol level || abnormal circulating non-HDL cholesterol level |
| LDL receptor-like module | 0.6389 | INHERITED FROM: increased circulating chloride level |
| Heme-dependent peroxidases | 0.6851 | INHERITED FROM: increased circulating pituitary hormone level || increased pituitary hormone level |
| HLH, helix-loop-helix DNA-binding domain | 0.694 | INHERITED FROM: decreased noradrenaline level || decreased circulating noradrenaline level || cyanosis || abnormal circulating estradiol level |
| Homeodomain-like | 0.7348 | INHERITED FROM: abnormal oxygen level || abnormal gas homeostasis || cyanosis |
| CCCH zinc finger | 0.783 | INHERITED FROM: abnormal circulating tumor necrosis factor level || increased circulating tumor necrosis factor level |
| CAD & PB1 domains | 0.7887 | INHERITED FROM: abnormal circulating leptin level || increased circulating alanine transaminase level || abnormal fatty acid level |
| Cytochrome P450 | 0.7948 | INHERITED FROM: abnormal aldosterone level || decreased circulating aldosterone level || abnormal lipid homeostasis || abnormal fat-soluble vitamin level || decreased circulating mineralocorticoid level |
| FAD/NAD(P)-binding domain | 0.7952 | INHERITED FROM: increased dopamine level |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.7965 | INHERITED FROM: abnormal platelet aggregation || abnormal platelet physiology || abnormal platelet activation |
| Thyroglobulin type-1 domain | 0.8152 | INHERITED FROM: increased insulin secretion || abnormal circulating insulin-like growth factor I level || decreased circulating insulin-like growth factor I level || abnormal insulin-like growth factor I level |
| EGF/Laminin | 0.8257 | INHERITED FROM: abnormal blood coagulation || abnormal oxygen level || abnormal hemostasis |
| alpha/beta-Hydrolases | 0.8299 | INHERITED FROM: abnormal lipid homeostasis || decreased glycerol level || abnormal circulating phospholipid level || decreased circulating glycerol level || abnormal cholesterol level |
| Kringle-like | 0.8456 | INHERITED FROM: abnormal blood coagulation || abnormal acute phase protein level |
| Caspase-like | 0.8572 | INHERITED FROM: abnormal circulating interleukin-18 level |
| PLC-like phosphodiesterases | 0.8572 | INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation || abnormal calcium ion homeostasis || abnormal platelet activation |
| Cyclin-like | 0.8603 | INHERITED FROM: hematuria |
| NAD(P)-binding Rossmann-fold domains | 0.8628 | INHERITED FROM: abnormal vitamin A level |
| Intermediate filament protein, coiled coil region | 0.878 | INHERITED FROM: impaired skin barrier function |
| Inhibitor of apoptosis (IAP) repeat | 0.9224 | INHERITED FROM: hemopericardium |
| Fibronectin type III | 0.9236 | INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || abnormal circulating interferon-gamma level |
| Protein kinase-like (PK-like) | 0.9243 | INHERITED FROM: abnormal glycogen homeostasis |
| Cytokine | 0.9624 | INHERITED FROM: abnormal body temperature homeostasis |
| Trypsin-like serine proteases | 0.9928 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
| ENTH/VHS domain | 0.9938 | INHERITED FROM: hypoglycemia |
| Immunoglobulin | 1 | INHERITED FROM: abnormal intercellular signaling peptide or protein level |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Anaphylotoxins (complement system) | 0 | Direct |
| Metallothionein | 0 | Direct |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| GLA-domain | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Ammonium transporter | 0 | Direct |
| Lipoxigenase | 0 | Direct |
| HMA, heavy metal-associated domain | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Notch domain | 0 | Direct |
| Hormone receptor domain | 0.0004016 | Direct |
| PLP-dependent transferases | 0.006067 | Inherited |
| Acyl-CoA dehydrogenase NM domain-like | 0.006368 | Inherited |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.006368 | Inherited |
| MFS general substrate transporter | 0.007831 | Inherited |
| Aquaporin-like | 0.008046 | Inherited |
| Glycerol-3-phosphate (1)-acyltransferase | 0.008046 | Inherited |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.01163 | Inherited |
| SMAD MH1 domain | 0.01189 | Inherited |
| STAT | 0.02164 | Inherited |
| Transcription factor STAT-4 N-domain | 0.02164 | Inherited |
| Thioesterase/thiol ester dehydrase-isomerase | 0.0391 | Inherited |
| KA1-like | 0.0391 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.04028 | Inherited |
| Insulin-like | 0.04028 | Inherited |
| C-type lectin-like | 0.04435 | Inherited |
| SNF-like | 0.04554 | Inherited |
| Nuclear receptor ligand-binding domain | 0.05388 | Inherited |
| Family A G protein-coupled receptor-like | 0.05643 | Inherited |
| Serum albumin-like | 0.06922 | Inherited |
| Nuclear receptor coactivator interlocking domain | 0.06922 | Inherited |
| FAD-binding/transporter-associated domain-like | 0.06922 | Inherited |
| Apolipoprotein A-I | 0.06922 | Inherited |
| ACT-like | 0.06922 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.08003 | Inherited |
| Galactose mutarotase-like | 0.1069 | Inherited |
| SH2 domain | 0.1211 | Inherited |
| Triple coiled coil domain of C-type lectins | 0.1212 | Inherited |
| ClpP/crotonase | 0.1321 | Inherited |
| Clathrin adaptor appendage domain | 0.1321 | Inherited |
| GAT-like domain | 0.1685 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.1685 | Inherited |
| (Trans)glycosidases | 0.1887 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.1887 | Inherited |
| p53-like transcription factors | 0.1983 | Inherited |
| GroEL equatorial domain-like | 0.2594 | Inherited |
| Integrin domains | 0.2814 | Inherited |
| Lipocalins | 0.2814 | Inherited |
| Alkaline phosphatase-like | 0.3062 | Inherited |
| 4-helical cytokines | 0.3094 | Inherited |
| Cystine-knot cytokines | 0.3296 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.3316 | Inherited |
| E set domains | 0.3708 | Inherited |
| HMG-box | 0.3728 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.3801 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.3965 | Inherited |
| Riboflavin synthase domain-like | 0.4219 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.4219 | Inherited |
| Bet v1-like | 0.4219 | Inherited |
| PH domain-like | 0.4449 | Inherited |
| CBS-domain pair | 0.4584 | Inherited |
| DEATH domain | 0.4618 | Inherited |
| Carbonic anhydrase | 0.4904 | Inherited |
| Phoshotransferase/anion transport protein | 0.5382 | Inherited |
| YWTD domain | 0.5382 | Inherited |
| Glycosyl hydrolase domain | 0.5382 | Inherited |
| Actin-like ATPase domain | 0.5571 | Inherited |
| Flavoproteins | 0.5833 | Inherited |
| Growth factor receptor domain | 0.6148 | Inherited |
| TNF receptor-like | 0.6203 | Inherited |
| Thioredoxin-like | 0.6213 | Inherited |
| Clc chloride channel | 0.6323 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6323 | Inherited |
| LDL receptor-like module | 0.6389 | Inherited |
| Heme-dependent peroxidases | 0.6851 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.694 | Inherited |
| Homeodomain-like | 0.7348 | Inherited |
| CCCH zinc finger | 0.783 | Inherited |
| CAD & PB1 domains | 0.7887 | Inherited |
| Cytochrome P450 | 0.7948 | Inherited |
| FAD/NAD(P)-binding domain | 0.7952 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.7965 | Inherited |
| Thyroglobulin type-1 domain | 0.8152 | Inherited |
| EGF/Laminin | 0.8257 | Inherited |
| alpha/beta-Hydrolases | 0.8299 | Inherited |
| Kringle-like | 0.8456 | Inherited |
| Caspase-like | 0.8572 | Inherited |
| PLC-like phosphodiesterases | 0.8572 | Inherited |
| Cyclin-like | 0.8603 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.8628 | Inherited |
| Intermediate filament protein, coiled coil region | 0.878 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.9224 | Inherited |
| Fibronectin type III | 0.9236 | Inherited |
| Protein kinase-like (PK-like) | 0.9243 | Inherited |
| Cytokine | 0.9624 | Inherited |
| Trypsin-like serine proteases | 0.9928 | Inherited |
| ENTH/VHS domain | 0.9938 | Inherited |
| Immunoglobulin | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (SDMP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Neurolysin-like | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Ferredoxin reductase FAD-binding domain-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Animal lipoxigenases | 0 | DIRECT |
| Multidomain cupredoxins | 0 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | DIRECT |
| Carboxylesterase | 0 | DIRECT |
| Choline/Carnitine O-acyltransferase | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| Sir2 family of transcriptional regulators | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Neurotrophin | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
| Cytidylyltransferase | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| Ammonium transporter | 0 | DIRECT |
| gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| HMA, heavy metal-associated domain | 0 | DIRECT |
| Phenylalanine metabolism regulatory domain | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| Hormone receptor domain | 0.0003055 | DIRECT |
| Short-chain cytokines | 0.0003433 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0003433 | DIRECT |
| GABA-aminotransferase-like | 0.004859 | INHERITED FROM: abnormal circulating amino acid level |
| Aquaporin-like | 0.006361 | INHERITED FROM: abnormal blood osmolality || increased blood osmolality || abnormal urine homeostasis || abnormal circulating glycerol level || decreased urine osmolality || increased blood urea nitrogen level || abnormal urine osmolality || abnormal glycerol level |
| SMAD MH1 domain | 0.0092 | INHERITED FROM: abnormal circulating gonadotropin level || abnormal follicle stimulating hormone level |
| SMAD domain | 0.0092 | INHERITED FROM: abnormal circulating gonadotropin level || abnormal follicle stimulating hormone level |
| STAT DNA-binding domain | 0.01706 | INHERITED FROM: abnormal adaptive thermogenesis || increased circulating leptin level || abnormal cytokine level || increased circulating insulin level || abnormal circulating leptin level || abnormal protein level || abnormal circulating triglyceride level || impaired glucose tolerance || abnormal interleukin level || increased triglyceride level || abnormal circulating interleukin level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || increased circulating triglyceride level || abnormal circulating interferon-gamma level || abnormal circulating insulin-like growth factor I level || abnormal circulating protein level || impaired adaptive thermogenesis || abnormal insulin-like growth factor I level |
| Transcription factor STAT-4 N-domain | 0.01706 | INHERITED FROM: abnormal adaptive thermogenesis || increased circulating leptin level || abnormal cytokine level || increased circulating insulin level || abnormal circulating leptin level || abnormal protein level || abnormal circulating triglyceride level || impaired glucose tolerance || abnormal interleukin level || increased triglyceride level || abnormal circulating interleukin level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || increased circulating triglyceride level || abnormal circulating interferon-gamma level || abnormal circulating insulin-like growth factor I level || abnormal circulating protein level || impaired adaptive thermogenesis || abnormal insulin-like growth factor I level |
| L domain | 0.01706 | INHERITED FROM: impaired glucose tolerance || abnormal gas homeostasis || increased circulating glucose level || hyperglycemia || cyanosis |
| STAT | 0.01706 | INHERITED FROM: abnormal adaptive thermogenesis || increased circulating leptin level || abnormal cytokine level || increased circulating insulin level || abnormal circulating leptin level || abnormal protein level || abnormal circulating triglyceride level || impaired glucose tolerance || abnormal interleukin level || increased triglyceride level || abnormal circulating interleukin level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || increased circulating triglyceride level || abnormal circulating interferon-gamma level || abnormal circulating insulin-like growth factor I level || abnormal circulating protein level || impaired adaptive thermogenesis || abnormal insulin-like growth factor I level |
| Pancreatic lipase, N-terminal domain | 0.01706 | INHERITED FROM: abnormal phospholipid level || abnormal lipid homeostasis || abnormal circulating phospholipid level || increased triglyceride level || abnormal circulating LDL cholesterol level || abnormal cholesterol level || increased circulating HDL cholesterol level || abnormal circulating lipid level || increased circulating triglyceride level |
| Fatty acid binding protein-like | 0.02473 | INHERITED FROM: decreased triglyceride level || abnormal vitamin A level || decreased circulating cholesterol level || abnormal vitamin homeostasis || abnormal vitamin level || abnormal fat-soluble vitamin level |
| Lipoxigenase N-terminal domain | 0.03125 | INHERITED FROM: impaired skin barrier function |
| C-type lectin domain | 0.03246 | INHERITED FROM: abnormal protein level |
| Insulin-like | 0.03306 | INHERITED FROM: abnormal hormone level || hyperglycemia |
| SNF-like | 0.03886 | INHERITED FROM: abnormal amino acid level |
| Nuclear receptor ligand-binding domain | 0.03909 | INHERITED FROM: abnormal circulating gonadotropin level || increased circulating leptin level || abnormal lipid homeostasis || abnormal circulating testosterone level || abnormal circulating hormone level || abnormal hormone level || abnormal lipoprotein level || abnormal circulating androgen level || abnormal triiodothyronine level || abnormal circulating lipoprotein level || abnormal testosterone level || abnormal circulating lipid level || abnormal energy expenditure || increased bile salt level || abnormal circulating pituitary hormone level || decreased circulating progesterone level || abnormal luteinizing hormone level || decreased circulating insulin-like growth factor I level |
| Nuclear receptor | 0.04729 | INHERITED FROM: abnormal circulating gonadotropin level || increased circulating leptin level || decreased circulating testosterone level || abnormal lipid homeostasis || abnormal circulating testosterone level || abnormal circulating hormone level || abnormal hormone level || abnormal circulating androgen level || abnormal triiodothyronine level || abnormal circulating lipid level || abnormal energy expenditure || abnormal circulating pituitary hormone level || decreased circulating progesterone level || abnormal luteinizing hormone level || decreased circulating insulin-like growth factor I level |
| Nuclear receptor coactivator interlocking domain | 0.05714 | INHERITED FROM: increased circulating leptin level || abnormal circulating leptin level |
| Serum albumin-like | 0.05714 | INHERITED FROM: abnormal sterol level || abnormal cholesterol homeostasis || abnormal circulating cholesterol level || abnormal cholesterol level |
| Transducin (alpha subunit), insertion domain | 0.07071 | INHERITED FROM: abnormal circulating parathyroid hormone level || abnormal blood coagulation || abnormal platelet aggregation || abnormal platelet physiology || decreased platelet aggregation || abnormal calcium ion homeostasis || abnormal circulating calcium level || abnormal platelet activation || increased circulating parathyroid hormone level |
| Rhodopsin-like | 0.07193 | INHERITED FROM: abnormal circulating corticosterone level || abnormal circulating hormone level || abnormal hormone level || abnormal catecholamine level || abnormal energy homeostasis || abnormal circulating glucocorticoid level || abnormal corticosterone level || abnormal dopamine level || abnormal body temperature homeostasis || decreased response to stress-induced hyperthermia |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.09235 | INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level |
| Pyrin domain, PYD | 0.09235 | INHERITED FROM: decreased circulating interleukin-18 level || abnormal circulating interleukin-18 level || abnormal protein level || abnormal circulating interleukin level || abnormal circulating interleukin-1 beta level || abnormal intercellular signaling peptide or protein level |
| Crotonase-like | 0.1033 | INHERITED FROM: abnormal fatty acid level |
| GAT domain | 0.1033 | INHERITED FROM: abnormal circulating glucose level || hypoglycemia || decreased circulating glucose level |
| beta-glycanases | 0.1033 | INHERITED FROM: abnormal enzyme/coenzyme level |
| Kinase associated domain 1, KA1 | 0.1033 | INHERITED FROM: increased energy expenditure || abnormal circulating glucose level || abnormal energy homeostasis || decreased circulating insulin level || abnormal energy expenditure || decreased susceptibility to diet-induced obesity || decreased circulating glucose level || abnormal circulating insulin level |
| Triple coiled coil domain of C-type lectins | 0.1033 | INHERITED FROM: abnormal cytokine level || abnormal intercellular signaling peptide or protein level |
| Acetyl-CoA synthetase-like | 0.1132 | INHERITED FROM: abnormal lipid homeostasis |
| Interferon regulatory factor | 0.117 | INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level |
| SH2 domain | 0.1313 | INHERITED FROM: increased circulating interleukin-17 level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || abnormal circulating interferon-gamma level || increased circulating interleukin-12 level |
| EGF-type module | 0.146 | INHERITED FROM: abnormal blood coagulation || abnormal oxygen level || hyperlipidemia || cyanosis || abnormal hemostasis |
| Noncollagenous (NC1) domain of collagen IV | 0.1489 | INHERITED FROM: abnormal circulating amino acid level || abnormal urine homeostasis || abnormal circulating creatinine level || abnormal amino acid level || abnormal blood urea nitrogen level || increased blood urea nitrogen level || increased urine protein level || uremia || increased circulating creatinine level || abnormal urine protein level |
| E2F dimerization segment | 0.1489 | INHERITED FROM: abnormal fluid regulation |
| Cation efflux protein transmembrane domain-like | 0.1489 | INHERITED FROM: abnormal mineral homeostasis || abnormal zinc homeostasis |
| Phosphotyrosine-binding domain (PTB) | 0.1518 | INHERITED FROM: abnormal hormone level || abnormal circulating insulin level |
| 28-residue LRR | 0.2222 | INHERITED FROM: abnormal circulating interleukin level |
| Integrin domains | 0.2426 | INHERITED FROM: decreased platelet aggregation |
| Chaperone J-domain | 0.2838 | INHERITED FROM: abnormal liver glycogen level |
| Toll/Interleukin receptor TIR domain | 0.3178 | INHERITED FROM: decreased circulating alanine transaminase level || abnormal protein level || decreased circulating interleukin-6 level || abnormal circulating protein level |
| TNF receptor-like | 0.3481 | INHERITED FROM: abnormal intercellular signaling peptide or protein level || abnormal body temperature homeostasis |
| T-box | 0.3481 | INHERITED FROM: edema |
| Forkhead DNA-binding domain | 0.3754 | INHERITED FROM: decreased circulating luteinizing hormone level || hyperglycemia || decreased luteinizing hormone level || decreased circulating follicle stimulating hormone level || abnormal insulin secretion |
| HMG-box | 0.3754 | INHERITED FROM: edema |
| Meta-cation ATPase, catalytic domain P | 0.3791 | INHERITED FROM: abnormal circulating mineral level || abnormal ion homeostasis || abnormal mineral level |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.3791 | INHERITED FROM: abnormal circulating noradrenaline level || abnormal hormone level || hyperglycemia || decreased noradrenaline level || abnormal gluconeogenesis || decreased circulating noradrenaline level |
| Transforming growth factor (TGF)-beta | 0.3815 | INHERITED FROM: abnormal circulating gonadotropin level || abnormal follicle stimulating hormone level || increased circulating follicle stimulating hormone level || abnormal pituitary hormone level || abnormal circulating pituitary hormone level || decreased circulating follicle stimulating hormone level |
| Pleckstrin-homology domain (PH domain) | 0.3945 | INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation |
| PLC-like (P variant) | 0.4012 | INHERITED FROM: abnormal blood coagulation || abnormal platelet calcium level || abnormal platelet aggregation || abnormal platelet physiology || abnormal calcium ion homeostasis || abnormal platelet activation || abnormal hemostasis |
| CBS-domain pair | 0.4156 | INHERITED FROM: abnormal renal protein reabsorption |
| Growth factor receptor domain | 0.4469 | INHERITED FROM: decreased circulating total protein level || increased insulin secretion || cyanosis |
| Carbonic anhydrase | 0.4767 | INHERITED FROM: abnormal pH regulation |
| YWTD domain | 0.4968 | INHERITED FROM: increased energy expenditure || abnormal lipoprotein level || abnormal sterol level || increased triglyceride level || increased circulating cholesterol level || abnormal circulating cholesterol level || increased cholesterol level || increased circulating triglyceride level || decreased susceptibility to diet-induced obesity || decreased liver triglyceride level |
| Arylsulfatase | 0.5008 | INHERITED FROM: abnormal glycosaminoglycan level |
| Interferons/interleukin-10 (IL-10) | 0.5008 | INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level |
| VHS domain | 0.5136 | INHERITED FROM: hypoglycemia |
| Mammalian PLC | 0.5414 | INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation || abnormal calcium ion homeostasis || abnormal platelet activation |
| Platelet-derived growth factor-like | 0.5414 | INHERITED FROM: abnormal fluid regulation || edema |
| Papain-like | 0.5414 | INHERITED FROM: abnormal thyroid hormone level || hyperglycemia |
| Anion transport protein, cytoplasmic domain | 0.5414 | INHERITED FROM: abnormal pH regulation || decreased circulating bicarbonate level || abnormal circulating bicarbonate level |
| ABC transporter transmembrane region | 0.5456 | INHERITED FROM: abnormal ion homeostasis || abnormal bile salt level |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.5666 | INHERITED FROM: decreased insulin secretion |
| Clc chloride channel | 0.5927 | INHERITED FROM: abnormal renal protein reabsorption |
| Cytochrome b5 | 0.5927 | INHERITED FROM: abnormal lipid homeostasis || abnormal lipid level |
| LDL receptor-like module | 0.5979 | INHERITED FROM: increased circulating chloride level |
| Pointed domain | 0.6476 | INHERITED FROM: edema |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.6476 | INHERITED FROM: hydrops fetalis |
| Interleukin-1 (IL-1) | 0.6476 | INHERITED FROM: abnormal cytokine level || abnormal protein level || abnormal interleukin level || abnormal circulating interleukin level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || abnormal circulating protein level || abnormal body temperature homeostasis |
| Myeloperoxidase-like | 0.6476 | INHERITED FROM: increased circulating pituitary hormone level || increased pituitary hormone level |
| p120GAP domain-like | 0.6476 | INHERITED FROM: abnormal circulating aspartate transaminase level |
| Homeodomain | 0.6728 | INHERITED FROM: abnormal oxygen level || abnormal gas homeostasis || cyanosis |
| ABC transporter ATPase domain-like | 0.6811 | INHERITED FROM: abnormal lipid homeostasis || abnormal circulating phytosterol level || abnormal phytosterol level || abnormal intestinal cholesterol absorption || abnormal fat-soluble vitamin level |
| CAD domain | 0.7076 | INHERITED FROM: decreased triglyceride level || abnormal circulating triglyceride level || decreased fatty acid level || abnormal fatty acid level || abnormal triglyceride level || decreased circulating triglyceride level |
| HLH, helix-loop-helix DNA-binding domain | 0.7246 | INHERITED FROM: decreased noradrenaline level || decreased circulating noradrenaline level || cyanosis || abnormal circulating estradiol level |
| G proteins | 0.7253 | INHERITED FROM: abnormal platelet aggregation || abnormal platelet activation |
| DEATH domain, DD | 0.7352 | INHERITED FROM: abnormal protein level || abnormal circulating interleukin level || decreased circulating interleukin-6 level || abnormal circulating protein level |
| Long-chain cytokines | 0.7563 | INHERITED FROM: abnormal cytokine level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level |
| Cytochrome P450 | 0.7618 | INHERITED FROM: abnormal aldosterone level || decreased circulating aldosterone level || abnormal lipid homeostasis || abnormal vitamin level || abnormal fat-soluble vitamin level || decreased circulating mineralocorticoid level |
| CCCH zinc finger | 0.7731 | INHERITED FROM: abnormal circulating tumor necrosis factor level || increased circulating tumor necrosis factor level |
| Thyroglobulin type-1 domain | 0.8077 | INHERITED FROM: increased insulin secretion || abnormal circulating insulin-like growth factor I level || decreased circulating insulin-like growth factor I level || abnormal insulin-like growth factor I level |
| Caspase catalytic domain | 0.8309 | INHERITED FROM: abnormal circulating interleukin-18 level |
| Caspase recruitment domain, CARD | 0.8309 | INHERITED FROM: abnormal circulating interleukin-18 level || abnormal circulating interferon-gamma level |
| Intermediate filament protein, coiled coil region | 0.8832 | INHERITED FROM: impaired skin barrier function |
| Inhibitor of apoptosis (IAP) repeat | 0.9022 | INHERITED FROM: abnormal fluid regulation || hemopericardium |
| Fibronectin type III | 0.912 | INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || abnormal circulating interferon-gamma level |
| Cyclin | 0.9548 | INHERITED FROM: hydrops fetalis |
| Kringle modules | 0.9565 | INHERITED FROM: abnormal blood coagulation || abnormal acute phase protein level || abnormal hemostasis |
| Eukaryotic proteases | 0.9667 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lamin A/C globular tail domain | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| Neurolysin-like | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| Notch domain | 0 | Direct |
| Ferredoxin reductase FAD-binding domain-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Animal lipoxigenases | 0 | Direct |
| Multidomain cupredoxins | 0 | Direct |
| NADPH-cytochrome p450 reductase-like | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| FAS1 domain | 0 | Direct |
| RUNT domain | 0 | Direct |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | Direct |
| Carboxylesterase | 0 | Direct |
| Choline/Carnitine O-acyltransferase | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| Sir2 family of transcriptional regulators | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Neurotrophin | 0 | Direct |
| GLA-domain | 0 | Direct |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
| Cytidylyltransferase | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Metallothionein | 0 | Direct |
| Ammonium transporter | 0 | Direct |
| gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| HMA, heavy metal-associated domain | 0 | Direct |
| Phenylalanine metabolism regulatory domain | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| Hormone receptor domain | 0.0003055 | Direct |
| Short-chain cytokines | 0.0003433 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0003433 | Direct |
| GABA-aminotransferase-like | 0.004859 | Inherited |
| Aquaporin-like | 0.006361 | Inherited |
| SMAD MH1 domain | 0.0092 | Inherited |
| SMAD domain | 0.0092 | Inherited |
| STAT DNA-binding domain | 0.01706 | Inherited |
| Transcription factor STAT-4 N-domain | 0.01706 | Inherited |
| L domain | 0.01706 | Inherited |
| STAT | 0.01706 | Inherited |
| Pancreatic lipase, N-terminal domain | 0.01706 | Inherited |
| Fatty acid binding protein-like | 0.02473 | Inherited |
| Lipoxigenase N-terminal domain | 0.03125 | Inherited |
| C-type lectin domain | 0.03246 | Inherited |
| Insulin-like | 0.03306 | Inherited |
| SNF-like | 0.03886 | Inherited |
| Nuclear receptor ligand-binding domain | 0.03909 | Inherited |
| Nuclear receptor | 0.04729 | Inherited |
| Nuclear receptor coactivator interlocking domain | 0.05714 | Inherited |
| Serum albumin-like | 0.05714 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.07071 | Inherited |
| Rhodopsin-like | 0.07193 | Inherited |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.09235 | Inherited |
| Pyrin domain, PYD | 0.09235 | Inherited |
| Crotonase-like | 0.1033 | Inherited |
| GAT domain | 0.1033 | Inherited |
| beta-glycanases | 0.1033 | Inherited |
| Kinase associated domain 1, KA1 | 0.1033 | Inherited |
| Triple coiled coil domain of C-type lectins | 0.1033 | Inherited |
| Acetyl-CoA synthetase-like | 0.1132 | Inherited |
| Interferon regulatory factor | 0.117 | Inherited |
| SH2 domain | 0.1313 | Inherited |
| EGF-type module | 0.146 | Inherited |
| Noncollagenous (NC1) domain of collagen IV | 0.1489 | Inherited |
| E2F dimerization segment | 0.1489 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.1489 | Inherited |
| Phosphotyrosine-binding domain (PTB) | 0.1518 | Inherited |
| 28-residue LRR | 0.2222 | Inherited |
| Integrin domains | 0.2426 | Inherited |
| Chaperone J-domain | 0.2838 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.3178 | Inherited |
| TNF receptor-like | 0.3481 | Inherited |
| T-box | 0.3481 | Inherited |
| Forkhead DNA-binding domain | 0.3754 | Inherited |
| HMG-box | 0.3754 | Inherited |
| Meta-cation ATPase, catalytic domain P | 0.3791 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.3791 | Inherited |
| Transforming growth factor (TGF)-beta | 0.3815 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.3945 | Inherited |
| PLC-like (P variant) | 0.4012 | Inherited |
| CBS-domain pair | 0.4156 | Inherited |
| Growth factor receptor domain | 0.4469 | Inherited |
| Carbonic anhydrase | 0.4767 | Inherited |
| YWTD domain | 0.4968 | Inherited |
| Arylsulfatase | 0.5008 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.5008 | Inherited |
| VHS domain | 0.5136 | Inherited |
| Mammalian PLC | 0.5414 | Inherited |
| Platelet-derived growth factor-like | 0.5414 | Inherited |
| Papain-like | 0.5414 | Inherited |
| Anion transport protein, cytoplasmic domain | 0.5414 | Inherited |
| ABC transporter transmembrane region | 0.5456 | Inherited |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.5666 | Inherited |
| Clc chloride channel | 0.5927 | Inherited |
| Cytochrome b5 | 0.5927 | Inherited |
| LDL receptor-like module | 0.5979 | Inherited |
| Pointed domain | 0.6476 | Inherited |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.6476 | Inherited |
| Interleukin-1 (IL-1) | 0.6476 | Inherited |
| Myeloperoxidase-like | 0.6476 | Inherited |
| p120GAP domain-like | 0.6476 | Inherited |
| Homeodomain | 0.6728 | Inherited |
| ABC transporter ATPase domain-like | 0.6811 | Inherited |
| CAD domain | 0.7076 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.7246 | Inherited |
| G proteins | 0.7253 | Inherited |
| DEATH domain, DD | 0.7352 | Inherited |
| Long-chain cytokines | 0.7563 | Inherited |
| Cytochrome P450 | 0.7618 | Inherited |
| CCCH zinc finger | 0.7731 | Inherited |
| Thyroglobulin type-1 domain | 0.8077 | Inherited |
| Caspase catalytic domain | 0.8309 | Inherited |
| Caspase recruitment domain, CARD | 0.8309 | Inherited |
| Intermediate filament protein, coiled coil region | 0.8832 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.9022 | Inherited |
| Fibronectin type III | 0.912 | Inherited |
| Cyclin | 0.9548 | Inherited |
| Kringle modules | 0.9565 | Inherited |
| Eukaryotic proteases | 0.9667 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this MP term (SPMP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Lipoxigenase | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| HMA, heavy metal-associated domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Ammonium transporter | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Hormone receptor domain | 0.0002097 | DIRECT |
| PLP-dependent transferases | 0.003669 | INHERITED FROM: abnormal amino acid level || abnormal circulating amino acid level |
| Acyl-CoA dehydrogenase NM domain-like | 0.003875 | INHERITED FROM: abnormal adaptive thermogenesis || aciduria || abnormal amino acid level || abnormal circulating amino acid level || abnormal circulating carnitine level |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.003875 | INHERITED FROM: abnormal adaptive thermogenesis || aciduria || abnormal amino acid level || abnormal circulating amino acid level || abnormal circulating carnitine level |
| MFS general substrate transporter | 0.004809 | INHERITED FROM: abnormal urine uric acid level |
| Aquaporin-like | 0.004954 | INHERITED FROM: increased blood urea nitrogen level || abnormal glycerol level || abnormal circulating glycerol level || abnormal urine osmolality || abnormal blood osmolality || increased blood osmolality || abnormal urine homeostasis || decreased urine osmolality |
| Glycerol-3-phosphate (1)-acyltransferase | 0.004954 | INHERITED FROM: increased oxygen consumption |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.007355 | INHERITED FROM: abnormal circulating phospholipid level || abnormal cholesterol level || abnormal circulating cholesterol level |
| SMAD MH1 domain | 0.007528 | INHERITED FROM: abnormal follicle stimulating hormone level || abnormal circulating gonadotropin level |
| STAT | 0.01429 | INHERITED FROM: abnormal circulating triglyceride level || abnormal adaptive thermogenesis || abnormal circulating cytokine level || impaired adaptive thermogenesis || increased triglyceride level || abnormal protein level || increased circulating leptin level || abnormal intercellular signaling peptide or protein level || abnormal circulating interleukin level || abnormal insulin-like growth factor I level || impaired glucose tolerance || abnormal circulating protein level || increased circulating triglyceride level || abnormal cytokine level || abnormal circulating leptin level || increased circulating insulin level || abnormal interleukin level || abnormal circulating insulin-like growth factor I level || abnormal circulating interferon-gamma level |
| Transcription factor STAT-4 N-domain | 0.01429 | INHERITED FROM: abnormal circulating triglyceride level || abnormal adaptive thermogenesis || abnormal circulating cytokine level || impaired adaptive thermogenesis || increased triglyceride level || abnormal protein level || increased circulating leptin level || abnormal intercellular signaling peptide or protein level || abnormal circulating interleukin level || abnormal insulin-like growth factor I level || impaired glucose tolerance || abnormal circulating protein level || increased circulating triglyceride level || abnormal cytokine level || abnormal circulating leptin level || increased circulating insulin level || abnormal interleukin level || abnormal circulating insulin-like growth factor I level || abnormal circulating interferon-gamma level |
| KA1-like | 0.02706 | INHERITED FROM: abnormal hormone level || abnormal energy expenditure || decreased circulating glucose level || abnormal energy homeostasis || abnormal circulating hormone level || decreased susceptibility to diet-induced obesity || decreased circulating insulin level |
| Thioesterase/thiol ester dehydrase-isomerase | 0.02706 | INHERITED FROM: abnormal lipid homeostasis || abnormal lipid level || abnormal fatty acid level |
| DHS-like NAD/FAD-binding domain | 0.028 | INHERITED FROM: increased liver triglyceride level || increased triglyceride level || increased circulating cholesterol level |
| Insulin-like | 0.028 | INHERITED FROM: abnormal hormone level || hyperglycemia |
| C-type lectin-like | 0.03103 | INHERITED FROM: abnormal protein level || abnormal circulating protein level |
| SNF-like | 0.03196 | INHERITED FROM: abnormal amino acid level |
| Nuclear receptor ligand-binding domain | 0.03829 | INHERITED FROM: decreased circulating pituitary hormone level || abnormal hormone level || abnormal circulating testosterone level || abnormal circulating androgen level || increased bile salt level || increased circulating leptin level || abnormal lipid homeostasis || abnormal energy expenditure || abnormal triiodothyronine level || abnormal lipoprotein level || decreased circulating progesterone level || decreased circulating insulin-like growth factor I level || abnormal circulating gonadotropin level || abnormal circulating hormone level || abnormal circulating lipoprotein level || abnormal testosterone level || abnormal circulating pituitary hormone level || abnormal circulating lipid level || abnormal luteinizing hormone level |
| Family A G protein-coupled receptor-like | 0.04034 | INHERITED FROM: abnormal catecholamine level || abnormal hormone level || abnormal corticosterone level || abnormal body temperature homeostasis || abnormal dopamine level || abnormal urine osmolality || abnormal circulating glucocorticoid level || abnormal energy homeostasis || abnormal urine sodium level || abnormal circulating hormone level || decreased response to stress-induced hyperthermia || abnormal circulating corticosterone level |
| Serum albumin-like | 0.0506 | INHERITED FROM: abnormal sterol level || abnormal cholesterol level || abnormal circulating cholesterol level || abnormal cholesterol homeostasis |
| ACT-like | 0.0506 | INHERITED FROM: abnormal hormone level || abnormal serotonin level |
| Nuclear receptor coactivator interlocking domain | 0.0506 | INHERITED FROM: increased circulating leptin level || abnormal circulating leptin level |
| Apolipoprotein A-I | 0.0506 | INHERITED FROM: abnormal circulating triglyceride level || abnormal sterol level || abnormal lipid homeostasis || abnormal lipid level || abnormal cholesterol level || abnormal lipoprotein level || abnormal circulating lipoprotein level || abnormal circulating cholesterol level || abnormal cholesterol homeostasis || decreased circulating HDL cholesterol level || abnormal circulating lipid level || abnormal triglyceride level |
| FAD-binding/transporter-associated domain-like | 0.0506 | INHERITED FROM: abnormal lipid homeostasis || abnormal lipid level |
| Transducin (alpha subunit), insertion domain | 0.05909 | INHERITED FROM: abnormal calcium ion homeostasis || abnormal platelet activation || abnormal circulating calcium level || abnormal platelet physiology || abnormal circulating parathyroid hormone level || decreased platelet aggregation || abnormal blood coagulation || abnormal platelet aggregation || increased circulating parathyroid hormone level |
| Galactose mutarotase-like | 0.08138 | INHERITED FROM: abnormal glycogen homeostasis |
| SH2 domain | 0.09343 | INHERITED FROM: increased circulating interleukin-17 level || abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || increased circulating interleukin-12 level || decreased platelet aggregation || abnormal circulating interferon-gamma level |
| Triple coiled coil domain of C-type lectins | 0.09346 | INHERITED FROM: abnormal intercellular signaling peptide or protein level || abnormal cytokine level |
| Acetyl-CoA synthetase-like | 0.09657 | INHERITED FROM: abnormal lipid homeostasis |
| Clathrin adaptor appendage domain | 0.103 | INHERITED FROM: hypoglycemia |
| ClpP/crotonase | 0.103 | INHERITED FROM: abnormal fatty acid level || increased circulating insulin level |
| Cation efflux protein transmembrane domain-like | 0.1348 | INHERITED FROM: abnormal mineral homeostasis || abnormal zinc homeostasis |
| GAT-like domain | 0.1348 | INHERITED FROM: hypoglycemia || decreased circulating glucose level |
| (Trans)glycosidases | 0.153 | INHERITED FROM: abnormal urine glycosaminoglycan level || increased brain glycogen level || abnormal skeletal muscle glycogen level || abnormal glycosaminoglycan level || abnormal brain glycogen level || abnormal muscle glycogen level || abnormal urine homeostasis || increased skeletal muscle glycogen level || increased glycogen level |
| PYP-like sensor domain (PAS domain) | 0.153 | INHERITED FROM: abnormal catecholamine level || abnormal hormone level || increased circulating leptin level || abnormal energy expenditure || decreased circulating noradrenaline level || abnormal circulating estradiol level || abnormal circulating hormone level || decreased noradrenaline level |
| p53-like transcription factors | 0.1616 | INHERITED FROM: impaired adaptive thermogenesis || abnormal intercellular signaling peptide or protein level || abnormal insulin-like growth factor I level || abnormal fluid regulation || abnormal interleukin level || abnormal circulating insulin-like growth factor I level || abnormal circulating interferon-gamma level |
| t-snare proteins | 0.1749 | INHERITED FROM: abnormal circulating insulin level |
| GroEL equatorial domain-like | 0.2184 | INHERITED FROM: increased circulating leptin level || abnormal circulating leptin level |
| Lipocalins | 0.2393 | INHERITED FROM: decreased cholesterol level || decreased sterol level || abnormal fat-soluble vitamin level || abnormal vitamin level || abnormal vitamin homeostasis || abnormal vitamin A level || decreased triglyceride level || decreased circulating cholesterol level |
| Integrin domains | 0.2393 | INHERITED FROM: albuminuria || decreased platelet aggregation |
| E2F-DP heterodimerization region | 0.2405 | INHERITED FROM: abnormal fluid regulation |
| Chaperone J-domain | 0.2446 | INHERITED FROM: abnormal liver glycogen level |
| Alkaline phosphatase-like | 0.2627 | INHERITED FROM: abnormal glycosaminoglycan level |
| 4-helical cytokines | 0.2656 | INHERITED FROM: increased circulating interleukin-17 level || abnormal circulating cytokine level || abnormal protein level || abnormal intercellular signaling peptide or protein level || decreased circulating creatinine level || decreased core body temperature |
| Cystine-knot cytokines | 0.285 | INHERITED FROM: abnormal follicle stimulating hormone level || abnormal circulating gonadotropin level || abnormal circulating pituitary hormone level || decreased circulating follicle stimulating hormone level |
| Toll/Interleukin receptor TIR domain | 0.287 | INHERITED FROM: abnormal circulating cytokine level || decreased circulating alanine transaminase level || abnormal protein level || abnormal intercellular signaling peptide or protein level || decreased macrophage nitric oxide production || abnormal circulating protein level || abnormal circulating interferon-alpha level || decreased circulating interleukin-6 level |
| E set domains | 0.3249 | INHERITED FROM: abnormal circulating amylase level |
| HMG-box | 0.3269 | INHERITED FROM: edema |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.3339 | INHERITED FROM: abnormal hormone level || abnormal circulating testosterone level || abnormal circulating androgen level || abnormal pituitary hormone level || abnormal circulating gonadotropin level || abnormal circulating pituitary hormone level || decreased circulating testosterone level |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.35 | INHERITED FROM: abnormal glycogen level |
| Bet v1-like | 0.3751 | INHERITED FROM: abnormal lipid homeostasis || abnormal cholesterol level |
| Riboflavin synthase domain-like | 0.3751 | INHERITED FROM: increased blood urea nitrogen level || increased pituitary hormone level || decreased urine sodium level || abnormal circulating LDL cholesterol level || increased circulating pituitary hormone level || increased circulating creatinine level || decreased adiponectin level || abnormal sodium ion homeostasis || abnormal nitric oxide homeostasis || abnormal blood osmolality || increased blood osmolality || abnormal urine sodium level || abnormal prostaglandin level || abnormal circulating alkaline phosphatase level || abnormal thrombosis || increased prostaglandin level || abnormal amino acid level || increased circulating alkaline phosphatase level || increased circulating LDL cholesterol level || abnormal kidney thrombosis || glomerular capillary thrombosis || decreased urine osmolality |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.3751 | INHERITED FROM: increased blood urea nitrogen level || increased pituitary hormone level || decreased urine sodium level || abnormal circulating LDL cholesterol level || increased circulating pituitary hormone level || increased circulating creatinine level || decreased adiponectin level || abnormal sodium ion homeostasis || abnormal nitric oxide homeostasis || abnormal blood osmolality || increased blood osmolality || abnormal urine sodium level || abnormal prostaglandin level || abnormal circulating alkaline phosphatase level || abnormal thrombosis || increased prostaglandin level || abnormal amino acid level || increased circulating alkaline phosphatase level || increased circulating LDL cholesterol level || abnormal kidney thrombosis || glomerular capillary thrombosis || decreased urine osmolality |
| PH domain-like | 0.3973 | INHERITED FROM: abnormal platelet activation |
| CBS-domain pair | 0.4106 | INHERITED FROM: abnormal renal protein reabsorption |
| DEATH domain | 0.4141 | INHERITED FROM: abnormal circulating cytokine level || abnormal protein level || abnormal intercellular signaling peptide or protein level || abnormal circulating protein level || abnormal circulating interleukin-18 level || abnormal circulating interferon-gamma level |
| Carbonic anhydrase | 0.4427 | INHERITED FROM: abnormal pH regulation |
| ABC transporter transmembrane region | 0.4802 | INHERITED FROM: abnormal bile salt level |
| YWTD domain | 0.4912 | INHERITED FROM: decreased liver triglyceride level || abnormal sterol level || increased triglyceride level || increased energy expenditure || abnormal lipoprotein level || increased circulating cholesterol level || increased circulating triglyceride level || abnormal circulating cholesterol level || decreased susceptibility to diet-induced obesity || increased cholesterol level |
| Phoshotransferase/anion transport protein | 0.4912 | INHERITED FROM: decreased circulating bicarbonate level || abnormal circulating bicarbonate level || abnormal urine calcium level || decreased urine osmolality || abnormal pH regulation |
| Glycosyl hydrolase domain | 0.4912 | INHERITED FROM: abnormal glycogen homeostasis || abnormal circulating enzyme level |
| Actin-like ATPase domain | 0.5104 | INHERITED FROM: increased circulating ketone body level || abnormal circulating ketone body level |
| Flavoproteins | 0.537 | INHERITED FROM: increased blood urea nitrogen level || abnormal circulating triglyceride level || decreased urine sodium level || abnormal circulating LDL cholesterol level || increased circulating creatinine level || decreased adiponectin level || abnormal sodium ion homeostasis || abnormal circulating enzyme level || abnormal lipid level || abnormal cholesterol level || abnormal nitric oxide homeostasis || abnormal urine osmolality || abnormal blood osmolality || increased blood osmolality || abnormal urine sodium level || abnormal prostaglandin level || abnormal circulating alkaline phosphatase level || abnormal thrombosis || increased prostaglandin level || abnormal amino acid level || increased circulating alkaline phosphatase level || increased circulating LDL cholesterol level || abnormal kidney thrombosis || abnormal circulating amino acid level || glomerular capillary thrombosis || abnormal blood coagulation || decreased urine osmolality || abnormal triglyceride level |
| Growth factor receptor domain | 0.5696 | INHERITED FROM: cyanosis |
| TNF receptor-like | 0.5753 | INHERITED FROM: abnormal body temperature homeostasis |
| Thioredoxin-like | 0.5764 | INHERITED FROM: increased circulating thyroxine level || increased thyroxine level || increased circulating levels of thyroid hormone |
| Multidrug efflux transporter AcrB transmembrane domain | 0.588 | INHERITED FROM: decreased liver cholesterol level || abnormal sterol level || abnormal circulating LDL cholesterol level || decreased cholesterol level || decreased sterol level || abnormal liver cholesterol level || abnormal cholesterol level || abnormal circulating non-HDL cholesterol level || abnormal cholesterol homeostasis |
| Clc chloride channel | 0.588 | INHERITED FROM: abnormal renal protein reabsorption |
| Phospholipase A2, PLA2 | 0.588 | INHERITED FROM: abnormal lipid homeostasis |
| LDL receptor-like module | 0.5947 | INHERITED FROM: increased circulating chloride level |
| Heme-dependent peroxidases | 0.6434 | INHERITED FROM: increased pituitary hormone level || increased circulating pituitary hormone level |
| HLH, helix-loop-helix DNA-binding domain | 0.6528 | INHERITED FROM: cyanosis || decreased circulating noradrenaline level || abnormal circulating estradiol level || decreased noradrenaline level |
| Homeodomain-like | 0.696 | INHERITED FROM: cyanosis || abnormal oxygen level || abnormal gas homeostasis |
| TNF-like | 0.7402 | INHERITED FROM: increased susceptibility to diet-induced obesity |
| CCCH zinc finger | 0.7472 | INHERITED FROM: abnormal tumor necrosis factor level || increased circulating tumor necrosis factor level || abnormal circulating tumor necrosis factor level |
| CAD & PB1 domains | 0.7532 | INHERITED FROM: increased circulating alanine transaminase level || abnormal fatty acid level || abnormal oxygen consumption || abnormal circulating leptin level |
| Cytochrome P450 | 0.7598 | INHERITED FROM: decreased circulating mineralocorticoid level || abnormal aldosterone level || decreased circulating aldosterone level || abnormal lipid homeostasis || abnormal fat-soluble vitamin level || abnormal vitamin level |
| FAD/NAD(P)-binding domain | 0.7602 | INHERITED FROM: increased dopamine level |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.7615 | INHERITED FROM: abnormal platelet calcium level || abnormal platelet activation || abnormal platelet physiology || abnormal platelet aggregation |
| Thyroglobulin type-1 domain | 0.7813 | INHERITED FROM: increased insulin secretion || abnormal insulin-like growth factor I level || decreased circulating insulin-like growth factor I level || abnormal circulating insulin-like growth factor I level |
| EGF/Laminin | 0.7928 | INHERITED FROM: cyanosis || abnormal oxygen level || abnormal blood coagulation || abnormal hemostasis |
| alpha/beta-Hydrolases | 0.7973 | INHERITED FROM: abnormal circulating phospholipid level || abnormal lipid homeostasis || abnormal cholesterol level || decreased glycerol level || abnormal phospholipid level || decreased circulating glycerol level |
| Kringle-like | 0.8141 | INHERITED FROM: abnormal acute phase protein level || abnormal blood coagulation |
| Caspase-like | 0.8266 | INHERITED FROM: abnormal circulating interleukin-18 level |
| PLC-like phosphodiesterases | 0.8266 | INHERITED FROM: abnormal calcium ion homeostasis || abnormal platelet activation || decreased platelet aggregation || abnormal platelet aggregation |
| Cyclin-like | 0.8301 | INHERITED FROM: hematuria |
| NAD(P)-binding Rossmann-fold domains | 0.8328 | INHERITED FROM: abnormal vitamin level || abnormal vitamin A level |
| Intermediate filament protein, coiled coil region | 0.8492 | INHERITED FROM: impaired skin barrier function |
| Inhibitor of apoptosis (IAP) repeat | 0.8976 | INHERITED FROM: hemopericardium || abnormal fluid regulation |
| Fibronectin type III | 0.8989 | INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || abnormal cytokine level || abnormal circulating interferon-gamma level |
| Protein kinase-like (PK-like) | 0.8997 | INHERITED FROM: abnormal glycogen homeostasis |
| FnI-like domain | 0.9121 | INHERITED FROM: abnormal blood coagulation |
| Cytokine | 0.9424 | INHERITED FROM: abnormal body temperature homeostasis |
| P-loop containing nucleoside triphosphate hydrolases | 0.9664 | INHERITED FROM: abnormal circulating phytosterol level || abnormal phytosterol level |
| Trypsin-like serine proteases | 0.9783 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
| ENTH/VHS domain | 0.9794 | INHERITED FROM: hypoglycemia |
| SMAD/FHA domain | 0.9988 | INHERITED FROM: abnormal follicle stimulating hormone level |
| Immunoglobulin | 1 | INHERITED FROM: abnormal intercellular signaling peptide or protein level |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Lipoxigenase | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| Metallothionein | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| HMA, heavy metal-associated domain | 0 | Direct |
| Notch domain | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| GLA-domain | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Ammonium transporter | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| Hormone receptor domain | 0.0002097 | Direct |
| PLP-dependent transferases | 0.003669 | Inherited |
| Acyl-CoA dehydrogenase NM domain-like | 0.003875 | Inherited |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.003875 | Inherited |
| MFS general substrate transporter | 0.004809 | Inherited |
| Aquaporin-like | 0.004954 | Inherited |
| Glycerol-3-phosphate (1)-acyltransferase | 0.004954 | Inherited |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.007355 | Inherited |
| SMAD MH1 domain | 0.007528 | Inherited |
| STAT | 0.01429 | Inherited |
| Transcription factor STAT-4 N-domain | 0.01429 | Inherited |
| KA1-like | 0.02706 | Inherited |
| Thioesterase/thiol ester dehydrase-isomerase | 0.02706 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.028 | Inherited |
| Insulin-like | 0.028 | Inherited |
| C-type lectin-like | 0.03103 | Inherited |
| SNF-like | 0.03196 | Inherited |
| Nuclear receptor ligand-binding domain | 0.03829 | Inherited |
| Family A G protein-coupled receptor-like | 0.04034 | Inherited |
| Serum albumin-like | 0.0506 | Inherited |
| ACT-like | 0.0506 | Inherited |
| Nuclear receptor coactivator interlocking domain | 0.0506 | Inherited |
| Apolipoprotein A-I | 0.0506 | Inherited |
| FAD-binding/transporter-associated domain-like | 0.0506 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.05909 | Inherited |
| Galactose mutarotase-like | 0.08138 | Inherited |
| SH2 domain | 0.09343 | Inherited |
| Triple coiled coil domain of C-type lectins | 0.09346 | Inherited |
| Acetyl-CoA synthetase-like | 0.09657 | Inherited |
| Clathrin adaptor appendage domain | 0.103 | Inherited |
| ClpP/crotonase | 0.103 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.1348 | Inherited |
| GAT-like domain | 0.1348 | Inherited |
| (Trans)glycosidases | 0.153 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.153 | Inherited |
| p53-like transcription factors | 0.1616 | Inherited |
| t-snare proteins | 0.1749 | Inherited |
| GroEL equatorial domain-like | 0.2184 | Inherited |
| Lipocalins | 0.2393 | Inherited |
| Integrin domains | 0.2393 | Inherited |
| E2F-DP heterodimerization region | 0.2405 | Inherited |
| Chaperone J-domain | 0.2446 | Inherited |
| Alkaline phosphatase-like | 0.2627 | Inherited |
| 4-helical cytokines | 0.2656 | Inherited |
| Cystine-knot cytokines | 0.285 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.287 | Inherited |
| E set domains | 0.3249 | Inherited |
| HMG-box | 0.3269 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.3339 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.35 | Inherited |
| Bet v1-like | 0.3751 | Inherited |
| Riboflavin synthase domain-like | 0.3751 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.3751 | Inherited |
| PH domain-like | 0.3973 | Inherited |
| CBS-domain pair | 0.4106 | Inherited |
| DEATH domain | 0.4141 | Inherited |
| Carbonic anhydrase | 0.4427 | Inherited |
| ABC transporter transmembrane region | 0.4802 | Inherited |
| YWTD domain | 0.4912 | Inherited |
| Phoshotransferase/anion transport protein | 0.4912 | Inherited |
| Glycosyl hydrolase domain | 0.4912 | Inherited |
| Actin-like ATPase domain | 0.5104 | Inherited |
| Flavoproteins | 0.537 | Inherited |
| Growth factor receptor domain | 0.5696 | Inherited |
| TNF receptor-like | 0.5753 | Inherited |
| Thioredoxin-like | 0.5764 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.588 | Inherited |
| Clc chloride channel | 0.588 | Inherited |
| Phospholipase A2, PLA2 | 0.588 | Inherited |
| LDL receptor-like module | 0.5947 | Inherited |
| Heme-dependent peroxidases | 0.6434 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.6528 | Inherited |
| Homeodomain-like | 0.696 | Inherited |
| TNF-like | 0.7402 | Inherited |
| CCCH zinc finger | 0.7472 | Inherited |
| CAD & PB1 domains | 0.7532 | Inherited |
| Cytochrome P450 | 0.7598 | Inherited |
| FAD/NAD(P)-binding domain | 0.7602 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.7615 | Inherited |
| Thyroglobulin type-1 domain | 0.7813 | Inherited |
| EGF/Laminin | 0.7928 | Inherited |
| alpha/beta-Hydrolases | 0.7973 | Inherited |
| Kringle-like | 0.8141 | Inherited |
| Caspase-like | 0.8266 | Inherited |
| PLC-like phosphodiesterases | 0.8266 | Inherited |
| Cyclin-like | 0.8301 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.8328 | Inherited |
| Intermediate filament protein, coiled coil region | 0.8492 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.8976 | Inherited |
| Fibronectin type III | 0.8989 | Inherited |
| Protein kinase-like (PK-like) | 0.8997 | Inherited |
| FnI-like domain | 0.9121 | Inherited |
| Cytokine | 0.9424 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.9664 | Inherited |
| Trypsin-like serine proteases | 0.9783 | Inherited |
| ENTH/VHS domain | 0.9794 | Inherited |
| SMAD/FHA domain | 0.9988 | Inherited |
| Immunoglobulin | 1 | Inherited |
(show details)
Supra-domains annotated to this MP term (SPMP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,82895
57184 - Growth factor receptor domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
48403,50044
48403 - Ankyrin repeat
50044 - SH3-domain | 0 | DIRECT |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0 | DIRECT |
50729,50156
50729 - PH domain-like
50156 - PDZ domain-like | 0 | DIRECT |
48452,57850
48452 - TPR-like
57850 - RING/U-box | 0 | DIRECT |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | DIRECT |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | DIRECT |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.003875 | INHERITED FROM: abnormal adaptive thermogenesis || aciduria || abnormal amino acid level || abnormal circulating amino acid level || abnormal circulating carnitine level |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.003875 | INHERITED FROM: abnormal sterol level || abnormal glycogen level || abnormal blood homeostasis || abnormal cholesterol level || abnormal platelet activation || abnormal platelet physiology || decreased glycogen level || abnormal circulating cholesterol level || abnormal cholesterol homeostasis || increased circulating insulin level || abnormal blood coagulation || abnormal platelet aggregation |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.007355 | INHERITED FROM: abnormal hormone level || increased circulating leptin level || abnormal circulating noradrenaline level || abnormal energy expenditure || decreased circulating noradrenaline level || abnormal circulating estradiol level || hyperglycemia || decreased noradrenaline level || abnormal gluconeogenesis |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.01429 | INHERITED FROM: abnormal circulating triglyceride level || abnormal adaptive thermogenesis || abnormal circulating cytokine level || impaired adaptive thermogenesis || increased triglyceride level || abnormal protein level || increased circulating leptin level || abnormal intercellular signaling peptide or protein level || abnormal circulating interleukin level || abnormal insulin-like growth factor I level || impaired glucose tolerance || abnormal circulating protein level || increased circulating triglyceride level || abnormal cytokine level || abnormal circulating leptin level || increased circulating insulin level || abnormal interleukin level || abnormal circulating insulin-like growth factor I level || abnormal circulating interferon-gamma level |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.01429 | INHERITED FROM: cyanosis || impaired glucose tolerance || abnormal gas homeostasis || increased circulating glucose level || hyperglycemia |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.01429 | INHERITED FROM: cyanosis || impaired glucose tolerance || abnormal gas homeostasis || increased circulating glucose level || hyperglycemia |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.01429 | INHERITED FROM: abnormal circulating triglyceride level || abnormal adaptive thermogenesis || abnormal circulating cytokine level || impaired adaptive thermogenesis || increased triglyceride level || abnormal protein level || increased circulating leptin level || abnormal intercellular signaling peptide or protein level || abnormal circulating interleukin level || abnormal insulin-like growth factor I level || impaired glucose tolerance || abnormal circulating protein level || increased circulating triglyceride level || abnormal cytokine level || abnormal circulating leptin level || increased circulating insulin level || abnormal interleukin level || abnormal circulating insulin-like growth factor I level || abnormal circulating interferon-gamma level |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.01429 | INHERITED FROM: abnormal circulating triglyceride level || abnormal sterol level || increased triglyceride level || increased circulating cholesterol level || increased circulating triglyceride level || increased cholesterol level |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.01429 | INHERITED FROM: abnormal circulating triglyceride level || abnormal adaptive thermogenesis || abnormal circulating cytokine level || impaired adaptive thermogenesis || increased triglyceride level || abnormal protein level || increased circulating leptin level || abnormal intercellular signaling peptide or protein level || abnormal circulating interleukin level || abnormal insulin-like growth factor I level || impaired glucose tolerance || abnormal circulating protein level || increased circulating triglyceride level || abnormal cytokine level || abnormal circulating leptin level || increased circulating insulin level || abnormal interleukin level || abnormal circulating insulin-like growth factor I level || abnormal circulating interferon-gamma level |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.02706 | INHERITED FROM: abnormal circulating interleukin level || abnormal circulating protein level || abnormal interleukin level || abnormal circulating interleukin-18 level |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.04832 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0.0506 | INHERITED FROM: abnormal sterol level || abnormal cholesterol level || abnormal circulating cholesterol level || abnormal cholesterol homeostasis |
50729,50729
50729 - PH domain-like
50729 - PH domain-like | 0.08134 | INHERITED FROM: decreased fatty acid level || decreased triglyceride level |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.08138 | INHERITED FROM: abnormal circulating triglyceride level || abnormal sterol level || increased triglyceride level || increased circulating cholesterol level || increased circulating triglyceride level || increased cholesterol level |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.08831 | INHERITED FROM: abnormal calcium ion homeostasis || abnormal platelet activation || abnormal circulating calcium level || abnormal platelet physiology || abnormal circulating parathyroid hormone level || decreased platelet aggregation || abnormal blood coagulation || abnormal platelet aggregation || increased circulating parathyroid hormone level |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.09346 | INHERITED FROM: abnormal intercellular signaling peptide or protein level || abnormal cytokine level |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.103 | INHERITED FROM: decreased liver triglyceride level || abnormal sterol level || increased triglyceride level || increased energy expenditure || abnormal glucose tolerance || abnormal energy expenditure || abnormal lipoprotein level || abnormal circulating non-HDL cholesterol level || abnormal liver triglyceride level || increased circulating cholesterol level || increased circulating triglyceride level || abnormal circulating lipoprotein level || abnormal circulating cholesterol level || decreased susceptibility to diet-induced obesity || increased cholesterol level |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0.1348 | INHERITED FROM: hypoglycemia || decreased circulating glucose level |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.1348 | INHERITED FROM: abnormal fluid regulation |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0.1348 | INHERITED FROM: decreased circulating insulin level |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.1396 | INHERITED FROM: decreased circulating pituitary hormone level || abnormal hormone level || abnormal circulating testosterone level || increased circulating leptin level || abnormal lipid homeostasis || abnormal energy expenditure || abnormal cholesterol level || abnormal triiodothyronine level || decreased circulating gonadotropin level || decreased circulating insulin-like growth factor I level || abnormal circulating hormone level || insulin resistance || abnormal thyroxine level || decreased pituitary hormone level || abnormal circulating pituitary hormone level || abnormal circulating lipid level || decreased circulating testosterone level |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.1593 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.1593 | INHERITED FROM: increased circulating insulin level || hyperglycemia |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.1749 | INHERITED FROM: edema || abnormal fluid regulation |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.2405 | INHERITED FROM: abnormal fluid regulation |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.287 | INHERITED FROM: decreased liver triglyceride level || abnormal sterol level || increased triglyceride level || decreased circulating VLDL cholesterol level || increased circulating triglyceride level || abnormal circulating cholesterol level || decreased susceptibility to diet-induced obesity |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.3174 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0.3541 | INHERITED FROM: abnormal insulin secretion || increased insulin secretion || decreased circulating glucose level || abnormal insulin-like growth factor I level || decreased circulating insulin-like growth factor I level || increased circulating insulin level || abnormal circulating insulin-like growth factor I level |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3557 | INHERITED FROM: abnormal intercellular signaling peptide or protein level || abnormal circulating interleukin level |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.363 | INHERITED FROM: increased dopamine level || abnormal urine homeostasis || increased urine protein level |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.4106 | INHERITED FROM: abnormal intercellular signaling peptide or protein level |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.4744 | INHERITED FROM: abnormal fluid regulation |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.4802 | INHERITED FROM: abnormal bile salt level |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0.4912 | INHERITED FROM: abnormal glycogen homeostasis || abnormal circulating enzyme level |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.5138 | INHERITED FROM: increased circulating creatinine level || abnormal urine protein level || increased urine protein level |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.5416 | INHERITED FROM: increased circulating ketone body level || abnormal circulating ketone body level |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.588 | INHERITED FROM: abnormal calcium ion homeostasis || abnormal platelet activation || decreased platelet aggregation || abnormal platelet aggregation |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.588 | INHERITED FROM: increased circulating leptin level || abnormal circulating hormone level |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0.588 | INHERITED FROM: abnormal calcium ion homeostasis || abnormal platelet activation || decreased platelet aggregation || abnormal platelet aggregation |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0.6434 | INHERITED FROM: abnormal ion homeostasis |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.6812 | INHERITED FROM: increased circulating interleukin-17 level || abnormal circulating cytokine level || abnormal protein level || abnormal intercellular signaling peptide or protein level || abnormal circulating protein level || abnormal circulating interferon-gamma level |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.703 | INHERITED FROM: hemopericardium || pericardial effusion |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.8171 | INHERITED FROM: decreased thyroid-stimulating hormone level |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.8976 | INHERITED FROM: abnormal acute phase protein level || abnormal blood coagulation || abnormal hemostasis |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.9121 | INHERITED FROM: decreased circulating alanine transaminase level || abnormal blood coagulation |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.9818 | INHERITED FROM: hydrops fetalis |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,82895
57184 - Growth factor receptor domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
48403,50044
48403 - Ankyrin repeat
50044 - SH3-domain | 0 | Direct |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0 | Direct |
50729,50156
50729 - PH domain-like
50156 - PDZ domain-like | 0 | Direct |
48452,57850
48452 - TPR-like
57850 - RING/U-box | 0 | Direct |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | Direct |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | Direct |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.003875 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.003875 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.007355 | Inherited |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.01429 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.01429 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.01429 | Inherited |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.01429 | Inherited |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.01429 | Inherited |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.01429 | Inherited |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.02706 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.04832 | Inherited |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0.0506 | Inherited |
50729,50729
50729 - PH domain-like
50729 - PH domain-like | 0.08134 | Inherited |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.08138 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.08831 | Inherited |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.09346 | Inherited |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.103 | Inherited |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0.1348 | Inherited |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.1348 | Inherited |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0.1348 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.1396 | Inherited |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.1593 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.1593 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.1749 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.2405 | Inherited |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.287 | Inherited |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.3174 | Inherited |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0.3541 | Inherited |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3557 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.363 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.4106 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.4744 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.4802 | Inherited |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0.4912 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.5138 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.5416 | Inherited |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.588 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.588 | Inherited |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0.588 | Inherited |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0.6434 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.6812 | Inherited |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.703 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.8171 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.8976 | Inherited |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.9121 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.9818 | Inherited |
(show details)
Supra-domains annotated to this MP term (SPMP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
50729,50156,50156
50729 - PH domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.01429 | INHERITED FROM: abnormal circulating triglyceride level || abnormal adaptive thermogenesis || abnormal circulating cytokine level || impaired adaptive thermogenesis || increased triglyceride level || abnormal protein level || increased circulating leptin level || abnormal intercellular signaling peptide or protein level || abnormal circulating interleukin level || abnormal insulin-like growth factor I level || impaired glucose tolerance || abnormal circulating protein level || increased circulating triglyceride level || abnormal cytokine level || abnormal circulating leptin level || increased circulating insulin level || abnormal interleukin level || abnormal circulating insulin-like growth factor I level || abnormal circulating interferon-gamma level |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.01429 | INHERITED FROM: abnormal circulating triglyceride level || abnormal adaptive thermogenesis || abnormal circulating cytokine level || impaired adaptive thermogenesis || increased triglyceride level || abnormal protein level || increased circulating leptin level || abnormal intercellular signaling peptide or protein level || abnormal circulating interleukin level || abnormal insulin-like growth factor I level || impaired glucose tolerance || abnormal circulating protein level || increased circulating triglyceride level || abnormal cytokine level || abnormal circulating leptin level || increased circulating insulin level || abnormal interleukin level || abnormal circulating insulin-like growth factor I level || abnormal circulating interferon-gamma level |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.01429 | INHERITED FROM: cyanosis || impaired glucose tolerance || abnormal gas homeostasis || increased circulating glucose level || hyperglycemia |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01442 | INHERITED FROM: abnormal blood coagulation |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0.02706 | INHERITED FROM: abnormal sterol level || abnormal circulating non-HDL cholesterol level || increased circulating cholesterol level || increased cholesterol level |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.02706 | INHERITED FROM: abnormal circulating triglyceride level || abnormal sterol level || increased triglyceride level || increased circulating cholesterol level || increased circulating triglyceride level || increased cholesterol level |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.02706 | INHERITED FROM: abnormal circulating triglyceride level || abnormal sterol level || increased triglyceride level || increased circulating cholesterol level || increased circulating triglyceride level || increased cholesterol level |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.04014 | INHERITED FROM: abnormal thrombosis |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0.09346 | INHERITED FROM: cyanosis || abnormal oxygen level || abnormal gas homeostasis |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1294 | INHERITED FROM: pericardial effusion |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0.1348 | INHERITED FROM: increased sterol level || abnormal lipoprotein level || abnormal circulating non-HDL cholesterol level || increased circulating cholesterol level || increased cholesterol level |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.1348 | INHERITED FROM: abnormal fluid regulation |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1593 | INHERITED FROM: abnormal hormone level || increased circulating leptin level || abnormal circulating hormone level |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.2184 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.2405 | INHERITED FROM: abnormal fluid regulation |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.3137 | INHERITED FROM: decreased liver triglyceride level || abnormal sterol level || increased triglyceride level || decreased circulating VLDL cholesterol level || abnormal lipid level || increased energy expenditure || increased circulating triglyceride level || abnormal circulating lipoprotein level || abnormal circulating cholesterol level || decreased susceptibility to diet-induced obesity |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.6441 | INHERITED FROM: abnormal blood coagulation |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.703 | INHERITED FROM: hemopericardium || pericardial effusion |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
50729,50156,50156
50729 - PH domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.01429 | Inherited |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.01429 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.01429 | Inherited |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01442 | Inherited |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0.02706 | Inherited |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.02706 | Inherited |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.02706 | Inherited |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.04014 | Inherited |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0.09346 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1294 | Inherited |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0.1348 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.1348 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1593 | Inherited |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.2184 | Inherited |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.2405 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.3137 | Inherited |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.6441 | Inherited |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.703 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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