Mammalian Phenotype (MP): abnormal eye morphology

(show info)

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: mammalian phenotype [MP:0000001] <29>

+ 1: vision/eye phenotype [MP:0005391] <2> (43|53) (50|27|17)

0: abnormal eye morphology [MP:0002092] <23> (39|49) (46|25|15)

- 1: abnormal eye development [MP:0001286] <22> (6|5) (6|2|2)

- 1: abnormal eyelid morphology [MP:0001340] <21> (4|8) (6|5|1)

- 1: abnormal anterior eye segment morphology [MP:0005193] <10> (13|13) (14|4|0)

- 1: abnormal eye pigmentation [MP:0001324] <8> (1|1) (2|0|1)

- 1: abnormal eye distance/ position [MP:0001299] <5> (0|0) (0|0|0)

- 1: abnormal eye muscle morphology [MP:0003686] <4> (1|1) (1|0|0)

- 1: abnormal ocular surface morphology [MP:0013754] <4> (0|1) (2|0|0)

- 1: abnormal posterior eye segment morphology [MP:0005195] <4> (21|24) (23|14|8)

- 1: abnormal eye size [MP:0002697] <3> (3|5) (4|2|1)

- 1: abnormal orbit morphology [MP:0010030] <3> (0|0) (0|0|0)

- 1: abnormal uvea morphology [MP:0005197] <3> (10|7) (10|5|1)

- 1: abnormal sclera morphology [MP:0002698] <2> (2|2) (2|1|0)

- 1: increased eye tumor incidence [MP:0010295] <2> (1|1) (1|0|0)

- 1: strabismus [MP:0005254] <2> (0|0) (0|0|0)

- 1: calcified intraocular region [MP:0006209] <1> (0|0) (0|0|0)

- 1: abnormal cornea limbus morphology [MP:0013477] (0|0) (0|0|0)

- 1: anophthalmia [MP:0001293] (0|0) (0|0|0)

- 1: decreased eye tumor incidence [MP:0012418] (0|0) (0|0|0)

- 1: eye lesions [MP:0013146] (0|0) (0|0|0)

- 1: eye opacity [MP:0009859] (0|0) (0|0|0)

- 1: eye swellings [MP:0013170] (0|0) (0|0|0)

- 1: ocular rupture [MP:0006225] (0|0) (0|0|0)

- 1: periorbital edema [MP:0001788] (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Tubby C-terminal domain-like	0	Direct
p53 tetramerization domain	0	Direct
Di-copper centre-containing domain	0	Direct
Notch domain	0	Direct
gamma-Crystallin-like	0.0000007668	Direct
Plexin repeat	0.000321	Direct
HLH, helix-loop-helix DNA-binding domain	0.001252	Inherited
Sema domain	0.008136	Inherited
Nuclear receptor ligand-binding domain	0.01265	Inherited
GroEL equatorial domain-like	0.01963	Inherited
TNF-like	0.03795	Inherited
GAF domain-like	0.03906	Inherited
Homeodomain-like	0.04835	Inherited
HMG-box	0.06128	Inherited
Cupredoxins	0.06401	Inherited
E2F-DP heterodimerization region	0.0641	Inherited
PGBD-like	0.06593	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.06839	Inherited
Clc chloride channel	0.0937	Inherited
Integrin domains	0.1104	Inherited
Cyclin-like	0.1282	Inherited
CBS-domain pair	0.1291	Inherited
Kringle-like	0.1385	Inherited
Tetraspanin	0.1882	Inherited
"Winged helix" DNA-binding domain	0.2178	Inherited
Metalloproteases ("zincins"), catalytic domain	0.2557	Inherited
HD-domain/PDEase-like	0.3201	Inherited
Blood coagulation inhibitor (disintegrin)	0.3201	Inherited
Toll/Interleukin receptor TIR domain	0.4571	Inherited
FnI-like domain	0.5465	Inherited
Cystine-knot cytokines	0.6718	Inherited
L domain-like	0.692	Inherited
EGF/Laminin	0.6988	Inherited
DBL homology domain (DH-domain)	0.73	Inherited
CalX-like	0.8041	Inherited
Trypsin-like serine proteases	0.9942	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	1	Inherited
Nicotinic receptor ligand binding domain-like	1	Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Transcriptional factor tubby, C-terminal domain	0	Direct
p53 DNA-binding domain-like	0	Direct
Notch domain	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
p53 tetramerization domain	0	Direct
Retinoblastoma tumor suppressor domains	0	Direct
Cytochrome p450 reductase N-terminal domain-like	0	Direct
Crystallins/Ca-binding development proteins	0.0000004777	Direct
Forkhead DNA-binding domain	0.00003875	Direct
Arylsulfatase	0.00005544	Direct
Plexin repeat	0.0002352	Direct
I set domains	0.000595	Direct
HLH, helix-loop-helix DNA-binding domain	0.001072	Inherited
YWTD domain	0.003814	Inherited
Noncollagenous (NC1) domain of collagen IV	0.004003	Inherited
Laminin-type module	0.005541	Inherited
Sema domain	0.006331	Inherited
Nuclear receptor	0.006873	Inherited
Nuclear receptor ligand-binding domain	0.01039	Inherited
Extracellular domain of cell surface receptors	0.01089	Inherited
GAF domain	0.03009	Inherited
E2F dimerization segment	0.03009	Inherited
TNF-like	0.03141	Inherited
Homeodomain	0.0476	Inherited
HMG-box	0.05225	Inherited
MMP N-terminal domain	0.05448	Inherited
Matrix metalloproteases, catalytic domain	0.06876	Inherited
Clc chloride channel	0.07709	Inherited
CBS-domain pair	0.08604	Inherited
TNF receptor-like	0.08697	Inherited
Integrin domains	0.09583	Inherited
Cell cycle transcription factor e2f-dp	0.1072	Inherited
Kringle modules	0.137	Inherited
PDEase	0.2288	Inherited
POU-specific domain	0.2288	Inherited
Blood coagulation inhibitor (disintegrin)	0.2961	Inherited
cAMP-binding domain	0.355	Inherited
PDZ domain	0.4265	Inherited
Cyclin	0.4931	Inherited
Transforming growth factor (TGF)-beta	0.5021	Inherited
EGF-type module	0.5281	Inherited
VWC domain	0.6227	Inherited
DBL homology domain (DH-domain)	0.7181	Inherited
CalX-beta domain	0.7714	Inherited
Ngr ectodomain-like	0.8046	Inherited
Calmodulin-like	0.9508	Inherited
Eukaryotic proteases	0.9984	Inherited
Nicotinic receptor ligand binding domain-like	1	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	1	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

Plot tree as:

Download Newick format tree:

(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Tubby C-terminal domain-like	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Di-copper centre-containing domain	0	Direct
Notch domain	0	Direct
p53 tetramerization domain	0	Direct
gamma-Crystallin-like	0.0000003112	Direct
Plexin repeat	0.0001662	Direct
Alkaline phosphatase-like	0.0005918	Direct
HLH, helix-loop-helix DNA-binding domain	0.0006929	Direct
Integrin beta tail domain	0.0008482	Direct
YWTD domain	0.003135	Inherited
Sema domain	0.005014	Inherited
Nuclear receptor ligand-binding domain	0.008036	Inherited
GroEL equatorial domain-like	0.01285	Inherited
TNF-like	0.02623	Inherited
GAF domain-like	0.02704	Inherited
Homeodomain-like	0.03405	Inherited
HMG-box	0.04421	Inherited
Cupredoxins	0.04643	Inherited
E2F-DP heterodimerization region	0.04649	Inherited
PGBD-like	0.04794	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.04991	Inherited
Clc chloride channel	0.07025	Inherited
Integrin domains	0.08439	Inherited
beta-sandwich domain of Sec23/24	0.09841	Inherited
Cyclin-like	0.09958	Inherited
CBS-domain pair	0.1004	Inherited
Kringle-like	0.1087	Inherited
Tetraspanin	0.1525	Inherited
TNF receptor-like	0.1638	Inherited
"Winged helix" DNA-binding domain	0.1797	Inherited
Metalloproteases ("zincins"), catalytic domain	0.215	Inherited
Blood coagulation inhibitor (disintegrin)	0.2759	Inherited
HD-domain/PDEase-like	0.2759	Inherited
Toll/Interleukin receptor TIR domain	0.4093	Inherited
Growth factor receptor domain	0.4559	Inherited
FnI-like domain	0.4998	Inherited
Cystine-knot cytokines	0.6296	Inherited
L domain-like	0.6507	Inherited
EGF/Laminin	0.6578	Inherited
Intermediate filament protein, coiled coil region	0.6839	Inherited
DBL homology domain (DH-domain)	0.6909	Inherited
CalX-like	0.7696	Inherited
Trypsin-like serine proteases	0.9798	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.9974	Inherited
Nicotinic receptor ligand binding domain-like	0.9974	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0	Direct
90193,90193 90193 - Notch domain 90193 - Notch domain	0	Direct
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain	0	Direct
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain	0	Direct
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.0008482	Direct
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.001669	Inherited
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.002991	Inherited
81296,81296 81296 - E set domains 81296 - E set domains	0.00453	Inherited
101912,103575 101912 - Sema domain 103575 - Plexin repeat	0.005014	Inherited
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain	0.008303	Inherited
101288,50156 101288 - L27 domain 50156 - PDZ domain-like	0.008303	Inherited
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.01594	Inherited
55781,55781 55781 - GAF domain-like 55781 - GAF domain-like	0.02704	Inherited
55781,109604 55781 - GAF domain-like 109604 - HD-domain/PDEase-like	0.02704	Inherited
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0.04649	Inherited
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.04794	Inherited
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.07025	Inherited
50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like	0.07779	Inherited
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.1814	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.2112	Inherited
52058,52058 52058 - L domain-like 52058 - L domain-like	0.2159	Inherited
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin)	0.2759	Inherited
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like	0.3088	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.6486	Inherited
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.9974	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
101288,50156,50044 101288 - L27 domain 50156 - PDZ domain-like 50044 - SH3-domain	0	Direct
49265,48726,49265 49265 - Fibronectin type III 48726 - Immunoglobulin 49265 - Fibronectin type III	0	Direct
57196,90193,90193 57196 - EGF/Laminin 90193 - Notch domain 90193 - Notch domain	0	Direct
52058,48726,48726 52058 - L domain-like 48726 - Immunoglobulin 48726 - Immunoglobulin	0	Direct
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.000005487	Direct
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.0008482	Direct
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain	0.003435	Inherited
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains	0.008895	Inherited
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0.01285	Inherited
57184,49899,49899 57184 - Growth factor receptor domain 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.01285	Inherited
49899,57196,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 57196 - EGF/Laminin	0.01594	Inherited
55781,55781,109604 55781 - GAF domain-like 55781 - GAF domain-like 109604 - HD-domain/PDEase-like	0.02704	Inherited
50156,50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like 50156 - PDZ domain-like	0.04649	Inherited
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.5879	Inherited
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.6911	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

Plot tree as:

Download Newick format tree:

(show help)

SEARCH

BROWSE

TOOLS

ABOUT

HELP

Mammalian Phenotype (MP): abnormal eye morphology

Superfamily

Family

Supra-domain (including individual superfamily)