|
|
Mammalian Phenotype (MP): muscle phenotype
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Protein kinase-like (PK-like) | 0.0000001293 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.000006205 | DIRECT |
| EGF/Laminin | 0.00001587 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.00009298 | DIRECT |
| p53-like transcription factors | 0.0001108 | DIRECT |
| Growth factor receptor domain | 0.0001444 | DIRECT |
| Spectrin repeat | 0.0002428 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0.000387 | DIRECT |
| SMAD MH1 domain | 0.0004152 | DIRECT |
| MIR domain | 0.0004152 | DIRECT |
| TB module/8-cys domain | 0.0004152 | DIRECT |
| Riboflavin synthase domain-like | 0.0008489 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0008489 | DIRECT |
| Calponin-homology domain, CH-domain | 0.0008597 | DIRECT |
| alpha-catenin/vinculin-like | 0.00163 | INHERITED FROM: cardiomyopathy || abnormal muscle fiber morphology || dilated cardiomyopathy |
| Notch domain | 0.001688 | INHERITED FROM: abnormal smooth muscle morphology |
| Calcium ATPase, transduction domain A | 0.002903 | INHERITED FROM: impaired muscle contractility |
| Myosin rod fragments | 0.003424 | INHERITED FROM: impaired muscle contractility |
| Calcium ATPase, transmembrane domain M | 0.00605 | INHERITED FROM: impaired muscle contractility |
| SRF-like | 0.006968 | INHERITED FROM: abnormal cardiac muscle tissue morphology || abnormal skeletal muscle morphology || decreased cardiac muscle contractility || abnormal muscle contractility || impaired muscle contractility |
| Flavoproteins | 0.0138 | INHERITED FROM: pyloric sphincter hypertrophy || abnormal pyloric sphincter morphology || decreased cardiac muscle contractility |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.01621 | INHERITED FROM: impaired muscle contractility |
| Homeodomain-like | 0.01749 | INHERITED FROM: absent hypaxial muscle || abnormal muscle precursor cell physiology || abnormal tongue muscle morphology || abnormal eye muscle morphology |
| HLH, helix-loop-helix DNA-binding domain | 0.01982 | INHERITED FROM: abnormal muscle morphology || abnormal skeletal muscle regeneration || abnormal skeletal muscle satellite cell proliferation || decreased satellite cell number || decreased skeletal muscle fiber number || abnormal muscle development |
| Cystine-knot cytokines | 0.02845 | INHERITED FROM: increased muscle weight || increased skeletal muscle weight |
| TIMP-like | 0.05654 | INHERITED FROM: abnormal skeletal muscle size || abnormal skeletal muscle fiber type ratio || decreased skeletal muscle size |
| Spermadhesin, CUB domain | 0.06665 | INHERITED FROM: abnormal tendon morphology |
| Inhibitor of apoptosis (IAP) repeat | 0.06674 | INHERITED FROM: decreased cardiac muscle contractility |
| E set domains | 0.06843 | INHERITED FROM: hypotonia |
| Voltage-gated potassium channels | 0.07443 | INHERITED FROM: muscle twitch |
| Transducin (alpha subunit), insertion domain | 0.08683 | INHERITED FROM: abnormal vascular smooth muscle physiology || impaired smooth muscle contractility || decreased vasoconstriction || abnormal vasoconstriction |
| WW domain | 0.1093 | INHERITED FROM: muscle degeneration || progressive muscle weakness |
| Actin-like ATPase domain | 0.1258 | INHERITED FROM: increased variability of skeletal muscle fiber size |
| (Trans)glycosidases | 0.1428 | INHERITED FROM: increased skeletal muscle glycogen level || abnormal skeletal muscle glycogen level || abnormal muscle glycogen level |
| Clavaminate synthase-like | 0.1613 | INHERITED FROM: myocardial trabeculae hypoplasia |
| BPTI-like | 0.1682 | INHERITED FROM: abnormal skeletal muscle weight || abnormal skeletal muscle regeneration || abnormal muscle weight || abnormal skeletal muscle size || decreased skeletal muscle weight || decreased skeletal muscle mass || decreased muscle weight || abnormal muscle regeneration || abnormal skeletal muscle mass || decreased skeletal muscle size |
| Nucleotide cyclase | 0.1821 | INHERITED FROM: abnormal vasodilation |
| Thyroglobulin type-1 domain | 0.1953 | INHERITED FROM: abnormal quadriceps weight || decreased quadriceps weight || abnormal quadriceps morphology |
| B-box zinc-binding domain | 0.2163 | INHERITED FROM: abnormal skeletal muscle fiber size |
| POZ domain | 0.3147 | INHERITED FROM: muscle spasm || muscle twitch |
| Kazal-type serine protease inhibitors | 0.3222 | INHERITED FROM: abnormal quadriceps weight || decreased quadriceps weight || abnormal muscle weight || abnormal skeletal muscle size || decreased skeletal muscle mass || decreased muscle weight || abnormal skeletal muscle mass || decreased skeletal muscle size |
| Lipocalins | 0.4355 | INHERITED FROM: abnormal muscle cell glucose uptake |
| Metalloproteases ("zincins"), catalytic domain | 0.4693 | INHERITED FROM: thin diaphragm muscle |
| "Winged helix" DNA-binding domain | 0.5521 | INHERITED FROM: abnormal esophageal smooth muscle morphology |
| RING/U-box | 0.5917 | INHERITED FROM: increased quadriceps weight |
| L domain-like | 0.8361 | INHERITED FROM: decreased tendon stiffness || abnormal tendon morphology || abnormal tendon stiffness |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Protein kinase-like (PK-like) | 0.0000001293 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.000006205 | Direct |
| EGF/Laminin | 0.00001587 | Direct |
| Nuclear receptor ligand-binding domain | 0.00009298 | Direct |
| p53-like transcription factors | 0.0001108 | Direct |
| Growth factor receptor domain | 0.0001444 | Direct |
| Spectrin repeat | 0.0002428 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0.000387 | Direct |
| SMAD MH1 domain | 0.0004152 | Direct |
| MIR domain | 0.0004152 | Direct |
| TB module/8-cys domain | 0.0004152 | Direct |
| Riboflavin synthase domain-like | 0.0008489 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0008489 | Direct |
| Calponin-homology domain, CH-domain | 0.0008597 | Direct |
| alpha-catenin/vinculin-like | 0.00163 | Inherited |
| Notch domain | 0.001688 | Inherited |
| Calcium ATPase, transduction domain A | 0.002903 | Inherited |
| Myosin rod fragments | 0.003424 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.00605 | Inherited |
| SRF-like | 0.006968 | Inherited |
| Flavoproteins | 0.0138 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.01621 | Inherited |
| Homeodomain-like | 0.01749 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.01982 | Inherited |
| Cystine-knot cytokines | 0.02845 | Inherited |
| TIMP-like | 0.05654 | Inherited |
| Spermadhesin, CUB domain | 0.06665 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.06674 | Inherited |
| E set domains | 0.06843 | Inherited |
| Voltage-gated potassium channels | 0.07443 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.08683 | Inherited |
| WW domain | 0.1093 | Inherited |
| Actin-like ATPase domain | 0.1258 | Inherited |
| (Trans)glycosidases | 0.1428 | Inherited |
| Clavaminate synthase-like | 0.1613 | Inherited |
| BPTI-like | 0.1682 | Inherited |
| Nucleotide cyclase | 0.1821 | Inherited |
| Thyroglobulin type-1 domain | 0.1953 | Inherited |
| B-box zinc-binding domain | 0.2163 | Inherited |
| POZ domain | 0.3147 | Inherited |
| Kazal-type serine protease inhibitors | 0.3222 | Inherited |
| Lipocalins | 0.4355 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.4693 | Inherited |
| "Winged helix" DNA-binding domain | 0.5521 | Inherited |
| RING/U-box | 0.5917 | Inherited |
| L domain-like | 0.8361 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Troponin T | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Protein kinases, catalytic subunit | 0.000003003 | DIRECT |
| Spectrin repeat | 0.00003992 | DIRECT |
| EGF-type module | 0.00004358 | DIRECT |
| Nuclear receptor | 0.00004652 | DIRECT |
| L domain | 0.00005975 | DIRECT |
| Meta-cation ATPase, catalytic domain P | 0.00008325 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.00009845 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.000256 | DIRECT |
| SMAD MH1 domain | 0.0003109 | DIRECT |
| MIR domain | 0.0003109 | DIRECT |
| TB module/8-cys domain | 0.0003109 | DIRECT |
| SMAD domain | 0.0003109 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0.0004421 | DIRECT |
| Calponin-homology domain, CH-domain | 0.0008595 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.0009041 | DIRECT |
| Notch domain | 0.001241 | INHERITED FROM: abnormal smooth muscle morphology |
| NADPH-cytochrome p450 reductase-like | 0.001241 | INHERITED FROM: pyloric sphincter hypertrophy || abnormal muscle morphology || abnormal pyloric sphincter morphology || decreased cardiac muscle contractility || abnormal muscle contractility || impaired muscle contractility |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.001241 | INHERITED FROM: pyloric sphincter hypertrophy || abnormal muscle morphology || abnormal pyloric sphincter morphology || decreased cardiac muscle contractility || abnormal muscle contractility || impaired muscle contractility |
| Growth factor receptor domain | 0.001334 | INHERITED FROM: abnormal quadriceps weight || abnormal muscle morphology || decreased quadriceps weight |
| Calcium ATPase, transduction domain A | 0.002572 | INHERITED FROM: impaired muscle contractility |
| Myosin rod fragments | 0.002897 | INHERITED FROM: impaired muscle contractility |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.004662 | INHERITED FROM: abnormal muscle physiology || impaired muscle contractility |
| SRF-like | 0.005282 | INHERITED FROM: abnormal cardiac muscle tissue morphology || abnormal skeletal muscle morphology || decreased cardiac muscle contractility || abnormal muscle contractility || impaired muscle contractility |
| Paired domain | 0.007158 | INHERITED FROM: abnormal myogenesis || abnormal hypaxial muscle morphology || abnormal myotome development |
| Homeodomain | 0.008848 | INHERITED FROM: absent hypaxial muscle || abnormal muscle precursor cell physiology || abnormal tongue muscle morphology || abnormal eye muscle morphology |
| alpha-catenin/vinculin | 0.01646 | INHERITED FROM: cardiomyopathy || dilated cardiomyopathy |
| Forkhead DNA-binding domain | 0.01836 | INHERITED FROM: abnormal esophageal smooth muscle morphology |
| Erythroid transcription factor GATA-1 | 0.021 | INHERITED FROM: abnormal fetal cardiomyocyte proliferation |
| HLH, helix-loop-helix DNA-binding domain | 0.02318 | INHERITED FROM: abnormal muscle morphology || abnormal skeletal muscle regeneration || abnormal skeletal muscle satellite cell proliferation || decreased satellite cell number || decreased skeletal muscle fiber number || abnormal muscle development |
| Laminin-type module | 0.0234 | INHERITED FROM: centrally nucleated skeletal muscle fibers || abnormal skeletal muscle mass |
| Tetramerization domain of potassium channels | 0.0234 | INHERITED FROM: muscle spasm || muscle twitch |
| I set domains | 0.02578 | INHERITED FROM: abnormal diaphragm morphology |
| Plakin repeat | 0.03375 | INHERITED FROM: abnormal muscle fiber morphology |
| Inhibitor of apoptosis (IAP) repeat | 0.03375 | INHERITED FROM: decreased cardiac muscle contractility || abnormal muscle contractility || impaired muscle contractility |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0447 | INHERITED FROM: abnormal muscle contractility |
| Spermadhesin, CUB domain | 0.06557 | INHERITED FROM: abnormal tendon morphology |
| Voltage-gated potassium channels | 0.06813 | INHERITED FROM: muscle spasm || muscle twitch |
| LIM domain | 0.06963 | INHERITED FROM: decreased cardiac muscle contractility |
| Transducin (alpha subunit), insertion domain | 0.07872 | INHERITED FROM: abnormal vascular smooth muscle physiology || impaired smooth muscle contractility || decreased vasoconstriction || abnormal vasoconstriction |
| ZZ domain | 0.08577 | INHERITED FROM: abnormal skeletal muscle fiber size || abnormal skeletal muscle fiber morphology |
| Transforming growth factor (TGF)-beta | 0.09309 | INHERITED FROM: abnormal skeletal muscle weight || increased skeletal muscle size || increased skeletal muscle mass || increased muscle weight || increased skeletal muscle weight |
| WW domain | 0.1059 | INHERITED FROM: muscle degeneration || progressive muscle weakness || increased cardiomyocyte apoptosis |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0.1541 | INHERITED FROM: abnormal skeletal muscle weight || abnormal skeletal muscle regeneration || abnormal muscle weight || abnormal skeletal muscle size || decreased skeletal muscle weight || decreased skeletal muscle mass || decreased muscle weight || abnormal muscle regeneration || abnormal skeletal muscle mass || decreased skeletal muscle size |
| Adenylyl and guanylyl cyclase catalytic domain | 0.1733 | INHERITED FROM: abnormal vasodilation |
| Thyroglobulin type-1 domain | 0.1842 | INHERITED FROM: abnormal quadriceps weight || decreased quadriceps weight || abnormal quadriceps morphology |
| B-box zinc-binding domain | 0.2117 | INHERITED FROM: abnormal skeletal muscle fiber size |
| EF-hand modules in multidomain proteins | 0.2514 | INHERITED FROM: skeletal muscle necrosis || dystrophic muscle |
| Ovomucoid domain III-like | 0.2867 | INHERITED FROM: abnormal skeletal muscle size || decreased skeletal muscle size |
| Fatty acid binding protein-like | 0.3602 | INHERITED FROM: abnormal muscle cell glucose uptake |
| 28-residue LRR | 0.4023 | INHERITED FROM: abnormal sarcomere morphology |
| Phosphotyrosine-binding domain (PTB) | 0.5756 | INHERITED FROM: abnormal vasodilation |
| Ngr ectodomain-like | 0.9342 | INHERITED FROM: decreased tendon stiffness || abnormal tendon morphology || abnormal tendon stiffness |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lamin A/C globular tail domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Troponin T | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Protein kinases, catalytic subunit | 0.000003003 | Direct |
| Spectrin repeat | 0.00003992 | Direct |
| EGF-type module | 0.00004358 | Direct |
| Nuclear receptor | 0.00004652 | Direct |
| L domain | 0.00005975 | Direct |
| Meta-cation ATPase, catalytic domain P | 0.00008325 | Direct |
| Nuclear receptor ligand-binding domain | 0.00009845 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.000256 | Direct |
| SMAD MH1 domain | 0.0003109 | Direct |
| MIR domain | 0.0003109 | Direct |
| TB module/8-cys domain | 0.0003109 | Direct |
| SMAD domain | 0.0003109 | Direct |
| Calcium ATPase, transmembrane domain M | 0.0004421 | Direct |
| Calponin-homology domain, CH-domain | 0.0008595 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.0009041 | Direct |
| Notch domain | 0.001241 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.001241 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.001241 | Inherited |
| Growth factor receptor domain | 0.001334 | Inherited |
| Calcium ATPase, transduction domain A | 0.002572 | Inherited |
| Myosin rod fragments | 0.002897 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.004662 | Inherited |
| SRF-like | 0.005282 | Inherited |
| Paired domain | 0.007158 | Inherited |
| Homeodomain | 0.008848 | Inherited |
| alpha-catenin/vinculin | 0.01646 | Inherited |
| Forkhead DNA-binding domain | 0.01836 | Inherited |
| Erythroid transcription factor GATA-1 | 0.021 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.02318 | Inherited |
| Laminin-type module | 0.0234 | Inherited |
| Tetramerization domain of potassium channels | 0.0234 | Inherited |
| I set domains | 0.02578 | Inherited |
| Plakin repeat | 0.03375 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.03375 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0447 | Inherited |
| Spermadhesin, CUB domain | 0.06557 | Inherited |
| Voltage-gated potassium channels | 0.06813 | Inherited |
| LIM domain | 0.06963 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.07872 | Inherited |
| ZZ domain | 0.08577 | Inherited |
| Transforming growth factor (TGF)-beta | 0.09309 | Inherited |
| WW domain | 0.1059 | Inherited |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0.1541 | Inherited |
| Adenylyl and guanylyl cyclase catalytic domain | 0.1733 | Inherited |
| Thyroglobulin type-1 domain | 0.1842 | Inherited |
| B-box zinc-binding domain | 0.2117 | Inherited |
| EF-hand modules in multidomain proteins | 0.2514 | Inherited |
| Ovomucoid domain III-like | 0.2867 | Inherited |
| Fatty acid binding protein-like | 0.3602 | Inherited |
| 28-residue LRR | 0.4023 | Inherited |
| Phosphotyrosine-binding domain (PTB) | 0.5756 | Inherited |
| Ngr ectodomain-like | 0.9342 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
 |
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Protein kinase-like (PK-like) | 0.00000005119 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.000002673 | DIRECT |
| EGF/Laminin | 0.000007065 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.00004466 | DIRECT |
| p53-like transcription factors | 0.00005401 | DIRECT |
| Growth factor receptor domain | 0.00007196 | DIRECT |
| Spectrin repeat | 0.0001234 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0.0002018 | DIRECT |
| TB module/8-cys domain | 0.0002178 | DIRECT |
| MIR domain | 0.0002178 | DIRECT |
| SMAD MH1 domain | 0.0002178 | DIRECT |
| Riboflavin synthase domain-like | 0.0004595 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0004595 | DIRECT |
| Calponin-homology domain, CH-domain | 0.0004661 | DIRECT |
| alpha-catenin/vinculin-like | 0.000917 | DIRECT |
| TSP type-3 repeat | 0.0009513 | DIRECT |
| Notch domain | 0.0009513 | DIRECT |
| Calcium ATPase, transduction domain A | 0.001682 | INHERITED FROM: impaired muscle contractility |
| Myosin rod fragments | 0.001999 | INHERITED FROM: impaired muscle contractility |
| Calcium ATPase, transmembrane domain M | 0.00366 | INHERITED FROM: impaired muscle contractility |
| SRF-like | 0.004263 | INHERITED FROM: abnormal skeletal muscle morphology || abnormal muscle contractility || abnormal cardiac muscle tissue morphology || impaired muscle contractility || decreased cardiac muscle contractility |
| Flavoproteins | 0.008828 | INHERITED FROM: pyloric sphincter hypertrophy || abnormal pyloric sphincter morphology || impaired muscle contractility || decreased cardiac muscle contractility |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.01048 | INHERITED FROM: impaired muscle contractility |
| Homeodomain-like | 0.0114 | INHERITED FROM: abnormal eye muscle morphology || absent hypaxial muscle || abnormal tongue muscle morphology || abnormal muscle precursor cell physiology |
| dsRNA-binding domain-like | 0.0125 | INHERITED FROM: decreased ventricle muscle contractility |
| HLH, helix-loop-helix DNA-binding domain | 0.01299 | INHERITED FROM: abnormal skeletal muscle satellite cell proliferation || abnormal skeletal muscle regeneration || abnormal muscle morphology || abnormal muscle development || decreased skeletal muscle fiber number || decreased satellite cell number |
| Cystine-knot cytokines | 0.01924 | INHERITED FROM: increased skeletal muscle weight || increased muscle weight |
| Plakin repeat | 0.02833 | INHERITED FROM: abnormal muscle fiber morphology |
| TIMP-like | 0.04044 | INHERITED FROM: abnormal skeletal muscle fiber type ratio || abnormal skeletal muscle size || decreased skeletal muscle size |
| Spermadhesin, CUB domain | 0.04846 | INHERITED FROM: abnormal tendon morphology |
| Inhibitor of apoptosis (IAP) repeat | 0.04854 | INHERITED FROM: impaired muscle contractility || decreased cardiac muscle contractility |
| E set domains | 0.04995 | INHERITED FROM: hypotonia |
| Voltage-gated potassium channels | 0.05471 | INHERITED FROM: muscle twitch || abnormal muscle physiology |
| Transducin (alpha subunit), insertion domain | 0.06463 | INHERITED FROM: impaired smooth muscle contractility || decreased vasoconstriction || abnormal vasoconstriction || abnormal vascular smooth muscle physiology |
| WW domain | 0.08346 | INHERITED FROM: muscle degeneration || progressive muscle weakness || increased cardiomyocyte apoptosis |
| Actin-like ATPase domain | 0.09755 | INHERITED FROM: increased variability of skeletal muscle fiber size |
| (Trans)glycosidases | 0.1123 | INHERITED FROM: abnormal skeletal muscle glycogen level || increased skeletal muscle glycogen level || abnormal muscle glycogen level |
| Clavaminate synthase-like | 0.1286 | INHERITED FROM: myocardial trabeculae hypoplasia |
| BPTI-like | 0.1345 | INHERITED FROM: abnormal muscle weight || abnormal skeletal muscle size || abnormal skeletal muscle regeneration || abnormal skeletal muscle weight || abnormal muscle regeneration || decreased skeletal muscle mass || abnormal skeletal muscle mass || decreased skeletal muscle weight || decreased muscle weight || decreased skeletal muscle size |
| Nucleotide cyclase | 0.1471 | INHERITED FROM: abnormal vasodilation |
| Thyroglobulin type-1 domain | 0.1591 | INHERITED FROM: abnormal quadriceps morphology || abnormal quadriceps weight || decreased quadriceps weight |
| B-box zinc-binding domain | 0.1784 | INHERITED FROM: abnormal skeletal muscle fiber size |
| Intermediate filament protein, coiled coil region | 0.2649 | INHERITED FROM: abnormal diaphragm morphology |
| POZ domain | 0.2706 | INHERITED FROM: muscle spasm || muscle twitch |
| Kazal-type serine protease inhibitors | 0.278 | INHERITED FROM: abnormal muscle weight || abnormal skeletal muscle size || decreased skeletal muscle mass || abnormal skeletal muscle mass || abnormal quadriceps weight || decreased muscle weight || decreased quadriceps weight || decreased skeletal muscle size |
| Lipocalins | 0.3882 | INHERITED FROM: abnormal muscle cell glucose uptake |
| Metalloproteases ("zincins"), catalytic domain | 0.4215 | INHERITED FROM: thin diaphragm muscle |
| "Winged helix" DNA-binding domain | 0.5053 | INHERITED FROM: abnormal esophageal smooth muscle morphology |
| RING/U-box | 0.5458 | INHERITED FROM: increased quadriceps weight |
| Family A G protein-coupled receptor-like | 0.7248 | INHERITED FROM: abnormal vascular smooth muscle physiology |
| L domain-like | 0.804 | INHERITED FROM: abnormal tendon morphology || decreased tendon stiffness || abnormal tendon stiffness |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Protein kinase-like (PK-like) | 0.00000005119 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.000002673 | Direct |
| EGF/Laminin | 0.000007065 | Direct |
| Nuclear receptor ligand-binding domain | 0.00004466 | Direct |
| p53-like transcription factors | 0.00005401 | Direct |
| Growth factor receptor domain | 0.00007196 | Direct |
| Spectrin repeat | 0.0001234 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0.0002018 | Direct |
| TB module/8-cys domain | 0.0002178 | Direct |
| MIR domain | 0.0002178 | Direct |
| SMAD MH1 domain | 0.0002178 | Direct |
| Riboflavin synthase domain-like | 0.0004595 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0004595 | Direct |
| Calponin-homology domain, CH-domain | 0.0004661 | Direct |
| alpha-catenin/vinculin-like | 0.000917 | Direct |
| TSP type-3 repeat | 0.0009513 | Direct |
| Notch domain | 0.0009513 | Direct |
| Calcium ATPase, transduction domain A | 0.001682 | Inherited |
| Myosin rod fragments | 0.001999 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.00366 | Inherited |
| SRF-like | 0.004263 | Inherited |
| Flavoproteins | 0.008828 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.01048 | Inherited |
| Homeodomain-like | 0.0114 | Inherited |
| dsRNA-binding domain-like | 0.0125 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.01299 | Inherited |
| Cystine-knot cytokines | 0.01924 | Inherited |
| Plakin repeat | 0.02833 | Inherited |
| TIMP-like | 0.04044 | Inherited |
| Spermadhesin, CUB domain | 0.04846 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.04854 | Inherited |
| E set domains | 0.04995 | Inherited |
| Voltage-gated potassium channels | 0.05471 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.06463 | Inherited |
| WW domain | 0.08346 | Inherited |
| Actin-like ATPase domain | 0.09755 | Inherited |
| (Trans)glycosidases | 0.1123 | Inherited |
| Clavaminate synthase-like | 0.1286 | Inherited |
| BPTI-like | 0.1345 | Inherited |
| Nucleotide cyclase | 0.1471 | Inherited |
| Thyroglobulin type-1 domain | 0.1591 | Inherited |
| B-box zinc-binding domain | 0.1784 | Inherited |
| Intermediate filament protein, coiled coil region | 0.2649 | Inherited |
| POZ domain | 0.2706 | Inherited |
| Kazal-type serine protease inhibitors | 0.278 | Inherited |
| Lipocalins | 0.3882 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.4215 | Inherited |
| "Winged helix" DNA-binding domain | 0.5053 | Inherited |
| RING/U-box | 0.5458 | Inherited |
| Family A G protein-coupled receptor-like | 0.7248 | Inherited |
| L domain-like | 0.804 | Inherited |
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
49265,56112
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
100909,49899
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.000007497 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.000007779 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.00004021 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.00004021 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.00006327 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.00006412 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.0001732 | DIRECT |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0.0002018 | DIRECT |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0.0002018 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.000917 | DIRECT |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0.0009513 | DIRECT |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0.0009513 | DIRECT |
48726,56112
48726 - Immunoglobulin
56112 - Protein kinase-like (PK-like) | 0.0009513 | DIRECT |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.00188 | INHERITED FROM: impaired muscle contractility |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.003263 | INHERITED FROM: abnormal muscle morphology |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0.00366 | INHERITED FROM: abnormal skeletal muscle morphology || abnormal hypaxial muscle morphology || abnormal quadriceps morphology || abnormal quadriceps weight || decreased quadriceps weight |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0.00366 | INHERITED FROM: abnormal muscle morphology |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.00366 | INHERITED FROM: abnormal muscle fiber morphology || abnormal muscle physiology |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.00366 | INHERITED FROM: abnormal muscle morphology |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.004263 | INHERITED FROM: abnormal vascular smooth muscle morphology || abnormal smooth muscle morphology |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.007764 | INHERITED FROM: centrally nucleated skeletal muscle fibers || abnormal diaphragm morphology |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.01048 | INHERITED FROM: impaired muscle contractility |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0.01352 | INHERITED FROM: abnormal muscle fiber morphology |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.01352 | INHERITED FROM: abnormal muscle contractility || impaired muscle contractility || decreased cardiac muscle contractility || abnormal cardiac muscle contractility |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0.01352 | INHERITED FROM: abnormal skeletal muscle morphology || cardiomyopathy || dystrophic muscle || skeletal muscle necrosis || abnormal muscle fiber morphology |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0.01466 | INHERITED FROM: abnormal skeletal muscle fiber size |
100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0.02833 | INHERITED FROM: abnormal skeletal muscle morphology || abnormal skeletal muscle size || decreased skeletal muscle mass || abnormal skeletal muscle mass || decreased skeletal muscle size |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.04913 | INHERITED FROM: abnormal skeletal muscle size |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.04913 | INHERITED FROM: impaired smooth muscle contractility || decreased vasoconstriction || abnormal vasoconstriction || abnormal vascular smooth muscle physiology |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.2904 | INHERITED FROM: abnormal diaphragm morphology |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.3245 | INHERITED FROM: cardiomyopathy || dystrophic muscle || skeletal muscle necrosis |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.3729 | INHERITED FROM: muscle spasm |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
49265,56112
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
100909,49899
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.000007497 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.000007779 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.00004021 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.00004021 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.00006327 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.00006412 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.0001732 | Direct |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0.0002018 | Direct |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0.0002018 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.000917 | Direct |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0.0009513 | Direct |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0.0009513 | Direct |
48726,56112
48726 - Immunoglobulin
56112 - Protein kinase-like (PK-like) | 0.0009513 | Direct |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.00188 | Inherited |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.003263 | Inherited |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0.00366 | Inherited |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0.00366 | Inherited |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.00366 | Inherited |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.00366 | Inherited |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.004263 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.007764 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.01048 | Inherited |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0.01352 | Inherited |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.01352 | Inherited |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0.01352 | Inherited |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0.01466 | Inherited |
100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0.02833 | Inherited |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.04913 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.04913 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.2904 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.3245 | Inherited |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.3729 | Inherited |
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,49854,57196
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
49854,49854,57196
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | DIRECT |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
82109,100909,49899
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.00004021 | DIRECT |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.00004071 | DIRECT |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.0002018 | DIRECT |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0.0002018 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0002928 | DIRECT |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.0009513 | DIRECT |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.0009513 | DIRECT |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0.0009513 | DIRECT |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0.0009513 | DIRECT |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.0009513 | DIRECT |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.001955 | INHERITED FROM: abnormal muscle morphology |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.001955 | INHERITED FROM: abnormal skeletal muscle fiber size || abnormal muscle physiology |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.00366 | INHERITED FROM: abnormal skeletal muscle morphology || abnormal muscle morphology || abnormal muscle physiology |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.00366 | INHERITED FROM: abnormal muscle morphology |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.004263 | INHERITED FROM: abnormal muscle fiber morphology |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.01048 | INHERITED FROM: impaired muscle contractility |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01053 | INHERITED FROM: abnormal diaphragm morphology |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.0116 | INHERITED FROM: centrally nucleated skeletal muscle fibers || abnormal diaphragm morphology |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.01352 | INHERITED FROM: abnormal muscle contractility || impaired muscle contractility || decreased cardiac muscle contractility || abnormal cardiac muscle contractility |
47473,47473,57850
47473 - EF-hand
47473 - EF-hand
57850 - RING/U-box | 0.01352 | INHERITED FROM: abnormal skeletal muscle morphology || cardiomyopathy || dystrophic muscle || skeletal muscle necrosis || abnormal muscle fiber morphology |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.01927 | INHERITED FROM: abnormal muscle fiber morphology || decreased cardiac muscle contractility |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.1052 | INHERITED FROM: abnormal myocardial trabeculae morphology |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,49854,57196
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
49854,49854,57196
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | Direct |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
82109,100909,49899
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.00004021 | Direct |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.00004071 | Direct |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.0002018 | Direct |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0.0002018 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0002928 | Direct |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.0009513 | Direct |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.0009513 | Direct |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0.0009513 | Direct |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0.0009513 | Direct |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.0009513 | Direct |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.001955 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.001955 | Inherited |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.00366 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.00366 | Inherited |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.004263 | Inherited |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.01048 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01053 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.0116 | Inherited |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.01352 | Inherited |
47473,47473,57850
47473 - EF-hand
47473 - EF-hand
57850 - RING/U-box | 0.01352 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.01927 | Inherited |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.1052 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
