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Mammalian Phenotype (MP): immune system phenotype
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (SDMP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Cysteine rich domain | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| Short-chain cytokines | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| STAT DNA-binding domain | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| DNA polymerase beta-like | 0 | DIRECT |
| BAFF receptor-like | 0 | DIRECT |
| Interleukin-1 (IL-1) | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| STAT | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Pyrin domain, PYD | 0 | DIRECT |
| Interleukin 17F, IL-17F | 0 | DIRECT |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
| DNA polymerase beta-like, second domain | 0 | DIRECT |
| Resistin | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| SH2 domain | 0.0000000009631 | DIRECT |
| C-type lectin domain | 0.000000001588 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0.00000001187 | DIRECT |
| C1 set domains (antibody constant domain-like) | 0.00000008025 | DIRECT |
| MHC antigen-recognition domain | 0.0000002058 | DIRECT |
| V set domains (antibody variable domain-like) | 0.0000002368 | DIRECT |
| TNF receptor-like | 0.000003257 | DIRECT |
| Protein kinases, catalytic subunit | 0.00001395 | DIRECT |
| Interleukin 8-like chemokines | 0.000279 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.0005874 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0006742 | DIRECT |
| Integrin domains | 0.0009559 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.001332 | INHERITED FROM: abnormal lymphopoiesis || abnormal immature B cell number || abnormal IgG level || abnormal B cell physiology || abnormal T cell physiology || enlarged lymph nodes || abnormal spleen physiology || abnormal immature B cell morphology || abnormal immune system organ morphology || abnormal pre-B cell morphology || abnormal mature B cell number || abnormal leukopoiesis || abnormal T cell number || abnormal T cell differentiation || abnormal T cell apoptosis || enlarged spleen || increased pre-B cell number || decreased mature B cell number |
| Interferon regulatory factor | 0.001332 | INHERITED FROM: abnormal circulating cytokine level || abnormal interferon-alpha secretion || increased lymphocyte cell number || abnormal plasmacytoid dendritic cell number || abnormal plasmacytoid dendritic cell morphology || enlarged lymph nodes || decreased dendritic cell number || decreased T cell number || decreased interferon-beta secretion || abnormal interferon secretion || increased susceptibility to viral infection || abnormal immune system physiology || decreased plasmacytoid dendritic cell number || abnormal mature B cell number || abnormal T cell number || abnormal lymphocyte physiology || abnormal response to infection || abnormal immune serum protein physiology || decreased mature B cell number |
| Integrin beta EGF-like domains | 0.002974 | INHERITED FROM: increased inflammatory response || abnormal leukocyte migration || abnormal inflammatory response |
| Caspase catalytic domain | 0.002996 | INHERITED FROM: abnormal thymus physiology || abnormal interleukin-1 secretion || abnormal T cell physiology || abnormal interleukin-1 beta secretion || abnormal leukocyte physiology || decreased susceptibility to bacterial infection || abnormal circulating interleukin-18 level || abnormal thymocyte apoptosis || abnormal immune organ physiology || abnormal immune system physiology || decreased susceptibility to infection induced morbidity/mortality || decreased susceptibility to bacterial infection induced morbidity/mortality || abnormal T cell apoptosis || abnormal lymphocyte physiology || decreased susceptibility to infection || abnormal macrophage apoptosis || decreased T cell apoptosis |
| MATH domain | 0.002996 | INHERITED FROM: abnormal immature B cell number || abnormal immature B cell morphology |
| Caspase recruitment domain, CARD | 0.003275 | INHERITED FROM: abnormal interferon-gamma secretion || abnormal acute inflammation || decreased interleukin-6 secretion || abnormal interleukin-1 secretion || abnormal T cell physiology || abnormal follicular B cell morphology || abnormal interleukin-1 beta secretion || abnormal leukocyte physiology || abnormal circulating interferon-gamma level || abnormal cytokine secretion || decreased susceptibility to endotoxin shock || abnormal circulating interleukin-18 level || abnormal thymocyte apoptosis || abnormal immune system physiology || altered susceptibility to infection || increased susceptibility to induced colitis || decreased susceptibility to bacterial infection induced morbidity/mortality || abnormal susceptibility to induced colitis |
| MMP N-terminal domain | 0.0041 | INHERITED FROM: altered susceptibility to bacterial infection || arthritis || altered susceptibility to infection |
| Nuclear receptor | 0.004308 | INHERITED FROM: abnormal phagocyte morphology || persistent cervical thymus || abnormal macrophage cell number || large intestinal inflammation |
| Pointed domain | 0.006507 | INHERITED FROM: abnormal B cell differentiation || decreased thymocyte number || abnormal mature B cell morphology || abnormal lymphocyte cell number || decreased lymphocyte cell number || decreased leukocyte cell number |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.006507 | INHERITED FROM: abnormal circulating cytokine level || increased B cell number || abnormal plasmacytoid dendritic cell number || abnormal B cell differentiation || abnormal plasmacytoid dendritic cell morphology || abnormal T cell physiology || decreased dendritic cell number || abnormal interferon secretion || increased susceptibility to viral infection || decreased plasmacytoid dendritic cell number || altered susceptibility to infection || abnormal dendritic cell number || absent B cells || abnormal response to infection || abnormal dendritic cell morphology || abnormal spleen white pulp morphology || absent lymphocyte || abnormal immune serum protein physiology || decreased mature B cell number |
| Complement components | 0.006507 | INHERITED FROM: increased inflammatory response || abnormal inflammatory response || increased susceptibility to bacterial infection |
| Alpha-macroglobulin receptor domain | 0.006507 | INHERITED FROM: increased inflammatory response || abnormal inflammatory response || increased susceptibility to bacterial infection |
| Matrix metalloproteases, catalytic domain | 0.008438 | INHERITED FROM: altered susceptibility to bacterial infection || arthritis || altered susceptibility to infection |
| Nuclear receptor ligand-binding domain | 0.009245 | INHERITED FROM: abnormal phagocyte morphology || persistent cervical thymus || abnormal macrophage cell number || large intestinal inflammation |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.01064 | INHERITED FROM: abnormal positive T cell selection || decreased thymocyte number |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.01125 | INHERITED FROM: decreased B cell proliferation || increased IgG2a level || abnormal phagocyte morphology || abnormal spleen germinal center morphology || abnormal B cell proliferation || abnormal immune system morphology || respiratory system inflammation || abnormal osteoclast cell number || increased inflammatory response || increased susceptibility to infection || abnormal B-1 B cell number || abnormal immune cell physiology || abnormal T cell physiology || decreased IgG2b level || abnormal IgG2a level || abnormal Peyer's patch morphology || abnormal B cell morphology || decreased dendritic cell number || abnormal leukocyte physiology || abnormal thymus morphology || abnormal macrophage cell number || small Peyer's patches || abnormal interleukin secretion || abnormal spleen secondary B follicle morphology || decreased T cell number || abnormal mature B cell morphology || abnormal leukocyte cell number || abnormal professional antigen presenting cell morphology || abnormal T cell proliferation || abnormal Peyer's patch size || abnormal humoral immune response || lung inflammation || abnormal immune system physiology || decreased CD8-positive, alpha-beta T cell number || altered susceptibility to infection || abnormal thymus medulla morphology || abnormal leukopoiesis || abnormal dendritic cell number || abnormal cell-mediated immunity || abnormal lymphocyte morphology || decreased CD4-positive, alpha beta T cell number || increased leukocyte cell number || abnormal T cell number || abnormal lymphocyte physiology || abnormal lymphocyte cell number || abnormal mononuclear cell morphology || abnormal dendritic cell morphology || decreased lymphocyte cell number || abnormal B cell number || decreased leukocyte cell number || abnormal T cell morphology || decreased IgG2a level || abnormal IgG2b level || abnormal adaptive immunity || abnormal immunoglobulin level |
| Interferons/interleukin-10 (IL-10) | 0.0122 | INHERITED FROM: abnormal phagocyte morphology || abnormal circulating cytokine level || increased susceptibility to infection || increased tumor necrosis factor secretion || abnormal cytokine secretion || colitis || altered susceptibility to bacterial infection || lung inflammation || altered susceptibility to infection || increased susceptibility to induced colitis || increased interleukin-12 secretion || decreased interleukin-10 secretion || abnormal susceptibility to induced colitis |
| Inhibitor of apoptosis (IAP) repeat | 0.01399 | INHERITED FROM: abnormal immune cell physiology || abnormal lymph node size || abnormal leukocyte physiology || abnormal B cell apoptosis || abnormal lymph node morphology || abnormal cell-mediated immunity || abnormal lymphocyte physiology || abnormal adaptive immunity |
| DNA polymerase I | 0.01399 | INHERITED FROM: abnormal B cell differentiation |
| E2F dimerization segment | 0.01399 | INHERITED FROM: abnormal lymphopoiesis || decreased double-positive T cell number || abnormal leukopoiesis || abnormal T cell number || abnormal thymus size || abnormal T cell differentiation || abnormal alpha-beta T cell morphology |
| TNF-like | 0.0157 | INHERITED FROM: abnormal spleen germinal center morphology || absent lymph nodes || absent inguinal lymph nodes || absent cervical lymph nodes || abnormal interferon-gamma secretion || abnormal IgG2a level || abnormal Peyer's patch morphology || abnormal response to transplant || small Peyer's patches || absent popliteal lymph nodes || arthritis || absent brachial lymph nodes || abnormal thymus epithelium morphology || abnormal immune system physiology || abnormal mesenteric lymph node morphology || abnormal lymph node morphology || decreased interleukin-10 secretion || autoimmune response || small thymus medulla || absent axillary lymph nodes || lymph node hypoplasia || abnormal self tolerance || abnormal lymph node B cell domain morphology |
| DEATH domain, DD | 0.01667 | INHERITED FROM: increased IgG2a level || abnormal spleen germinal center morphology || abnormal IgG level || abnormal B-1 B cell number || enlarged lymph nodes || abnormal Peyer's patch morphology || abnormal thymus morphology || decreased circulating interleukin-6 level || abnormal interleukin secretion || abnormal spleen secondary B follicle morphology || abnormal Peyer's patch size || abnormal immune system physiology || altered susceptibility to infection || abnormal thymus medulla morphology || abnormal thymus cortex morphology || autoimmune response || abnormal lymphocyte cell number || abnormal mononuclear cell morphology || increased transitional stage B cell number || abnormal circulating interleukin level || abnormal self tolerance || abnormal IgG2b level |
| PLC-like (P variant) | 0.02326 | INHERITED FROM: abnormal B cell proliferation || decreased interleukin-2 secretion || abnormal B-1 B cell number || decreased interferon-gamma secretion || abnormal leukopoiesis || autoimmune response || abnormal cytotoxic T cell cytolysis || kidney inflammation || decreased B-2 B cell number |
| Hemopexin-like domain | 0.02562 | INHERITED FROM: altered susceptibility to bacterial infection || arthritis || altered susceptibility to infection |
| EGF-type module | 0.02578 | INHERITED FROM: abnormal leukocyte adhesion |
| ets domain | 0.02584 | INHERITED FROM: abnormal B cell proliferation || decreased thymocyte number || increased B cell apoptosis || decreased pro-B cell number |
| Notch domain | 0.02942 | INHERITED FROM: abnormal interleukin secretion || increased spleen red pulp amount || abnormal spleen red pulp morphology || enlarged spleen |
| Tetraspanin | 0.02942 | INHERITED FROM: abnormal macrophage morphology |
| Eukaryotic proteases | 0.03043 | INHERITED FROM: abnormal complement pathway || altered susceptibility to infection |
| 28-residue LRR | 0.03939 | INHERITED FROM: abnormal immune cell physiology || abnormal interleukin-1 beta secretion || abnormal leukocyte physiology || colitis || abnormal interleukin secretion || abnormal cell-mediated immunity || large intestinal inflammation || abnormal susceptibility to induced colitis || abnormal circulating interleukin level || abnormal adaptive immunity || abnormal immune serum protein physiology |
| Integrin alpha N-terminal domain | 0.04036 | INHERITED FROM: abnormal cellular extravasation |
| SH3-domain | 0.04395 | INHERITED FROM: abnormal interleukin-2 secretion || abnormal B cell proliferation || abnormal CD8-positive, alpha-beta T cell differentiation || decreased interleukin-2 secretion || abnormal immune cell physiology || decreased single-positive T cell number || abnormal cell-mediated immunity || abnormal adaptive immunity || abnormal neutrophil physiology |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.04528 | INHERITED FROM: abnormal CD4-positive, alpha beta T cell morphology || abnormal alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell number || abnormal neutrophil cell number || abnormal CD8-positive, alpha beta T cell morphology || abnormal effector T cell morphology || increased granulocyte number || abnormal CD8-positive, alpha-beta T cell number || increased neutrophil cell number |
| C2 set domains | 0.0544 | INHERITED FROM: decreased susceptibility to autoimmune disorder || decreased susceptibility to autoimmune diabetes || abnormal monocyte morphology |
| I set domains | 0.05843 | INHERITED FROM: increased IgG1 level |
| Tissue inhibitor of metalloproteinases, TIMP | 0.06127 | INHERITED FROM: abnormal phagocyte morphology || abnormal granulocyte morphology || abnormal neutrophil cell number || increased granulocyte number || abnormal granulocyte number || abnormal neutrophil morphology || increased neutrophil cell number |
| beta-glycanases | 0.06127 | INHERITED FROM: abnormal phagocyte morphology || abnormal mononuclear phagocyte morphology || abnormal macrophage morphology |
| Triple coiled coil domain of C-type lectins | 0.06127 | INHERITED FROM: abnormal phagocyte morphology || abnormal monocyte cell number || increased susceptibility to infection || abnormal cytokine level || altered susceptibility to infection || abnormal mononuclear phagocyte morphology || abnormal monocyte morphology || abnormal response to infection || abnormal macrophage morphology |
| Cytochrome p450 reductase N-terminal domain-like | 0.06127 | INHERITED FROM: abnormal phagocyte morphology || abnormal macrophage physiology || abnormal osteoclast physiology || abnormal osteoclast cell number || increased osteoclast cell number || abnormal macrophage cell number || increased macrophage cell number || abnormal mononuclear phagocyte morphology || abnormal osteoclast morphology || abnormal macrophage morphology || abnormal innate immunity |
| VWC domain | 0.06211 | INHERITED FROM: increased inflammatory response |
| Complement control module/SCR domain | 0.06484 | INHERITED FROM: abnormal eosinophil physiology || abnormal cervical lymph node morphology || impaired eosinophil recruitment || abnormal leukocyte tethering or rolling || abnormal complement pathway || impaired leukocyte tethering or rolling || abnormal innate immunity || lymph node hypoplasia |
| WWE domain | 0.08419 | INHERITED FROM: decreased marginal zone B cell number || abnormal B cell proliferation || abnormal spleen marginal zone morphology || abnormal mature B cell number || abnormal spleen white pulp morphology || abnormal marginal zone B cell morphology || abnormal B cell activation || decreased mature B cell number |
| Platelet-derived growth factor-like | 0.09455 | INHERITED FROM: abnormal lymphatic vessel morphology |
| Ran binding protein zinc finger-like | 0.09639 | INHERITED FROM: decreased B cell number || abnormal B-1 B cell number || abnormal B-1a B cell morphology || abnormal B cell morphology || abnormal mature B cell morphology || abnormal B cell number || decreased B-1a cell number |
| Long-chain cytokines | 0.09865 | INHERITED FROM: abnormal circulating cytokine level || altered susceptibility to autoimmune disorder || increased susceptibility to infection || abnormal osteoclast differentiation || decreased susceptibility to experimental autoimmune encephalomyelitis || altered susceptibility to bacterial infection || abnormal cytokine level || autoimmune response || abnormal self tolerance |
| Rhodopsin-like | 0.1064 | INHERITED FROM: abnormal acute inflammation || abnormal hypersensitivity reaction || abnormal leukocyte migration || decreased inflammatory response || abnormal type I hypersensitivity reaction |
| Calponin-homology domain, CH-domain | 0.1111 | INHERITED FROM: abnormal transitional stage T2 B cell morphology || abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number || decreased transitional stage T2 B cell number |
| Integrin A (or I) domain | 0.1137 | INHERITED FROM: abnormal leukocyte migration |
| Transforming growth factor (TGF)-beta | 0.1329 | INHERITED FROM: granulomatous inflammation || chronic inflammation |
| Myb/SANT domain | 0.1363 | INHERITED FROM: arrested B cell differentiation |
| Transducin (alpha subunit), insertion domain | 0.1428 | INHERITED FROM: increased tumor necrosis factor secretion || increased interleukin-2 secretion |
| Pleckstrin-homology domain (PH domain) | 0.1491 | INHERITED FROM: abnormal B cell proliferation || decreased interleukin-2 secretion || abnormal B-1 B cell number || abnormal cell-mediated immunity || decreased transitional stage B cell number |
| NADPH-cytochrome p450 reductase-like | 0.1514 | INHERITED FROM: abnormal macrophage physiology || abnormal osteoclast physiology || abnormal osteoclast cell number || increased osteoclast cell number || abnormal macrophage cell number || increased macrophage cell number || abnormal osteoclast morphology || abnormal macrophage morphology |
| Netrin-like domain (NTR/C345C module) | 0.1514 | INHERITED FROM: increased susceptibility to infection || altered susceptibility to bacterial infection || autoimmune response || increased susceptibility to bacterial infection || abnormal self tolerance || abnormal immune tolerance |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.1514 | INHERITED FROM: abnormal macrophage physiology || abnormal osteoclast physiology || abnormal osteoclast cell number || increased osteoclast cell number || abnormal macrophage cell number || increased macrophage cell number || abnormal osteoclast morphology || abnormal macrophage morphology |
| Nuclear receptor coactivator interlocking domain | 0.1514 | INHERITED FROM: increased T cell number || enlarged spleen |
| Cell cycle transcription factor e2f-dp | 0.1583 | INHERITED FROM: decreased double-positive T cell number || abnormal T cell differentiation |
| CCCH zinc finger | 0.2195 | INHERITED FROM: enlarged lymph nodes || abnormal lymph node size || increased mature B cell number || abnormal lymph node morphology || abnormal thymus development || enlarged spleen || increased circulating tumor necrosis factor level || abnormal circulating tumor necrosis factor level |
| Fibronectin type II module | 0.2326 | INHERITED FROM: decreased susceptibility to infection |
| Fibronectin type III | 0.2513 | INHERITED FROM: abnormal circulating cytokine level || abnormal circulating interferon-gamma level || autoimmune response || abnormal self tolerance |
| EF-hand modules in multidomain proteins | 0.2519 | INHERITED FROM: increased interleukin-2 secretion |
| Noncollagenous (NC1) domain of collagen IV | 0.2575 | INHERITED FROM: kidney inflammation |
| Fibrinogen C-terminal domain-like | 0.2721 | INHERITED FROM: abnormal lymphatic vessel morphology |
| Papain-like | 0.291 | INHERITED FROM: pancreas inflammation || salivary gland inflammation || decreased susceptibility to autoimmune diabetes || insulitis |
| Linker histone H1/H5 | 0.3402 | INHERITED FROM: abnormal thymus size || small thymus |
| Kringle modules | 0.3659 | INHERITED FROM: abnormal acute phase protein level |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.3659 | INHERITED FROM: abnormal spleen weight |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.3868 | INHERITED FROM: abnormal immature B cell number || abnormal follicular B cell morphology || increased mature B cell number || abnormal B-2 B cell morphology |
| Ankyrin repeat | 0.3946 | INHERITED FROM: abnormal Peyer's patch T cell area morphology |
| RING finger domain, C3HC4 | 0.4183 | INHERITED FROM: skin inflammation || increased interleukin-2 secretion || dermatitis |
| Double-stranded RNA-binding domain (dsRBD) | 0.4796 | INHERITED FROM: increased susceptibility to viral infection |
| Cell cycle control phosphatase, catalytic domain | 0.5231 | INHERITED FROM: increased tumor necrosis factor secretion |
| DBL homology domain (DH-domain) | 0.5769 | INHERITED FROM: decreased B cell proliferation || abnormal transitional stage B cell morphology || decreased interleukin-2 secretion || abnormal transitional stage T2 B cell morphology || abnormal transitional stage T1 B cell morphology || decreased transitional stage B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number || decreased transitional stage T2 B cell number |
| Ngr ectodomain-like | 0.6568 | INHERITED FROM: osteoarthritis |
| FHA domain | 0.8024 | INHERITED FROM: abnormal class switch recombination |
| Homeodomain | 1 | INHERITED FROM: abnormal spleen development || ectopic thymus || abnormal spleen mesenchyme morphology || athymia |
| Nicotinic receptor ligand binding domain-like | 1 | INHERITED FROM: urinary bladder inflammation |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | INHERITED FROM: urinary bladder inflammation |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Anaphylotoxins (complement system) | 0 | Direct |
| Cysteine rich domain | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| Short-chain cytokines | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| STAT DNA-binding domain | 0 | Direct |
| RUNT domain | 0 | Direct |
| DNA polymerase beta-like | 0 | Direct |
| BAFF receptor-like | 0 | Direct |
| Interleukin-1 (IL-1) | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| STAT | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Pyrin domain, PYD | 0 | Direct |
| Interleukin 17F, IL-17F | 0 | Direct |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
| DNA polymerase beta-like, second domain | 0 | Direct |
| Resistin | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| SH2 domain | 0.0000000009631 | Direct |
| C-type lectin domain | 0.000000001588 | Direct |
| Toll/Interleukin receptor TIR domain | 0.00000001187 | Direct |
| C1 set domains (antibody constant domain-like) | 0.00000008025 | Direct |
| MHC antigen-recognition domain | 0.0000002058 | Direct |
| V set domains (antibody variable domain-like) | 0.0000002368 | Direct |
| TNF receptor-like | 0.000003257 | Direct |
| Protein kinases, catalytic subunit | 0.00001395 | Direct |
| Interleukin 8-like chemokines | 0.000279 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.0005874 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0006742 | Direct |
| Integrin domains | 0.0009559 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0.001332 | Inherited |
| Interferon regulatory factor | 0.001332 | Inherited |
| Integrin beta EGF-like domains | 0.002974 | Inherited |
| Caspase catalytic domain | 0.002996 | Inherited |
| MATH domain | 0.002996 | Inherited |
| Caspase recruitment domain, CARD | 0.003275 | Inherited |
| MMP N-terminal domain | 0.0041 | Inherited |
| Nuclear receptor | 0.004308 | Inherited |
| Pointed domain | 0.006507 | Inherited |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.006507 | Inherited |
| Complement components | 0.006507 | Inherited |
| Alpha-macroglobulin receptor domain | 0.006507 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.008438 | Inherited |
| Nuclear receptor ligand-binding domain | 0.009245 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.01064 | Inherited |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.01125 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.0122 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.01399 | Inherited |
| DNA polymerase I | 0.01399 | Inherited |
| E2F dimerization segment | 0.01399 | Inherited |
| TNF-like | 0.0157 | Inherited |
| DEATH domain, DD | 0.01667 | Inherited |
| PLC-like (P variant) | 0.02326 | Inherited |
| Hemopexin-like domain | 0.02562 | Inherited |
| EGF-type module | 0.02578 | Inherited |
| ets domain | 0.02584 | Inherited |
| Notch domain | 0.02942 | Inherited |
| Tetraspanin | 0.02942 | Inherited |
| Eukaryotic proteases | 0.03043 | Inherited |
| 28-residue LRR | 0.03939 | Inherited |
| Integrin alpha N-terminal domain | 0.04036 | Inherited |
| SH3-domain | 0.04395 | Inherited |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.04528 | Inherited |
| C2 set domains | 0.0544 | Inherited |
| I set domains | 0.05843 | Inherited |
| Tissue inhibitor of metalloproteinases, TIMP | 0.06127 | Inherited |
| beta-glycanases | 0.06127 | Inherited |
| Triple coiled coil domain of C-type lectins | 0.06127 | Inherited |
| Cytochrome p450 reductase N-terminal domain-like | 0.06127 | Inherited |
| VWC domain | 0.06211 | Inherited |
| Complement control module/SCR domain | 0.06484 | Inherited |
| WWE domain | 0.08419 | Inherited |
| Platelet-derived growth factor-like | 0.09455 | Inherited |
| Ran binding protein zinc finger-like | 0.09639 | Inherited |
| Long-chain cytokines | 0.09865 | Inherited |
| Rhodopsin-like | 0.1064 | Inherited |
| Calponin-homology domain, CH-domain | 0.1111 | Inherited |
| Integrin A (or I) domain | 0.1137 | Inherited |
| Transforming growth factor (TGF)-beta | 0.1329 | Inherited |
| Myb/SANT domain | 0.1363 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.1428 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.1491 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.1514 | Inherited |
| Netrin-like domain (NTR/C345C module) | 0.1514 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.1514 | Inherited |
| Nuclear receptor coactivator interlocking domain | 0.1514 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.1583 | Inherited |
| CCCH zinc finger | 0.2195 | Inherited |
| Fibronectin type II module | 0.2326 | Inherited |
| Fibronectin type III | 0.2513 | Inherited |
| EF-hand modules in multidomain proteins | 0.2519 | Inherited |
| Noncollagenous (NC1) domain of collagen IV | 0.2575 | Inherited |
| Fibrinogen C-terminal domain-like | 0.2721 | Inherited |
| Papain-like | 0.291 | Inherited |
| Linker histone H1/H5 | 0.3402 | Inherited |
| Kringle modules | 0.3659 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.3659 | Inherited |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.3868 | Inherited |
| Ankyrin repeat | 0.3946 | Inherited |
| RING finger domain, C3HC4 | 0.4183 | Inherited |
| Double-stranded RNA-binding domain (dsRBD) | 0.4796 | Inherited |
| Cell cycle control phosphatase, catalytic domain | 0.5231 | Inherited |
| DBL homology domain (DH-domain) | 0.5769 | Inherited |
| Ngr ectodomain-like | 0.6568 | Inherited |
| FHA domain | 0.8024 | Inherited |
| Homeodomain | 1 | Inherited |
| Nicotinic receptor ligand binding domain-like | 1 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this MP term (SPMP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
52047,52058
52047 - RNI-like
52058 - L domain-like | 0 | DIRECT |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
55550,50729
55550 - SH2 domain
50729 - PH domain-like | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
57302,57302
57302 - Snake toxin-like
57302 - Snake toxin-like | 0 | DIRECT |
47802,81585
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like | 0 | DIRECT |
81585,81301
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
49562,51045
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
51045 - WW domain | 0 | DIRECT |
57440,56436
57440 - Kringle-like
56436 - C-type lectin-like | 0 | DIRECT |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | DIRECT |
50370,57440
50370 - Ricin B-like lectins
57440 - Kringle-like | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
48366,47473
48366 - Ras GEF
47473 - EF-hand | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.000002096 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.00004908 | DIRECT |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.0000592 | DIRECT |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.00007493 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.0001599 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.000467 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.0009744 | DIRECT |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.001078 | INHERITED FROM: increased lymphocyte cell number || abnormal interferon-gamma secretion || arrested B cell differentiation || decreased IgG3 level || decreased IgM level || decreased IgG2b level || abnormal T cell activation || abnormal CD4-positive, alpha beta T cell number || abnormal lymphocyte physiology || abnormal IgG1 level || abnormal mature B cell number || decreased IgG1 level || abnormal B cell proliferation || increased immature B cell number || abnormal lymphocyte cell number || decreased mature B cell number || abnormal transitional stage B cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number || decreased single-positive T cell number || abnormal interleukin-2 secretion || decreased interleukin-10 secretion || abnormal B cell activation || decreased IgG2 level || abnormal IgM level || increased leukocyte cell number || decreased interleukin-2 secretion || abnormal interferon secretion || abnormal effector T cell morphology || decreased interferon-gamma secretion || abnormal cytokine secretion || abnormal immature B cell morphology || abnormal spleen marginal zone morphology || decreased immature B cell number || abnormal IgG3 level || abnormal double-negative T cell morphology || decreased immunoglobulin level || abnormal follicular B cell morphology || abnormal alpha-beta T cell morphology || abnormal leukocyte physiology || decreased tumor necrosis factor secretion || abnormal lymphocyte morphology || abnormal B-1 B cell number || abnormal IgG2 level || abnormal NK cell physiology || abnormal immature B cell number || abnormal transitional stage T2 B cell morphology || abnormal IgG2b level || decreased double-negative T cell number || abnormal T cell proliferation || decreased B cell proliferation || decreased follicular B cell number |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.002453 | INHERITED FROM: abnormal immune system organ morphology || abnormal T cell differentiation || small thymus || abnormal thymus morphology || abnormal leukocyte cell number || abnormal lymphocyte cell number || abnormal leukopoiesis || abnormal T cell number || decreased leukocyte cell number || abnormal mononuclear cell morphology || abnormal T cell morphology || abnormal double-positive T cell morphology || decreased lymphocyte cell number || abnormal alpha-beta T cell morphology || abnormal lymphopoiesis || abnormal lymphocyte morphology || decreased T cell number |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.002453 | INHERITED FROM: large intestinal inflammation || abnormal circulating interleukin level || abnormal cell-mediated immunity || colitis || abnormal interleukin secretion || decreased acute inflammation || abnormal interleukin-1 beta secretion || intestinal inflammation || abnormal immune serum protein physiology || increased susceptibility to bacterial infection || abnormal immune cell physiology || abnormal leukocyte physiology || abnormal adaptive immunity || abnormal susceptibility to induced colitis || decreased susceptibility to autoimmune disorder |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.0032 | INHERITED FROM: altered susceptibility to infection || arthritis || altered susceptibility to bacterial infection |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.005512 | INHERITED FROM: abnormal leukocyte migration || abnormal inflammatory response || increased inflammatory response |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.01159 | INHERITED FROM: decreased T cell number || abnormal cellular extravasation |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.01159 | INHERITED FROM: decreased T cell number || abnormal cellular extravasation |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.01205 | INHERITED FROM: abnormal cell-mediated immunity || abnormal phagocyte morphology || abnormal CD4-positive, alpha beta T cell number || abnormal lymphocyte physiology || abnormal leukocyte cell number || abnormal lymphocyte cell number || abnormal mononuclear cell morphology || increased leukocyte cell number || abnormal macrophage morphology || abnormal leukocyte morphology || abnormal immune cell physiology || abnormal leukocyte physiology || abnormal lymphocyte morphology || abnormal adaptive immunity || abnormal immunoglobulin level || abnormal myeloid leukocyte morphology |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.01205 | INHERITED FROM: increased lymphocyte cell number || abnormal spleen size || abnormal neutrophil morphology || abnormal leukopoiesis || increased neutrophil cell number || abnormal mononuclear cell morphology || abnormal neutrophil cell number || decreased B cell number || abnormal B cell number || abnormal leukocyte morphology || abnormal lymphocyte morphology || abnormal monocyte morphology || abnormal lymph organ size || abnormal mature B cell morphology || abnormal IgG level || enlarged spleen |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01362 | INHERITED FROM: increased inflammatory response |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.02063 | INHERITED FROM: arthritis || abnormal macrophage physiology || abnormal acute phase protein level || abnormal inflammatory response || increased inflammatory response |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.02063 | INHERITED FROM: large intestinal inflammation || joint inflammation || colitis || arthritis || abnormal inflammatory response || increased inflammatory response |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.02631 | INHERITED FROM: abnormal B cell apoptosis |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.03345 | INHERITED FROM: altered susceptibility to bacterial infection |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.04017 | INHERITED FROM: abnormal T cell differentiation || abnormal leukopoiesis || decreased double-positive T cell number || abnormal alpha-beta T cell morphology || abnormal lymphopoiesis |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.04017 | INHERITED FROM: abnormal CD8-positive, alpha beta T cell morphology || abnormal CD4-positive, alpha beta T cell number || increased granulocyte number || abnormal neutrophil morphology || abnormal CD4-positive, alpha beta T cell morphology || increased neutrophil cell number || abnormal effector T cell morphology || abnormal neutrophil cell number || abnormal alpha-beta T cell number || abnormal alpha-beta T cell morphology || abnormal CD8-positive, alpha-beta T cell number |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.04809 | INHERITED FROM: decreased T cell proliferation |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.04809 | INHERITED FROM: abnormal CD8-positive, alpha beta T cell morphology || abnormal CD4-positive, alpha beta T cell number || abnormal CD4-positive, alpha beta T cell morphology || increased neutrophil cell number || abnormal CD8-positive, alpha-beta T cell number |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.05581 | INHERITED FROM: abnormal spleen size || abnormal spleen red pulp morphology || increased spleen red pulp amount || enlarged spleen |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0.05581 | INHERITED FROM: abnormal innate immunity || abnormal macrophage physiology |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.05581 | INHERITED FROM: abnormal phagocyte morphology || altered susceptibility to infection || abnormal response to infection || abnormal monocyte cell number || abnormal macrophage morphology || abnormal mononuclear phagocyte morphology || abnormal cytokine level || abnormal monocyte morphology || increased susceptibility to infection |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.07631 | INHERITED FROM: small thymus || abnormal lymph node size || abnormal lymph node morphology || abnormal thymus size || enlarged lymph nodes |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.07631 | INHERITED FROM: renal/urinary system inflammation || kidney inflammation |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.0849 | INHERITED FROM: abnormal T cell activation || increased alpha-beta T cell number || decreased CD4-positive, alpha beta T cell number || increased susceptibility to bacterial infection || increased CD8-positive, alpha-beta T cell number || abnormal T cell proliferation |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.09558 | INHERITED FROM: impaired neutrophil recruitment || abnormal humoral immune response || abnormal innate immunity || impaired eosinophil recruitment || abnormal leukocyte tethering or rolling || abnormal cervical lymph node morphology || impaired leukocyte tethering or rolling || abnormal leukocyte adhesion || abnormal eosinophil physiology || abnormal complement pathway || abnormal cellular extravasation |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0.1444 | INHERITED FROM: increased tumor necrosis factor secretion |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.1459 | INHERITED FROM: abnormal interleukin secretion || abnormal cytokine secretion |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1878 | INHERITED FROM: abnormal hypersensitivity reaction || increased T cell proliferation || increased interleukin-2 secretion |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.2286 | INHERITED FROM: abnormal immature B cell morphology || abnormal immature B cell number |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0.2454 | INHERITED FROM: decreased interleukin-6 secretion |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0.5512 | INHERITED FROM: altered susceptibility to viral infection || increased susceptibility to viral infection |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.5622 | INHERITED FROM: abnormal transitional stage B cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number || decreased interleukin-2 secretion || abnormal transitional stage T1 B cell morphology || decreased transitional stage T2 B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || decreased B cell proliferation |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.6184 | INHERITED FROM: decreased DN2 thymocyte number |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.9913 | INHERITED FROM: urinary bladder inflammation |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
52047,52058
52047 - RNI-like
52058 - L domain-like | 0 | Direct |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
55550,50729
55550 - SH2 domain
50729 - PH domain-like | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
57302,57302
57302 - Snake toxin-like
57302 - Snake toxin-like | 0 | Direct |
47802,81585
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like | 0 | Direct |
81585,81301
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
49562,51045
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
51045 - WW domain | 0 | Direct |
57440,56436
57440 - Kringle-like
56436 - C-type lectin-like | 0 | Direct |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | Direct |
50370,57440
50370 - Ricin B-like lectins
57440 - Kringle-like | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
48366,47473
48366 - Ras GEF
47473 - EF-hand | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.000002096 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.00004908 | Direct |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.0000592 | Direct |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.00007493 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.0001599 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.000467 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.0009744 | Direct |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.001078 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.002453 | Inherited |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.002453 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.0032 | Inherited |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.005512 | Inherited |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.01159 | Inherited |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.01159 | Inherited |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.01205 | Inherited |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.01205 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01362 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.02063 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.02063 | Inherited |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.02631 | Inherited |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.03345 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.04017 | Inherited |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.04017 | Inherited |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.04809 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.04809 | Inherited |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.05581 | Inherited |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0.05581 | Inherited |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.05581 | Inherited |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.07631 | Inherited |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.07631 | Inherited |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.0849 | Inherited |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.09558 | Inherited |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0.1444 | Inherited |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.1459 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1878 | Inherited |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.2286 | Inherited |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0.2454 | Inherited |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0.5512 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.5622 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.6184 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.9913 | Inherited |
(show details)
Supra-domains annotated to this MP term (SPMP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550
50729 - PH domain-like
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
47802,81585,81301
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | DIRECT |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | DIRECT |
56436,56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
50370,57440,56436
50370 - Ricin B-like lectins
57440 - Kringle-like
56436 - C-type lectin-like | 0 | DIRECT |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
48366,47473,57889
48366 - Ras GEF
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | DIRECT |
57440,56436,56436
57440 - Kringle-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.001688 | INHERITED FROM: abnormal interleukin-5 secretion || abnormal immune system cell morphology || small thymus || abnormal IgG2a level || altered susceptibility to infection || decreased T cell proliferation || decreased leukocyte cell number || abnormal immune system morphology || abnormal mononuclear cell morphology || abnormal mature gamma-delta T cell morphology || abnormal spleen white pulp morphology || abnormal spleen secondary B follicle morphology || abnormal pre-B cell morphology || abnormal leukocyte physiology || thymus hypoplasia || abnormal IgG2 level || increased susceptibility to infection |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.01159 | INHERITED FROM: decreased T cell number || abnormal cellular extravasation |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.01876 | INHERITED FROM: altered susceptibility to bacterial infection |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.02631 | INHERITED FROM: large intestinal inflammation || colitis || abnormal inflammatory response || increased inflammatory response |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.02631 | INHERITED FROM: abnormal B cell apoptosis |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.02631 | INHERITED FROM: abnormal macrophage physiology || abnormal inflammatory response || increased inflammatory response |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.03345 | INHERITED FROM: abnormal cellular extravasation |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.04017 | INHERITED FROM: abnormal CD8-positive, alpha beta T cell morphology || abnormal CD4-positive, alpha beta T cell number || increased granulocyte number || abnormal neutrophil morphology || abnormal CD4-positive, alpha beta T cell morphology || increased neutrophil cell number || abnormal effector T cell morphology || abnormal neutrophil cell number || abnormal alpha-beta T cell number || abnormal alpha-beta T cell morphology || abnormal CD8-positive, alpha-beta T cell number |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.05405 | INHERITED FROM: decreased leukocyte cell number || abnormal T cell morphology || increased spleen red pulp amount || decreased interleukin-4 secretion || abnormal interleukin-4 secretion |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.0849 | INHERITED FROM: abnormal T cell activation || increased alpha-beta T cell number || decreased CD4-positive, alpha beta T cell number || increased susceptibility to bacterial infection || increased CD8-positive, alpha-beta T cell number || abnormal T cell proliferation |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.1094 | INHERITED FROM: increased spleen red pulp amount |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1124 | INHERITED FROM: absent mast cells |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.1341 | INHERITED FROM: increased spleen red pulp amount || decreased interleukin-4 secretion || abnormal interleukin-4 secretion || enlarged spleen |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.1638 | INHERITED FROM: abnormal humoral immune response || abnormal complement pathway |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.2475 | INHERITED FROM: increased IgG level |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550
50729 - PH domain-like
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
47802,81585,81301
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | Direct |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | Direct |
56436,56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
50370,57440,56436
50370 - Ricin B-like lectins
57440 - Kringle-like
56436 - C-type lectin-like | 0 | Direct |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
48366,47473,57889
48366 - Ras GEF
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | Direct |
57440,56436,56436
57440 - Kringle-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.001688 | Inherited |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.01159 | Inherited |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.01876 | Inherited |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.02631 | Inherited |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.02631 | Inherited |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.02631 | Inherited |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.03345 | Inherited |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.04017 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.05405 | Inherited |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.0849 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.1094 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1124 | Inherited |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.1341 | Inherited |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.1638 | Inherited |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.2475 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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