Mammalian Phenotype (MP): vision/eye phenotype

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ 1: mammalian phenotype [MP:0000001] <29>

0: vision/eye phenotype [MP:0005391] <2> (43|53) (50|27|17)

- 1: abnormal eye physiology [MP:0005253] <25> (8|9) (9|5|2)

- 1: abnormal eye morphology [MP:0002092] <23> (39|49) (46|25|15)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Tubby C-terminal domain-like	0	Direct
p53 tetramerization domain	0	Direct
Di-copper centre-containing domain	0	Direct
Notch domain	0	Direct
gamma-Crystallin-like	0.000001654	Direct
EGF/Laminin	0.00003168	Direct
FnI-like domain	0.0002626	Direct
Plexin repeat	0.0007391	Direct
Cystine-knot cytokines	0.001078	Inherited
Homeodomain-like	0.0011	Inherited
HLH, helix-loop-helix DNA-binding domain	0.003763	Inherited
CalX-like	0.005544	Inherited
Sema domain	0.01356	Inherited
Nuclear receptor ligand-binding domain	0.02254	Inherited
GroEL equatorial domain-like	0.02423	Inherited
GAF domain-like	0.0475	Inherited
TNF-like	0.05753	Inherited
Transducin (heterotrimeric G protein), gamma chain	0.07054	Inherited
E2F-DP heterodimerization region	0.07687	Inherited
Cupredoxins	0.08172	Inherited
PGBD-like	0.08636	Inherited
HMG-box	0.08961	Inherited
Clc chloride channel	0.1109	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.1235	Inherited
Integrin domains	0.1434	Inherited
CBS-domain pair	0.1554	Inherited
Cyclin-like	0.165	Inherited
Kringle-like	0.174	Inherited
"Winged helix" DNA-binding domain	0.1936	Inherited
Tetraspanin	0.2229	Inherited
Metalloproteases ("zincins"), catalytic domain	0.3454	Inherited
Regulator of G-protein signaling, RGS	0.3698	Inherited
HD-domain/PDEase-like	0.3699	Inherited
Blood coagulation inhibitor (disintegrin)	0.3699	Inherited
Transducin (alpha subunit), insertion domain	0.4064	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.4211	Inherited
Nicotinic receptor ligand binding domain-like	0.4211	Inherited
Toll/Interleukin receptor TIR domain	0.5156	Inherited
L domain-like	0.5355	Inherited
NAD(P)-binding Rossmann-fold domains	0.5373	Inherited
DBL homology domain (DH-domain)	0.7948	Inherited
Trypsin-like serine proteases	0.9865	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Transcriptional factor tubby, C-terminal domain	0	Direct
p53 DNA-binding domain-like	0	Direct
Notch domain	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
p53 tetramerization domain	0	Direct
Retinoblastoma tumor suppressor domains	0	Direct
Cytochrome p450 reductase N-terminal domain-like	0	Direct
Crystallins/Ca-binding development proteins	0.000001044	Direct
VWC domain	0.00006576	Direct
Arylsulfatase	0.00009349	Direct
Forkhead DNA-binding domain	0.0001033	Direct
Homeodomain	0.0005273	Direct
EGF-type module	0.0005349	Direct
Plexin repeat	0.0005567	Direct
I set domains	0.002003	Inherited
HLH, helix-loop-helix DNA-binding domain	0.003376	Inherited
CalX-beta domain	0.003969	Inherited
Noncollagenous (NC1) domain of collagen IV	0.00535	Inherited
YWTD domain	0.005811	Inherited
Laminin-type module	0.008723	Inherited
Sema domain	0.01087	Inherited
Transforming growth factor (TGF)-beta	0.01245	Inherited
Nuclear receptor	0.01303	Inherited
Extracellular domain of cell surface receptors	0.01489	Inherited
Nuclear receptor ligand-binding domain	0.01911	Inherited
GAF domain	0.03718	Inherited
E2F dimerization segment	0.03718	Inherited
TNF-like	0.04945	Inherited
MMP N-terminal domain	0.07306	Inherited
HMG-box	0.07882	Inherited
Matrix metalloproteases, catalytic domain	0.09102	Inherited
Clc chloride channel	0.09338	Inherited
Tyrosine-dependent oxidoreductases	0.0956	Inherited
CBS-domain pair	0.1067	Inherited
TNF receptor-like	0.111	Inherited
Integrin domains	0.1273	Inherited
Transducin (heterotrimeric G protein), gamma chain	0.1281	Inherited
Cell cycle transcription factor e2f-dp	0.1281	Inherited
Kringle modules	0.1672	Inherited
Calmodulin-like	0.1927	Inherited
PDZ domain	0.234	Inherited
PDEase	0.2722	Inherited
POU-specific domain	0.2722	Inherited
Ngr ectodomain-like	0.2875	Inherited
Blood coagulation inhibitor (disintegrin)	0.3478	Inherited
Regulator of G-protein signaling, RGS	0.3513	Inherited
Transducin (alpha subunit), insertion domain	0.3817	Inherited
Nicotinic receptor ligand binding domain-like	0.4054	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.4054	Inherited
cAMP-binding domain	0.4176	Inherited
Cyclin	0.5476	Inherited
DBL homology domain (DH-domain)	0.7863	Inherited
Eukaryotic proteases	0.9917	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Tubby C-terminal domain-like	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Di-copper centre-containing domain	0	Direct
Notch domain	0	Direct
p53 tetramerization domain	0	Direct
gamma-Crystallin-like	0.0000006795	Direct
EGF/Laminin	0.00001457	Direct
FnI-like domain	0.0001343	Direct
Plexin repeat	0.0003967	Direct
Cystine-knot cytokines	0.0005914	Direct
Homeodomain-like	0.0006047	Direct
Alkaline phosphatase-like	0.001031	Inherited
Growth factor receptor domain	0.001078	Inherited
Integrin beta tail domain	0.001217	Inherited
HLH, helix-loop-helix DNA-binding domain	0.002207	Inherited
CalX-like	0.003335	Inherited
YWTD domain	0.004766	Inherited
Sema domain	0.008655	Inherited
Nuclear receptor ligand-binding domain	0.01493	Inherited
GroEL equatorial domain-like	0.01614	Inherited
GAF domain-like	0.03345	Inherited
TNF-like	0.04123	Inherited
Transducin (heterotrimeric G protein), gamma chain	0.05159	Inherited
E2F-DP heterodimerization region	0.0566	Inherited
Cupredoxins	0.06047	Inherited
PGBD-like	0.06426	Inherited
HMG-box	0.06688	Inherited
Clc chloride channel	0.08485	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.09553	Inherited
Integrin domains	0.1129	Inherited
beta-sandwich domain of Sec23/24	0.1175	Inherited
CBS-domain pair	0.1235	Inherited
Cyclin-like	0.1319	Inherited
Kringle-like	0.1398	Inherited
"Winged helix" DNA-binding domain	0.1575	Inherited
Tetraspanin	0.1845	Inherited
TNF receptor-like	0.2023	Inherited
Metalloproteases ("zincins"), catalytic domain	0.3	Inherited
Regulator of G-protein signaling, RGS	0.324	Inherited
Blood coagulation inhibitor (disintegrin)	0.3241	Inherited
HD-domain/PDEase-like	0.3241	Inherited
Transducin (alpha subunit), insertion domain	0.3596	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.3743	Inherited
Nicotinic receptor ligand binding domain-like	0.3743	Inherited
Toll/Interleukin receptor TIR domain	0.4681	Inherited
L domain-like	0.4884	Inherited
NAD(P)-binding Rossmann-fold domains	0.4903	Inherited
Intermediate filament protein, coiled coil region	0.7484	Inherited
DBL homology domain (DH-domain)	0.7598	Inherited
Trypsin-like serine proteases	0.9707	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0	Direct
90193,90193 90193 - Notch domain 90193 - Notch domain	0	Direct
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain	0	Direct
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain	0	Direct
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.000003648	Direct
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.001217	Inherited
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.00282	Inherited
48670,48097 48670 - Transducin (heterotrimeric G protein), gamma chain 48097 - Regulator of G-protein signaling, RGS	0.005137	Inherited
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.005419	Inherited
81296,81296 81296 - E set domains 81296 - E set domains	0.007133	Inherited
101912,103575 101912 - Sema domain 103575 - Plexin repeat	0.008655	Inherited
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain	0.01094	Inherited
101288,50156 101288 - L27 domain 50156 - PDZ domain-like	0.01094	Inherited
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.02081	Inherited
55781,55781 55781 - GAF domain-like 55781 - GAF domain-like	0.03345	Inherited
55781,109604 55781 - GAF domain-like 109604 - HD-domain/PDEase-like	0.03345	Inherited
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0.0566	Inherited
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.06426	Inherited
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.08485	Inherited
50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like	0.107	Inherited
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.2178	Inherited
52058,52058 52058 - L domain-like 52058 - L domain-like	0.262	Inherited
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.3174	Inherited
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin)	0.3241	Inherited
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like	0.36	Inherited
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.3743	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.7203	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
101288,50156,50044 101288 - L27 domain 50156 - PDZ domain-like 50044 - SH3-domain	0	Direct
49265,48726,49265 49265 - Fibronectin type III 48726 - Immunoglobulin 49265 - Fibronectin type III	0	Direct
57196,90193,90193 57196 - EGF/Laminin 90193 - Notch domain 90193 - Notch domain	0	Direct
52058,48726,48726 52058 - L domain-like 48726 - Immunoglobulin 48726 - Immunoglobulin	0	Direct
141072,141072,141072 141072 - CalX-like 141072 - CalX-like 141072 - CalX-like	0	Direct
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.00001535	Direct
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.001217	Inherited
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain	0.004576	Inherited
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.005519	Inherited
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.007725	Inherited
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains	0.0126	Inherited
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0.01614	Inherited
57184,49899,49899 57184 - Growth factor receptor domain 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.01614	Inherited
49899,57196,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 57196 - EGF/Laminin	0.02081	Inherited
55781,55781,109604 55781 - GAF domain-like 55781 - GAF domain-like 109604 - HD-domain/PDEase-like	0.03345	Inherited
50156,50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like 50156 - PDZ domain-like	0.0566	Inherited
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.07234	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Mammalian Phenotype (MP): vision/eye phenotype

Superfamily

Family

Supra-domain (including individual superfamily)