|
|
Mammalian Phenotype (MP): hematopoietic system phenotype
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (SDMP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Cysteine rich domain | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| Short-chain cytokines | 0 | DIRECT |
| DUSP, domain in ubiquitin-specific proteases | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| MHC antigen-recognition domain | 0 | DIRECT |
| STAT DNA-binding domain | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
| DNA polymerase beta-like | 0 | DIRECT |
| BAFF receptor-like | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| Interleukin-1 (IL-1) | 0 | DIRECT |
| beta-glycanases | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| MAPEG domain | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| C1 set domains (antibody constant domain-like) | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Alpha-adaptin ear subdomain-like | 0 | DIRECT |
| Pyrin domain, PYD | 0 | DIRECT |
| Interleukin 17F, IL-17F | 0 | DIRECT |
| DNA polymerase beta-like, second domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| SH2 domain | 0.000000001381 | DIRECT |
| V set domains (antibody variable domain-like) | 0.0000005973 | DIRECT |
| TNF receptor-like | 0.000002446 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0.000004075 | DIRECT |
| Interleukin 8-like chemokines | 0.00004039 | DIRECT |
| C-type lectin domain | 0.00006521 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0005604 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.001148 | INHERITED FROM: abnormal B cell physiology || abnormal IgG level || abnormal T cell differentiation || abnormal T cell number || abnormal mature B cell number || abnormal leukopoiesis || abnormal immature B cell number || abnormal lymphopoiesis || abnormal pre-B cell morphology || increased pre-B cell number || decreased mature B cell number || abnormal immature B cell morphology || enlarged spleen || abnormal T cell apoptosis || abnormal T cell physiology |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.001978 | INHERITED FROM: abnormal hematopoietic system morphology/development || decreased CD4-positive, alpha beta T cell number || increased leukocyte cell number || abnormal B-1 B cell number || increased hematopoietic cell number || abnormal T cell number || abnormal leukopoiesis || abnormal dendritic cell number || decreased hematopoietic cell number || abnormal lymphocyte morphology || abnormal blood cell physiology || abnormal definitive hematopoiesis || abnormal spleen germinal center morphology || abnormal thymus medulla morphology || abnormal osteoclast cell number || abnormal B cell proliferation || decreased CD8-positive, alpha-beta T cell number || abnormal T cell proliferation || abnormal phagocyte morphology || abnormal blood cell morphology/development || decreased B cell proliferation || increased IgG2a level || abnormal spleen secondary B follicle morphology || decreased T cell number || abnormal mature B cell morphology || abnormal leukocyte cell number || abnormal immunoglobulin level || abnormal blood cell morphology || abnormal T cell morphology || decreased leukocyte cell number || abnormal IgG2b level || decreased IgG2a level || abnormal leukocyte physiology || abnormal thymus morphology || abnormal macrophage cell number || abnormal dendritic cell morphology || abnormal mononuclear cell morphology || decreased dendritic cell number || abnormal B cell number || decreased lymphocyte cell number || abnormal lymphocyte cell number || abnormal lymphocyte physiology || abnormal B cell morphology || abnormal T cell physiology || decreased IgG2b level || abnormal IgG2a level |
| 28-residue LRR | 0.002726 | INHERITED FROM: abnormal leukocyte physiology |
| ARID domain | 0.003989 | INHERITED FROM: abnormal hematopoietic cell morphology || abnormal hematopoietic stem cell morphology |
| Integrin beta tail domain | 0.005847 | INHERITED FROM: abnormal myeloid cell morphology || abnormal hematocrit || abnormal leukocyte migration |
| Nuclear receptor | 0.007294 | INHERITED FROM: abnormal phagocyte morphology || abnormal macrophage cell number || persistent cervical thymus |
| Integrin domains | 0.008438 | INHERITED FROM: decreased CD4-positive, alpha beta T cell number || abnormal cellular extravasation || abnormal blood cell physiology || abnormal eosinophil cell number || abnormal hematopoietic cell morphology || decreased T cell number || decreased platelet aggregation || abnormal leukocyte migration |
| SH3-domain | 0.01009 | INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation || abnormal B cell proliferation || decreased single-positive T cell number || abnormal neutrophil physiology |
| Interferons/interleukin-10 (IL-10) | 0.0109 | INHERITED FROM: abnormal phagocyte morphology || decreased erythroid progenitor cell number |
| Caspase recruitment domain, CARD | 0.01123 | INHERITED FROM: abnormal blood cell physiology || abnormal thymocyte apoptosis || abnormal leukocyte physiology || abnormal hematopoietic system physiology || abnormal T cell physiology || abnormal follicular B cell morphology |
| TNF-like | 0.01264 | INHERITED FROM: abnormal blood cell physiology || abnormal spleen germinal center morphology || abnormal thymus epithelium morphology || small thymus medulla || abnormal IgG2a level |
| Inhibitor of apoptosis (IAP) repeat | 0.01279 | INHERITED FROM: abnormal blood cell physiology || abnormal B cell apoptosis || abnormal leukocyte physiology || abnormal lymphocyte physiology || abnormal hematopoietic system physiology |
| DNA polymerase I | 0.01279 | INHERITED FROM: abnormal B cell differentiation |
| DEATH domain, DD | 0.01374 | INHERITED FROM: abnormal IgG level || abnormal B-1 B cell number || abnormal blood cell physiology || abnormal thymus cortex morphology || abnormal spleen germinal center morphology || abnormal thymus medulla morphology || increased IgG2a level || abnormal spleen secondary B follicle morphology || abnormal IgG2b level || increased transitional stage B cell number || abnormal thymus morphology || abnormal mononuclear cell morphology || abnormal lymphocyte cell number |
| Nuclear receptor ligand-binding domain | 0.01447 | INHERITED FROM: abnormal phagocyte morphology || abnormal macrophage cell number || persistent cervical thymus |
| Caspase catalytic domain | 0.01478 | INHERITED FROM: abnormal blood cell physiology || abnormal thymocyte apoptosis || abnormal thymus physiology || decreased T cell apoptosis || abnormal macrophage apoptosis || abnormal leukocyte physiology || abnormal lymphocyte physiology || abnormal hematopoietic system physiology || abnormal T cell apoptosis || abnormal T cell physiology |
| PLC-like (P variant) | 0.01901 | INHERITED FROM: abnormal B-1 B cell number || abnormal leukopoiesis || abnormal blood cell physiology || abnormal definitive hematopoiesis || abnormal B cell proliferation || abnormal platelet aggregation || abnormal platelet dense granule morphology || decreased B-2 B cell number || abnormal platelet physiology || abnormal platelet activation || abnormal cytotoxic T cell cytolysis || abnormal platelet calcium level |
| Myb/SANT domain | 0.02093 | INHERITED FROM: arrested B cell differentiation || abnormal megakaryocyte morphology || increased megakaryocyte cell number || abnormal common lymphocyte progenitor cell morphology |
| Integrin beta EGF-like domains | 0.02155 | INHERITED FROM: abnormal myeloid cell morphology || abnormal hematocrit || abnormal leukocyte migration |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.02155 | INHERITED FROM: reticulocytosis || increased myeloid cell number || abnormal erythroid lineage cell morphology || abnormal reticulocyte cell number |
| Notch domain | 0.02731 | INHERITED FROM: increased hematopoietic cell number || extramedullary hematopoiesis || abnormal spleen red pulp morphology || increased spleen red pulp amount || enlarged spleen |
| Tetraspanin | 0.02731 | INHERITED FROM: abnormal macrophage morphology |
| DNA polymerase beta, N-terminal domain-like | 0.02731 | INHERITED FROM: abnormal B cell differentiation || abnormal leukopoiesis || abnormal definitive hematopoiesis || abnormal blood cell morphology/development || abnormal lymphopoiesis || abnormal hemopoiesis || decreased leukocyte cell number || decreased lymphocyte cell number || abnormal lymphocyte cell number || abnormal B cell morphology || abnormal immunoglobulin V(D)J recombination |
| Long-chain cytokines | 0.03347 | INHERITED FROM: abnormal osteoclast differentiation |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.03869 | INHERITED FROM: abnormal positive T cell selection || decreased thymocyte number |
| Pointed domain | 0.04172 | INHERITED FROM: abnormal B cell differentiation || abnormal mature B cell morphology || decreased leukocyte cell number || thrombocytopenia || decreased lymphocyte cell number || abnormal lymphocyte cell number || decreased thymocyte number |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.04172 | INHERITED FROM: increased granulocyte number || abnormal effector T cell morphology || abnormal alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell morphology || abnormal CD8-positive, alpha beta T cell morphology || abnormal platelet aggregation || abnormal CD8-positive, alpha-beta T cell number || abnormal platelet physiology || increased neutrophil cell number || abnormal platelet activation || abnormal neutrophil cell number || abnormal CD4-positive, alpha beta T cell number |
| Interferon regulatory factor | 0.04993 | INHERITED FROM: abnormal plasmacytoid dendritic cell number || abnormal plasmacytoid dendritic cell morphology || abnormal T cell number || abnormal mature B cell number || decreased plasmacytoid dendritic cell number || increased lymphocyte cell number || decreased T cell number || decreased mature B cell number || decreased dendritic cell number || abnormal lymphocyte physiology |
| C2 set domains | 0.04993 | INHERITED FROM: abnormal monocyte morphology |
| ets domain | 0.05147 | INHERITED FROM: abnormal definitive hematopoiesis || abnormal B cell proliferation || increased B cell apoptosis || decreased pro-B cell number || abnormal hematopoietic stem cell morphology || decreased thymocyte number |
| MATH domain | 0.05415 | INHERITED FROM: abnormal immature B cell number || abnormal immature B cell morphology |
| Transducin (alpha subunit), insertion domain | 0.05657 | INHERITED FROM: abnormal platelet aggregation || abnormal platelet physiology || decreased platelet aggregation || abnormal platelet activation |
| AraD-like aldolase/epimerase | 0.05785 | INHERITED FROM: reticulocytosis || spherocytosis || increased myeloid cell number || abnormal reticulocyte cell number || anemia || decreased hematocrit || abnormal hematocrit || abnormal reticulocyte morphology || abnormal myeloid cell number || decreased mean corpuscular volume || abnormal mean corpuscular volume || abnormal erythrocyte morphology |
| Tissue inhibitor of metalloproteinases, TIMP | 0.05785 | INHERITED FROM: increased granulocyte number || abnormal phagocyte morphology || abnormal granulocyte morphology || increased neutrophil cell number || abnormal neutrophil cell number || abnormal neutrophil morphology || abnormal granulocyte number |
| SWIRM domain | 0.05785 | INHERITED FROM: abnormal bone marrow cell morphology/development |
| Triple coiled coil domain of C-type lectins | 0.05785 | INHERITED FROM: abnormal monocyte morphology || abnormal mononuclear phagocyte morphology || abnormal monocyte cell number || abnormal phagocyte morphology || abnormal macrophage morphology |
| Cytochrome p450 reductase N-terminal domain-like | 0.05785 | INHERITED FROM: increased osteoclast cell number || abnormal osteoclast morphology || abnormal mononuclear phagocyte morphology || abnormal osteoclast physiology || abnormal macrophage physiology || abnormal osteoclast cell number || abnormal phagocyte morphology || increased macrophage cell number || abnormal macrophage cell number || abnormal macrophage morphology |
| Pleckstrin-homology domain (PH domain) | 0.06415 | INHERITED FROM: abnormal B-1 B cell number || abnormal blood cell physiology || abnormal B cell proliferation || abnormal platelet aggregation || decreased platelet aggregation || decreased transitional stage B cell number |
| Noncollagenous (NC1) domain of collagen IV | 0.07878 | INHERITED FROM: abnormal erythroid lineage cell morphology || decreased erythrocyte cell number || decreased myeloid cell number || decreased hematocrit || abnormal hemoglobin content || abnormal erythrocyte morphology || decreased hemoglobin content || abnormal hemoglobin |
| WWE domain | 0.07878 | INHERITED FROM: abnormal mature B cell number || abnormal B cell proliferation || decreased marginal zone B cell number || decreased mature B cell number || abnormal marginal zone B cell morphology || abnormal B cell activation || abnormal spleen marginal zone morphology || abnormal spleen white pulp morphology |
| E2F dimerization segment | 0.07878 | INHERITED FROM: abnormal T cell differentiation || abnormal thymus size || abnormal T cell number || decreased double-positive T cell number || abnormal leukopoiesis || abnormal lymphopoiesis || abnormal alpha-beta T cell morphology |
| A DNA-binding domain in eukaryotic transcription factors | 0.08702 | INHERITED FROM: abnormal erythrocyte physiology || abnormal megakaryocyte morphology || thrombocytopenia |
| Ran binding protein zinc finger-like | 0.08702 | INHERITED FROM: abnormal B-1 B cell number || decreased B cell number || abnormal mature B cell morphology || decreased B-1a cell number || abnormal B cell number || abnormal B-1a B cell morphology || abnormal B cell morphology |
| Erythroid transcription factor GATA-1 | 0.08789 | INHERITED FROM: abnormal erythroid lineage cell morphology || decreased erythrocyte cell number || abnormal erythrocyte morphology |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.09124 | INHERITED FROM: abnormal bone marrow hematopoietic cell morphology || abnormal megakaryocyte morphology || abnormal megakaryocyte progenitor cell morphology |
| I set domains | 0.1227 | INHERITED FROM: increased IgG1 level |
| NADPH-cytochrome p450 reductase-like | 0.144 | INHERITED FROM: increased osteoclast cell number || abnormal osteoclast morphology || abnormal osteoclast physiology || abnormal macrophage physiology || abnormal osteoclast cell number || increased macrophage cell number || abnormal macrophage cell number || abnormal macrophage morphology |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.144 | INHERITED FROM: increased osteoclast cell number || abnormal osteoclast morphology || abnormal osteoclast physiology || abnormal macrophage physiology || abnormal osteoclast cell number || increased macrophage cell number || abnormal macrophage cell number || abnormal macrophage morphology |
| Nuclear receptor coactivator interlocking domain | 0.144 | INHERITED FROM: increased T cell number || enlarged spleen |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.1495 | INHERITED FROM: abnormal plasmacytoid dendritic cell number || abnormal B cell differentiation || abnormal plasmacytoid dendritic cell morphology || absent B cells || abnormal dendritic cell number || decreased plasmacytoid dendritic cell number || increased B cell number || decreased mature B cell number || absent lymphocyte || abnormal dendritic cell morphology || decreased dendritic cell number || abnormal spleen white pulp morphology || abnormal T cell physiology |
| Integrin alpha N-terminal domain | 0.1572 | INHERITED FROM: abnormal cellular extravasation |
| Mammalian PLC | 0.2059 | INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation || abnormal platelet activation |
| CCCH zinc finger | 0.2059 | INHERITED FROM: abnormal thymus development || increased mature B cell number || enlarged spleen |
| Eps15 homology domain (EH domain) | 0.2463 | INHERITED FROM: abnormal mean corpuscular hemoglobin || abnormal hemoglobin |
| Complement control module/SCR domain | 0.2488 | INHERITED FROM: impaired leukocyte tethering or rolling || abnormal eosinophil physiology || abnormal leukocyte tethering or rolling || impaired eosinophil recruitment |
| Linker histone H1/H5 | 0.3247 | INHERITED FROM: abnormal thymus size || small thymus |
| Cell cycle transcription factor e2f-dp | 0.3247 | INHERITED FROM: abnormal T cell differentiation || decreased double-positive T cell number |
| EGF-type module | 0.3393 | INHERITED FROM: abnormal leukocyte adhesion |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.3474 | INHERITED FROM: abnormal hemoglobin content || abnormal spleen weight |
| Cyclin | 0.356 | INHERITED FROM: decreased erythrocyte cell number || decreased hematopoietic stem cell number || abnormal common myeloid progenitor cell morphology || abnormal hematopoietic stem cell morphology |
| Integrin A (or I) domain | 0.3572 | INHERITED FROM: abnormal leukocyte migration |
| G proteins | 0.3836 | INHERITED FROM: abnormal platelet aggregation || abnormal platelet activation |
| DBL homology domain (DH-domain) | 0.4319 | INHERITED FROM: abnormal transitional stage B cell morphology || decreased B cell proliferation || decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology |
| Rhodopsin-like | 0.4486 | INHERITED FROM: abnormal leukocyte migration |
| Calponin-homology domain, CH-domain | 0.5268 | INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology |
| Ankyrin repeat | 0.5401 | INHERITED FROM: extramedullary hematopoiesis |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.7235 | INHERITED FROM: abnormal immature B cell number || increased mature B cell number || abnormal B-2 B cell morphology || abnormal follicular B cell morphology |
| FHA domain | 0.7836 | INHERITED FROM: abnormal class switch recombination |
| Homeodomain | 1 | INHERITED FROM: abnormal spleen development || ectopic thymus || athymia || abnormal spleen mesenchyme morphology |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Cysteine rich domain | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| Short-chain cytokines | 0 | Direct |
| DUSP, domain in ubiquitin-specific proteases | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| MHC antigen-recognition domain | 0 | Direct |
| STAT DNA-binding domain | 0 | Direct |
| RUNT domain | 0 | Direct |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
| DNA polymerase beta-like | 0 | Direct |
| BAFF receptor-like | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| Interleukin-1 (IL-1) | 0 | Direct |
| beta-glycanases | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| MAPEG domain | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| C1 set domains (antibody constant domain-like) | 0 | Direct |
| STAT | 0 | Direct |
| Alpha-adaptin ear subdomain-like | 0 | Direct |
| Pyrin domain, PYD | 0 | Direct |
| Interleukin 17F, IL-17F | 0 | Direct |
| DNA polymerase beta-like, second domain | 0 | Direct |
| BAG domain | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| SH2 domain | 0.000000001381 | Direct |
| V set domains (antibody variable domain-like) | 0.0000005973 | Direct |
| TNF receptor-like | 0.000002446 | Direct |
| Toll/Interleukin receptor TIR domain | 0.000004075 | Direct |
| Interleukin 8-like chemokines | 0.00004039 | Direct |
| C-type lectin domain | 0.00006521 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0005604 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0.001148 | Inherited |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.001978 | Inherited |
| 28-residue LRR | 0.002726 | Inherited |
| ARID domain | 0.003989 | Inherited |
| Integrin beta tail domain | 0.005847 | Inherited |
| Nuclear receptor | 0.007294 | Inherited |
| Integrin domains | 0.008438 | Inherited |
| SH3-domain | 0.01009 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.0109 | Inherited |
| Caspase recruitment domain, CARD | 0.01123 | Inherited |
| TNF-like | 0.01264 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.01279 | Inherited |
| DNA polymerase I | 0.01279 | Inherited |
| DEATH domain, DD | 0.01374 | Inherited |
| Nuclear receptor ligand-binding domain | 0.01447 | Inherited |
| Caspase catalytic domain | 0.01478 | Inherited |
| PLC-like (P variant) | 0.01901 | Inherited |
| Myb/SANT domain | 0.02093 | Inherited |
| Integrin beta EGF-like domains | 0.02155 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.02155 | Inherited |
| Notch domain | 0.02731 | Inherited |
| Tetraspanin | 0.02731 | Inherited |
| DNA polymerase beta, N-terminal domain-like | 0.02731 | Inherited |
| Long-chain cytokines | 0.03347 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.03869 | Inherited |
| Pointed domain | 0.04172 | Inherited |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.04172 | Inherited |
| Interferon regulatory factor | 0.04993 | Inherited |
| C2 set domains | 0.04993 | Inherited |
| ets domain | 0.05147 | Inherited |
| MATH domain | 0.05415 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.05657 | Inherited |
| AraD-like aldolase/epimerase | 0.05785 | Inherited |
| Tissue inhibitor of metalloproteinases, TIMP | 0.05785 | Inherited |
| SWIRM domain | 0.05785 | Inherited |
| Triple coiled coil domain of C-type lectins | 0.05785 | Inherited |
| Cytochrome p450 reductase N-terminal domain-like | 0.05785 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.06415 | Inherited |
| Noncollagenous (NC1) domain of collagen IV | 0.07878 | Inherited |
| WWE domain | 0.07878 | Inherited |
| E2F dimerization segment | 0.07878 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.08702 | Inherited |
| Ran binding protein zinc finger-like | 0.08702 | Inherited |
| Erythroid transcription factor GATA-1 | 0.08789 | Inherited |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.09124 | Inherited |
| I set domains | 0.1227 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.144 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.144 | Inherited |
| Nuclear receptor coactivator interlocking domain | 0.144 | Inherited |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.1495 | Inherited |
| Integrin alpha N-terminal domain | 0.1572 | Inherited |
| Mammalian PLC | 0.2059 | Inherited |
| CCCH zinc finger | 0.2059 | Inherited |
| Eps15 homology domain (EH domain) | 0.2463 | Inherited |
| Complement control module/SCR domain | 0.2488 | Inherited |
| Linker histone H1/H5 | 0.3247 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.3247 | Inherited |
| EGF-type module | 0.3393 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.3474 | Inherited |
| Cyclin | 0.356 | Inherited |
| Integrin A (or I) domain | 0.3572 | Inherited |
| G proteins | 0.3836 | Inherited |
| DBL homology domain (DH-domain) | 0.4319 | Inherited |
| Rhodopsin-like | 0.4486 | Inherited |
| Calponin-homology domain, CH-domain | 0.5268 | Inherited |
| Ankyrin repeat | 0.5401 | Inherited |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.7235 | Inherited |
| FHA domain | 0.7836 | Inherited |
| Homeodomain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
 |
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this MP term (SPMP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| PsbU/PolX domain-like | 0 | DIRECT |
| STAT | 0 | DIRECT |
| MHC antigen-recognition domain | 0 | DIRECT |
| Hairpin loop containing domain-like | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| SH2 domain | 0.0000000004792 | DIRECT |
| DEATH domain | 0.000000001072 | DIRECT |
| Immunoglobulin | 0.00000001032 | DIRECT |
| TNF receptor-like | 0.000001031 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0.000001101 | DIRECT |
| 4-helical cytokines | 0.000001583 | DIRECT |
| Interleukin 8-like chemokines | 0.00002762 | DIRECT |
| C-type lectin-like | 0.00005761 | DIRECT |
| Protein kinase-like (PK-like) | 0.0001089 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.0009535 | DIRECT |
| ARID-like | 0.00329 | INHERITED FROM: abnormal hematopoietic stem cell morphology || abnormal hematopoietic cell morphology |
| p53-like transcription factors | 0.003684 | INHERITED FROM: decreased T cell number || decreased B cell proliferation || abnormal myeloid leukocyte morphology || abnormal granulocyte number || abnormal lymphocyte morphology || abnormal leukocyte physiology || abnormal lymphopoiesis || abnormal leukopoiesis || abnormal thymus medulla morphology || abnormal dendritic cell number || increased hematopoietic cell number || abnormal B cell proliferation || abnormal definitive hematopoiesis || abnormal blood cell physiology || abnormal level of surface class II molecules || abnormal leukocyte morphology || abnormal blood cell morphology || impaired natural killer cell mediated cytotoxicity || abnormal cytotoxic T cell physiology || abnormal granulocyte morphology || abnormal thymus morphology || abnormal blood cell morphology/development || decreased erythroid progenitor cell number || abnormal T cell differentiation || abnormal hematopoietic system physiology || increased IgG2a level || decreased dendritic cell number || abnormal hemopoiesis || abnormal dendritic cell morphology || abnormal T cell morphology || increased leukocyte cell number || abnormal mononuclear cell morphology |
| Integrin beta tail domain | 0.005016 | INHERITED FROM: abnormal hematocrit || abnormal leukocyte migration || abnormal myeloid cell morphology |
| Cysteine-rich domain | 0.005729 | INHERITED FROM: decreased thymocyte number || abnormal leukocyte physiology || abnormal blood cell physiology || abnormal positive T cell selection |
| SH3-domain | 0.006315 | INHERITED FROM: abnormal neutrophil physiology || decreased single-positive T cell number || abnormal B cell proliferation || abnormal CD8-positive, alpha-beta T cell differentiation || arrested B cell differentiation |
| Caspase-like | 0.006546 | INHERITED FROM: abnormal T cell physiology || decreased T cell apoptosis || abnormal leukocyte physiology || abnormal blood cell physiology || abnormal lymphocyte physiology || abnormal spleen marginal zone morphology || abnormal hematopoietic system physiology || abnormal T cell apoptosis || abnormal thymocyte apoptosis || abnormal macrophage apoptosis || abnormal thymus physiology |
| DNA/RNA polymerases | 0.006546 | INHERITED FROM: abnormal somatic hypermutation frequency || abnormal B cell differentiation |
| Integrin domains | 0.006732 | INHERITED FROM: decreased T cell number || abnormal T cell number || abnormal cellular extravasation || decreased platelet aggregation || abnormal blood cell physiology || abnormal hematopoietic cell morphology || abnormal leukocyte migration || abnormal eosinophil cell number || decreased CD4-positive, alpha beta T cell number |
| TNF-like | 0.009902 | INHERITED FROM: abnormal thymus epithelium morphology || abnormal thymus medulla morphology || abnormal blood cell physiology || abnormal IgG2a level || small thymus medulla || abnormal spleen germinal center morphology || abnormal osteoclast morphology |
| Nuclear receptor ligand-binding domain | 0.01116 | INHERITED FROM: persistent cervical thymus || abnormal phagocyte morphology || abnormal macrophage morphology || abnormal macrophage cell number |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.01264 | INHERITED FROM: decreased T cell number || abnormal B lymphocyte antigen presentation || abnormal CD8-positive, alpha-beta T cell number || decreased CD8-positive, alpha-beta T cell number |
| L30e-like | 0.01901 | INHERITED FROM: increased hematopoietic cell number || increased immunoglobulin level || increased IgM level || increased IgG1 level || abnormal IgG1 level || increased IgG level || abnormal leukocyte cell number || abnormal IgM level || increased leukocyte cell number |
| Notch domain | 0.02475 | INHERITED FROM: enlarged spleen || increased hematopoietic cell number || increased spleen red pulp amount || extramedullary hematopoiesis || abnormal spleen red pulp morphology |
| DNA polymerase beta, N-terminal domain-like | 0.02475 | INHERITED FROM: decreased leukocyte cell number || abnormal B cell differentiation || abnormal lymphocyte morphology || abnormal lymphocyte cell number || abnormal lymphopoiesis || abnormal leukopoiesis || abnormal definitive hematopoiesis || decreased lymphocyte cell number || abnormal immunoglobulin V(D)J recombination || abnormal blood cell morphology/development || abnormal B cell morphology || abnormal hemopoiesis |
| Flavoproteins | 0.03756 | INHERITED FROM: abnormal myeloid leukocyte morphology || increased osteoclast cell number || increased hematopoietic cell number || abnormal osteoclast morphology || abnormal osteoclast physiology || increased leukocyte cell number || abnormal osteoclast cell number |
| Inhibitor of apoptosis (IAP) repeat | 0.03756 | INHERITED FROM: abnormal lymphocyte physiology || abnormal B cell apoptosis |
| RNI-like | 0.03775 | INHERITED FROM: abnormal macrophage physiology |
| BRCT domain | 0.04431 | INHERITED FROM: abnormal lymphocyte morphology || abnormal definitive hematopoiesis || abnormal immunoglobulin V(D)J recombination |
| Transducin (alpha subunit), insertion domain | 0.04977 | INHERITED FROM: abnormal platelet activation || abnormal platelet physiology || decreased platelet aggregation || increased T cell proliferation || abnormal platelet aggregation |
| Triple coiled coil domain of C-type lectins | 0.05324 | INHERITED FROM: abnormal monocyte cell number || abnormal monocyte morphology || abnormal phagocyte morphology || abnormal mononuclear phagocyte morphology || abnormal macrophage morphology |
| AraD/HMP-PK domain-like | 0.05324 | INHERITED FROM: spherocytosis || reticulocytosis || decreased mean corpuscular volume || abnormal erythroid lineage cell morphology || abnormal reticulocyte morphology || abnormal mean corpuscular volume || anemia || abnormal hematocrit || increased myeloid cell number || abnormal myeloid cell number || abnormal reticulocyte cell number || decreased hematocrit || abnormal erythrocyte morphology |
| Ran binding protein zinc finger-like | 0.07734 | INHERITED FROM: decreased B-1a cell number || abnormal mature B cell morphology || abnormal B-1 B cell number || abnormal B cell number || decreased B cell number || abnormal B cell morphology || abnormal B-1a B cell morphology |
| A DNA-binding domain in eukaryotic transcription factors | 0.07734 | INHERITED FROM: thrombocytopenia || abnormal megakaryocyte morphology || abnormal erythrocyte physiology |
| Terpenoid cyclases/Protein prenyltransferases | 0.08233 | INHERITED FROM: abnormal neutrophil morphology || abnormal neutrophil cell number |
| NAD kinase/diacylglycerol kinase-like | 0.1317 | INHERITED FROM: increased leukocyte cell number |
| Nuclear receptor coactivator interlocking domain | 0.1345 | INHERITED FROM: enlarged spleen || increased T cell number |
| WWE domain | 0.1389 | INHERITED FROM: abnormal B cell activation || decreased mature B cell number || abnormal marginal zone B cell morphology || abnormal B cell proliferation || abnormal mature B cell number || abnormal spleen marginal zone morphology || decreased marginal zone B cell number || abnormal spleen white pulp morphology |
| E2F-DP heterodimerization region | 0.1389 | INHERITED FROM: decreased double-positive T cell number || abnormal lymphopoiesis || abnormal alpha-beta T cell morphology || abnormal leukopoiesis || abnormal T cell differentiation |
| Integrin alpha N-terminal domain | 0.1693 | INHERITED FROM: decreased T cell number || abnormal cellular extravasation |
| PLC-like phosphodiesterases | 0.1767 | INHERITED FROM: abnormal platelet activation || decreased platelet aggregation || abnormal platelet aggregation |
| CCCH zinc finger | 0.1902 | INHERITED FROM: enlarged spleen || increased mature B cell number || abnormal thymus development |
| (Trans)glycosidases | 0.203 | INHERITED FROM: abnormal phagocyte morphology |
| Complement control module/SCR domain | 0.2239 | INHERITED FROM: abnormal leukocyte tethering or rolling || impaired leukocyte tethering or rolling || abnormal eosinophil physiology || impaired eosinophil recruitment || impaired neutrophil recruitment |
| PH domain-like | 0.258 | INHERITED FROM: abnormal platelet activation || abnormal megakaryocyte morphology || decreased cellular hemoglobin content |
| SET domain | 0.2804 | INHERITED FROM: abnormal B cell differentiation |
| E set domains | 0.2922 | INHERITED FROM: abnormal B cell activation || abnormal thymus medulla morphology || abnormal B cell proliferation |
| TIMP-like | 0.3038 | INHERITED FROM: abnormal neutrophil cell number |
| beta-beta-alpha zinc fingers | 0.3416 | INHERITED FROM: decreased DN2 thymocyte number |
| Nucleic acid-binding proteins | 0.3455 | INHERITED FROM: reticulocytosis |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.3677 | INHERITED FROM: persistent cervical thymus || abnormal osteoclast morphology |
| DBL homology domain (DH-domain) | 0.3956 | INHERITED FROM: decreased B cell proliferation || abnormal T cell proliferation || abnormal transitional stage T2 B cell morphology || abnormal transitional stage B cell morphology || decreased transitional stage B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number || decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology |
| vWA-like | 0.3997 | INHERITED FROM: abnormal leukocyte migration |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.4292 | INHERITED FROM: abnormal platelet activation || abnormal platelet calcium level || abnormal cytotoxic T cell cytolysis || abnormal platelet physiology || abnormal platelet aggregation |
| SMAD/FHA domain | 0.4331 | INHERITED FROM: abnormal plasmacytoid dendritic cell number || abnormal plasmacytoid dendritic cell morphology || decreased plasmacytoid dendritic cell number || abnormal class switch recombination |
| Family A G protein-coupled receptor-like | 0.4377 | INHERITED FROM: decreased IgE level || abnormal leukocyte migration |
| Cyclin-like | 0.4403 | INHERITED FROM: decreased hematopoietic stem cell number || abnormal common myeloid progenitor cell morphology || decreased myeloid cell number || abnormal definitive hematopoiesis || abnormal hematopoietic stem cell morphology || abnormal bone marrow cell morphology/development || decreased erythrocyte cell number || abnormal hemopoiesis |
| EGF/Laminin | 0.4796 | INHERITED FROM: abnormal leukocyte migration || impaired macrophage chemotaxis |
| Riboflavin synthase domain-like | 0.4826 | INHERITED FROM: increased osteoclast cell number || increased macrophage cell number || abnormal osteoclast cell number |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.4826 | INHERITED FROM: increased osteoclast cell number || increased macrophage cell number || abnormal osteoclast cell number |
| Calponin-homology domain, CH-domain | 0.4908 | INHERITED FROM: abnormal transitional stage T2 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number || decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology |
| Ankyrin repeat | 0.5107 | INHERITED FROM: extramedullary hematopoiesis |
| Nucleotidyltransferase | 0.5125 | INHERITED FROM: abnormal immunoglobulin V(D)J recombination |
| BAR/IMD domain-like | 0.6358 | INHERITED FROM: decreased mean corpuscular hemoglobin concentration || increased hematocrit |
| Acyl-CoA N-acyltransferases (Nat) | 0.8032 | INHERITED FROM: decreased double-negative T cell number |
| L domain-like | 0.9569 | INHERITED FROM: decreased macrophage cytokine production |
| Homeodomain-like | 1 | INHERITED FROM: ectopic thymus || athymia || abnormal spleen mesenchyme morphology |
(show details)
Supra-domains annotated to this MP term (SPMP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
57302,57302
57302 - Snake toxin-like
57302 - Snake toxin-like | 0 | DIRECT |
47802,81585
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
81585,81301
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
49562,51045
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
51045 - WW domain | 0 | DIRECT |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0 | DIRECT |
57440,56436
57440 - Kringle-like
56436 - C-type lectin-like | 0 | DIRECT |
50370,57440
50370 - Ricin B-like lectins
57440 - Kringle-like | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
48366,47473
48366 - Ras GEF
47473 - EF-hand | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.00003695 | DIRECT |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.00005747 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.0002674 | DIRECT |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.001031 | INHERITED FROM: abnormal T cell proliferation || absent mast cells || abnormal hematopoietic system physiology |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.002205 | INHERITED FROM: decreased T cell number || abnormal T cell number || decreased leukocyte cell number || abnormal lymphocyte morphology || abnormal lymphocyte cell number || abnormal lymphopoiesis || abnormal alpha-beta T cell morphology || abnormal leukopoiesis || abnormal double-positive T cell morphology || abnormal definitive hematopoiesis || decreased lymphocyte cell number || abnormal blood cell morphology || decreased hematopoietic cell number || abnormal thymus morphology || abnormal leukocyte cell number || abnormal blood cell morphology/development || abnormal T cell differentiation || small thymus || abnormal hemopoiesis || abnormal T cell morphology || abnormal mononuclear cell morphology |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.002205 | INHERITED FROM: abnormal leukocyte physiology || abnormal blood cell physiology |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.005016 | INHERITED FROM: abnormal hematocrit || abnormal leukocyte migration || abnormal myeloid cell morphology |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.005016 | INHERITED FROM: abnormal hematocrit || abnormal leukocyte migration || abnormal myeloid cell morphology |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.006797 | INHERITED FROM: abnormal myeloid leukocyte morphology || abnormal leukocyte morphology || persistent cervical thymus || abnormal phagocyte morphology || abnormal macrophage morphology || abnormal macrophage cell number |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.009377 | INHERITED FROM: decreased B cell proliferation || abnormal T cell proliferation || decreased double-negative T cell number || abnormal IgG2b level || abnormal transitional stage T2 B cell morphology || decreased follicular B cell number || abnormal B cell activation || abnormal NK cell physiology || abnormal IgG2 level || abnormal immature B cell number || abnormal transitional stage B cell morphology || abnormal lymphocyte morphology || decreased mature B cell number || abnormal lymphocyte cell number || abnormal leukocyte physiology || abnormal alpha-beta T cell morphology || decreased single-positive T cell number || abnormal B-1 B cell number || decreased transitional stage B cell number || increased transitional stage B cell number || increased hematopoietic cell number || abnormal double-negative T cell morphology || abnormal B cell proliferation || decreased IgG1 level || increased immature B cell number || abnormal follicular B cell morphology || decreased immunoglobulin level || abnormal mature B cell number || decreased immature B cell number || abnormal IgG1 level || abnormal IgG3 level || abnormal immature B cell morphology || abnormal lymphocyte physiology || abnormal spleen marginal zone morphology || abnormal CD4-positive, alpha beta T cell number || decreased IgG2b level || decreased IgM level || abnormal effector T cell morphology || decreased IgG3 level || abnormal T cell activation || abnormal IgM level || decreased IgG2 level || increased lymphocyte cell number || increased leukocyte cell number || arrested B cell differentiation |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.01124 | INHERITED FROM: abnormal myeloid leukocyte morphology || abnormal immunoglobulin level || abnormal lymphocyte morphology || abnormal lymphocyte cell number || abnormal leukocyte physiology || increased hematopoietic cell number || abnormal definitive hematopoiesis || abnormal blood cell physiology || abnormal leukocyte morphology || abnormal blood cell morphology || abnormal phagocyte morphology || abnormal leukocyte cell number || abnormal lymphocyte physiology || abnormal CD4-positive, alpha beta T cell number || abnormal myeloid cell morphology || abnormal hematopoietic system physiology || abnormal macrophage morphology || increased leukocyte cell number || abnormal mononuclear cell morphology |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.01124 | INHERITED FROM: enlarged spleen || abnormal IgG level || abnormal mature B cell morphology || abnormal monocyte morphology || abnormal lymphocyte morphology || abnormal erythroid lineage cell morphology || abnormal neutrophil morphology || abnormal megakaryocyte morphology || abnormal leukopoiesis || abnormal definitive hematopoiesis || abnormal hematopoietic stem cell morphology || abnormal leukocyte morphology || abnormal blood cell morphology || abnormal B cell number || abnormal blood cell morphology/development || abnormal neutrophil cell number || decreased B cell number || increased neutrophil cell number || abnormal hemopoiesis || abnormal spleen size || increased lymphocyte cell number || abnormal mononuclear cell morphology || abnormal bone marrow hematopoietic cell morphology |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.01124 | INHERITED FROM: abnormal T cell physiology || abnormal leukocyte physiology || abnormal blood cell physiology || decreased macrophage apoptosis || abnormal lymphocyte physiology || abnormal hematopoietic system physiology || abnormal T cell apoptosis || abnormal thymocyte apoptosis || abnormal macrophage apoptosis || abnormal thymus physiology |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.01901 | INHERITED FROM: abnormal macrophage physiology |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.03756 | INHERITED FROM: abnormal platelet activation || abnormal CD8-positive, alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell morphology || abnormal neutrophil morphology || abnormal alpha-beta T cell morphology || abnormal platelet physiology || increased granulocyte number || abnormal CD4-positive, alpha beta T cell number || abnormal alpha-beta T cell number || abnormal platelet aggregation || abnormal neutrophil cell number || abnormal effector T cell morphology || abnormal CD8-positive, alpha beta T cell morphology || increased neutrophil cell number |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.04473 | INHERITED FROM: abnormal platelet activation || abnormal CD8-positive, alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell morphology || abnormal platelet physiology || abnormal CD4-positive, alpha beta T cell number || abnormal platelet aggregation || abnormal CD8-positive, alpha beta T cell morphology || increased neutrophil cell number |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.04473 | INHERITED FROM: abnormal common myeloid progenitor cell morphology || abnormal hematopoietic stem cell morphology |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.05324 | INHERITED FROM: enlarged spleen || increased spleen red pulp amount || extramedullary hematopoiesis || abnormal spleen red pulp morphology || abnormal spleen size |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0.05324 | INHERITED FROM: abnormal macrophage physiology |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.05324 | INHERITED FROM: abnormal monocyte cell number || abnormal monocyte morphology || abnormal phagocyte morphology || abnormal mononuclear phagocyte morphology || abnormal macrophage morphology |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.07213 | INHERITED FROM: abnormal thymus size || small thymus |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.07387 | INHERITED FROM: decreased T cell number || abnormal cellular extravasation |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.07387 | INHERITED FROM: decreased T cell number || abnormal cellular extravasation |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.07994 | INHERITED FROM: abnormal T cell proliferation || increased alpha-beta T cell number || increased CD8-positive, alpha-beta T cell number || abnormal T cell activation || decreased CD4-positive, alpha beta T cell number |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.08004 | INHERITED FROM: abnormal platelet activation || abnormal platelet physiology || decreased platelet aggregation || increased T cell proliferation || abnormal platelet aggregation |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.1185 | INHERITED FROM: thrombocytopenia || abnormal megakaryocyte morphology || abnormal erythrocyte physiology |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.1317 | INHERITED FROM: abnormal platelet activation || decreased platelet aggregation || abnormal platelet aggregation |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0.1317 | INHERITED FROM: abnormal platelet activation || decreased platelet aggregation || abnormal platelet aggregation |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.1345 | INHERITED FROM: abnormal B cell apoptosis |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.1366 | INHERITED FROM: decreased T cell proliferation |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.1389 | INHERITED FROM: decreased double-positive T cell number || abnormal lymphopoiesis || abnormal alpha-beta T cell morphology || abnormal leukopoiesis || abnormal T cell differentiation |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.157 | INHERITED FROM: abnormal leukocyte tethering or rolling || abnormal cellular extravasation || abnormal leukocyte adhesion || impaired leukocyte tethering or rolling || abnormal eosinophil physiology || impaired eosinophil recruitment || impaired neutrophil recruitment |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.1638 | INHERITED FROM: decreased hematopoietic stem cell number || abnormal common myeloid progenitor cell morphology || decreased myeloid cell number || abnormal definitive hematopoiesis || abnormal hematopoietic stem cell morphology || abnormal blood cell morphology/development || decreased erythrocyte cell number || abnormal hemopoiesis |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1638 | INHERITED FROM: decreased hemoglobin content || abnormal hemoglobin |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.2156 | INHERITED FROM: abnormal hemoglobin content || abnormal hemoglobin |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0.2326 | INHERITED FROM: abnormal hemoglobin |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.306 | INHERITED FROM: abnormal hemoglobin content |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.4212 | INHERITED FROM: decreased B cell proliferation || abnormal transitional stage T2 B cell morphology || abnormal transitional stage B cell morphology || decreased transitional stage B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number || decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.4409 | INHERITED FROM: abnormal immature B cell number || abnormal immature B cell morphology |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.4438 | INHERITED FROM: decreased DN2 thymocyte number |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.9875 | INHERITED FROM: decreased erythroid progenitor cell number |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
57302,57302
57302 - Snake toxin-like
57302 - Snake toxin-like | 0 | Direct |
47802,81585
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
81585,81301
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
49562,51045
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
51045 - WW domain | 0 | Direct |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0 | Direct |
57440,56436
57440 - Kringle-like
56436 - C-type lectin-like | 0 | Direct |
50370,57440
50370 - Ricin B-like lectins
57440 - Kringle-like | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
48366,47473
48366 - Ras GEF
47473 - EF-hand | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.00003695 | Direct |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.00005747 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.0002674 | Direct |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.001031 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.002205 | Inherited |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.002205 | Inherited |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.005016 | Inherited |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.005016 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.006797 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.009377 | Inherited |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.01124 | Inherited |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.01124 | Inherited |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.01124 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.01901 | Inherited |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.03756 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.04473 | Inherited |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.04473 | Inherited |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.05324 | Inherited |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0.05324 | Inherited |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.05324 | Inherited |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.07213 | Inherited |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.07387 | Inherited |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.07387 | Inherited |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.07994 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.08004 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.1185 | Inherited |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.1317 | Inherited |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0.1317 | Inherited |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.1345 | Inherited |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.1366 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.1389 | Inherited |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.157 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.1638 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1638 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.2156 | Inherited |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0.2326 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.306 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.4212 | Inherited |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.4409 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.4438 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.9875 | Inherited |
(show details)
Supra-domains annotated to this MP term (SPMP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550
50729 - PH domain-like
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
47802,81585,81301
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
50370,57440,56436
50370 - Ricin B-like lectins
57440 - Kringle-like
56436 - C-type lectin-like | 0 | DIRECT |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
48366,47473,57889
48366 - Ras GEF
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | DIRECT |
57440,56436,56436
57440 - Kringle-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.0002666 | DIRECT |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.005016 | INHERITED FROM: abnormal hematocrit || abnormal leukocyte migration || abnormal myeloid cell morphology |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.03756 | INHERITED FROM: abnormal platelet activation || abnormal CD8-positive, alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell morphology || abnormal neutrophil morphology || abnormal alpha-beta T cell morphology || abnormal platelet physiology || increased granulocyte number || abnormal CD4-positive, alpha beta T cell number || abnormal alpha-beta T cell number || abnormal platelet aggregation || abnormal neutrophil cell number || abnormal effector T cell morphology || abnormal CD8-positive, alpha beta T cell morphology || increased neutrophil cell number |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04967 | INHERITED FROM: enlarged spleen || increased spleen red pulp amount |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.04967 | INHERITED FROM: decreased leukocyte cell number || decreased hematopoietic cell number || increased spleen red pulp amount || abnormal T cell morphology |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.07387 | INHERITED FROM: decreased T cell number || abnormal cellular extravasation |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.07994 | INHERITED FROM: abnormal T cell proliferation || increased alpha-beta T cell number || increased CD8-positive, alpha-beta T cell number || abnormal T cell activation || decreased CD4-positive, alpha beta T cell number |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.1185 | INHERITED FROM: increased IgG level |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.1345 | INHERITED FROM: abnormal B cell apoptosis |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.1638 | INHERITED FROM: abnormal cellular extravasation |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.2189 | INHERITED FROM: abnormal hemoglobin content |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3339 | INHERITED FROM: absent mast cells |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3785 | INHERITED FROM: increased spleen red pulp amount |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550
50729 - PH domain-like
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
47802,81585,81301
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
50370,57440,56436
50370 - Ricin B-like lectins
57440 - Kringle-like
56436 - C-type lectin-like | 0 | Direct |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
48366,47473,57889
48366 - Ras GEF
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | Direct |
57440,56436,56436
57440 - Kringle-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.0002666 | Direct |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.005016 | Inherited |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.03756 | Inherited |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04967 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.04967 | Inherited |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.07387 | Inherited |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.07994 | Inherited |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.1185 | Inherited |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.1345 | Inherited |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.1638 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.2189 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3339 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3785 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
