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Mammalian Phenotype (MP): abnormal skeleton morphology
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| p53 DNA-binding domain-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Homeodomain | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
| BTG domain-like | 0 | DIRECT |
| Alpha-adaptin ear subdomain-like | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| Growth factor receptor domain | 0.00004274 | DIRECT |
| VWC domain | 0.0004812 | DIRECT |
| Paired domain | 0.0004868 | DIRECT |
| Transforming growth factor (TGF)-beta | 0.0009347 | DIRECT |
| DIX domain | 0.001149 | INHERITED FROM: rib fusion || abnormal axial skeleton morphology |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.001531 | INHERITED FROM: osteopetrosis || abnormal epiphyseal plate morphology || abnormal craniofacial bone morphology || abnormal jaw morphology || abnormal viscerocranium morphology || abnormal osteoclast cell number || abnormal long bone epiphyseal plate morphology || abnormal cranium morphology |
| T-box | 0.001759 | INHERITED FROM: abnormal vertebral arch morphology || rib fusion || abnormal intervertebral disk morphology || abnormal presacral vertebrae morphology || abnormal cervical atlas morphology || abnormal occipital bone morphology |
| Notch domain | 0.003937 | INHERITED FROM: abnormal axial skeleton morphology |
| Arylsulfatase | 0.00437 | INHERITED FROM: abnormal epiphyseal plate morphology || abnormal craniofacial bone morphology || abnormal long bone epiphyseal plate morphology || abnormal cranium morphology |
| Hect, E3 ligase catalytic domain | 0.009061 | INHERITED FROM: decreased bone mineral content |
| TB module/8-cys domain | 0.01178 | INHERITED FROM: abnormal jaw morphology || abnormal viscerocranium morphology || abnormal appendicular skeleton morphology || abnormal presacral vertebrae morphology || abnormal incisor morphology |
| beta-glycanases | 0.0128 | INHERITED FROM: abnormal bone structure || abnormal skeleton development |
| Cytochrome p450 reductase N-terminal domain-like | 0.0128 | INHERITED FROM: abnormal bone structure || abnormal bone mineral density || abnormal trabecular bone morphology || abnormal osteoclast cell number || increased bone mineral density || increased osteoclast cell number || abnormal osteoclast morphology || abnormal skeleton development |
| MBT repeat | 0.01355 | INHERITED FROM: abnormal vertebral column morphology || abnormal presacral vertebrae morphology || abnormal vertebrae morphology |
| TNF receptor-like | 0.01553 | INHERITED FROM: abnormal bone structure || abnormal jaw morphology |
| Fibroblast growth factors (FGF) | 0.0178 | INHERITED FROM: abnormal limb long bone morphology |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.02122 | INHERITED FROM: osteopetrosis || abnormal jaw morphology || abnormal viscerocranium morphology || abnormal osteoclast cell number |
| Laminin G-like module | 0.02289 | INHERITED FROM: abnormal spine curvature |
| Bromodomain | 0.02371 | INHERITED FROM: short nasal bone || decreased vertebrae number || small nasal bone |
| Transducin (alpha subunit), insertion domain | 0.03191 | INHERITED FROM: domed cranium || abnormal sternocostal joint morphology || lumbar vertebral fusion || vertebral fusion || abnormal rib morphology |
| Laminin-type module | 0.03325 | INHERITED FROM: abnormal jaw morphology || abnormal cranium morphology |
| NADPH-cytochrome p450 reductase-like | 0.0371 | INHERITED FROM: abnormal bone mineral density || abnormal trabecular bone morphology || abnormal osteoclast cell number || increased bone mineral density || increased osteoclast cell number || abnormal osteoclast morphology || abnormal skeleton development |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.0371 | INHERITED FROM: abnormal bone mineral density || abnormal trabecular bone morphology || abnormal osteoclast cell number || increased bone mineral density || increased osteoclast cell number || abnormal osteoclast morphology || abnormal skeleton development |
| HMG-box | 0.05161 | INHERITED FROM: abnormal sternum morphology || absent cartilage || chondrodystrophy |
| Clc chloride channel | 0.05368 | INHERITED FROM: kyphosis |
| Forkhead DNA-binding domain | 0.05561 | INHERITED FROM: abnormal jaw morphology || abnormal cranium morphology |
| YWTD domain | 0.06295 | INHERITED FROM: abnormal metacarpal bone morphology |
| Classic zinc finger, C2H2 | 0.06867 | INHERITED FROM: small clavicle || clavicle hypoplasia |
| Neutral endopeptidase (neprilysin) | 0.1168 | INHERITED FROM: small mandible || abnormal mandible morphology |
| HLH, helix-loop-helix DNA-binding domain | 0.2114 | INHERITED FROM: rib bifurcation || small clavicle || clavicle hypoplasia |
| Long-chain cytokines | 0.3011 | INHERITED FROM: abnormal osteoclast differentiation |
| Ngr ectodomain-like | 0.3377 | INHERITED FROM: osteophytes || decreased trabecular bone mass || abnormal articular cartilage morphology || abnormal tendon morphology || decreased compact bone mass |
| EF-hand modules in multidomain proteins | 0.4497 | INHERITED FROM: kyphosis |
| SAM (sterile alpha motif) domain | 0.4558 | INHERITED FROM: cervical vertebral fusion || cervical vertebral transformation |
| Nuclear receptor ligand-binding domain | 0.4625 | INHERITED FROM: abnormal basioccipital bone morphology || abnormal incus morphology || abnormal stapes morphology || split cervical axis || fusion of atlas and occipital bones || abnormal squamosal bone morphology || decreased compact bone area || increased trabecular bone volume || abnormal stapedial artery morphology || abnormal cricoid cartilage morphology || osteoporosis || fusion of vertebral arches || cervical vertebral transformation || fusion of atlas and odontoid process || abnormal odontoid process morphology || abnormal laryngeal cartilage morphology || increased bone volume || split cervical atlas |
| Nuclear receptor | 0.4625 | INHERITED FROM: abnormal basioccipital bone morphology || abnormal incus morphology || abnormal stapes morphology || split cervical axis || fusion of atlas and occipital bones || abnormal squamosal bone morphology || decreased compact bone area || abnormal cervical axis morphology || increased trabecular bone volume || abnormal stapedial artery morphology || abnormal cricoid cartilage morphology || osteoporosis || fusion of vertebral arches || cervical vertebral transformation || fusion of atlas and odontoid process || abnormal odontoid process morphology || abnormal laryngeal cartilage morphology || increased bone volume || split cervical atlas |
| TSP-1 type 1 repeat | 0.5743 | INHERITED FROM: increased compact bone thickness |
| EGF-type module | 0.5816 | INHERITED FROM: increased trabecular bone mass || abnormal tendon morphology || ectopic cartilage |
| Spermadhesin, CUB domain | 0.6001 | INHERITED FROM: abnormal tendon morphology || abnormal bone volume || abnormal osteoblast morphology || abnormal osteoblast cell number |
| DEATH domain, DD | 0.6543 | INHERITED FROM: abnormal tooth morphology |
| Nicotinic receptor ligand binding domain-like | 0.6693 | INHERITED FROM: abnormal ligament morphology || abnormal spiral ligament fibrocyte morphology || abnormal spiral ligament morphology || abnormal type IV spiral ligament fibrocytes |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.6693 | INHERITED FROM: abnormal ligament morphology || abnormal spiral ligament fibrocyte morphology || abnormal spiral ligament morphology || abnormal type IV spiral ligament fibrocytes |
| Hemopexin-like domain | 0.6835 | INHERITED FROM: abnormal trabecular bone morphology || abnormal femur morphology || small maxilla |
| MMP N-terminal domain | 0.7134 | INHERITED FROM: abnormal trabecular bone morphology || abnormal femur morphology || abnormal long bone hypertrophic chondrocyte zone || decreased length of long bones || small maxilla |
| Matrix metalloproteases, catalytic domain | 0.7134 | INHERITED FROM: abnormal trabecular bone morphology || abnormal femur morphology || abnormal long bone hypertrophic chondrocyte zone || decreased length of long bones || small maxilla |
| Extracellular domain of cell surface receptors | 0.7452 | INHERITED FROM: abnormal tooth morphology || abnormal vertebral column morphology |
| G proteins | 0.7782 | INHERITED FROM: domed cranium |
| GLA-domain | 0.7784 | INHERITED FROM: abnormal trabecular bone thickness |
| Kringle modules | 0.9709 | INHERITED FROM: abnormal bone volume |
| I set domains | 1 | INHERITED FROM: axial skeleton hypoplasia |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| p53 DNA-binding domain-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Homeodomain | 0 | Direct |
| RUNT domain | 0 | Direct |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
| BTG domain-like | 0 | Direct |
| Alpha-adaptin ear subdomain-like | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| Growth factor receptor domain | 0.00004274 | Direct |
| VWC domain | 0.0004812 | Direct |
| Paired domain | 0.0004868 | Direct |
| Transforming growth factor (TGF)-beta | 0.0009347 | Direct |
| DIX domain | 0.001149 | Inherited |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.001531 | Inherited |
| T-box | 0.001759 | Inherited |
| Notch domain | 0.003937 | Inherited |
| Arylsulfatase | 0.00437 | Inherited |
| Hect, E3 ligase catalytic domain | 0.009061 | Inherited |
| TB module/8-cys domain | 0.01178 | Inherited |
| beta-glycanases | 0.0128 | Inherited |
| Cytochrome p450 reductase N-terminal domain-like | 0.0128 | Inherited |
| MBT repeat | 0.01355 | Inherited |
| TNF receptor-like | 0.01553 | Inherited |
| Fibroblast growth factors (FGF) | 0.0178 | Inherited |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.02122 | Inherited |
| Laminin G-like module | 0.02289 | Inherited |
| Bromodomain | 0.02371 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.03191 | Inherited |
| Laminin-type module | 0.03325 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.0371 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.0371 | Inherited |
| HMG-box | 0.05161 | Inherited |
| Clc chloride channel | 0.05368 | Inherited |
| Forkhead DNA-binding domain | 0.05561 | Inherited |
| YWTD domain | 0.06295 | Inherited |
| Classic zinc finger, C2H2 | 0.06867 | Inherited |
| Neutral endopeptidase (neprilysin) | 0.1168 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.2114 | Inherited |
| Long-chain cytokines | 0.3011 | Inherited |
| Ngr ectodomain-like | 0.3377 | Inherited |
| EF-hand modules in multidomain proteins | 0.4497 | Inherited |
| SAM (sterile alpha motif) domain | 0.4558 | Inherited |
| Nuclear receptor ligand-binding domain | 0.4625 | Inherited |
| Nuclear receptor | 0.4625 | Inherited |
| TSP-1 type 1 repeat | 0.5743 | Inherited |
| EGF-type module | 0.5816 | Inherited |
| Spermadhesin, CUB domain | 0.6001 | Inherited |
| DEATH domain, DD | 0.6543 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.6693 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.6693 | Inherited |
| Hemopexin-like domain | 0.6835 | Inherited |
| MMP N-terminal domain | 0.7134 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.7134 | Inherited |
| Extracellular domain of cell surface receptors | 0.7452 | Inherited |
| G proteins | 0.7782 | Inherited |
| GLA-domain | 0.7784 | Inherited |
| Kringle modules | 0.9709 | Inherited |
| I set domains | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,82895
57184 - Growth factor receptor domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
49265,53300
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.00003642 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.00098 | DIRECT |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.0009828 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.001059 | INHERITED FROM: abnormal phalanx morphology |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.001269 | INHERITED FROM: abnormal epiphyseal plate morphology || osteopetrosis || abnormal craniofacial bone morphology || abnormal viscerocranium morphology || abnormal long bone epiphyseal plate morphology || abnormal jaw morphology || abnormal osteoclast cell number || abnormal cranium morphology |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0.003423 | INHERITED FROM: abnormal long bone morphology || abnormal limb long bone morphology |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0.004036 | INHERITED FROM: abnormal rib morphology || abnormal presacral vertebrae morphology || abnormal craniofacial bone morphology || abnormal cranium morphology || abnormal vertebrae development || abnormal intervertebral disk morphology |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.005621 | INHERITED FROM: abnormal cervical atlas morphology || fusion of atlas and odontoid process || fusion of atlas and occipital bones || abnormal stapes morphology || abnormal odontoid process morphology || thoracic vertebral transformation || increased trabecular bone volume || abnormal incus morphology || abnormal cervical axis morphology || abnormal basioccipital bone morphology || abnormal stapedial artery morphology || abnormal laryngeal cartilage morphology || abnormal squamosal bone morphology || cervical vertebral fusion || fusion of vertebral arches || cricoid and tracheal cartilage fusion || osteoporosis || abnormal cricoid cartilage morphology || split cervical atlas || cervical vertebral transformation || split cervical axis || decreased compact bone area |
53300,49265
53300 - vWA-like
49265 - Fibronectin type III | 0.0114 | INHERITED FROM: abnormal bone structure |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0.0114 | INHERITED FROM: abnormal bone structure || abnormal vertebral column morphology |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0.01192 | INHERITED FROM: abnormal appendicular skeleton morphology || abnormal jaw morphology || abnormal bone structure || abnormal long bone morphology |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.01192 | INHERITED FROM: abnormal appendicular skeleton morphology || abnormal jaw morphology || abnormal bone structure || abnormal long bone morphology |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0.01192 | INHERITED FROM: abnormal limb bone morphology || abnormal metacarpal bone morphology || abnormal craniofacial bone morphology || abnormal jaw morphology || abnormal cranium morphology || abnormal limb long bone morphology |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.02053 | INHERITED FROM: abnormal metacarpal bone morphology |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.02053 | INHERITED FROM: abnormal bone volume || decreased bone volume |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.02551 | INHERITED FROM: abnormal bone structure |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0.03379 | INHERITED FROM: abnormal spine curvature || kyphosis |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.05615 | INHERITED FROM: abnormal spine curvature |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.05615 | INHERITED FROM: vertebral fusion || domed cranium |
48726,56436
48726 - Immunoglobulin
56436 - C-type lectin-like | 0.0666 | INHERITED FROM: abnormal limb bone morphology |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.1011 | INHERITED FROM: abnormal metacarpal bone morphology || abnormal long bone hypertrophic chondrocyte zone |
63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0.1103 | INHERITED FROM: abnormal presacral vertebrae morphology |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1283 | INHERITED FROM: decreased bone volume |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0.2079 | INHERITED FROM: kyphosis |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.2249 | INHERITED FROM: abnormal temporal bone morphology |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.2629 | INHERITED FROM: vertebral transformation || thoracic vertebral transformation || abnormal thoracic vertebrae morphology || abnormal cervical vertebrae morphology |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3447 | INHERITED FROM: abnormal jaw morphology || abnormal cranium morphology |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.6428 | INHERITED FROM: abnormal spiral ligament morphology || abnormal ligament morphology || abnormal type IV spiral ligament fibrocytes || abnormal spiral ligament fibrocyte morphology |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.7245 | INHERITED FROM: abnormal femur morphology || decreased length of long bones || abnormal trabecular bone morphology || small maxilla || abnormal long bone hypertrophic chondrocyte zone |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.7872 | INHERITED FROM: short femur || abnormal long bone hypertrophic chondrocyte zone |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.8548 | INHERITED FROM: abnormal joint morphology |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.958 | INHERITED FROM: abnormal bone marrow cavity morphology |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | INHERITED FROM: axial skeleton hypoplasia |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,82895
57184 - Growth factor receptor domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
49265,53300
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.00003642 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.00098 | Direct |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.0009828 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.001059 | Inherited |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.001269 | Inherited |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0.003423 | Inherited |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0.004036 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.005621 | Inherited |
53300,49265
53300 - vWA-like
49265 - Fibronectin type III | 0.0114 | Inherited |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0.0114 | Inherited |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0.01192 | Inherited |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.01192 | Inherited |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0.01192 | Inherited |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.02053 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.02053 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.02551 | Inherited |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0.03379 | Inherited |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.05615 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.05615 | Inherited |
48726,56436
48726 - Immunoglobulin
56436 - C-type lectin-like | 0.0666 | Inherited |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.1011 | Inherited |
63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0.1103 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1283 | Inherited |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0.2079 | Inherited |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.2249 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.2629 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3447 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.6428 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.7245 | Inherited |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.7872 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.8548 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.958 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | Inherited |
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.0004216 | DIRECT |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0.00098 | DIRECT |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.002445 | INHERITED FROM: abnormal viscerocranium morphology |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.002445 | INHERITED FROM: abnormal lumbar vertebrae morphology |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.003423 | INHERITED FROM: abnormal appendicular skeleton morphology || abnormal viscerocranium morphology || abnormal jaw morphology || abnormal bone structure || abnormal long bone morphology |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.003423 | INHERITED FROM: abnormal appendicular skeleton morphology || abnormal viscerocranium morphology || abnormal jaw morphology || abnormal bone structure || abnormal long bone morphology |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.004036 | INHERITED FROM: abnormal appendicular skeleton morphology |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.01026 | INHERITED FROM: abnormal bone volume || decreased bone volume |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0.0114 | INHERITED FROM: abnormal appendicular skeleton morphology || abnormal limb bone morphology || abnormal bone structure || abnormal long bone morphology || abnormal limb long bone morphology |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0.01192 | INHERITED FROM: abnormal rib morphology || abnormal thoracic cage morphology |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0.01192 | INHERITED FROM: abnormal metacarpal bone morphology || abnormal vertebral column morphology || abnormal limb long bone morphology |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.0259 | INHERITED FROM: abnormal axial skeleton morphology |
57581,57196,57581
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.03379 | INHERITED FROM: abnormal long bone morphology |
47473,47473,57850
47473 - EF-hand
47473 - EF-hand
57850 - RING/U-box | 0.03379 | INHERITED FROM: abnormal spine curvature || kyphosis |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.04862 | INHERITED FROM: micrognathia |
48726,56436,56436
48726 - Immunoglobulin
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.0666 | INHERITED FROM: abnormal limb bone morphology |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.07696 | INHERITED FROM: abnormal metacarpal bone morphology || abnormal long bone hypertrophic chondrocyte zone |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.7694 | INHERITED FROM: polyphalangy |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.7872 | INHERITED FROM: short femur || abnormal long bone hypertrophic chondrocyte zone |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.921 | INHERITED FROM: axial skeleton hypoplasia || abnormal jaw morphology || abnormal cranium morphology || short nasal bone |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.9328 | INHERITED FROM: micrognathia |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.0004216 | Direct |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0.00098 | Direct |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.002445 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.002445 | Inherited |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.003423 | Inherited |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.003423 | Inherited |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.004036 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.01026 | Inherited |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0.0114 | Inherited |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0.01192 | Inherited |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0.01192 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.0259 | Inherited |
57581,57196,57581
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.03379 | Inherited |
47473,47473,57850
47473 - EF-hand
47473 - EF-hand
57850 - RING/U-box | 0.03379 | Inherited |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.04862 | Inherited |
48726,56436,56436
48726 - Immunoglobulin
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.0666 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.07696 | Inherited |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.7694 | Inherited |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.7872 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.921 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.9328 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
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heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
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