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Mammalian Phenotype (MP): abnormal blood homeostasis
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Lamin A/C globular tail domain | 0 | DIRECT |
alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
Multidomain cupredoxins | 0 | DIRECT |
NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
Carboxylesterase | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
GLA-domain | 0 | DIRECT |
NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
Cytidylyltransferase | 0 | DIRECT |
Ammonium transporter | 0 | DIRECT |
gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
Apolipoprotein A-I | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.00001046 | DIRECT |
STAT DNA-binding domain | 0.00317 | INHERITED FROM: abnormal circulating leptin level || abnormal circulating interleukin level || abnormal circulating triglyceride level || abnormal circulating interferon-gamma level || increased circulating leptin level || increased circulating triglyceride level || abnormal circulating cytokine level || increased circulating insulin level || abnormal circulating protein level || abnormal circulating insulin-like growth factor I level |
Transcription factor STAT-4 N-domain | 0.00317 | INHERITED FROM: abnormal circulating leptin level || abnormal circulating interleukin level || abnormal circulating triglyceride level || abnormal circulating interferon-gamma level || increased circulating leptin level || increased circulating triglyceride level || abnormal circulating cytokine level || increased circulating insulin level || abnormal circulating protein level || abnormal circulating insulin-like growth factor I level |
L domain | 0.00317 | INHERITED FROM: increased circulating glucose level || cyanosis || hyperglycemia |
STAT | 0.00317 | INHERITED FROM: abnormal circulating leptin level || abnormal circulating interleukin level || abnormal circulating triglyceride level || abnormal circulating interferon-gamma level || increased circulating leptin level || increased circulating triglyceride level || abnormal circulating cytokine level || increased circulating insulin level || abnormal circulating protein level || abnormal circulating insulin-like growth factor I level |
Insulin-like | 0.005683 | INHERITED FROM: hyperglycemia |
Interleukin-1 (IL-1) | 0.01814 | INHERITED FROM: abnormal circulating interleukin level || abnormal circulating cytokine level || abnormal circulating protein level |
Nuclear receptor coactivator interlocking domain | 0.01814 | INHERITED FROM: abnormal circulating leptin level || increased circulating leptin level |
Serum albumin-like | 0.01814 | INHERITED FROM: abnormal circulating cholesterol level |
Interferon regulatory factor 3 (IRF3), transactivation domain | 0.02636 | INHERITED FROM: abnormal circulating cytokine level |
Interferon regulatory factor | 0.03009 | INHERITED FROM: abnormal circulating cytokine level |
Toll/Interleukin receptor TIR domain | 0.03715 | INHERITED FROM: decreased circulating alanine transaminase level || decreased circulating interleukin-6 level || abnormal circulating protein level |
GAT domain | 0.04184 | INHERITED FROM: decreased circulating glucose level || hypoglycemia || abnormal circulating glucose level |
Kinase associated domain 1, KA1 | 0.04184 | INHERITED FROM: decreased circulating glucose level || abnormal circulating insulin level || decreased circulating insulin level || abnormal circulating glucose level |
Phosphotyrosine-binding domain (PTB) | 0.04696 | INHERITED FROM: abnormal circulating insulin level |
Long-chain cytokines | 0.05193 | INHERITED FROM: abnormal circulating cytokine level |
Noncollagenous (NC1) domain of collagen IV | 0.05448 | INHERITED FROM: increased circulating creatinine level || uremia || abnormal circulating amino acid level || increased blood urea nitrogen level || abnormal blood urea nitrogen level || abnormal circulating creatinine level |
CAD domain | 0.1087 | INHERITED FROM: decreased circulating triglyceride level || abnormal circulating triglyceride level |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0.1155 | INHERITED FROM: decreased circulating noradrenaline level || abnormal circulating noradrenaline level || hyperglycemia |
YWTD domain | 0.1258 | INHERITED FROM: increased circulating cholesterol level || increased circulating triglyceride level || abnormal circulating cholesterol level |
Myeloperoxidase-like | 0.1736 | INHERITED FROM: increased circulating pituitary hormone level |
GABA-aminotransferase-like | 0.1786 | INHERITED FROM: abnormal circulating amino acid level |
Papain-like | 0.1927 | INHERITED FROM: hyperglycemia |
SH2 domain | 0.1974 | INHERITED FROM: increased circulating interleukin-12 level || increased circulating interleukin-17 level || abnormal circulating interferon-gamma level || abnormal circulating cytokine level |
SMAD MH1 domain | 0.2218 | INHERITED FROM: abnormal circulating gonadotropin level |
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0.2218 | INHERITED FROM: abnormal circulating amino acid level || abnormal circulating carnitine level |
Sir2 family of transcriptional regulators | 0.2218 | INHERITED FROM: increased circulating cholesterol level |
SMAD domain | 0.2218 | INHERITED FROM: abnormal circulating gonadotropin level |
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0.2218 | INHERITED FROM: abnormal circulating amino acid level || abnormal circulating carnitine level |
Interferons/interleukin-10 (IL-10) | 0.2475 | INHERITED FROM: abnormal circulating cytokine level |
Kringle modules | 0.2505 | INHERITED FROM: abnormal hemostasis || abnormal blood coagulation |
Growth factor receptor domain | 0.2567 | INHERITED FROM: cyanosis || decreased circulating total protein level |
Pancreatic lipase, N-terminal domain | 0.2756 | INHERITED FROM: increased circulating HDL cholesterol level || abnormal circulating phospholipid level || abnormal circulating LDL cholesterol level || abnormal circulating lipid level || increased circulating triglyceride level |
VHS domain | 0.2833 | INHERITED FROM: hypoglycemia |
Nuclear receptor | 0.3145 | INHERITED FROM: abnormal circulating androgen level || abnormal circulating testosterone level || abnormal circulating hormone level || decreased circulating insulin-like growth factor I level || increased circulating leptin level || abnormal circulating lipid level || abnormal circulating pituitary hormone level || abnormal circulating gonadotropin level || decreased circulating progesterone level || decreased circulating testosterone level |
G proteins | 0.3187 | INHERITED FROM: abnormal platelet aggregation || abnormal platelet activation |
Hormone receptor domain | 0.3242 | INHERITED FROM: abnormal circulating hormone level |
DEATH domain, DD | 0.3242 | INHERITED FROM: abnormal circulating interleukin level || decreased circulating interleukin-6 level || abnormal circulating protein level |
p120GAP domain-like | 0.3273 | INHERITED FROM: abnormal circulating aspartate transaminase level |
Meta-cation ATPase, catalytic domain P | 0.3403 | INHERITED FROM: abnormal circulating mineral level |
Transducin (alpha subunit), insertion domain | 0.3403 | INHERITED FROM: abnormal platelet aggregation || abnormal circulating calcium level || decreased platelet aggregation || abnormal platelet physiology || abnormal blood coagulation || abnormal circulating parathyroid hormone level || abnormal platelet activation || increased circulating parathyroid hormone level |
Pyrin domain, PYD | 0.3434 | INHERITED FROM: abnormal circulating interleukin level || abnormal circulating interleukin-1 beta level || abnormal circulating interleukin-18 level || decreased circulating interleukin-18 level |
Nuclear receptor ligand-binding domain | 0.3858 | INHERITED FROM: abnormal circulating androgen level || abnormal circulating testosterone level || abnormal circulating hormone level || decreased circulating insulin-like growth factor I level || increased circulating leptin level || abnormal circulating lipid level || abnormal circulating pituitary hormone level || abnormal circulating gonadotropin level || abnormal circulating lipoprotein level || decreased circulating progesterone level |
Transforming growth factor (TGF)-beta | 0.3891 | INHERITED FROM: decreased circulating follicle stimulating hormone level || increased circulating follicle stimulating hormone level || abnormal circulating pituitary hormone level || abnormal circulating gonadotropin level |
Pleckstrin-homology domain (PH domain) | 0.4011 | INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation |
FAS1 domain | 0.4255 | INHERITED FROM: abnormal circulating enzyme level |
EGF-type module | 0.4572 | INHERITED FROM: cyanosis || abnormal hemostasis || hyperlipidemia || abnormal blood coagulation |
CCCH zinc finger | 0.4848 | INHERITED FROM: increased circulating tumor necrosis factor level || abnormal circulating tumor necrosis factor level |
Thyroglobulin type-1 domain | 0.4959 | INHERITED FROM: decreased circulating insulin-like growth factor I level || abnormal circulating insulin-like growth factor I level |
Rhodopsin-like | 0.5168 | INHERITED FROM: abnormal circulating glucocorticoid level || abnormal circulating corticosterone level || abnormal circulating hormone level |
HLH, helix-loop-helix DNA-binding domain | 0.5325 | INHERITED FROM: cyanosis || decreased circulating noradrenaline level || abnormal circulating estradiol level |
PLC-like (P variant) | 0.5364 | INHERITED FROM: abnormal platelet aggregation || abnormal platelet physiology || abnormal hemostasis || abnormal blood coagulation || abnormal platelet activation |
Integrin domains | 0.5382 | INHERITED FROM: decreased platelet aggregation |
Aquaporin-like | 0.6044 | INHERITED FROM: increased blood osmolality || abnormal blood osmolality || abnormal circulating glycerol level || increased blood urea nitrogen level |
Mammalian PLC | 0.6203 | INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation || abnormal platelet activation |
Caspase catalytic domain | 0.6203 | INHERITED FROM: abnormal circulating interleukin-18 level |
Homeodomain | 0.65 | INHERITED FROM: cyanosis |
28-residue LRR | 0.6712 | INHERITED FROM: abnormal circulating interleukin level |
Eukaryotic proteases | 0.688 | INHERITED FROM: abnormal hemostasis || abnormal blood coagulation |
Notch domain | 0.7068 | INHERITED FROM: abnormal circulating enzyme level |
Caspase recruitment domain, CARD | 0.7393 | INHERITED FROM: abnormal circulating interferon-gamma level || abnormal circulating interleukin-18 level |
Fibronectin type III | 0.809 | INHERITED FROM: abnormal circulating interferon-gamma level || abnormal circulating cytokine level |
Cytochrome P450 | 0.8092 | INHERITED FROM: decreased circulating mineralocorticoid level || decreased circulating aldosterone level |
Anion transport protein, cytoplasmic domain | 0.8709 | INHERITED FROM: abnormal circulating bicarbonate level || decreased circulating bicarbonate level |
ABC transporter ATPase domain-like | 0.886 | INHERITED FROM: abnormal circulating phytosterol level |
Fatty acid binding protein-like | 0.9126 | INHERITED FROM: decreased circulating cholesterol level |
Forkhead DNA-binding domain | 0.9178 | INHERITED FROM: decreased circulating follicle stimulating hormone level || decreased circulating luteinizing hormone level || hyperglycemia |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Lamin A/C globular tail domain | 0 | Direct |
alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
Multidomain cupredoxins | 0 | Direct |
NADPH-cytochrome p450 reductase-like | 0 | Direct |
Carboxylesterase | 0 | Direct |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
GLA-domain | 0 | Direct |
NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
Cytidylyltransferase | 0 | Direct |
Ammonium transporter | 0 | Direct |
gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
Apolipoprotein A-I | 0 | Direct |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.00001046 | Direct |
STAT DNA-binding domain | 0.00317 | Inherited |
Transcription factor STAT-4 N-domain | 0.00317 | Inherited |
L domain | 0.00317 | Inherited |
STAT | 0.00317 | Inherited |
Insulin-like | 0.005683 | Inherited |
Interleukin-1 (IL-1) | 0.01814 | Inherited |
Nuclear receptor coactivator interlocking domain | 0.01814 | Inherited |
Serum albumin-like | 0.01814 | Inherited |
Interferon regulatory factor 3 (IRF3), transactivation domain | 0.02636 | Inherited |
Interferon regulatory factor | 0.03009 | Inherited |
Toll/Interleukin receptor TIR domain | 0.03715 | Inherited |
GAT domain | 0.04184 | Inherited |
Kinase associated domain 1, KA1 | 0.04184 | Inherited |
Phosphotyrosine-binding domain (PTB) | 0.04696 | Inherited |
Long-chain cytokines | 0.05193 | Inherited |
Noncollagenous (NC1) domain of collagen IV | 0.05448 | Inherited |
CAD domain | 0.1087 | Inherited |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0.1155 | Inherited |
YWTD domain | 0.1258 | Inherited |
Myeloperoxidase-like | 0.1736 | Inherited |
GABA-aminotransferase-like | 0.1786 | Inherited |
Papain-like | 0.1927 | Inherited |
SH2 domain | 0.1974 | Inherited |
SMAD MH1 domain | 0.2218 | Inherited |
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0.2218 | Inherited |
Sir2 family of transcriptional regulators | 0.2218 | Inherited |
SMAD domain | 0.2218 | Inherited |
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0.2218 | Inherited |
Interferons/interleukin-10 (IL-10) | 0.2475 | Inherited |
Kringle modules | 0.2505 | Inherited |
Growth factor receptor domain | 0.2567 | Inherited |
Pancreatic lipase, N-terminal domain | 0.2756 | Inherited |
VHS domain | 0.2833 | Inherited |
Nuclear receptor | 0.3145 | Inherited |
G proteins | 0.3187 | Inherited |
Hormone receptor domain | 0.3242 | Inherited |
DEATH domain, DD | 0.3242 | Inherited |
p120GAP domain-like | 0.3273 | Inherited |
Meta-cation ATPase, catalytic domain P | 0.3403 | Inherited |
Transducin (alpha subunit), insertion domain | 0.3403 | Inherited |
Pyrin domain, PYD | 0.3434 | Inherited |
Nuclear receptor ligand-binding domain | 0.3858 | Inherited |
Transforming growth factor (TGF)-beta | 0.3891 | Inherited |
Pleckstrin-homology domain (PH domain) | 0.4011 | Inherited |
FAS1 domain | 0.4255 | Inherited |
EGF-type module | 0.4572 | Inherited |
CCCH zinc finger | 0.4848 | Inherited |
Thyroglobulin type-1 domain | 0.4959 | Inherited |
Rhodopsin-like | 0.5168 | Inherited |
HLH, helix-loop-helix DNA-binding domain | 0.5325 | Inherited |
PLC-like (P variant) | 0.5364 | Inherited |
Integrin domains | 0.5382 | Inherited |
Aquaporin-like | 0.6044 | Inherited |
Mammalian PLC | 0.6203 | Inherited |
Caspase catalytic domain | 0.6203 | Inherited |
Homeodomain | 0.65 | Inherited |
28-residue LRR | 0.6712 | Inherited |
Eukaryotic proteases | 0.688 | Inherited |
Notch domain | 0.7068 | Inherited |
Caspase recruitment domain, CARD | 0.7393 | Inherited |
Fibronectin type III | 0.809 | Inherited |
Cytochrome P450 | 0.8092 | Inherited |
Anion transport protein, cytoplasmic domain | 0.8709 | Inherited |
ABC transporter ATPase domain-like | 0.886 | Inherited |
Fatty acid binding protein-like | 0.9126 | Inherited |
Forkhead DNA-binding domain | 0.9178 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
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(show details)
Supra-domains annotated to this MP term (SPMP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,50494 57196 - EGF/Laminin 50494 - Trypsin-like serine proteases | 0 | DIRECT |
54534,54534 54534 - FKBP-like 54534 - FKBP-like | 0 | DIRECT |
57196,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module | 0 | DIRECT |
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain | 0 | DIRECT |
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin | 0 | DIRECT |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | DIRECT |
49503,49503 49503 - Cupredoxins 49503 - Cupredoxins | 0 | DIRECT |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0.0003957 | DIRECT |
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT | 0.002594 | INHERITED FROM: abnormal circulating triglyceride level || abnormal circulating cytokine level || abnormal circulating interleukin level || abnormal circulating insulin-like growth factor I level || increased circulating triglyceride level || abnormal circulating interferon-gamma level || abnormal circulating leptin level || increased circulating insulin level || increased circulating leptin level || abnormal circulating protein level |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0.002594 | INHERITED FROM: hyperglycemia || cyanosis || increased circulating glucose level |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0.002594 | INHERITED FROM: hyperglycemia || cyanosis || increased circulating glucose level |
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain | 0.002594 | INHERITED FROM: abnormal circulating triglyceride level || abnormal circulating cytokine level || abnormal circulating interleukin level || abnormal circulating insulin-like growth factor I level || increased circulating triglyceride level || abnormal circulating interferon-gamma level || abnormal circulating leptin level || increased circulating insulin level || increased circulating leptin level || abnormal circulating protein level |
57424,57184 57424 - LDL receptor-like module 57184 - Growth factor receptor domain | 0.002594 | INHERITED FROM: abnormal circulating triglyceride level || increased circulating cholesterol level || increased circulating triglyceride level |
47655,49417 47655 - STAT 49417 - p53-like transcription factors | 0.002594 | INHERITED FROM: abnormal circulating triglyceride level || abnormal circulating cytokine level || abnormal circulating interleukin level || abnormal circulating insulin-like growth factor I level || increased circulating triglyceride level || abnormal circulating interferon-gamma level || abnormal circulating leptin level || increased circulating insulin level || increased circulating leptin level || abnormal circulating protein level |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0.0104 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
48552,48552 48552 - Serum albumin-like 48552 - Serum albumin-like | 0.01571 | INHERITED FROM: abnormal circulating cholesterol level |
57184,63825 57184 - Growth factor receptor domain 63825 - YWTD domain | 0.02283 | INHERITED FROM: abnormal circulating triglyceride level || increased circulating cholesterol level || increased circulating triglyceride level |
63825,57196 63825 - YWTD domain 57196 - EGF/Laminin | 0.02582 | INHERITED FROM: increased circulating cholesterol level || increased circulating triglyceride level || abnormal circulating lipoprotein level || abnormal circulating cholesterol level || abnormal circulating non-HDL cholesterol level |
48464,89009 48464 - ENTH/VHS domain 89009 - GAT-like domain | 0.04835 | INHERITED FROM: decreased circulating glucose level || hypoglycemia |
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0.04835 | INHERITED FROM: decreased circulating insulin level |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.05625 | INHERITED FROM: hyperglycemia || decreased circulating noradrenaline level || abnormal circulating estradiol level || abnormal circulating noradrenaline level || increased circulating leptin level |
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0.08069 | INHERITED FROM: abnormal blood coagulation || decreased circulating alanine transaminase level |
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.0908 | INHERITED FROM: abnormal circulating hormone level || increased circulating leptin level |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1387 | INHERITED FROM: abnormal circulating calcium level || abnormal platelet physiology || abnormal blood coagulation || abnormal platelet aggregation || abnormal circulating parathyroid hormone level || increased circulating parathyroid hormone level || decreased platelet aggregation || abnormal platelet activation |
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases | 0.1582 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
111418,81321 111418 - Hormone receptor domain 81321 - Family A G protein-coupled receptor-like | 0.1668 | INHERITED FROM: abnormal circulating hormone level |
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.1729 | INHERITED FROM: abnormal circulating carnitine level || abnormal circulating amino acid level |
57184,57610 57184 - Growth factor receptor domain 57610 - Thyroglobulin type-1 domain | 0.1768 | INHERITED FROM: abnormal circulating insulin-like growth factor I level || decreased circulating glucose level || increased circulating insulin level || decreased circulating insulin-like growth factor I level |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.1962 | INHERITED FROM: increased circulating ketone body level || abnormal circulating ketone body level |
51445,51011 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain | 0.2158 | INHERITED FROM: abnormal circulating enzyme level |
53474,49723 53474 - alpha/beta-Hydrolases 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.335 | INHERITED FROM: increased circulating triglyceride level || abnormal circulating lipid level || increased circulating HDL cholesterol level || abnormal circulating LDL cholesterol level || abnormal circulating phospholipid level || abnormal circulating cholesterol level |
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0.335 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
47986,52129 47986 - DEATH domain 52129 - Caspase-like | 0.335 | INHERITED FROM: abnormal circulating interleukin level || abnormal circulating interleukin-18 level || abnormal circulating protein level |
56436,56436 56436 - C-type lectin-like 56436 - C-type lectin-like | 0.3463 | INHERITED FROM: increased circulating creatinine level |
51695,49562 51695 - PLC-like phosphodiesterases 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.3801 | INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation || abnormal platelet activation |
50729,47473 50729 - PH domain-like 47473 - EF-hand | 0.3801 | INHERITED FROM: abnormal platelet aggregation || decreased platelet aggregation || abnormal platelet activation |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.4116 | INHERITED FROM: abnormal circulating cytokine level || abnormal circulating interferon-gamma level || increased circulating interleukin-17 level || abnormal circulating protein level |
57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0.4137 | INHERITED FROM: increased circulating triglyceride level || abnormal circulating cholesterol level || decreased circulating VLDL cholesterol level |
47986,52540 47986 - DEATH domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.4175 | INHERITED FROM: abnormal circulating interleukin level |
82153,82153 82153 - FAS1 domain 82153 - FAS1 domain | 0.4175 | INHERITED FROM: abnormal circulating enzyme level |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0.4342 | INHERITED FROM: abnormal circulating testosterone level || abnormal circulating pituitary hormone level || abnormal circulating lipid level || decreased circulating testosterone level || abnormal circulating hormone level || decreased circulating pituitary hormone level || decreased circulating gonadotropin level || increased circulating leptin level || decreased circulating insulin-like growth factor I level |
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0.47 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0.6995 | INHERITED FROM: hyperglycemia || increased circulating insulin level |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,50494 57196 - EGF/Laminin 50494 - Trypsin-like serine proteases | 0 | Direct |
54534,54534 54534 - FKBP-like 54534 - FKBP-like | 0 | Direct |
57196,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module | 0 | Direct |
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain | 0 | Direct |
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin | 0 | Direct |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | Direct |
49503,49503 49503 - Cupredoxins 49503 - Cupredoxins | 0 | Direct |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) | 0 | Direct |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0.0003957 | Direct |
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT | 0.002594 | Inherited |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0.002594 | Inherited |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0.002594 | Inherited |
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain | 0.002594 | Inherited |
57424,57184 57424 - LDL receptor-like module 57184 - Growth factor receptor domain | 0.002594 | Inherited |
47655,49417 47655 - STAT 49417 - p53-like transcription factors | 0.002594 | Inherited |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0.0104 | Inherited |
48552,48552 48552 - Serum albumin-like 48552 - Serum albumin-like | 0.01571 | Inherited |
57184,63825 57184 - Growth factor receptor domain 63825 - YWTD domain | 0.02283 | Inherited |
63825,57196 63825 - YWTD domain 57196 - EGF/Laminin | 0.02582 | Inherited |
48464,89009 48464 - ENTH/VHS domain 89009 - GAT-like domain | 0.04835 | Inherited |
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0.04835 | Inherited |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.05625 | Inherited |
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0.08069 | Inherited |
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.0908 | Inherited |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1387 | Inherited |
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases | 0.1582 | Inherited |
111418,81321 111418 - Hormone receptor domain 81321 - Family A G protein-coupled receptor-like | 0.1668 | Inherited |
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.1729 | Inherited |
57184,57610 57184 - Growth factor receptor domain 57610 - Thyroglobulin type-1 domain | 0.1768 | Inherited |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.1962 | Inherited |
51445,51011 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain | 0.2158 | Inherited |
53474,49723 53474 - alpha/beta-Hydrolases 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.335 | Inherited |
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0.335 | Inherited |
47986,52129 47986 - DEATH domain 52129 - Caspase-like | 0.335 | Inherited |
56436,56436 56436 - C-type lectin-like 56436 - C-type lectin-like | 0.3463 | Inherited |
51695,49562 51695 - PLC-like phosphodiesterases 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.3801 | Inherited |
50729,47473 50729 - PH domain-like 47473 - EF-hand | 0.3801 | Inherited |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.4116 | Inherited |
57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0.4137 | Inherited |
47986,52540 47986 - DEATH domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.4175 | Inherited |
82153,82153 82153 - FAS1 domain 82153 - FAS1 domain | 0.4175 | Inherited |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0.4342 | Inherited |
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0.47 | Inherited |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0.6995 | Inherited |
(show details)
Supra-domains annotated to this MP term (SPMP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
63825,57196,57424 63825 - YWTD domain 57196 - EGF/Laminin 57424 - LDL receptor-like module | 0 | DIRECT |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | DIRECT |
57196,57424,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0 | DIRECT |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
49503,49503,49503 49503 - Cupredoxins 49503 - Cupredoxins 49503 - Cupredoxins | 0 | DIRECT |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0 | DIRECT |
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors | 0.002594 | INHERITED FROM: abnormal circulating triglyceride level || abnormal circulating cytokine level || abnormal circulating interleukin level || abnormal circulating insulin-like growth factor I level || increased circulating triglyceride level || abnormal circulating interferon-gamma level || abnormal circulating leptin level || increased circulating insulin level || increased circulating leptin level || abnormal circulating protein level |
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain | 0.002594 | INHERITED FROM: abnormal circulating triglyceride level || abnormal circulating cytokine level || abnormal circulating interleukin level || abnormal circulating insulin-like growth factor I level || increased circulating triglyceride level || abnormal circulating interferon-gamma level || abnormal circulating leptin level || increased circulating insulin level || increased circulating leptin level || abnormal circulating protein level |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0.002594 | INHERITED FROM: hyperglycemia || cyanosis || increased circulating glucose level |
63825,57196,63825 63825 - YWTD domain 57196 - EGF/Laminin 63825 - YWTD domain | 0.006472 | INHERITED FROM: increased circulating cholesterol level || abnormal circulating non-HDL cholesterol level |
57424,57184,63825 57424 - LDL receptor-like module 57184 - Growth factor receptor domain 63825 - YWTD domain | 0.006472 | INHERITED FROM: abnormal circulating triglyceride level || increased circulating cholesterol level || increased circulating triglyceride level |
57424,57424,57184 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57184 - Growth factor receptor domain | 0.006472 | INHERITED FROM: abnormal circulating triglyceride level || increased circulating cholesterol level || increased circulating triglyceride level |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0.03748 | INHERITED FROM: cyanosis |
57196,63825,57196 57196 - EGF/Laminin 63825 - YWTD domain 57196 - EGF/Laminin | 0.04835 | INHERITED FROM: increased circulating cholesterol level || abnormal circulating non-HDL cholesterol level |
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.05092 | INHERITED FROM: abnormal circulating hormone level || increased circulating leptin level |
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0.08877 | INHERITED FROM: abnormal blood coagulation |
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases | 0.0989 | INHERITED FROM: abnormal blood coagulation || abnormal hemostasis |
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.3316 | INHERITED FROM: abnormal blood coagulation |
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0.4554 | INHERITED FROM: abnormal thrombosis |
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0.47 | INHERITED FROM: increased circulating triglyceride level || abnormal circulating lipoprotein level || abnormal circulating cholesterol level || decreased circulating VLDL cholesterol level |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
63825,57196,57424 63825 - YWTD domain 57196 - EGF/Laminin 57424 - LDL receptor-like module | 0 | Direct |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | Direct |
57196,57424,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0 | Direct |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
49503,49503,49503 49503 - Cupredoxins 49503 - Cupredoxins 49503 - Cupredoxins | 0 | Direct |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0 | Direct |
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors | 0.002594 | Inherited |
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain | 0.002594 | Inherited |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0.002594 | Inherited |
63825,57196,63825 63825 - YWTD domain 57196 - EGF/Laminin 63825 - YWTD domain | 0.006472 | Inherited |
57424,57184,63825 57424 - LDL receptor-like module 57184 - Growth factor receptor domain 63825 - YWTD domain | 0.006472 | Inherited |
57424,57424,57184 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57184 - Growth factor receptor domain | 0.006472 | Inherited |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0.03748 | Inherited |
57196,63825,57196 57196 - EGF/Laminin 63825 - YWTD domain 57196 - EGF/Laminin | 0.04835 | Inherited |
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.05092 | Inherited |
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0.08877 | Inherited |
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases | 0.0989 | Inherited |
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.3316 | Inherited |
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0.4554 | Inherited |
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0.47 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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