Mammalian Phenotype (MP): abnormal immune system cell morphology

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + 3: mammalian phenotype [MP:0000001] <29>

+ + 2: immune system phenotype [MP:0005387] <2> (76|114) (86|66|35)

+ 1: abnormal immune system morphology [MP:0000685] <3> (51|76) (60|35|18)

0: abnormal immune system cell morphology [MP:0000716] <5> (38|63) (48|29|16)

- 1: abnormal leukocyte morphology [MP:0008246] <4> (37|62) (47|29|15)

- 1: abnormal leukopoiesis [MP:0005460] <3> (19|28) (21|18|8)

- 1: abnormal professional antigen presenting cell morphology [MP:0008195] <3> (17|32) (20|11|5)

- 1: abnormal follicular dendritic cell morphology [MP:0008196] <2> (0|0) (0|0|0)

- 1: abnormal large unstained cell number [MP:0012360] <2> (0|0) (0|0|0)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
SPOC domain-like	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
PsbU/PolX domain-like	0	Direct
TNF receptor-like	0.00000001144	Direct
Interleukin 8-like chemokines	0.0000312	Direct
L30e-like	0.002416	Inherited
Immunoglobulin	0.00431	Inherited
DNA polymerase beta, N-terminal domain-like	0.005953	Inherited
Flavoproteins	0.006991	Inherited
Toll/Interleukin receptor TIR domain	0.01282	Inherited
BRCT domain	0.01282	Inherited
Terpenoid cyclases/Protein prenyltransferases	0.01363	Inherited
Triple coiled coil domain of C-type lectins	0.01814	Inherited
Ran binding protein zinc finger-like	0.02149	Inherited
E2F-DP heterodimerization region	0.04044	Inherited
SH2 domain	0.05128	Inherited
SH3-domain	0.06478	Inherited
TIMP-like	0.09745	Inherited
SET domain	0.1208	Inherited
WWE domain	0.1417	Inherited
Integrin domains	0.1809	Inherited
DEATH domain	0.218	Inherited
DBL homology domain (DH-domain)	0.2556	Inherited
Cysteine-rich domain	0.2743	Inherited
SMAD/FHA domain	0.2751	Inherited
Integrin alpha N-terminal domain	0.2965	Inherited
p53-like transcription factors	0.3153	Inherited
Nucleotidyltransferase	0.3358	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.4306	Inherited
Bcl-2 inhibitors of programmed cell death	0.4879	Inherited
Calponin-homology domain, CH-domain	0.5102	Inherited
Riboflavin synthase domain-like	0.6249	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.6249	Inherited
MHC antigen-recognition domain	0.6923	Inherited
Nuclear receptor ligand-binding domain	0.7242	Inherited
DNA/RNA polymerases	0.9512	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Proteasome subunits	0	Direct
STAT DNA-binding domain	0	Direct
RUNT domain	0	Direct
DNA polymerase beta-like	0	Direct
BAFF receptor-like	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
C5 cytosine-specific DNA methylase, DCM	0	Direct
STAT	0	Direct
Interleukin 17F, IL-17F	0	Direct
DNA polymerase beta-like, second domain	0	Direct
TNF receptor-like	0.00000006433	Direct
Interleukin 8-like chemokines	0.00002032	Direct
Interleukin-1 (IL-1)	0.004083	Inherited
DNA polymerase beta, N-terminal domain-like	0.004083	Inherited
Interferons/interleukin-10 (IL-10)	0.004591	Inherited
Pointed domain	0.004901	Inherited
Tissue inhibitor of metalloproteinases, TIMP	0.01316	Inherited
beta-glycanases	0.01316	Inherited
Triple coiled coil domain of C-type lectins	0.01316	Inherited
Cytochrome p450 reductase N-terminal domain-like	0.01316	Inherited
E2F dimerization segment	0.01405	Inherited
Ran binding protein zinc finger-like	0.01638	Inherited
V set domains (antibody variable domain-like)	0.01783	Inherited
Toll/Interleukin receptor TIR domain	0.01892	Inherited
Interferon regulatory factor	0.02405	Inherited
C2 set domains	0.02405	Inherited
Pleckstrin-homology domain (PH domain)	0.02954	Inherited
SH2 domain	0.03797	Inherited
NADPH-cytochrome p450 reductase-like	0.03814	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.03814	Inherited
Nuclear receptor coactivator interlocking domain	0.03814	Inherited
Tetraspanin	0.03814	Inherited
SH3-domain	0.04953	Inherited
Myb/SANT domain	0.06516	Inherited
WWE domain	0.07438	Inherited
Cell cycle transcription factor e2f-dp	0.08651	Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain	0.1194	Inherited
DEATH domain, DD	0.131	Inherited
Integrin domains	0.1501	Inherited
ets domain	0.1723	Inherited
Short-chain cytokines	0.2263	Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases	0.2263	Inherited
DBL homology domain (DH-domain)	0.2358	Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.2591	Inherited
C1 set domains (antibody constant domain-like)	0.2941	Inherited
Rel/Dorsal transcription factors, DNA-binding domain	0.2974	Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0.3611	Inherited
Long-chain cytokines	0.3902	Inherited
Pyrin domain, PYD	0.3902	Inherited
CCCH zinc finger	0.4475	Inherited
Bcl-2 inhibitors of programmed cell death	0.4475	Inherited
FHA domain	0.4539	Inherited
Calponin-homology domain, CH-domain	0.4912	Inherited
Caspase recruitment domain, CARD	0.5125	Inherited
Phoshoinositide 3-kinase (PI3K) helical domain	0.5125	Inherited
PLC-like (P variant)	0.5743	Inherited
MHC antigen-recognition domain	0.6574	Inherited
Nuclear receptor ligand-binding domain	0.6909	Inherited
Nuclear receptor	0.6909	Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.7845	Inherited
MATH domain	0.7986	Inherited
DNA polymerase I	0.8555	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
SPOC domain-like	0	Direct
PsbU/PolX domain-like	0	Direct
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
TNF receptor-like	0.000000004345	Direct
Interleukin 8-like chemokines	0.00001435	Direct
L30e-like	0.001385	Inherited
Immunoglobulin	0.002553	Inherited
DNA polymerase beta, N-terminal domain-like	0.003594	Inherited
Flavoproteins	0.004279	Inherited
BRCT domain	0.008152	Inherited
Toll/Interleukin receptor TIR domain	0.008152	Inherited
Terpenoid cyclases/Protein prenyltransferases	0.008708	Inherited
TNF-like	0.01127	Inherited
Triple coiled coil domain of C-type lectins	0.01183	Inherited
Ran binding protein zinc finger-like	0.01418	Inherited
NAD kinase/diacylglycerol kinase-like	0.01616	Inherited
E2F-DP heterodimerization region	0.02812	Inherited
Nuclear receptor coactivator interlocking domain	0.03505	Inherited
SH2 domain	0.03626	Inherited
C-type lectin-like	0.04022	Inherited
SH3-domain	0.04701	Inherited
TIMP-like	0.07339	Inherited
SET domain	0.09316	Inherited
WWE domain	0.1113	Inherited
Integrin domains	0.146	Inherited
(Trans)glycosidases	0.1676	Inherited
DEATH domain	0.18	Inherited
DBL homology domain (DH-domain)	0.2149	Inherited
Cysteine-rich domain	0.2326	Inherited
SMAD/FHA domain	0.2334	Inherited
Integrin alpha N-terminal domain	0.2534	Inherited
p53-like transcription factors	0.2712	Inherited
Nucleotidyltransferase	0.2908	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.3836	Inherited
beta-beta-alpha zinc fingers	0.434	Inherited
CCCH zinc finger	0.4403	Inherited
Bcl-2 inhibitors of programmed cell death	0.4403	Inherited
Calponin-homology domain, CH-domain	0.4627	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.5265	Inherited
Riboflavin synthase domain-like	0.5802	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.5802	Inherited
MHC antigen-recognition domain	0.651	Inherited
Nuclear receptor ligand-binding domain	0.6846	Inherited
Acyl-CoA N-acyltransferases (Nat)	0.7565	Inherited
Protein kinase-like (PK-like)	0.7764	Inherited
DNA/RNA polymerases	0.9299	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0	Direct
47802,81585 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like	0	Direct
81585,81301 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase	0	Direct
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0	Direct
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0	Direct
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain)	0	Direct
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.00000002451	Direct
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.00000009135	Direct
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.000000288	Direct
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0.001044	Inherited
50729,55550 50729 - PH domain-like 55550 - SH2 domain	0.001044	Inherited
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0.001385	Inherited
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain	0.01183	Inherited
57944,56436 57944 - Triple coiled coil domain of C-type lectins 56436 - C-type lectin-like	0.01183	Inherited
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0.02812	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.02958	Inherited
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain	0.0506	Inherited
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like	0.1601	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.1726	Inherited
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.2912	Inherited
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.2912	Inherited
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.2912	Inherited
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.3836	Inherited
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.4321	Inherited
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0.5053	Inherited
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.6338	Inherited
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.6361	Inherited
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.7929	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50729,50044,55550 50729 - PH domain-like 50044 - SH3-domain 55550 - SH2 domain	0	Direct
47802,81585,81301 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase	0	Direct
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0	Direct
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0	Direct
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0	Direct
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain	0	Direct
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	Direct
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.000003975	Direct
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.002662	Inherited
57586,57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like 57586 - TNF receptor-like	0.003594	Inherited
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0.01183	Inherited
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.0506	Inherited
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.2912	Inherited
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.3871	Inherited
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.5053	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Mammalian Phenotype (MP): abnormal immune system cell morphology

Superfamily

Family

Supra-domain (including individual superfamily)