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Mammalian Phenotype (MP): abnormal cardiovascular system physiology
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (SDMP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Rhodopsin-like | 0.00003629 | DIRECT |
| GLA-domain | 0.0000441 | DIRECT |
| L domain | 0.000125 | DIRECT |
| VWC domain | 0.0001342 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.0003329 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.0005606 | DIRECT |
| Cell cycle transcription factor e2f-dp | 0.001853 | INHERITED FROM: hemorrhage |
| NADPH-cytochrome p450 reductase-like | 0.002044 | INHERITED FROM: decreased systemic arterial blood pressure || abnormal heart rate || abnormal vascular wound healing || abnormal blood circulation || abnormal heart left ventricle pressure || abnormal heart ventricle pressure || pathological neovascularization || decreased heart rate || abnormal vascular endothelial cell physiology || hypertension || increased systemic arterial blood pressure || decreased cardiac muscle contractility || congestive heart failure || increased systemic arterial systolic blood pressure |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.002044 | INHERITED FROM: decreased systemic arterial blood pressure || abnormal heart rate || abnormal vascular wound healing || abnormal blood circulation || abnormal heart left ventricle pressure || abnormal heart ventricle pressure || pathological neovascularization || decreased heart rate || abnormal vascular endothelial cell physiology || hypertension || increased systemic arterial blood pressure || decreased cardiac muscle contractility || congestive heart failure || increased systemic arterial systolic blood pressure |
| Histone deacetylase, HDAC | 0.004261 | INHERITED FROM: hemorrhage |
| Inhibitor of apoptosis (IAP) repeat | 0.007479 | INHERITED FROM: abnormal blood circulation || internal hemorrhage || hemopericardium || decreased cardiac muscle contractility || congestive heart failure || hemorrhage |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.007794 | INHERITED FROM: abnormal heartbeat |
| Phenylalanine metabolism regulatory domain | 0.007794 | INHERITED FROM: abnormal heartbeat |
| Anion transport protein, cytoplasmic domain | 0.01201 | INHERITED FROM: abnormal heart rate |
| alpha-catenin/vinculin | 0.02351 | INHERITED FROM: cardiomyopathy || dilated cardiomyopathy |
| Transducin (alpha subunit), insertion domain | 0.0946 | INHERITED FROM: abnormal vascular smooth muscle physiology || decreased vasoconstriction || decreased systemic arterial blood pressure || abnormal vasoconstriction |
| Toll/Interleukin receptor TIR domain | 0.1055 | INHERITED FROM: gastrointestinal hemorrhage || abnormal vascular wound healing || rectal hemorrhage |
| Adenylyl and guanylyl cyclase catalytic domain | 0.1275 | INHERITED FROM: abnormal vasodilation || increased systemic arterial systolic blood pressure |
| Erythroid transcription factor GATA-1 | 0.1719 | INHERITED FROM: abnormal fetal cardiomyocyte proliferation || abnormal fetal cardiomyocyte physiology || hemorrhage |
| Cytochrome P450 | 0.1896 | INHERITED FROM: abnormal systemic arterial blood pressure || increased systemic arterial blood pressure |
| LIM domain | 0.2197 | INHERITED FROM: decreased cardiac muscle contractility |
| Pointed domain | 0.2311 | INHERITED FROM: abnormal blood vessel physiology || hemorrhage |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.2407 | INHERITED FROM: abnormal heart rate || decreased heart rate |
| Eukaryotic proteases | 0.2975 | INHERITED FROM: choroidal neovascularization || decreased susceptibility to induced choroidal neovascularization |
| SMAD MH1 domain | 0.3029 | INHERITED FROM: hemoperitoneum |
| SMAD domain | 0.3029 | INHERITED FROM: hemoperitoneum |
| YWTD domain | 0.3772 | INHERITED FROM: abnormal blood vessel physiology |
| Kringle modules | 0.3772 | INHERITED FROM: choroidal neovascularization || decreased susceptibility to induced choroidal neovascularization || pathological neovascularization |
| Nuclear receptor ligand-binding domain | 0.4258 | INHERITED FROM: abnormal vasodilation || ovary hemorrhage |
| Nuclear receptor | 0.4258 | INHERITED FROM: abnormal vasodilation || ovary hemorrhage |
| WW domain | 0.431 | INHERITED FROM: intraventricular block || prolonged QRS complex duration || increased cardiomyocyte apoptosis |
| Growth factor receptor domain | 0.4316 | INHERITED FROM: prolonged QT interval || cardiac valve regurgitation || abnormal heart electrocardiography waveform feature |
| Forkhead DNA-binding domain | 0.4545 | INHERITED FROM: corneal vascularization |
| Spectrin repeat | 0.5002 | INHERITED FROM: abnormal QRS complex || intraventricular block || prolonged QRS complex duration || heart block |
| C-type lectin domain | 0.8128 | INHERITED FROM: skin hemorrhage |
| Phosphotyrosine-binding domain (PTB) | 0.8216 | INHERITED FROM: abnormal vasodilation |
| Matrix metalloproteases, catalytic domain | 0.8407 | INHERITED FROM: retinal neovascularization || abnormal induced retinal neovascularization |
| MMP N-terminal domain | 0.8977 | INHERITED FROM: retinal neovascularization || pathological neovascularization || abnormal induced retinal neovascularization |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
| SRF-like | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Rhodopsin-like | 0.00003629 | Direct |
| GLA-domain | 0.0000441 | Direct |
| L domain | 0.000125 | Direct |
| VWC domain | 0.0001342 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.0003329 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.0005606 | Direct |
| Cell cycle transcription factor e2f-dp | 0.001853 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.002044 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.002044 | Inherited |
| Histone deacetylase, HDAC | 0.004261 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.007479 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.007794 | Inherited |
| Phenylalanine metabolism regulatory domain | 0.007794 | Inherited |
| Anion transport protein, cytoplasmic domain | 0.01201 | Inherited |
| alpha-catenin/vinculin | 0.02351 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.0946 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.1055 | Inherited |
| Adenylyl and guanylyl cyclase catalytic domain | 0.1275 | Inherited |
| Erythroid transcription factor GATA-1 | 0.1719 | Inherited |
| Cytochrome P450 | 0.1896 | Inherited |
| LIM domain | 0.2197 | Inherited |
| Pointed domain | 0.2311 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.2407 | Inherited |
| Eukaryotic proteases | 0.2975 | Inherited |
| SMAD MH1 domain | 0.3029 | Inherited |
| SMAD domain | 0.3029 | Inherited |
| YWTD domain | 0.3772 | Inherited |
| Kringle modules | 0.3772 | Inherited |
| Nuclear receptor ligand-binding domain | 0.4258 | Inherited |
| Nuclear receptor | 0.4258 | Inherited |
| WW domain | 0.431 | Inherited |
| Growth factor receptor domain | 0.4316 | Inherited |
| Forkhead DNA-binding domain | 0.4545 | Inherited |
| Spectrin repeat | 0.5002 | Inherited |
| C-type lectin domain | 0.8128 | Inherited |
| Phosphotyrosine-binding domain (PTB) | 0.8216 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.8407 | Inherited |
| MMP N-terminal domain | 0.8977 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
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Supra-domains annotated to this MP term (SPMP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.0000185 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.00008587 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.00008587 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.000386 | DIRECT |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.000444 | DIRECT |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0.001651 | INHERITED FROM: hemorrhage |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.004432 | INHERITED FROM: decreased susceptibility to induced choroidal neovascularization || internal hemorrhage || choroidal neovascularization || pathological neovascularization || hemorrhage |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.006312 | INHERITED FROM: abnormal heartbeat |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.01372 | INHERITED FROM: dilated cardiomyopathy || cardiomyopathy |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.01955 | INHERITED FROM: heart hemorrhage || hemopericardium || congestive heart failure || internal hemorrhage || abnormal cardiac muscle contractility || hemorrhage || decreased cardiac muscle contractility |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0.01955 | INHERITED FROM: cardiomyopathy |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.08153 | INHERITED FROM: decreased vasoconstriction || abnormal vasoconstriction || decreased systemic arterial blood pressure || abnormal systemic arterial blood pressure || abnormal vascular smooth muscle physiology |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0.09942 | INHERITED FROM: abnormal systemic arterial blood pressure || increased systemic arterial blood pressure || hypertension |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1362 | INHERITED FROM: abnormal heart ventricle pressure |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0.1543 | INHERITED FROM: abnormal heart rate || abnormal heart electrocardiography waveform feature |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.2074 | INHERITED FROM: pathological neovascularization |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.2154 | INHERITED FROM: decreased heart rate || abnormal heart rate |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.4013 | INHERITED FROM: cardiomyopathy |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.6616 | INHERITED FROM: intracranial hemorrhage |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.673 | INHERITED FROM: hemorrhage |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.8752 | INHERITED FROM: retinal neovascularization || pathological neovascularization || abnormal induced retinal neovascularization |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.0000185 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.00008587 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.00008587 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.000386 | Direct |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.000444 | Direct |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0.001651 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.004432 | Inherited |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.006312 | Inherited |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.01372 | Inherited |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.01955 | Inherited |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0.01955 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.08153 | Inherited |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0.09942 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1362 | Inherited |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0.1543 | Inherited |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.2074 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.2154 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.4013 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.6616 | Inherited |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.673 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.8752 | Inherited |
(show details)
Supra-domains annotated to this MP term (SPMP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.00008587 | DIRECT |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0.0003793 | DIRECT |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.001571 | INHERITED FROM: decreased susceptibility to induced choroidal neovascularization || choroidal neovascularization || pathological neovascularization |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.001571 | INHERITED FROM: internal hemorrhage || abnormal blood circulation || hemorrhage |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.005884 | INHERITED FROM: dilated cardiomyopathy || cardiomyopathy |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.01955 | INHERITED FROM: heart hemorrhage || hemopericardium || congestive heart failure || internal hemorrhage || abnormal cardiac muscle contractility || hemorrhage || decreased cardiac muscle contractility |
47473,47473,57850
47473 - EF-hand
47473 - EF-hand
57850 - RING/U-box | 0.01955 | INHERITED FROM: cardiomyopathy |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.08153 | INHERITED FROM: abnormal blood circulation |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.09942 | INHERITED FROM: abnormal heart ventricle pressure |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.09977 | INHERITED FROM: decreased cardiac muscle contractility |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.2154 | INHERITED FROM: internal hemorrhage |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.2885 | INHERITED FROM: abnormal blood vessel physiology |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.2885 | INHERITED FROM: abnormal blood vessel physiology |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.4363 | INHERITED FROM: internal hemorrhage |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.00008587 | Direct |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0.0003793 | Direct |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.001571 | Inherited |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.001571 | Inherited |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.005884 | Inherited |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.01955 | Inherited |
47473,47473,57850
47473 - EF-hand
47473 - EF-hand
57850 - RING/U-box | 0.01955 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.08153 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.09942 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.09977 | Inherited |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.2154 | Inherited |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.2885 | Inherited |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.2885 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.4363 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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