Mammalian Phenotype (MP): abnormal blood vessel morphology

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
EGF/Laminin	0.0000146	Direct
Calcium-dependent phosphotriesterase	0.0001678	Direct
Integrin beta tail domain	0.000756	Direct
Notch domain	0.0008755	Direct
FnI-like domain	0.005379	Inherited
YWTD domain	0.0107	Inherited
Cytokine	0.01573	Inherited
Integrin domains	0.02221	Inherited
Growth factor receptor domain	0.02947	Inherited
p53-like transcription factors	0.03407	Inherited
Tetraspanin	0.05046	Inherited
PYP-like sensor domain (PAS domain)	0.06155	Inherited
PGBD-like	0.08535	Inherited
Hemopexin-like domain	0.1172	Inherited
Metalloproteases ("zincins"), catalytic domain	0.1707	Inherited
Homeodomain-like	0.1889	Inherited
TB module/8-cys domain	0.2189	Inherited
Nuclear receptor ligand-binding domain	0.2361	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.2926	Inherited
Interleukin 8-like chemokines	0.2954	Inherited
Kringle-like	0.2954	Inherited
Flavoproteins	0.2976	Inherited
Riboflavin synthase domain-like	0.3449	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.3449	Inherited
Frizzled cysteine-rich domain	0.3619	Inherited
E set domains	0.3676	Inherited
Snake toxin-like	0.3686	Inherited
SH3-domain	0.4816	Inherited
Trypsin-like serine proteases	0.7562	Inherited
Protein kinase-like (PK-like)	0.9538	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Interleukin-1 (IL-1)	0	Direct
Integrin beta EGF-like domains	0.000114	Direct
Integrin beta tail domain	0.0005412	Direct
Pointed domain	0.0005412	Direct
Notch domain	0.0006104	Direct
EGF-type module	0.001066	Inherited
Erythroid transcription factor GATA-1	0.001528	Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain	0.001804	Inherited
YWTD domain	0.008838	Inherited
ets domain	0.01378	Inherited
Integrin domains	0.01783	Inherited
Forkhead DNA-binding domain	0.01886	Inherited
Transforming growth factor (TGF)-beta	0.04725	Inherited
MMP N-terminal domain	0.07178	Inherited
Fibroblast growth factors (FGF)	0.07178	Inherited
Matrix metalloproteases, catalytic domain	0.07178	Inherited
Linker histone H1/H5	0.07842	Inherited
Hemopexin-like domain	0.1009	Inherited
DBL homology domain (DH-domain)	0.1218	Inherited
Homeodomain	0.1253	Inherited
ZZ domain	0.1953	Inherited
TB module/8-cys domain	0.1953	Inherited
Nuclear receptor ligand-binding domain	0.2262	Inherited
Nuclear receptor	0.2262	Inherited
Fibronectin type III	0.2282	Inherited
NADPH-cytochrome p450 reductase-like	0.2715	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.2715	Inherited
Cytochrome p450 reductase N-terminal domain-like	0.2715	Inherited
Interleukin 8-like chemokines	0.2874	Inherited
Growth factor receptor domain	0.3106	Inherited
Kringle modules	0.3222	Inherited
Frizzled cysteine-rich domain	0.343	Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.4106	Inherited
Eukaryotic proteases	0.4183	Inherited
SH3-domain	0.5234	Inherited
LIM domain	0.8368	Inherited
Protein kinases, catalytic subunit	0.8915	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
EGF/Laminin	0.000006487	Direct
Calcium-dependent phosphotriesterase	0.00008416	Direct
Integrin beta tail domain	0.0004063	Direct
Notch domain	0.0004738	Direct
FnI-like domain	0.003231	Inherited
YWTD domain	0.006714	Inherited
Cytokine	0.01013	Inherited
Integrin domains	0.0147	Inherited
Growth factor receptor domain	0.02002	Inherited
p53-like transcription factors	0.02338	Inherited
Tetraspanin	0.03565	Inherited
PYP-like sensor domain (PAS domain)	0.04444	Inherited
PGBD-like	0.06338	Inherited
4-helical cytokines	0.07127	Inherited
Hemopexin-like domain	0.09024	Inherited
DBL homology domain (DH-domain)	0.09636	Inherited
Metalloproteases ("zincins"), catalytic domain	0.1367	Inherited
Homeodomain-like	0.1532	Inherited
Fibronectin type III	0.1668	Inherited
TB module/8-cys domain	0.1807	Inherited
Nuclear receptor ligand-binding domain	0.1968	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.2498	Inherited
Kringle-like	0.2524	Inherited
Interleukin 8-like chemokines	0.2524	Inherited
Flavoproteins	0.2544	Inherited
Riboflavin synthase domain-like	0.2995	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.2995	Inherited
Frizzled cysteine-rich domain	0.3162	Inherited
E set domains	0.3217	Inherited
Snake toxin-like	0.3228	Inherited
Ankyrin repeat	0.4274	Inherited
SH3-domain	0.4339	Inherited
Trypsin-like serine proteases	0.7182	Inherited
PH domain-like	0.8454	Inherited
Protein kinase-like (PK-like)	0.9328	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0	Direct
90193,90193 90193 - Notch domain 90193 - Notch domain	0	Direct
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.000000639	Direct
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.00000118	Direct
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.000002153	Direct
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.0002654	Direct
53300,69179 53300 - vWA-like 69179 - Integrin domains	0.0004063	Direct
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain	0.0004063	Direct
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.0004063	Direct
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.001156	Inherited
57581,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0.001888	Inherited
57196,57581 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.001888	Inherited
63825,57196 63825 - YWTD domain 57196 - EGF/Laminin	0.002577	Inherited
49785,57184 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain	0.002577	Inherited
57184,63825 57184 - Growth factor receptor domain 63825 - YWTD domain	0.0047	Inherited
57424,57184 57424 - LDL receptor-like module 57184 - Growth factor receptor domain	0.0047	Inherited
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain)	0.005207	Inherited
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0.01013	Inherited
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.02137	Inherited
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.055	Inherited
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.06338	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.07711	Inherited
49854,49854 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain	0.128	Inherited
57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.2297	Inherited
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.2524	Inherited
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.2741	Inherited
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.7511	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,90193,90193 57196 - EGF/Laminin 90193 - Notch domain 90193 - Notch domain	0	Direct
57184,57196,57184 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0	Direct
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0.0000108	Direct
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain	0.00008416	Direct
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.00008416	Direct
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0.00008611	Direct
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.0001403	Direct
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.0004063	Direct
57184,57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.0004063	Direct
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0.0004063	Direct
57581,57196,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0.0004738	Direct
57196,57196,57581 57196 - EGF/Laminin 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.0004738	Direct
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0.0004738	Direct
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.0004738	Direct
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.0007164	Direct
57424,57184,63825 57424 - LDL receptor-like module 57184 - Growth factor receptor domain 63825 - YWTD domain	0.001888	Inherited
57424,57424,57184 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57184 - Growth factor receptor domain	0.001888	Inherited
57196,57581,57184 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0.002481	Inherited
57581,57196,57581 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.008207	Inherited
63825,57196,63825 63825 - YWTD domain 57196 - EGF/Laminin 63825 - YWTD domain	0.01758	Inherited
48726,49265,49265 48726 - Immunoglobulin 49265 - Fibronectin type III 49265 - Fibronectin type III	0.1807	Inherited
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.2297	Inherited
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.2544	Inherited
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.6377	Inherited

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Mammalian Phenotype (MP): abnormal blood vessel morphology

Superfamily

Family

Supra-domain (including individual superfamily)