Mammalian Phenotype (MP): abnormal immune system physiology

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: mammalian phenotype [MP:0000001] <29>

+ 1: immune system phenotype [MP:0005387] <2> (76|114) (86|66|35)

0: abnormal immune system physiology [MP:0001790] <16> (59|84) (66|49|28)

- 1: abnormal adaptive immunity [MP:0002420] <8> (36|48) (38|33|21)

- 1: abnormal antigen presentation [MP:0001835] <6> (7|8) (7|4|2)

- 1: abnormal innate immunity [MP:0002419] <5> (17|15) (18|9|5)

- 1: abnormal humoral immune response [MP:0001800] <4> (10|14) (12|10|8)

- 1: abnormal hypersensitivity reaction [MP:0002148] <4> (1|2) (1|1|0)

- 1: abnormal immune organ physiology [MP:0003762] <4> (3|5) (3|1|0)

- 1: abnormal immune serum protein physiology [MP:0002723] <4> (25|40) (32|24|12)

- 1: abnormal inflammatory response [MP:0001845] <4> (27|38) (29|18|5)

- 1: abnormal response to transplant [MP:0005671] <4> (2|2) (2|0|0)

- 1: abnormal cell-mediated immunity [MP:0002421] <3> (35|48) (37|33|21)

- 1: abnormal immune cell physiology [MP:0001819] <3> (35|48) (37|33|21)

- 1: abnormal immune tolerance [MP:0005000] <3> (11|19) (13|8|1)

- 1: abnormal lymphatic system physiology [MP:0010368] <2> (0|0) (0|0|0)

- 1: abnormal response to antigen [MP:0020000] <2> (0|0) (0|0|0)

- 1: abnormal response to infection [MP:0005025] <2> (18|31) (21|17|5)

- 1: abnormal immunoglobulin transcytosis [MP:0010223] (0|0) (0|0|0)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Anaphylotoxins (complement system)	0	Direct
Resistin	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
N-acetylmuramoyl-L-alanine amidase-like	0	Direct
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
p53 tetramerization domain	0	Direct
Toll/Interleukin receptor TIR domain	0.000000000003094	Direct
Immunoglobulin	0.00001561	Direct
DEATH domain	0.00009773	Direct
Caspase-like	0.000113	Direct
C-type lectin-like	0.0001147	Direct
TNF-like	0.000279	Direct
Alpha-macroglobulin receptor domain	0.001475	Inherited
Inhibitor of apoptosis (IAP) repeat	0.001475	Inherited
p53-like transcription factors	0.002552	Inherited
SH3-domain	0.003964	Inherited
SH2 domain	0.00916	Inherited
Family A G protein-coupled receptor-like	0.0102	Inherited
4-helical cytokines	0.01027	Inherited
TNF receptor-like	0.01894	Inherited
Fibronectin type III	0.02113	Inherited
Kringle-like	0.02842	Inherited
Triple coiled coil domain of C-type lectins	0.03014	Inherited
Transducin (alpha subunit), insertion domain	0.03516	Inherited
Hemopexin-like domain	0.0616	Inherited
PGBD-like	0.0616	Inherited
SMAD/FHA domain	0.06362	Inherited
WWE domain	0.06983	Inherited
Trypsin-like serine proteases	0.09217	Inherited
E set domains	0.09345	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.1197	Inherited
Riboflavin synthase domain-like	0.135	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.135	Inherited
vWA-like	0.1455	Inherited
L domain-like	0.147	Inherited
Interleukin 8-like chemokines	0.1479	Inherited
Integrin alpha N-terminal domain	0.1712	Inherited
Cysteine-rich domain	0.1834	Inherited
Bcl-2 inhibitors of programmed cell death	0.1855	Inherited
DBL homology domain (DH-domain)	0.1876	Inherited
Integrin domains	0.2018	Inherited
MHC antigen-recognition domain	0.2018	Inherited
Integrin beta tail domain	0.2297	Inherited
Complement control module/SCR domain	0.3701	Inherited
RNI-like	0.4165	Inherited
EGF/Laminin	0.4224	Inherited
Terpenoid cyclases/Protein prenyltransferases	0.4633	Inherited
dsRNA-binding domain-like	0.4633	Inherited
Nuclear receptor ligand-binding domain	0.493	Inherited
Growth factor receptor domain	0.6176	Inherited
DNA/RNA polymerases	0.6631	Inherited
Flavoproteins	0.7079	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.733	Inherited
Cystine-knot cytokines	0.7401	Inherited
CCCH zinc finger	0.8691	Inherited
L30e-like	0.8691	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.9358	Inherited
Nicotinic receptor ligand binding domain-like	0.9358	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Anaphylotoxins (complement system)	0	Direct
Cysteine rich domain	0	Direct
p53 DNA-binding domain-like	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Proteasome subunits	0	Direct
STAT DNA-binding domain	0	Direct
Interleukin-1 (IL-1)	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
STAT	0	Direct
p53 tetramerization domain	0	Direct
Interleukin 17F, IL-17F	0	Direct
N-acetylmuramoyl-L-alanine amidase-like	0	Direct
Resistin	0	Direct
Toll/Interleukin receptor TIR domain	0.00000000001054	Direct
TNF receptor-like	0.00000002492	Direct
Rel/Dorsal transcription factors, DNA-binding domain	0.00003699	Direct
Interferon regulatory factor	0.0001156	Direct
Caspase recruitment domain, CARD	0.0001403	Direct
Caspase catalytic domain	0.0002311	Direct
TNF-like	0.0002428	Direct
DEATH domain, DD	0.0004761	Direct
C-type lectin domain	0.0005266	Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.0008924	Direct
Interferon regulatory factor 3 (IRF3), transactivation domain	0.001049	Inherited
Complement components	0.001049	Inherited
Alpha-macroglobulin receptor domain	0.001049	Inherited
Interferons/interleukin-10 (IL-10)	0.001734	Inherited
Inhibitor of apoptosis (IAP) repeat	0.003065	Inherited
SH3-domain	0.00375	Inherited
Rhodopsin-like	0.008347	Inherited
SH2 domain	0.008586	Inherited
PLC-like (P variant)	0.009302	Inherited
C2 set domains	0.01199	Inherited
Triple coiled coil domain of C-type lectins	0.02349	Inherited
Cytochrome p450 reductase N-terminal domain-like	0.02349	Inherited
Fibronectin type III	0.02492	Inherited
V set domains (antibody variable domain-like)	0.02698	Inherited
WWE domain	0.02774	Inherited
Transducin (alpha subunit), insertion domain	0.02964	Inherited
I set domains	0.04549	Inherited
Short-chain cytokines	0.05116	Inherited
MMP N-terminal domain	0.05116	Inherited
Hemopexin-like domain	0.05116	Inherited
Matrix metalloproteases, catalytic domain	0.05116	Inherited
Pleckstrin-homology domain (PH domain)	0.05159	Inherited
EF-hand modules in multidomain proteins	0.06427	Inherited
NADPH-cytochrome p450 reductase-like	0.06482	Inherited
Netrin-like domain (NTR/C345C module)	0.06482	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.06482	Inherited
Fibronectin type II module	0.08185	Inherited
Integrin A (or I) domain	0.0867	Inherited
Papain-like	0.09751	Inherited
Eukaryotic proteases	0.09763	Inherited
28-residue LRR	0.1038	Inherited
Noncollagenous (NC1) domain of collagen IV	0.1206	Inherited
Kringle modules	0.1327	Inherited
Interleukin 8-like chemokines	0.1339	Inherited
C1 set domains (antibody constant domain-like)	0.158	Inherited
VWC domain	0.1642	Inherited
Bcl-2 inhibitors of programmed cell death	0.1642	Inherited
Long-chain cytokines	0.1642	Inherited
DBL homology domain (DH-domain)	0.1852	Inherited
MHC antigen-recognition domain	0.1856	Inherited
Integrin domains	0.1856	Inherited
Integrin beta tail domain	0.2063	Inherited
Integrin beta EGF-like domains	0.2063	Inherited
Pyrin domain, PYD	0.2063	Inherited
Integrin alpha N-terminal domain	0.2214	Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.2644	Inherited
Ngr ectodomain-like	0.2928	Inherited
Complement control module/SCR domain	0.3548	Inherited
Double-stranded RNA-binding domain (dsRBD)	0.39	Inherited
Notch domain	0.4082	Inherited
Cell cycle control phosphatase, catalytic domain	0.476	Inherited
Nuclear receptor ligand-binding domain	0.4853	Inherited
Nuclear receptor	0.4853	Inherited
EGF-type module	0.5976	Inherited
FHA domain	0.6354	Inherited
RING finger domain, C3HC4	0.8331	Inherited
CCCH zinc finger	0.8567	Inherited
Transforming growth factor (TGF)-beta	0.8618	Inherited
ets domain	0.8951	Inherited
Nicotinic receptor ligand binding domain-like	0.9351	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.9351	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
STAT	0	Direct
Resistin	0	Direct
p53 tetramerization domain	0	Direct
Anaphylotoxins (complement system)	0	Direct
N-acetylmuramoyl-L-alanine amidase-like	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
Toll/Interleukin receptor TIR domain	0.000000000001117	Direct
Immunoglobulin	0.000006937	Direct
DEATH domain	0.0000472	Direct
Caspase-like	0.00005516	Direct
C-type lectin-like	0.00005609	Direct
TNF-like	0.0001431	Direct
Alpha-macroglobulin receptor domain	0.0008261	Direct
Inhibitor of apoptosis (IAP) repeat	0.0008261	Direct
p53-like transcription factors	0.001468	Inherited
SH3-domain	0.002337	Inherited
SH2 domain	0.00568	Inherited
Family A G protein-coupled receptor-like	0.00638	Inherited
4-helical cytokines	0.006429	Inherited
TNF receptor-like	0.01236	Inherited
Fibronectin type III	0.01392	Inherited
Kringle-like	0.01922	Inherited
Triple coiled coil domain of C-type lectins	0.0205	Inherited
Transducin (alpha subunit), insertion domain	0.02419	Inherited
PGBD-like	0.04449	Inherited
Hemopexin-like domain	0.04449	Inherited
SMAD/FHA domain	0.04611	Inherited
WWE domain	0.05105	Inherited
Protein kinase-like (PK-like)	0.05323	Inherited
Trypsin-like serine proteases	0.06904	Inherited
E set domains	0.07002	Inherited
PH domain-like	0.08761	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.09225	Inherited
Riboflavin synthase domain-like	0.1056	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.1056	Inherited
vWA-like	0.1148	Inherited
L domain-like	0.116	Inherited
Interleukin 8-like chemokines	0.1167	Inherited
Integrin alpha N-terminal domain	0.1373	Inherited
Cysteine-rich domain	0.1484	Inherited
Bcl-2 inhibitors of programmed cell death	0.1502	Inherited
DBL homology domain (DH-domain)	0.152	Inherited
Integrin domains	0.1649	Inherited
MHC antigen-recognition domain	0.1649	Inherited
Integrin beta tail domain	0.1907	Inherited
Complement control module/SCR domain	0.3242	Inherited
RNI-like	0.3694	Inherited
EGF/Laminin	0.3756	Inherited
Notch domain	0.3889	Inherited
Rhodanese/Cell cycle control phosphatase	0.3974	Inherited
dsRNA-binding domain-like	0.4156	Inherited
Terpenoid cyclases/Protein prenyltransferases	0.4156	Inherited
Nuclear receptor ligand-binding domain	0.4453	Inherited
Growth factor receptor domain	0.5725	Inherited
DNA/RNA polymerases	0.6205	Inherited
Flavoproteins	0.6676	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.6941	Inherited
Cystine-knot cytokines	0.7016	Inherited
RING/U-box	0.8314	Inherited
"Winged helix" DNA-binding domain	0.8314	Inherited
CCCH zinc finger	0.8395	Inherited
L30e-like	0.8395	Inherited
Cytokine	0.879	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.9126	Inherited
Nicotinic receptor ligand binding domain-like	0.9126	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0	Direct
52047,52058 52047 - RNI-like 52058 - L domain-like	0	Direct
90188,53649 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like	0	Direct
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0	Direct
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain	0	Direct
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain	0	Direct
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
57440,56436 57440 - Kringle-like 56436 - C-type lectin-like	0	Direct
50370,57440 50370 - Ricin B-like lectins 57440 - Kringle-like	0	Direct
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0	Direct
49410,50242 49410 - Alpha-macroglobulin receptor domain 50242 - TIMP-like	0	Direct
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0	Direct
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0	Direct
48366,47473 48366 - Ras GEF 47473 - EF-hand	0	Direct
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain)	0	Direct
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.0000254	Direct
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.001137	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.002455	Inherited
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0.002475	Inherited
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.003648	Inherited
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.003648	Inherited
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0.007257	Inherited
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0.00974	Inherited
57603,82895 57603 - FnI-like domain 82895 - TSP-1 type 1 repeat	0.0205	Inherited
57944,56436 57944 - Triple coiled coil domain of C-type lectins 56436 - C-type lectin-like	0.0205	Inherited
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain	0.02286	Inherited
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.04449	Inherited
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.04611	Inherited
52058,52058 52058 - L domain-like 52058 - L domain-like	0.04726	Inherited
55550,158235 55550 - SH2 domain 158235 - SOCS box-like	0.05105	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.08124	Inherited
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.09286	Inherited
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.1167	Inherited
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.1502	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.1788	Inherited
47986,52540 47986 - DEATH domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.1907	Inherited
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.1907	Inherited
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.202	Inherited
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.202	Inherited
53300,69179 53300 - vWA-like 69179 - Integrin domains	0.2414	Inherited
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.269	Inherited
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like	0.3061	Inherited
52821,52799 52821 - Rhodanese/Cell cycle control phosphatase 52799 - (Phosphotyrosine protein) phosphatases II	0.3065	Inherited
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.3638	Inherited
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0.3889	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.3943	Inherited
50729,55550 50729 - PH domain-like 55550 - SH2 domain	0.6676	Inherited
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.7121	Inherited
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.9126	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50729,50044,55550 50729 - PH domain-like 50044 - SH3-domain 55550 - SH2 domain	0	Direct
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like	0	Direct
56436,56436,56436 56436 - C-type lectin-like 56436 - C-type lectin-like 56436 - C-type lectin-like	0	Direct
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0	Direct
50370,57440,56436 50370 - Ricin B-like lectins 57440 - Kringle-like 56436 - C-type lectin-like	0	Direct
57586,57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like 57586 - TNF receptor-like	0	Direct
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
90188,90188,53649 90188 - Somatomedin B domain 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like	0	Direct
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	Direct
48366,47473,57889 48366 - Ras GEF 47473 - EF-hand 57889 - Cysteine-rich domain	0	Direct
57440,56436,56436 57440 - Kringle-like 56436 - C-type lectin-like 56436 - C-type lectin-like	0	Direct
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain	0	Direct
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	Direct
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0.007257	Inherited
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0.007257	Inherited
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.007257	Inherited
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.02286	Inherited
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.09286	Inherited
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains	0.09286	Inherited
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.1373	Inherited
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.1907	Inherited
49265,49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III 49265 - Fibronectin type III	0.1907	Inherited
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.202	Inherited
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.3491	Inherited
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0.3889	Inherited
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.3889	Inherited
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0.4909	Inherited
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.6941	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Mammalian Phenotype (MP): abnormal immune system physiology

Superfamily

Family

Supra-domain (including individual superfamily)