Mammalian Phenotype (MP): increased inflammatory response

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + 4: mammalian phenotype [MP:0000001] <29>

+ + + 3: immune system phenotype [MP:0005387] <2> (76|114) (86|66|35)

+ + 2: abnormal immune system physiology [MP:0001790] <16> (59|84) (66|49|28)

+ 1: abnormal inflammatory response [MP:0001845] <4> (27|38) (29|18|5)

0: increased inflammatory response [MP:0001846] <35> (23|35) (25|17|4)

- 1: eye inflammation [MP:0001851] <12> (0|0) (0|0|0)

- 1: reproductive system inflammation [MP:0002254] <8> (0|0) (0|0|0)

- 1: increased acute inflammation [MP:0005088] <5> (0|0) (0|0|0)

- 1: pancreas inflammation [MP:0001869] <5> (0|2) (0|0|0)

- 1: joint inflammation [MP:0002933] <4> (6|6) (6|5|0)

- 1: renal/urinary system inflammation [MP:0011762] <4> (3|5) (4|3|0)

- 1: respiratory system inflammation [MP:0002405] <4> (2|5) (3|1|0)

- 1: heart inflammation [MP:0001853] <3> (0|0) (0|0|0)

- 1: salivary gland inflammation [MP:0001870] <3> (0|1) (0|0|0)

- 1: skin inflammation [MP:0004947] <3> (0|2) (1|0|0)

- 1: intestinal inflammation [MP:0001858] <2> (8|9) (8|3|2)

- 1: CNS inflammation [MP:0006082] <1> (0|1) (1|0|0)

- 1: ear inflammation [MP:0001849] <1> (0|0) (0|0|0)

- 1: vascular inflammation [MP:0001863] <1> (0|0) (0|0|0)

- 1: adipose tissue inflammation [MP:0020386] (0|0) (0|0|0)

- 1: bile duct inflammation [MP:0003254] (0|0) (0|0|0)

- 1: diaphragmitis [MP:0013467] (0|0) (0|0|0)

- 1: esophageal inflammation [MP:0003278] (0|0) (0|0|0)

- 1: folliculitis [MP:0000376] (0|0) (0|0|0)

- 1: gallbladder inflammation [MP:0003251] (0|0) (0|0|0)

- 1: lacrimal gland inflammation [MP:0008880] (0|0) (0|0|0)

- 1: lip inflammation [MP:0003777] (0|0) (0|0|0)

- 1: liver inflammation [MP:0001860] (0|0) (0|0|0)

- 1: lymph node inflammation [MP:0003865] (0|0) (0|0|0)

- 1: mastitis [MP:0013148] (0|0) (0|0|0)

- 1: myositis [MP:0004510] (0|0) (0|0|0)

- 1: osteomyelitis [MP:0005190] (0|0) (0|0|0)

- 1: palate inflammation [MP:0003767] (0|0) (0|0|0)

- 1: panniculitis [MP:0011164] (0|0) (0|0|0)

- 1: peritoneal inflammation [MP:0003303] (0|0) (0|0|0)

- 1: perivasculitis [MP:0012565] (0|0) (0|0|0)

- 1: prostate gland inflammation [MP:0003608] (0|0) (0|0|0)

- 1: stomach inflammation [MP:0001873] (0|0) (0|0|0)

- 1: stomatitis [MP:0003746] (0|0) (0|0|0)

- 1: thyroid inflammation [MP:0003504] (0|0) (0|0|0)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Anaphylotoxins (complement system)	0	Direct
Resistin	0	Direct
N-acetylmuramoyl-L-alanine amidase-like	0	Direct
p53 tetramerization domain	0	Direct
Alpha-macroglobulin receptor domain	0.00001848	Direct
Integrin beta tail domain	0.00001848	Direct
Terpenoid cyclases/Protein prenyltransferases	0.0007818	Direct
RNI-like	0.006662	Inherited
Kringle-like	0.007772	Inherited
Growth factor receptor domain	0.02804	Inherited
L30e-like	0.05404	Inherited
Nuclear receptor ligand-binding domain	0.1831	Inherited
Toll/Interleukin receptor TIR domain	0.2741	Inherited
p53-like transcription factors	0.2994	Inherited
4-helical cytokines	0.3779	Inherited
TNF-like	0.5818	Inherited
Riboflavin synthase domain-like	0.6185	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.6185	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.6264	Inherited
Nicotinic receptor ligand binding domain-like	0.6264	Inherited
DEATH domain	0.7692	Inherited
Hemopexin-like domain	0.9095	Inherited
PGBD-like	0.9095	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Anaphylotoxins (complement system)	0	Direct
p53 DNA-binding domain-like	0	Direct
Interleukin-1 (IL-1)	0	Direct
p53 tetramerization domain	0	Direct
N-acetylmuramoyl-L-alanine amidase-like	0	Direct
Resistin	0	Direct
Rel/Dorsal transcription factors, DNA-binding domain	0.00000004619	Direct
Integrin beta tail domain	0.0000136	Direct
Complement components	0.0000136	Direct
Alpha-macroglobulin receptor domain	0.0000136	Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.00001793	Direct
Integrin beta EGF-like domains	0.00007667	Direct
Interleukin 17F, IL-17F	0.0004645	Direct
VWC domain	0.0006683	Direct
PLC-like (P variant)	0.002438	Inherited
Interferons/interleukin-10 (IL-10)	0.002478	Inherited
28-residue LRR	0.0135	Inherited
Noncollagenous (NC1) domain of collagen IV	0.01735	Inherited
Papain-like	0.06295	Inherited
Nuclear receptor ligand-binding domain	0.1525	Inherited
Nuclear receptor	0.1525	Inherited
V set domains (antibody variable domain-like)	0.1709	Inherited
RING finger domain, C3HC4	0.1978	Inherited
Ngr ectodomain-like	0.2136	Inherited
Toll/Interleukin receptor TIR domain	0.2666	Inherited
TNF receptor-like	0.4165	Inherited
Pyrin domain, PYD	0.5193	Inherited
TNF-like	0.5429	Inherited
Caspase recruitment domain, CARD	0.5798	Inherited
Nicotinic receptor ligand binding domain-like	0.6362	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.6362	Inherited
Short-chain cytokines	0.716	Inherited
MMP N-terminal domain	0.89	Inherited
Hemopexin-like domain	0.89	Inherited
Matrix metalloproteases, catalytic domain	0.89	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Resistin	0	Direct
p53 tetramerization domain	0	Direct
Anaphylotoxins (complement system)	0	Direct
N-acetylmuramoyl-L-alanine amidase-like	0	Direct
Alpha-macroglobulin receptor domain	0.000008236	Direct
Integrin beta tail domain	0.000008236	Direct
Terpenoid cyclases/Protein prenyltransferases	0.0004214	Direct
RNI-like	0.004064	Inherited
Kringle-like	0.004772	Inherited
Growth factor receptor domain	0.01895	Inherited
L30e-like	0.03844	Inherited
Nuclear receptor ligand-binding domain	0.1481	Inherited
Cytokine	0.2057	Inherited
Toll/Interleukin receptor TIR domain	0.2324	Inherited
p53-like transcription factors	0.2562	Inherited
4-helical cytokines	0.3318	Inherited
TNF receptor-like	0.3646	Inherited
TNF-like	0.5355	Inherited
Riboflavin synthase domain-like	0.5734	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.5734	Inherited
Neurotransmitter-gated ion-channel transmembrane pore	0.5818	Inherited
Nicotinic receptor ligand binding domain-like	0.5818	Inherited
DEATH domain	0.7319	Inherited
PGBD-like	0.8834	Inherited
Hemopexin-like domain	0.8834	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
52047,52058 52047 - RNI-like 52058 - L domain-like	0	Direct
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain	0	Direct
49410,50242 49410 - Alpha-macroglobulin receptor domain 50242 - TIMP-like	0	Direct
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0	Direct
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.00000002123	Direct
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.000008236	Direct
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.0000489	Direct
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.0000489	Direct
53300,69179 53300 - vWA-like 69179 - Integrin domains	0.0002716	Direct
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.0004112	Direct
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.000604	Direct
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0.01386	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.08463	Inherited
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.5116	Inherited
47986,52540 47986 - DEATH domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.5734	Inherited
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.5818	Inherited
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.8834	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.000008236	Direct
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0.0003382	Direct
57586,57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like 57586 - TNF receptor-like	0.0003382	Direct
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.0003382	Direct

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Mammalian Phenotype (MP): increased inflammatory response

Superfamily

Family

Supra-domain (including individual superfamily)