SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from supfam.org. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal craniofacial bone morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   skeleton phenotype [MP:0005390] <2>(46|63) (50|41|26)
+ + 2:   craniofacial phenotype [MP:0005382] <1>(20|36) (24|17|10)
+ + 2:   abnormal skeleton morphology [MP:0005508] <15>(41|59) (47|38|25)
+ 1:   abnormal craniofacial morphology [MP:0000428] <5>(20|36) (24|17|10)
+ 1:   abnormal axial skeleton morphology [MP:0002114] <4>(24|40) (25|21|14)
0:   abnormal craniofacial bone morphology [MP:0002116] <3>(16|25) (16|13|7)
- 1:   abnormal cranium morphology [MP:0000438] <11>(16|25) (16|13|7)
- 1:   abnormal middle ear ossicle morphology [MP:0005105] <7>(2|3) (2|1|0)
- 1:   absent craniofacial bones [MP:0000073](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
TB module/8-cys domain0.001885Inherited
Growth factor receptor domain0.01001Inherited
PGBD-like0.01377Inherited
Cystine-knot cytokines0.01961Inherited
Hemopexin-like domain0.02584Inherited
Metalloproteases ("zincins"), catalytic domain0.03268Inherited
EGF/Laminin0.05277Inherited
p53-like transcription factors0.06706Inherited
lambda repressor-like DNA-binding domains0.1106Inherited
Homeodomain-like0.1191Inherited
FnI-like domain0.1523Inherited
4-helical cytokines0.1769Inherited
Transducin (alpha subunit), insertion domain0.3901Inherited
Nuclear receptor ligand-binding domain0.4744Inherited
Bromodomain0.832Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Paired domain0.0000003573Direct
Arylsulfatase0.000228Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0004663Direct
TB module/8-cys domain0.001353Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.003279Inherited
Neutral endopeptidase (neprilysin)0.007173Inherited
Laminin-type module0.007722Inherited
Growth factor receptor domain0.009972Inherited
MMP N-terminal domain0.01108Inherited
Transforming growth factor (TGF)-beta0.01231Inherited
Matrix metalloproteases, catalytic domain0.01403Inherited
Hemopexin-like domain0.0214Inherited
Forkhead DNA-binding domain0.03208Inherited
TNF receptor-like0.0827Inherited
DEATH domain, DD0.0827Inherited
Homeodomain0.08758Inherited
G proteins0.3106Inherited
Extracellular domain of cell surface receptors0.3577Inherited
Transducin (alpha subunit), insertion domain0.3577Inherited
Nuclear receptor ligand-binding domain0.4439Inherited
Nuclear receptor0.4439Inherited
T-box0.5772Inherited
Bromodomain0.8122Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
TB module/8-cys domain0.001069Inherited
Growth factor receptor domain0.006253Inherited
PGBD-like0.008806Inherited
Cystine-knot cytokines0.01284Inherited
Hemopexin-like domain0.01732Inherited
Metalloproteases ("zincins"), catalytic domain0.02236Inherited
EGF/Laminin0.03741Inherited
p53-like transcription factors0.0488Inherited
lambda repressor-like DNA-binding domains0.08465Inherited
Homeodomain-like0.09185Inherited
FnI-like domain0.1208Inherited
4-helical cytokines0.1424Inherited
Transducin (alpha subunit), insertion domain0.3437Inherited
Nuclear receptor ligand-binding domain0.4268Inherited
Bromodomain0.7996Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0001818Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0003533Direct
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.0004996Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.003186Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.003186Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.008806Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.04855Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.05215Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.09701Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1657Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1657Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2107Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00136Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.00136Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.009729Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.01853Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0481Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.07715Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.4561Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)