Mammalian Phenotype (MP): abnormal kidney morphology

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + 3: mammalian phenotype [MP:0000001] <29>

+ + 2: renal/urinary system phenotype [MP:0005367] <2> (41|47) (46|26|11)

+ 1: abnormal renal/urinary system morphology [MP:0000516] <14> (31|36) (36|22|11)

0: abnormal kidney morphology [MP:0002135] <29> (26|28) (28|15|6)

- 1: abnormal kidney cortex morphology [MP:0000521] <9> (10|16) (12|9|3)

- 1: abnormal kidney medulla morphology [MP:0003014] <9> (1|0) (1|0|0)

- 1: abnormal nephron morphology [MP:0003881] <8> (19|22) (21|12|3)

- 1: abnormal kidney blood vessel morphology [MP:0000530] <7> (5|5) (5|0|0)

- 1: abnormal kidney pelvis morphology [MP:0004194] <7> (0|1) (0|0|0)

- 1: abnormal kidney development [MP:0000527] <6> (2|3) (3|1|1)

- 1: abnormal kidney collecting duct morphology [MP:0004754] <5> (0|0) (0|0|0)

- 1: abnormal kidney size [MP:0002706] <5> (2|3) (2|5|2)

- 1: kidney cysts [MP:0003675] <5> (1|0) (1|1|0)

- 1: abnormal kidney epithelium morphology [MP:0004967] <3> (4|3) (4|2|0)

- 1: abnormal kidney interstitium morphology [MP:0011425] <2> (0|0) (0|0|0)

- 1: abnormal kidney iron level [MP:0008742] <2> (0|0) (0|0|0)

- 1: renal fibrosis [MP:0003985] <2> (0|0) (2|0|0)

- 1: ectopic kidney [MP:0003600] <1> (1|1) (1|0|0)

- 1: kidney degeneration [MP:0009641] <1> (4|4) (4|0|0)

- 1: abnormal kidney capsule morphology [MP:0011383] (0|0) (0|0|0)

- 1: abnormal kidney corticomedullary boundary morphology [MP:0011376] (2|1) (2|1|1)

- 1: abnormal kidney lobe morphology [MP:0011381] (0|0) (0|0|0)

- 1: abnormal kidney lobule morphology [MP:0011382] (0|0) (0|0|0)

- 1: absent kidney [MP:0000520] (1|1) (2|0|0)

- 1: bifid kidney [MP:0003601] (0|0) (0|0|0)

- 1: duplex kidney [MP:0004017] (0|0) (0|1|1)

- 1: fused kidneys [MP:0003605] (0|0) (0|0|0)

- 1: granular kidney [MP:0011534] (0|0) (0|0|0)

- 1: nephrocalcinosis [MP:0003197] (0|0) (0|0|0)

- 1: nephrolithiasis [MP:0002708] (0|0) (0|0|0)

- 1: nephrosclerosis [MP:0009860] (0|0) (0|0|0)

- 1: pale kidney [MP:0004969] (0|1) (0|1|0)

- 1: single kidney [MP:0003604] (1|1) (1|0|0)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Families 57/38 glycoside transferase middle domain	0.0002059	Direct
(Trans)glycosidases	0.0003116	Direct
Glycoside hydrolase/deacetylase	0.0008343	Direct
Galactose mutarotase-like	0.002088	Inherited
Flavoproteins	0.002088	Inherited
FnI-like domain	0.003854	Inherited
TNF receptor-like	0.01435	Inherited
Riboflavin synthase domain-like	0.0169	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.0169	Inherited
HCP-like	0.01733	Inherited
L30e-like	0.027	Inherited
C-type lectin-like	0.03442	Inherited
Bcl-2 inhibitors of programmed cell death	0.03874	Inherited
Cadherin-like	0.1849	Inherited
Metalloproteases ("zincins"), catalytic domain	0.2216	Inherited
Cystine-knot cytokines	0.3983	Inherited
Sema domain	0.6739	Inherited
Integrin domains	0.7477	Inherited
CalX-like	0.8304	Inherited
Notch domain	0.8304	Inherited
Plexin repeat	0.8791	Inherited
Nuclear receptor ligand-binding domain	0.9006	Inherited
Homeodomain-like	0.9065	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.9475	Inherited
TPR-like	0.9723	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Cytochrome p450 reductase N-terminal domain-like	0	Direct
NADPH-cytochrome p450 reductase-like	0.0001286	Direct
alpha-mannosidase	0.0001286	Direct
alpha-mannosidase, domain 2	0.0001286	Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.0001286	Direct
Noncollagenous (NC1) domain of collagen IV	0.0005476	Direct
VWC domain	0.0008553	Direct
alpha-mannosidase, C-terminal domain	0.0009169	Direct
Platelet-derived growth factor-like	0.002982	Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.00535	Inherited
Laminin-type module	0.006386	Inherited
TNF receptor-like	0.01452	Inherited
Forkhead DNA-binding domain	0.02661	Inherited
Bcl-2 inhibitors of programmed cell death	0.03026	Inherited
Short-chain cytokines	0.08667	Inherited
Cadherin	0.1425	Inherited
Transforming growth factor (TGF)-beta	0.5049	Inherited
Homeodomain	0.6184	Inherited
Sema domain	0.6358	Inherited
Leucine zipper domain	0.7134	Inherited
Integrin domains	0.7134	Inherited
Notch domain	0.8018	Inherited
CalX-beta domain	0.8018	Inherited
Plexin repeat	0.8553	Inherited
Nuclear receptor ligand-binding domain	0.8784	Inherited
Nuclear receptor	0.8784	Inherited
Tetratricopeptide repeat (TPR)	0.9874	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Families 57/38 glycoside transferase middle domain	0.0001042	Direct
(Trans)glycosidases	0.0001607	Direct
Glycoside hydrolase/deacetylase	0.0004514	Direct
Flavoproteins	0.001189	Inherited
Galactose mutarotase-like	0.001189	Inherited
FnI-like domain	0.002265	Inherited
TNF receptor-like	0.009199	Inherited
Riboflavin synthase domain-like	0.01096	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.01096	Inherited
HCP-like	0.01128	Inherited
L30e-like	0.01816	Inherited
C-type lectin-like	0.02364	Inherited
Bcl-2 inhibitors of programmed cell death	0.02679	Inherited
Cadherin-like	0.1497	Inherited
Metalloproteases ("zincins"), catalytic domain	0.1833	Inherited
EGF/Laminin	0.335	Inherited
Cystine-knot cytokines	0.3517	Inherited
Sema domain	0.6318	Inherited
Leucine zipper domain	0.7093	Inherited
Integrin domains	0.7093	Inherited
CalX-like	0.7978	Inherited
Notch domain	0.7978	Inherited
Plexin repeat	0.8504	Inherited
Nuclear receptor ligand-binding domain	0.8737	Inherited
Homeodomain-like	0.8803	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.9256	Inherited
TPR-like	0.9536	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
88713,88688 88713 - Glycoside hydrolase/deacetylase 88688 - Families 57/38 glycoside transferase middle domain	0.0001042	Direct
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0.0007784	Direct
48452,81901 48452 - TPR-like 81901 - HCP-like	0.0007784	Direct
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain	0.001189	Inherited
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0.006191	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.01915	Inherited
56436,56436 56436 - C-type lectin-like 56436 - C-type lectin-like	0.04496	Inherited
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.06292	Inherited
50044,50044 50044 - SH3-domain 50044 - SH3-domain	0.2122	Inherited
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0.596	Inherited
101912,103575 101912 - Sema domain 103575 - Plexin repeat	0.6318	Inherited
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.6693	Inherited
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.6693	Inherited
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.8962	Inherited
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.9176	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.0001137	Direct
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain	0.0004514	Direct
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.01816	Inherited
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like	0.1878	Inherited
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.1907	Inherited
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.7093	Inherited

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Mammalian Phenotype (MP): abnormal kidney morphology

Superfamily

Family

Supra-domain (including individual superfamily)