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Mammalian Phenotype (MP): abnormal hematopoietic system morphology/development
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| STAT DNA-binding domain | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
| DNA polymerase beta-like | 0 | DIRECT |
| BAFF receptor-like | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| beta-glycanases | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Alpha-adaptin ear subdomain-like | 0 | DIRECT |
| Pyrin domain, PYD | 0 | DIRECT |
| Interleukin 17F, IL-17F | 0 | DIRECT |
| DNA polymerase beta-like, second domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.000156 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.0005988 | DIRECT |
| Nuclear receptor | 0.001049 | INHERITED FROM: abnormal macrophage cell number || persistent cervical thymus || abnormal phagocyte morphology |
| ARID domain | 0.001359 | INHERITED FROM: abnormal hematopoietic stem cell morphology || abnormal hematopoietic cell morphology |
| Integrin domains | 0.002097 | INHERITED FROM: decreased T cell number || decreased CD4-positive, alpha beta T cell number || abnormal eosinophil cell number || abnormal hematopoietic cell morphology |
| Nuclear receptor ligand-binding domain | 0.002396 | INHERITED FROM: abnormal macrophage cell number || persistent cervical thymus || abnormal phagocyte morphology |
| Integrin beta tail domain | 0.002804 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
| Interferons/interleukin-10 (IL-10) | 0.00499 | INHERITED FROM: decreased erythroid progenitor cell number || abnormal phagocyte morphology |
| DNA polymerase I | 0.00695 | INHERITED FROM: abnormal B cell differentiation |
| Integrin beta EGF-like domains | 0.0112 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.0112 | INHERITED FROM: reticulocytosis || increased myeloid cell number || abnormal erythroid lineage cell morphology || abnormal reticulocyte cell number |
| Notch domain | 0.0167 | INHERITED FROM: increased spleen red pulp amount || enlarged spleen || increased hematopoietic cell number || extramedullary hematopoiesis || abnormal spleen red pulp morphology |
| DNA polymerase beta, N-terminal domain-like | 0.0167 | INHERITED FROM: abnormal hemopoiesis || decreased leukocyte cell number || decreased lymphocyte cell number || abnormal lymphocyte cell number || abnormal immunoglobulin V(D)J recombination || abnormal B cell morphology || abnormal B cell differentiation || abnormal leukopoiesis || abnormal definitive hematopoiesis || abnormal lymphopoiesis || abnormal blood cell morphology/development |
| ets domain | 0.01951 | INHERITED FROM: decreased pro-B cell number || abnormal hematopoietic stem cell morphology || decreased thymocyte number || abnormal definitive hematopoiesis |
| Pointed domain | 0.02407 | INHERITED FROM: abnormal mature B cell morphology || decreased leukocyte cell number || thrombocytopenia || decreased lymphocyte cell number || abnormal lymphocyte cell number || decreased thymocyte number || abnormal B cell differentiation |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.02407 | INHERITED FROM: abnormal CD8-positive, alpha-beta T cell number || increased neutrophil cell number || abnormal neutrophil cell number || abnormal CD4-positive, alpha beta T cell number || increased granulocyte number || abnormal effector T cell morphology || abnormal CD4-positive, alpha beta T cell morphology || abnormal alpha-beta T cell number || abnormal CD8-positive, alpha beta T cell morphology |
| C2 set domains | 0.02721 | INHERITED FROM: abnormal monocyte morphology |
| SH2 domain | 0.03221 | INHERITED FROM: abnormal spleen secondary B follicle morphology || abnormal hemopoiesis || decreased splenocyte number || abnormal thymus morphology || decreased thymocyte number || abnormal B-1 B cell number || abnormal immature B cell number || abnormal leukopoiesis || abnormal definitive hematopoiesis || arrested B cell differentiation || abnormal spleen morphology || increased lymphocyte cell number || decreased immature B cell number || abnormal lymphopoiesis || abnormal blood cell morphology/development || decreased single-positive T cell number || abnormal pre-B cell morphology |
| AraD-like aldolase/epimerase | 0.03924 | INHERITED FROM: abnormal hematocrit || decreased hematocrit || abnormal reticulocyte morphology || decreased mean corpuscular volume || abnormal myeloid cell number || abnormal erythrocyte morphology || abnormal mean corpuscular volume || spherocytosis || reticulocytosis || increased myeloid cell number || abnormal reticulocyte cell number || anemia |
| Tissue inhibitor of metalloproteinases, TIMP | 0.03924 | INHERITED FROM: increased neutrophil cell number || abnormal neutrophil morphology || abnormal neutrophil cell number || abnormal granulocyte number || increased granulocyte number || abnormal granulocyte morphology || abnormal phagocyte morphology |
| SWIRM domain | 0.03924 | INHERITED FROM: abnormal bone marrow cell morphology/development |
| Triple coiled coil domain of C-type lectins | 0.03924 | INHERITED FROM: abnormal macrophage morphology || abnormal monocyte morphology || abnormal mononuclear phagocyte morphology || abnormal monocyte cell number || abnormal phagocyte morphology |
| Cytochrome p450 reductase N-terminal domain-like | 0.03924 | INHERITED FROM: abnormal macrophage cell number || abnormal macrophage morphology || increased osteoclast cell number || abnormal mononuclear phagocyte morphology || abnormal osteoclast morphology || abnormal osteoclast cell number || increased macrophage cell number || abnormal phagocyte morphology |
| Noncollagenous (NC1) domain of collagen IV | 0.05074 | INHERITED FROM: decreased hematocrit || decreased myeloid cell number || abnormal hemoglobin content || abnormal erythrocyte morphology || abnormal hemoglobin || decreased hemoglobin content || abnormal erythroid lineage cell morphology || decreased erythrocyte cell number |
| WWE domain | 0.05074 | INHERITED FROM: decreased mature B cell number || abnormal marginal zone B cell morphology || abnormal spleen marginal zone morphology || abnormal spleen white pulp morphology || abnormal mature B cell number || decreased marginal zone B cell number |
| E2F dimerization segment | 0.05074 | INHERITED FROM: abnormal alpha-beta T cell morphology || decreased double-positive T cell number || abnormal T cell number || abnormal T cell differentiation || abnormal thymus size || abnormal leukopoiesis || abnormal lymphopoiesis |
| Erythroid transcription factor GATA-1 | 0.05345 | INHERITED FROM: abnormal erythrocyte morphology || abnormal erythroid lineage cell morphology || decreased erythrocyte cell number |
| NADPH-cytochrome p450 reductase-like | 0.103 | INHERITED FROM: abnormal macrophage cell number || abnormal macrophage morphology || increased osteoclast cell number || abnormal osteoclast morphology || abnormal osteoclast cell number || increased macrophage cell number |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.103 | INHERITED FROM: abnormal macrophage cell number || abnormal macrophage morphology || increased osteoclast cell number || abnormal osteoclast morphology || abnormal osteoclast cell number || increased macrophage cell number |
| Nuclear receptor coactivator interlocking domain | 0.103 | INHERITED FROM: increased T cell number || enlarged spleen |
| CCCH zinc finger | 0.1297 | INHERITED FROM: enlarged spleen || increased mature B cell number || abnormal thymus development |
| PLC-like (P variant) | 0.1589 | INHERITED FROM: decreased B-2 B cell number || abnormal platelet dense granule morphology || abnormal platelet calcium level || abnormal B-1 B cell number || abnormal leukopoiesis || abnormal definitive hematopoiesis |
| Eps15 homology domain (EH domain) | 0.1823 | INHERITED FROM: abnormal hemoglobin || abnormal mean corpuscular hemoglobin |
| Cyclin | 0.2263 | INHERITED FROM: abnormal common myeloid progenitor cell morphology || abnormal hematopoietic stem cell morphology || decreased erythrocyte cell number || decreased hematopoietic stem cell number |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.2344 | INHERITED FROM: abnormal hemoglobin content || abnormal spleen weight |
| Linker histone H1/H5 | 0.2345 | INHERITED FROM: small thymus || abnormal thymus size |
| Cell cycle transcription factor e2f-dp | 0.2345 | INHERITED FROM: decreased double-positive T cell number || abnormal T cell differentiation |
| TNF receptor-like | 0.2524 | INHERITED FROM: abnormal spleen secondary B follicle morphology || abnormal thymus epithelium morphology || abnormal mononuclear cell morphology || enlarged spleen || increased CD4-positive, alpha beta T cell number || abnormal spleen white pulp morphology || abnormal lymphocyte cell number || increased leukocyte cell number || abnormal spleen B cell follicle morphology || increased hematopoietic cell number || enlarged thymus || abnormal negative T cell selection || abnormal spleen germinal center morphology || abnormal definitive hematopoiesis || abnormal leukocyte morphology || abnormal thymus medulla morphology || abnormal hematopoietic cell morphology || abnormal phagocyte morphology |
| Short-chain cytokines | 0.3041 | INHERITED FROM: abnormal blood cell morphology || abnormal bone marrow cell morphology/development || abnormal hemoglobin || increased granulocyte number || decreased hematopoietic cell number || abnormal hematopoietic cell number || abnormal definitive hematopoiesis || abnormal hematopoietic cell morphology |
| Pleckstrin-homology domain (PH domain) | 0.3292 | INHERITED FROM: decreased transitional stage B cell number || abnormal B-1 B cell number |
| Myb/SANT domain | 0.3659 | INHERITED FROM: abnormal megakaryocyte morphology || increased megakaryocyte cell number || abnormal common lymphocyte progenitor cell morphology || arrested B cell differentiation |
| C1 set domains (antibody constant domain-like) | 0.4085 | INHERITED FROM: absent CD8-positive, alpha-beta T cells || abnormal leukocyte cell number || abnormal mononuclear cell morphology |
| A DNA-binding domain in eukaryotic transcription factors | 0.4403 | INHERITED FROM: abnormal megakaryocyte morphology || thrombocytopenia |
| Ran binding protein zinc finger-like | 0.4403 | INHERITED FROM: abnormal mature B cell morphology || decreased B-1a cell number || abnormal B cell number || abnormal B-1a B cell morphology || abnormal B cell morphology || abnormal B-1 B cell number || decreased B cell number |
| Long-chain cytokines | 0.4403 | INHERITED FROM: abnormal osteoclast differentiation |
| Ankyrin repeat | 0.451 | INHERITED FROM: extramedullary hematopoiesis |
| DBL homology domain (DH-domain) | 0.4652 | INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || decreased transitional stage B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage B cell morphology |
| DEATH domain, DD | 0.4966 | INHERITED FROM: abnormal spleen secondary B follicle morphology || abnormal mononuclear cell morphology || abnormal thymus morphology || increased transitional stage B cell number || abnormal lymphocyte cell number || abnormal B-1 B cell number || abnormal thymus cortex morphology || abnormal spleen germinal center morphology || abnormal thymus medulla morphology |
| MATH domain | 0.5296 | INHERITED FROM: abnormal immature B cell morphology || abnormal immature B cell number |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.5803 | INHERITED FROM: abnormal megakaryocyte morphology || abnormal megakaryocyte progenitor cell morphology || abnormal bone marrow hematopoietic cell morphology |
| Interferon regulatory factor | 0.5803 | INHERITED FROM: decreased T cell number || decreased mature B cell number || decreased dendritic cell number || abnormal plasmacytoid dendritic cell number || abnormal T cell number || abnormal plasmacytoid dendritic cell morphology || abnormal mature B cell number || increased lymphocyte cell number || decreased plasmacytoid dendritic cell number |
| Interleukin 8-like chemokines | 0.6321 | INHERITED FROM: abnormal hematopoietic cell morphology |
| Interleukin-1 (IL-1) | 0.637 | INHERITED FROM: increased neutrophil cell number || abnormal neutrophil morphology || abnormal neutrophil cell number || increased granulocyte number || abnormal granulocyte morphology |
| FHA domain | 0.6475 | INHERITED FROM: abnormal class switch recombination |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.662 | INHERITED FROM: increased mature B cell number || abnormal B-2 B cell morphology || abnormal follicular B cell morphology || abnormal immature B cell number |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.6891 | INHERITED FROM: decreased thymocyte number || abnormal positive T cell selection |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.6982 | INHERITED FROM: decreased mature B cell number || absent lymphocyte || decreased dendritic cell number || abnormal dendritic cell morphology || abnormal spleen white pulp morphology || abnormal plasmacytoid dendritic cell number || absent B cells || abnormal plasmacytoid dendritic cell morphology || abnormal B cell differentiation || abnormal dendritic cell number || increased B cell number || decreased plasmacytoid dendritic cell number |
| Tetraspanin | 0.6982 | INHERITED FROM: abnormal macrophage morphology |
| Calponin-homology domain, CH-domain | 0.7747 | INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology |
| Bcl-2 inhibitors of programmed cell death | 0.82 | INHERITED FROM: increased pre-B cell number || decreased mature B cell number || abnormal immature B cell morphology || enlarged spleen || abnormal T cell number || abnormal T cell differentiation || abnormal immature B cell number || abnormal leukopoiesis || abnormal mature B cell number || abnormal lymphopoiesis || abnormal pre-B cell morphology |
| MHC antigen-recognition domain | 0.867 | INHERITED FROM: absent CD8-positive, alpha-beta T cells || abnormal T cell morphology || abnormal mononuclear cell morphology || abnormal T cell number |
| V set domains (antibody variable domain-like) | 0.8678 | INHERITED FROM: abnormal T-helper 17 cell number || abnormal T-helper 17 cell morphology || abnormal B-1 B cell number || abnormal definitive hematopoiesis |
| TNF-like | 0.9376 | INHERITED FROM: abnormal thymus epithelium morphology || small thymus medulla || abnormal spleen germinal center morphology |
| SH3-domain | 0.999 | INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation || decreased single-positive T cell number |
| Homeodomain | 1 | INHERITED FROM: ectopic thymus || athymia || abnormal spleen mesenchyme morphology || abnormal spleen development |
| Caspase recruitment domain, CARD | 1 | INHERITED FROM: abnormal follicular B cell morphology |
| Toll/Interleukin receptor TIR domain | 1 | INHERITED FROM: decreased mature B cell number || increased mature B cell number || abnormal B-1 B cell number |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| STAT DNA-binding domain | 0 | Direct |
| RUNT domain | 0 | Direct |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
| DNA polymerase beta-like | 0 | Direct |
| BAFF receptor-like | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| beta-glycanases | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| STAT | 0 | Direct |
| Alpha-adaptin ear subdomain-like | 0 | Direct |
| Pyrin domain, PYD | 0 | Direct |
| Interleukin 17F, IL-17F | 0 | Direct |
| DNA polymerase beta-like, second domain | 0 | Direct |
| BAG domain | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.000156 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.0005988 | Direct |
| Nuclear receptor | 0.001049 | Inherited |
| ARID domain | 0.001359 | Inherited |
| Integrin domains | 0.002097 | Inherited |
| Nuclear receptor ligand-binding domain | 0.002396 | Inherited |
| Integrin beta tail domain | 0.002804 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.00499 | Inherited |
| DNA polymerase I | 0.00695 | Inherited |
| Integrin beta EGF-like domains | 0.0112 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.0112 | Inherited |
| Notch domain | 0.0167 | Inherited |
| DNA polymerase beta, N-terminal domain-like | 0.0167 | Inherited |
| ets domain | 0.01951 | Inherited |
| Pointed domain | 0.02407 | Inherited |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.02407 | Inherited |
| C2 set domains | 0.02721 | Inherited |
| SH2 domain | 0.03221 | Inherited |
| AraD-like aldolase/epimerase | 0.03924 | Inherited |
| Tissue inhibitor of metalloproteinases, TIMP | 0.03924 | Inherited |
| SWIRM domain | 0.03924 | Inherited |
| Triple coiled coil domain of C-type lectins | 0.03924 | Inherited |
| Cytochrome p450 reductase N-terminal domain-like | 0.03924 | Inherited |
| Noncollagenous (NC1) domain of collagen IV | 0.05074 | Inherited |
| WWE domain | 0.05074 | Inherited |
| E2F dimerization segment | 0.05074 | Inherited |
| Erythroid transcription factor GATA-1 | 0.05345 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.103 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.103 | Inherited |
| Nuclear receptor coactivator interlocking domain | 0.103 | Inherited |
| CCCH zinc finger | 0.1297 | Inherited |
| PLC-like (P variant) | 0.1589 | Inherited |
| Eps15 homology domain (EH domain) | 0.1823 | Inherited |
| Cyclin | 0.2263 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.2344 | Inherited |
| Linker histone H1/H5 | 0.2345 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.2345 | Inherited |
| TNF receptor-like | 0.2524 | Inherited |
| Short-chain cytokines | 0.3041 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.3292 | Inherited |
| Myb/SANT domain | 0.3659 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.4085 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.4403 | Inherited |
| Ran binding protein zinc finger-like | 0.4403 | Inherited |
| Long-chain cytokines | 0.4403 | Inherited |
| Ankyrin repeat | 0.451 | Inherited |
| DBL homology domain (DH-domain) | 0.4652 | Inherited |
| DEATH domain, DD | 0.4966 | Inherited |
| MATH domain | 0.5296 | Inherited |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.5803 | Inherited |
| Interferon regulatory factor | 0.5803 | Inherited |
| Interleukin 8-like chemokines | 0.6321 | Inherited |
| Interleukin-1 (IL-1) | 0.637 | Inherited |
| FHA domain | 0.6475 | Inherited |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.662 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.6891 | Inherited |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.6982 | Inherited |
| Tetraspanin | 0.6982 | Inherited |
| Calponin-homology domain, CH-domain | 0.7747 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.82 | Inherited |
| MHC antigen-recognition domain | 0.867 | Inherited |
| V set domains (antibody variable domain-like) | 0.8678 | Inherited |
| TNF-like | 0.9376 | Inherited |
| SH3-domain | 0.999 | Inherited |
| Homeodomain | 1 | Inherited |
| Caspase recruitment domain, CARD | 1 | Inherited |
| Toll/Interleukin receptor TIR domain | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| PsbU/PolX domain-like | 0 | DIRECT |
| STAT | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| ARID-like | 0.00113 | INHERITED FROM: abnormal hematopoietic cell morphology || abnormal hematopoietic stem cell morphology |
| Integrin domains | 0.001681 | INHERITED FROM: abnormal hematopoietic cell morphology || decreased CD4-positive, alpha beta T cell number || abnormal eosinophil cell number || abnormal T cell number || decreased T cell number |
| Nuclear receptor ligand-binding domain | 0.001821 | INHERITED FROM: abnormal phagocyte morphology || persistent cervical thymus || abnormal macrophage cell number || abnormal macrophage morphology |
| Integrin beta tail domain | 0.002429 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.005582 | INHERITED FROM: abnormal CD8-positive, alpha-beta T cell number || decreased T cell number || decreased CD8-positive, alpha-beta T cell number |
| L30e-like | 0.009818 | INHERITED FROM: abnormal leukocyte cell number || increased leukocyte cell number || increased hematopoietic cell number |
| Notch domain | 0.01504 | INHERITED FROM: abnormal spleen red pulp morphology || extramedullary hematopoiesis || increased spleen red pulp amount || enlarged spleen || increased hematopoietic cell number |
| DNA polymerase beta, N-terminal domain-like | 0.01504 | INHERITED FROM: abnormal blood cell morphology/development || abnormal hemopoiesis || abnormal B cell morphology || decreased leukocyte cell number || abnormal definitive hematopoiesis || abnormal immunoglobulin V(D)J recombination || decreased lymphocyte cell number || abnormal lymphopoiesis || abnormal lymphocyte cell number || abnormal lymphocyte morphology || abnormal B cell differentiation || abnormal leukopoiesis |
| Flavoproteins | 0.02173 | INHERITED FROM: abnormal osteoclast cell number || increased leukocyte cell number || abnormal osteoclast morphology || abnormal myeloid leukocyte morphology || increased osteoclast cell number || increased hematopoietic cell number |
| SH2 domain | 0.03379 | INHERITED FROM: abnormal immature B cell morphology || abnormal thymus morphology || abnormal blood cell morphology/development || decreased immature B cell number || abnormal spleen secondary B follicle morphology || increased lymphocyte cell number || abnormal hemopoiesis || arrested B cell differentiation || decreased splenocyte number || abnormal immature B cell number || decreased thymocyte number || abnormal spleen morphology || abnormal definitive hematopoiesis || abnormal pre-B cell morphology || abnormal lymphopoiesis || abnormal leukopoiesis || abnormal B-1 B cell number || decreased single-positive T cell number |
| Triple coiled coil domain of C-type lectins | 0.03619 | INHERITED FROM: abnormal mononuclear phagocyte morphology || abnormal phagocyte morphology || abnormal macrophage morphology || abnormal monocyte cell number || abnormal monocyte morphology |
| AraD/HMP-PK domain-like | 0.03619 | INHERITED FROM: increased myeloid cell number || abnormal reticulocyte cell number || abnormal myeloid cell number || abnormal hematocrit || abnormal erythrocyte morphology || decreased hematocrit || spherocytosis || reticulocytosis || anemia || abnormal mean corpuscular volume || abnormal reticulocyte morphology || abnormal erythroid lineage cell morphology || decreased mean corpuscular volume |
| Terpenoid cyclases/Protein prenyltransferases | 0.04774 | INHERITED FROM: abnormal neutrophil cell number || abnormal neutrophil morphology |
| NAD kinase/diacylglycerol kinase-like | 0.07947 | INHERITED FROM: increased leukocyte cell number |
| beta-beta-alpha zinc fingers | 0.08058 | INHERITED FROM: decreased DN2 thymocyte number |
| Integrin alpha N-terminal domain | 0.08591 | INHERITED FROM: decreased T cell number |
| p53-like transcription factors | 0.09143 | INHERITED FROM: abnormal thymus morphology || abnormal granulocyte morphology || decreased erythroid progenitor cell number || abnormal blood cell morphology/development || abnormal leukocyte morphology || abnormal blood cell morphology || abnormal hemopoiesis || decreased dendritic cell number || abnormal mononuclear cell morphology || increased leukocyte cell number || abnormal T cell morphology || abnormal dendritic cell morphology || abnormal T cell differentiation || abnormal granulocyte number || abnormal myeloid leukocyte morphology || decreased T cell number || abnormal definitive hematopoiesis || abnormal lymphopoiesis || abnormal lymphocyte morphology || increased hematopoietic cell number || abnormal thymus medulla morphology || abnormal dendritic cell number || abnormal leukopoiesis |
| WWE domain | 0.09367 | INHERITED FROM: decreased marginal zone B cell number || abnormal spleen marginal zone morphology || abnormal mature B cell number || abnormal spleen white pulp morphology || abnormal marginal zone B cell morphology || decreased mature B cell number |
| E2F-DP heterodimerization region | 0.09367 | INHERITED FROM: abnormal T cell differentiation || decreased double-positive T cell number || abnormal alpha-beta T cell morphology || abnormal lymphopoiesis || abnormal leukopoiesis |
| Nuclear receptor coactivator interlocking domain | 0.09605 | INHERITED FROM: enlarged spleen || increased T cell number |
| (Trans)glycosidases | 0.09658 | INHERITED FROM: abnormal phagocyte morphology |
| CCCH zinc finger | 0.1196 | INHERITED FROM: increased mature B cell number || enlarged spleen || abnormal thymus development |
| Nucleic acid-binding proteins | 0.1824 | INHERITED FROM: reticulocytosis |
| TIMP-like | 0.1838 | INHERITED FROM: abnormal neutrophil cell number |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1902 | INHERITED FROM: persistent cervical thymus || abnormal osteoclast morphology |
| TNF receptor-like | 0.1925 | INHERITED FROM: abnormal phagocyte morphology || abnormal leukocyte morphology || abnormal spleen secondary B follicle morphology || abnormal hematopoietic cell morphology || abnormal plasma cell number || abnormal mononuclear cell morphology || abnormal spleen germinal center morphology || abnormal spleen white pulp morphology || abnormal negative T cell selection || enlarged thymus || enlarged spleen || abnormal definitive hematopoiesis || abnormal spleen B cell follicle morphology || increased CD4-positive, alpha beta T cell number || abnormal lymphocyte cell number || abnormal thymus epithelium morphology || abnormal thymus medulla morphology |
| 4-helical cytokines | 0.2198 | INHERITED FROM: abnormal bone marrow cell morphology/development || decreased hematopoietic cell number || abnormal definitive hematopoiesis |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.2551 | INHERITED FROM: abnormal platelet calcium level |
| Cyclin-like | 0.2809 | INHERITED FROM: abnormal bone marrow cell morphology/development || abnormal hemopoiesis || decreased erythrocyte cell number || decreased myeloid cell number || abnormal common myeloid progenitor cell morphology || decreased hematopoietic stem cell number || abnormal definitive hematopoiesis || abnormal hematopoietic stem cell morphology |
| Protein kinase-like (PK-like) | 0.292 | INHERITED FROM: abnormal hemopoiesis || decreased thymocyte number |
| BRCT domain | 0.3045 | INHERITED FROM: abnormal definitive hematopoiesis || abnormal immunoglobulin V(D)J recombination || abnormal lymphocyte morphology |
| E set domains | 0.3415 | INHERITED FROM: abnormal thymus medulla morphology |
| SMAD/FHA domain | 0.3456 | INHERITED FROM: abnormal class switch recombination || abnormal plasmacytoid dendritic cell morphology || abnormal plasmacytoid dendritic cell number || decreased plasmacytoid dendritic cell number |
| Riboflavin synthase domain-like | 0.371 | INHERITED FROM: increased macrophage cell number || abnormal osteoclast cell number || increased osteoclast cell number |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.371 | INHERITED FROM: increased macrophage cell number || abnormal osteoclast cell number || increased osteoclast cell number |
| Nucleotidyltransferase | 0.3869 | INHERITED FROM: abnormal immunoglobulin V(D)J recombination |
| PH domain-like | 0.3973 | INHERITED FROM: decreased cellular hemoglobin content || abnormal megakaryocyte morphology |
| Ankyrin repeat | 0.4295 | INHERITED FROM: extramedullary hematopoiesis |
| Ran binding protein zinc finger-like | 0.4399 | INHERITED FROM: abnormal B cell number || abnormal B-1a B cell morphology || abnormal B cell morphology || decreased B cell number || abnormal mature B cell morphology || decreased B-1a cell number || abnormal B-1 B cell number |
| A DNA-binding domain in eukaryotic transcription factors | 0.4399 | INHERITED FROM: thrombocytopenia || abnormal megakaryocyte morphology |
| DBL homology domain (DH-domain) | 0.4671 | INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage T2 B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage B cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number |
| Interleukin 8-like chemokines | 0.6354 | INHERITED FROM: abnormal hematopoietic cell morphology |
| BAR/IMD domain-like | 0.6591 | INHERITED FROM: increased hematocrit || decreased mean corpuscular hemoglobin concentration |
| SET domain | 0.7203 | INHERITED FROM: abnormal B cell differentiation |
| Cysteine-rich domain | 0.7332 | INHERITED FROM: abnormal positive T cell selection || decreased thymocyte number |
| Calponin-homology domain, CH-domain | 0.7772 | INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage T2 B cell morphology || increased transitional stage T1 B cell number || increased transitional stage B cell number |
| DNA/RNA polymerases | 0.7822 | INHERITED FROM: abnormal somatic hypermutation frequency || abnormal B cell differentiation |
| Acyl-CoA N-acyltransferases (Nat) | 0.7969 | INHERITED FROM: decreased double-negative T cell number |
| Bcl-2 inhibitors of programmed cell death | 0.8196 | INHERITED FROM: abnormal immature B cell morphology || abnormal mature B cell number || abnormal T cell differentiation || abnormal immature B cell number || abnormal T cell number || enlarged spleen || abnormal pre-B cell morphology || increased pre-B cell number || abnormal lymphopoiesis || decreased mature B cell number || abnormal leukopoiesis |
| C-type lectin-like | 0.8565 | INHERITED FROM: decreased mast cell number |
| MHC antigen-recognition domain | 0.8666 | INHERITED FROM: abnormal mononuclear cell morphology || abnormal T cell morphology || abnormal T cell number || absent CD8-positive, alpha-beta T cells |
| DEATH domain | 0.9218 | INHERITED FROM: abnormal granulocyte morphology || abnormal phagocyte morphology || decreased activated T cell number || abnormal spleen germinal center morphology || abnormal definitive hematopoiesis || abnormal B-1 B cell number |
| TNF-like | 0.9353 | INHERITED FROM: small thymus medulla || abnormal osteoclast morphology || abnormal spleen germinal center morphology || abnormal thymus epithelium morphology || abnormal thymus medulla morphology |
| Homeodomain-like | 0.967 | INHERITED FROM: abnormal spleen mesenchyme morphology || ectopic thymus || athymia |
| Immunoglobulin | 0.9743 | INHERITED FROM: abnormal B-1 B cell number |
| SH3-domain | 0.9929 | INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation || arrested B cell differentiation || decreased single-positive T cell number |
| Toll/Interleukin receptor TIR domain | 1 | INHERITED FROM: increased mature B cell number || decreased mature B cell number || abnormal B-1 B cell number |
| Caspase-like | 1 | INHERITED FROM: abnormal spleen marginal zone morphology |
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47802,81585
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like | 0 | DIRECT |
81585,81301
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
49562,51045
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
51045 - WW domain | 0 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.000003346 | DIRECT |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.000006455 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.001436 | INHERITED FROM: abnormal phagocyte morphology || persistent cervical thymus || abnormal leukocyte morphology || abnormal macrophage cell number || abnormal macrophage morphology || abnormal myeloid leukocyte morphology |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.002429 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.002429 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.004313 | INHERITED FROM: abnormal immature B cell morphology || abnormal CD4-positive, alpha beta T cell number || abnormal spleen marginal zone morphology || decreased immature B cell number || abnormal mature B cell number || increased lymphocyte cell number || arrested B cell differentiation || increased leukocyte cell number || abnormal effector T cell morphology || abnormal immature B cell number || abnormal transitional stage T2 B cell morphology || decreased double-negative T cell number || decreased follicular B cell number || abnormal double-negative T cell morphology || abnormal follicular B cell morphology || increased immature B cell number || abnormal alpha-beta T cell morphology || abnormal lymphocyte cell number || decreased mature B cell number || abnormal lymphocyte morphology || abnormal transitional stage B cell morphology || increased hematopoietic cell number || increased transitional stage B cell number || decreased transitional stage B cell number || abnormal B-1 B cell number || decreased single-positive T cell number |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.00615 | INHERITED FROM: abnormal phagocyte morphology || abnormal CD4-positive, alpha beta T cell number || abnormal leukocyte cell number || abnormal leukocyte morphology || abnormal blood cell morphology || abnormal mononuclear cell morphology || increased leukocyte cell number || abnormal myeloid cell morphology || abnormal macrophage morphology || abnormal myeloid leukocyte morphology || abnormal definitive hematopoiesis || abnormal lymphocyte cell number || abnormal lymphocyte morphology || increased hematopoietic cell number |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.00615 | INHERITED FROM: abnormal B cell number || abnormal blood cell morphology/development || abnormal leukocyte morphology || abnormal blood cell morphology || increased lymphocyte cell number || abnormal spleen size || abnormal hemopoiesis || increased neutrophil cell number || abnormal bone marrow hematopoietic cell morphology || abnormal mononuclear cell morphology || abnormal neutrophil cell number || decreased B cell number || abnormal mature B cell morphology || enlarged spleen || abnormal definitive hematopoiesis || abnormal hematopoietic stem cell morphology || abnormal erythroid lineage cell morphology || abnormal neutrophil morphology || abnormal lymphocyte morphology || abnormal monocyte morphology || abnormal leukopoiesis || abnormal megakaryocyte morphology |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.02154 | INHERITED FROM: increased megakaryocyte cell number || abnormal definitive hematopoiesis |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.02173 | INHERITED FROM: abnormal alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell number || increased granulocyte number || increased neutrophil cell number || abnormal effector T cell morphology || abnormal neutrophil cell number || abnormal CD8-positive, alpha beta T cell morphology || abnormal CD4-positive, alpha beta T cell morphology || abnormal CD8-positive, alpha-beta T cell number || abnormal alpha-beta T cell morphology || abnormal neutrophil morphology |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.02452 | INHERITED FROM: abnormal CD4-positive, alpha beta T cell number || increased neutrophil cell number || abnormal CD8-positive, alpha beta T cell morphology || abnormal CD4-positive, alpha beta T cell morphology || abnormal CD8-positive, alpha-beta T cell number |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.02452 | INHERITED FROM: abnormal common myeloid progenitor cell morphology || abnormal hematopoietic stem cell morphology |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.03436 | INHERITED FROM: decreased T cell number |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.03436 | INHERITED FROM: decreased T cell number |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.03619 | INHERITED FROM: abnormal spleen size || abnormal spleen red pulp morphology || extramedullary hematopoiesis || increased spleen red pulp amount || enlarged spleen |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.03619 | INHERITED FROM: abnormal mononuclear phagocyte morphology || abnormal phagocyte morphology || abnormal macrophage morphology || abnormal monocyte cell number || abnormal monocyte morphology |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.04658 | INHERITED FROM: small thymus || abnormal thymus size |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.04876 | INHERITED FROM: increased CD8-positive, alpha-beta T cell number || decreased CD4-positive, alpha beta T cell number || increased alpha-beta T cell number |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.09317 | INHERITED FROM: abnormal blood cell morphology/development || abnormal hemopoiesis || decreased erythrocyte cell number || decreased myeloid cell number || abnormal common myeloid progenitor cell morphology || decreased hematopoietic stem cell number || abnormal definitive hematopoiesis || abnormal hematopoietic stem cell morphology |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.09367 | INHERITED FROM: abnormal T cell differentiation || decreased double-positive T cell number || abnormal alpha-beta T cell morphology || abnormal lymphopoiesis || abnormal leukopoiesis |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1275 | INHERITED FROM: abnormal hemoglobin || abnormal hemoglobin content |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.153 | INHERITED FROM: decreased DN2 thymocyte number |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0.172 | INHERITED FROM: abnormal hemoglobin |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.2216 | INHERITED FROM: abnormal hemoglobin content |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.317 | INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage T2 B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage B cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.3339 | INHERITED FROM: abnormal phagocyte morphology || abnormal leukocyte morphology || abnormal spleen secondary B follicle morphology || abnormal hematopoietic cell morphology || abnormal mononuclear cell morphology || increased leukocyte cell number || abnormal neutrophil cell number || abnormal spleen germinal center morphology || abnormal spleen white pulp morphology || enlarged spleen || abnormal definitive hematopoiesis || abnormal spleen B cell follicle morphology || abnormal lymphocyte cell number || abnormal thymus epithelium morphology || increased hematopoietic cell number || abnormal thymus medulla morphology |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.3462 | INHERITED FROM: abnormal immature B cell morphology || abnormal immature B cell number |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.4821 | INHERITED FROM: abnormal hemoglobin || decreased hemoglobin content |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.4821 | INHERITED FROM: thrombocytopenia || abnormal megakaryocyte morphology |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.5285 | INHERITED FROM: abnormal thymus morphology || decreased hematopoietic cell number || abnormal blood cell morphology/development || abnormal leukocyte cell number || abnormal blood cell morphology || abnormal hemopoiesis || abnormal mononuclear cell morphology || abnormal T cell morphology || abnormal T cell differentiation || small thymus || abnormal T cell number || decreased T cell number || decreased leukocyte cell number || abnormal definitive hematopoiesis || abnormal double-positive T cell morphology || decreased lymphocyte cell number || abnormal alpha-beta T cell morphology || abnormal lymphopoiesis || abnormal lymphocyte cell number || abnormal lymphocyte morphology || abnormal leukopoiesis |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.5294 | INHERITED FROM: abnormal leukocyte cell number || abnormal mononuclear cell morphology || abnormal T cell morphology || abnormal T cell number || absent CD8-positive, alpha-beta T cells |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0.6971 | INHERITED FROM: abnormal lymphopoiesis || abnormal leukopoiesis |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8678 | INHERITED FROM: absent mast cells |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.9343 | INHERITED FROM: decreased erythroid progenitor cell number |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
47802,81585
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like | 0 | Direct |
81585,81301
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
49562,51045
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
51045 - WW domain | 0 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.000003346 | Direct |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.000006455 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.001436 | Inherited |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.002429 | Inherited |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.002429 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.004313 | Inherited |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.00615 | Inherited |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.00615 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.02154 | Inherited |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.02173 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.02452 | Inherited |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.02452 | Inherited |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.03436 | Inherited |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.03436 | Inherited |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.03619 | Inherited |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.03619 | Inherited |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.04658 | Inherited |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.04876 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.09317 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.09367 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1275 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.153 | Inherited |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0.172 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.2216 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.317 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.3339 | Inherited |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.3462 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.4821 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.4821 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.5285 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.5294 | Inherited |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0.6971 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8678 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.9343 | Inherited |
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550
50729 - PH domain-like
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
47802,81585,81301
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.00005114 | DIRECT |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.002429 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.02173 | INHERITED FROM: abnormal alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell number || increased granulocyte number || increased neutrophil cell number || abnormal effector T cell morphology || abnormal neutrophil cell number || abnormal CD8-positive, alpha beta T cell morphology || abnormal CD4-positive, alpha beta T cell morphology || abnormal CD8-positive, alpha-beta T cell number || abnormal alpha-beta T cell morphology || abnormal neutrophil morphology |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.02452 | INHERITED FROM: decreased hematopoietic cell number || abnormal T cell morphology || increased spleen red pulp amount || decreased leukocyte cell number |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.03436 | INHERITED FROM: decreased T cell number |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.04876 | INHERITED FROM: increased CD8-positive, alpha-beta T cell number || decreased CD4-positive, alpha beta T cell number || increased alpha-beta T cell number |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1533 | INHERITED FROM: abnormal hemoglobin content |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3339 | INHERITED FROM: increased spleen red pulp amount |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.4821 | INHERITED FROM: increased spleen red pulp amount || enlarged spleen |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.5773 | INHERITED FROM: absent mast cells |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.6361 | INHERITED FROM: abnormal spleen secondary B follicle morphology || abnormal spleen germinal center morphology || abnormal spleen white pulp morphology || enlarged spleen || abnormal spleen B cell follicle morphology |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.6971 | INHERITED FROM: abnormal lymphopoiesis || abnormal leukopoiesis |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550
50729 - PH domain-like
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
47802,81585,81301
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.00005114 | Direct |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.002429 | Inherited |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.02173 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.02452 | Inherited |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.03436 | Inherited |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.04876 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1533 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3339 | Inherited |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.4821 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.5773 | Inherited |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.6361 | Inherited |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.6971 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
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