Mammalian Phenotype (MP): abnormal leukocyte physiology

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + 4: mammalian phenotype [MP:0000001] <29>

+ + + 3: hematopoietic system phenotype [MP:0005397] <2> (72|102) (78|63|30)

+ + + 3: immune system phenotype [MP:0005387] <2> (76|114) (86|66|35)

+ + 2: abnormal immune system physiology [MP:0001790] <16> (59|84) (66|49|28)

+ + 2: abnormal hematopoietic system physiology [MP:0001545] <5> (39|53) (40|38|21)

+ 1: abnormal immune cell physiology [MP:0001819] <3> (35|48) (37|33|21)

+ 1: abnormal blood cell physiology [MP:0012382] <3> (38|53) (39|38|21)

+ 1: abnormal adaptive immunity [MP:0002420] <8> (36|48) (38|33|21)

+ 1: abnormal cell-mediated immunity [MP:0002421] <3> (35|48) (37|33|21)

0: abnormal leukocyte physiology [MP:0002442] <5> (34|48) (36|33|20)

- 1: abnormal macrophage physiology [MP:0002451] <10> (7|6) (8|4|2)

- 1: abnormal leukocyte migration [MP:0003156] <7> (8|9) (8|5|3)

- 1: abnormal granulocyte physiology [MP:0002462] <6> (3|3) (3|2|1)

- 1: abnormal lymphocyte physiology [MP:0003945] <4> (21|31) (23|22|13)

- 1: leukostasis [MP:0008541] (0|0) (0|0|0)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
TNF receptor-like	0.00000004616	Direct
p53-like transcription factors	0.0000004954	Direct
MHC antigen-recognition domain	0.000002706	Direct
4-helical cytokines	0.00001393	Direct
Caspase-like	0.00002697	Direct
Interleukin 8-like chemokines	0.0001239	Direct
Cysteine-rich domain	0.0004156	Direct
Bcl-2 inhibitors of programmed cell death	0.00149	Inherited
Inhibitor of apoptosis (IAP) repeat	0.001926	Inherited
Integrin beta tail domain	0.01561	Inherited
DBL homology domain (DH-domain)	0.01582	Inherited
DEATH domain	0.04295	Inherited
E set domains	0.05632	Inherited
SH2 domain	0.07148	Inherited
WWE domain	0.07264	Inherited
Flavoproteins	0.07264	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.09041	Inherited
L30e-like	0.1055	Inherited
SMAD/FHA domain	0.1404	Inherited
SH3-domain	0.1455	Inherited
Toll/Interleukin receptor TIR domain	0.2509	Inherited
vWA-like	0.3911	Inherited
C-type lectin-like	0.4399	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.5903	Inherited
TNF-like	0.5986	Inherited
L domain-like	0.6645	Inherited
Integrin domains	0.7205	Inherited
EGF/Laminin	0.7653	Inherited
Integrin alpha N-terminal domain	0.8157	Inherited
Family A G protein-coupled receptor-like	0.9637	Inherited
Complement control module/SCR domain	0.9657	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Cysteine rich domain	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Proteasome subunits	0	Direct
STAT DNA-binding domain	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
STAT	0	Direct
C1 set domains (antibody constant domain-like)	0.00000003327	Direct
TNF receptor-like	0.00000004073	Direct
Rel/Dorsal transcription factors, DNA-binding domain	0.0000005154	Direct
MHC antigen-recognition domain	0.000001892	Direct
Short-chain cytokines	0.000004107	Direct
Caspase recruitment domain, CARD	0.00001052	Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.0000143	Direct
Pyrin domain, PYD	0.00006545	Direct
Caspase catalytic domain	0.00007293	Direct
Interleukin 8-like chemokines	0.00009152	Direct
Inhibitor of apoptosis (IAP) repeat	0.0003017	Direct
28-residue LRR	0.0006265	Direct
Bcl-2 inhibitors of programmed cell death	0.001037	Inherited
Interferon regulatory factor	0.001037	Inherited
Cytochrome p450 reductase N-terminal domain-like	0.005543	Inherited
Integrin beta tail domain	0.01176	Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain	0.01176	Inherited
DBL homology domain (DH-domain)	0.01355	Inherited
NADPH-cytochrome p450 reductase-like	0.01726	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.01726	Inherited
Interleukin 17F, IL-17F	0.01726	Inherited
Integrin beta EGF-like domains	0.02213	Inherited
WWE domain	0.03526	Inherited
SH2 domain	0.04606	Inherited
ets domain	0.08401	Inherited
SH3-domain	0.1027	Inherited
I set domains	0.2106	Inherited
Toll/Interleukin receptor TIR domain	0.2192	Inherited
V set domains (antibody variable domain-like)	0.2248	Inherited
DEATH domain, DD	0.2828	Inherited
FHA domain	0.4077	Inherited
C-type lectin domain	0.4125	Inherited
Integrin A (or I) domain	0.4328	Inherited
Pleckstrin-homology domain (PH domain)	0.4337	Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.513	Inherited
TNF-like	0.5385	Inherited
PLC-like (P variant)	0.5385	Inherited
Integrin domains	0.6687	Inherited
Integrin alpha N-terminal domain	0.8079	Inherited
EGF-type module	0.8094	Inherited
Rhodopsin-like	0.9318	Inherited
Complement control module/SCR domain	0.9464	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
TNF receptor-like	0.0000000178	Direct
p53-like transcription factors	0.0000001997	Direct
MHC antigen-recognition domain	0.000001137	Direct
4-helical cytokines	0.000006171	Direct
Caspase-like	0.00001236	Direct
Interleukin 8-like chemokines	0.00006096	Direct
Cysteine-rich domain	0.000218	Direct
Bcl-2 inhibitors of programmed cell death	0.0008341	Direct
Inhibitor of apoptosis (IAP) repeat	0.001092	Inherited
Integrin beta tail domain	0.01004	Inherited
DBL homology domain (DH-domain)	0.01019	Inherited
RNI-like	0.01793	Inherited
DEATH domain	0.03	Inherited
E set domains	0.04026	Inherited
SH2 domain	0.05234	Inherited
WWE domain	0.05331	Inherited
Flavoproteins	0.05331	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.06754	Inherited
L30e-like	0.08015	Inherited
SMAD/FHA domain	0.1102	Inherited
SH3-domain	0.1147	Inherited
Toll/Interleukin receptor TIR domain	0.2106	Inherited
vWA-like	0.3447	Inherited
C-type lectin-like	0.3925	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.5443	Inherited
TNF-like	0.5531	Inherited
L domain-like	0.622	Inherited
Integrin domains	0.6808	Inherited
EGF/Laminin	0.7278	Inherited
Integrin alpha N-terminal domain	0.7818	Inherited
Family A G protein-coupled receptor-like	0.944	Inherited
Complement control module/SCR domain	0.9463	Inherited
Transducin (alpha subunit), insertion domain	0.9844	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0	Direct
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain	0	Direct
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
57440,56436 57440 - Kringle-like 56436 - C-type lectin-like	0	Direct
50370,57440 50370 - Ricin B-like lectins 57440 - Kringle-like	0	Direct
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0	Direct
48366,47473 48366 - Ras GEF 47473 - EF-hand	0	Direct
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain)	0	Direct
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.0000003283	Direct
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.0000005374	Direct
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.000005358	Direct
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.00000688	Direct
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.00000803	Direct
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0.0002429	Direct
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0.0002429	Direct
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0.0002429	Direct
47986,52540 47986 - DEATH domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0002695	Direct
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.0008341	Direct
57603,82895 57603 - FnI-like domain 82895 - TSP-1 type 1 repeat	0.004771	Inherited
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0.006395	Inherited
53300,69179 53300 - vWA-like 69179 - Integrin domains	0.01004	Inherited
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.01004	Inherited
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0.0151	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.01545	Inherited
50729,55550 50729 - PH domain-like 55550 - SH2 domain	0.03136	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.2831	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.5531	Inherited
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.667	Inherited
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain	0.667	Inherited
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.8152	Inherited
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.8152	Inherited
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.974	Inherited
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.9844	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50729,50044,55550 50729 - PH domain-like 50044 - SH3-domain 55550 - SH2 domain	0	Direct
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0	Direct
50370,57440,56436 50370 - Ricin B-like lectins 57440 - Kringle-like 56436 - C-type lectin-like	0	Direct
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	Direct
48366,47473,57889 48366 - Ras GEF 47473 - EF-hand 57889 - Cysteine-rich domain	0	Direct
57440,56436,56436 57440 - Kringle-like 56436 - C-type lectin-like 56436 - C-type lectin-like	0	Direct
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain	0	Direct
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	Direct
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.0000889	Direct
57586,57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like 57586 - TNF receptor-like	0.001105	Inherited
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0.004771	Inherited
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.004771	Inherited
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.01004	Inherited
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0.0151	Inherited
49265,49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III 49265 - Fibronectin type III	0.02492	Inherited
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.667	Inherited
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.7245	Inherited
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.8152	Inherited
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains	0.8488	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Mammalian Phenotype (MP): abnormal leukocyte physiology

Superfamily

Family

Supra-domain (including individual superfamily)