Mammalian Phenotype (MP): abnormal lymphocyte morphology

(show info)

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + + + 6: mammalian phenotype [MP:0000001] <29>

+ + + + + 5: immune system phenotype [MP:0005387] <2> (76|114) (86|66|35)

+ + + + + 5: hematopoietic system phenotype [MP:0005397] <2> (72|102) (78|63|30)

+ + + + 4: abnormal immune system morphology [MP:0000685] <3> (51|76) (60|35|18)

+ + + + 4: abnormal hematopoietic system morphology/development [MP:0002396] <5> (58|86) (66|47|21)

+ + + 3: abnormal immune system cell morphology [MP:0000716] <5> (38|63) (48|29|16)

+ + + 3: abnormal hematopoietic cell morphology [MP:0013656] <9> (49|77) (60|43|18)

+ + 2: abnormal leukocyte morphology [MP:0008246] <4> (37|62) (47|29|15)

+ 1: abnormal mononuclear cell morphology [MP:0008247] <2> (34|57) (41|28|14)

0: abnormal lymphocyte morphology [MP:0002619] <5> (28|46) (33|26|14)

- 1: abnormal T cell morphology [MP:0008037] <9> (14|25) (18|19|11)

- 1: abnormal B cell morphology [MP:0004939] <6> (18|28) (20|11|6)

- 1: abnormal lymphocyte cell number [MP:0000717] <6> (18|38) (25|21|9)

- 1: abnormal NK cell morphology [MP:0005068] <5> (0|0) (0|0|0)

- 1: abnormal lymphopoiesis [MP:0002401] <3> (19|25) (21|15|6)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
SPOC domain-like	0	Direct
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
PsbU/PolX domain-like	0	Direct
p53-like transcription factors	0.0000009579	Direct
BRCT domain	0.0009633	Direct
DNA polymerase beta, N-terminal domain-like	0.00156	Inherited
Bcl-2 inhibitors of programmed cell death	0.008088	Inherited
Toll/Interleukin receptor TIR domain	0.01208	Inherited
Ran binding protein zinc finger-like	0.01225	Inherited
E2F-DP heterodimerization region	0.01291	Inherited
SH2 domain	0.01523	Inherited
DEATH domain	0.01972	Inherited
Integrin alpha N-terminal domain	0.03308	Inherited
WWE domain	0.0636	Inherited
DNA/RNA polymerases	0.1016	Inherited
TNF receptor-like	0.1174	Inherited
SH3-domain	0.1332	Inherited
Cysteine-rich domain	0.1337	Inherited
Immunoglobulin	0.1364	Inherited
Nucleotidyltransferase	0.1562	Inherited
SMAD/FHA domain	0.2533	Inherited
MHC antigen-recognition domain	0.2533	Inherited
DBL homology domain (DH-domain)	0.2533	Inherited
SET domain	0.2869	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.4788	Inherited
Integrin domains	0.5564	Inherited
Calponin-homology domain, CH-domain	0.6572	Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Proteasome subunits	0	Direct
STAT DNA-binding domain	0	Direct
RUNT domain	0	Direct
DNA polymerase beta-like	0	Direct
BAFF receptor-like	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
C5 cytosine-specific DNA methylase, DCM	0	Direct
STAT	0	Direct
Interleukin 17F, IL-17F	0	Direct
DNA polymerase beta-like, second domain	0	Direct
Rel/Dorsal transcription factors, DNA-binding domain	0.0000121	Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.00009219	Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.0003334	Direct
Pointed domain	0.001021	Inherited
DNA polymerase beta, N-terminal domain-like	0.001051	Inherited
E2F dimerization segment	0.004033	Inherited
Bcl-2 inhibitors of programmed cell death	0.006012	Inherited
Interferon regulatory factor	0.006012	Inherited
Ran binding protein zinc finger-like	0.009563	Inherited
Phoshoinositide 3-kinase (PI3K) helical domain	0.009666	Inherited
PLC-like (P variant)	0.01117	Inherited
SH2 domain	0.01443	Inherited
Nuclear receptor coactivator interlocking domain	0.01464	Inherited
Toll/Interleukin receptor TIR domain	0.02112	Inherited
Cell cycle transcription factor e2f-dp	0.03023	Inherited
WWE domain	0.03024	Inherited
DNA polymerase I	0.03024	Inherited
V set domains (antibody variable domain-like)	0.03473	Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain	0.05153	Inherited
MATH domain	0.06456	Inherited
CCCH zinc finger	0.08652	Inherited
Pleckstrin-homology domain (PH domain)	0.1047	Inherited
SH3-domain	0.1296	Inherited
C1 set domains (antibody constant domain-like)	0.1376	Inherited
TNF receptor-like	0.1575	Inherited
DEATH domain, DD	0.1575	Inherited
Caspase recruitment domain, CARD	0.1978	Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0.2059	Inherited
FHA domain	0.2077	Inherited
MHC antigen-recognition domain	0.2345	Inherited
ets domain	0.2345	Inherited
DBL homology domain (DH-domain)	0.2345	Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases	0.3065	Inherited
Myb/SANT domain	0.3998	Inherited
Integrin domains	0.5417	Inherited
Calponin-homology domain, CH-domain	0.6429	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

Plot tree as:

Download Newick format tree:

(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
SPOC domain-like	0	Direct
PsbU/PolX domain-like	0	Direct
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
p53-like transcription factors	0.0000003902	Direct
BRCT domain	0.0005247	Direct
DNA polymerase beta, N-terminal domain-like	0.0008744	Direct
Bcl-2 inhibitors of programmed cell death	0.004979	Inherited
Toll/Interleukin receptor TIR domain	0.007646	Inherited
Ran binding protein zinc finger-like	0.007763	Inherited
E2F-DP heterodimerization region	0.008207	Inherited
SH2 domain	0.009791	Inherited
Nuclear receptor coactivator interlocking domain	0.01273	Inherited
DEATH domain	0.01291	Inherited
Integrin alpha N-terminal domain	0.02264	Inherited
WWE domain	0.04609	Inherited
CCCH zinc finger	0.07688	Inherited
DNA/RNA polymerases	0.07688	Inherited
TNF receptor-like	0.09044	Inherited
SH3-domain	0.104	Inherited
Cysteine-rich domain	0.1045	Inherited
Immunoglobulin	0.1068	Inherited
Nucleotidyltransferase	0.1242	Inherited
SMAD/FHA domain	0.2128	Inherited
DBL homology domain (DH-domain)	0.2128	Inherited
MHC antigen-recognition domain	0.2128	Inherited
SET domain	0.2445	Inherited
beta-beta-alpha zinc fingers	0.2487	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.4312	Inherited
Acyl-CoA N-acyltransferases (Nat)	0.4722	Inherited
Integrin domains	0.5098	Inherited
Protein kinase-like (PK-like)	0.5387	Inherited
Calponin-homology domain, CH-domain	0.6141	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0	Direct
47802,81585 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like	0	Direct
81585,81301 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase	0	Direct
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0	Direct
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0	Direct
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain)	0	Direct
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.000008429	Direct
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0.0001818	Direct
50729,55550 50729 - PH domain-like 55550 - SH2 domain	0.0001818	Direct
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0.0001932	Direct
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.0006103	Direct
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain	0.003999	Inherited
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0.008207	Inherited
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0.008207	Inherited
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.01595	Inherited
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.01595	Inherited
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.02644	Inherited
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like	0.06972	Inherited
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain	0.06972	Inherited
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.07515	Inherited
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.2128	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.2128	Inherited
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.2128	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.4358	Inherited
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.473	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50729,50044,55550 50729 - PH domain-like 50044 - SH3-domain 55550 - SH2 domain	0	Direct
47802,81585,81301 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase	0	Direct
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0	Direct
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0	Direct
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0	Direct
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain	0	Direct
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	Direct
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0.003999	Inherited
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.008207	Inherited
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.01595	Inherited
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.06972	Inherited
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.3251	Inherited
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.6808	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

Plot tree as:

Download Newick format tree:

(show help)

SEARCH

BROWSE

TOOLS

ABOUT

HELP

Mammalian Phenotype (MP): abnormal lymphocyte morphology

Superfamily

Family

Supra-domain (including individual superfamily)