Mammalian Phenotype (MP): abnormal lymphocyte physiology

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + + 5: mammalian phenotype [MP:0000001] <29>

+ + + + 4: hematopoietic system phenotype [MP:0005397] <2> (72|102) (78|63|30)

+ + + + 4: immune system phenotype [MP:0005387] <2> (76|114) (86|66|35)

+ + + 3: abnormal hematopoietic system physiology [MP:0001545] <5> (39|53) (40|38|21)

+ + + 3: abnormal immune system physiology [MP:0001790] <16> (59|84) (66|49|28)

+ + 2: abnormal adaptive immunity [MP:0002420] <8> (36|48) (38|33|21)

+ + 2: abnormal blood cell physiology [MP:0012382] <3> (38|53) (39|38|21)

+ + 2: abnormal immune cell physiology [MP:0001819] <3> (35|48) (37|33|21)

+ + 2: abnormal cell-mediated immunity [MP:0002421] <3> (35|48) (37|33|21)

+ 1: abnormal leukocyte physiology [MP:0002442] <5> (34|48) (36|33|20)

0: abnormal lymphocyte physiology [MP:0003945] <4> (21|31) (23|22|13)

- 1: abnormal B cell physiology [MP:0002459] <9> (19|27) (20|16|10)

- 1: abnormal T cell physiology [MP:0002444] <7> (8|15) (11|16|7)

- 1: abnormal NK cell physiology [MP:0010766] <2> (7|5) (7|5|3)

- 1: abnormal lymphocyte activation involved in immune response [MP:0020191] <2> (0|0) (0|0|0)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
TNF receptor-like	0.000000000527	Direct
MHC antigen-recognition domain	0.00000006637	Direct
Caspase-like	0.000002016	Direct
Inhibitor of apoptosis (IAP) repeat	0.000482	Direct
p53-like transcription factors	0.01039	Inherited
E set domains	0.016	Inherited
SH2 domain	0.02794	Inherited
SMAD/FHA domain	0.03437	Inherited
WWE domain	0.03466	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.03838	Inherited
L30e-like	0.05239	Inherited
TNF-like	0.05656	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.116	Inherited
SH3-domain	0.2238	Inherited
4-helical cytokines	0.2327	Inherited
Bcl-2 inhibitors of programmed cell death	0.3271	Inherited
DBL homology domain (DH-domain)	0.6021	Inherited
Toll/Interleukin receptor TIR domain	0.6494	Inherited
Family A G protein-coupled receptor-like	0.9937	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Proteasome subunits	0	Direct
STAT DNA-binding domain	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
STAT	0	Direct
TNF receptor-like	0.0000000008056	Direct
Rel/Dorsal transcription factors, DNA-binding domain	0.00000003174	Direct
MHC antigen-recognition domain	0.00000004888	Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.0000008483	Direct
Caspase catalytic domain	0.000007562	Direct
Inhibitor of apoptosis (IAP) repeat	0.00006676	Direct
Interferon regulatory factor	0.0002021	Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.0005283	Direct
Interferon regulatory factor 3 (IRF3), transactivation domain	0.003992	Inherited
Interleukin 17F, IL-17F	0.007216	Inherited
WWE domain	0.0155	Inherited
SH2 domain	0.02225	Inherited
TNF-like	0.0443	Inherited
PLC-like (P variant)	0.0443	Inherited
C1 set domains (antibody constant domain-like)	0.0443	Inherited
DEATH domain, DD	0.05501	Inherited
Pleckstrin-homology domain (PH domain)	0.07492	Inherited
V set domains (antibody variable domain-like)	0.107	Inherited
I set domains	0.1859	Inherited
SH3-domain	0.2043	Inherited
FHA domain	0.2211	Inherited
ets domain	0.2386	Inherited
Bcl-2 inhibitors of programmed cell death	0.2939	Inherited
Caspase recruitment domain, CARD	0.3138	Inherited
Short-chain cytokines	0.3658	Inherited
DBL homology domain (DH-domain)	0.5744	Inherited
Toll/Interleukin receptor TIR domain	0.6715	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
TNF receptor-like	0.0000000001935	Direct
MHC antigen-recognition domain	0.00000002596	Direct
Caspase-like	0.0000008353	Direct
Inhibitor of apoptosis (IAP) repeat	0.000254	Direct
p53-like transcription factors	0.006501	Inherited
E set domains	0.01033	Inherited
SH2 domain	0.01887	Inherited
SMAD/FHA domain	0.0236	Inherited
WWE domain	0.02382	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.02654	Inherited
L30e-like	0.03714	Inherited
TNF-like	0.04046	Inherited
Transducin (alpha subunit), insertion domain	0.07829	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.08922	Inherited
SH3-domain	0.1854	Inherited
4-helical cytokines	0.1936	Inherited
Bcl-2 inhibitors of programmed cell death	0.2827	Inherited
DBL homology domain (DH-domain)	0.5566	Inherited
Toll/Interleukin receptor TIR domain	0.6059	Inherited
DEATH domain	0.6185	Inherited
Family A G protein-coupled receptor-like	0.9792	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0	Direct
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain	0	Direct
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0	Direct
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain)	0	Direct
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.00000001873	Direct
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.00000002412	Direct
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.0000002835	Direct
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0.00005102	Direct
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0.00005102	Direct
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0.00005102	Direct
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.0001541	Direct
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0.001671	Inherited
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0.006172	Inherited
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain	0.006627	Inherited
50729,55550 50729 - PH domain-like 55550 - SH2 domain	0.01334	Inherited
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.04567	Inherited
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.06292	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.3388	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.4684	Inherited
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.5566	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.6112	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50729,50044,55550 50729 - PH domain-like 50044 - SH3-domain 55550 - SH2 domain	0	Direct
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0	Direct
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	Direct
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain	0	Direct
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	Direct
57586,57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like 57586 - TNF receptor-like	0.00032	Direct
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0.00183	Inherited
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.00183	Inherited
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0.006172	Inherited
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.006627	Inherited
49265,49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III 49265 - Fibronectin type III	0.2827	Inherited
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.5541	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Mammalian Phenotype (MP): abnormal lymphocyte physiology

Superfamily

Family

Supra-domain (including individual superfamily)