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Mammalian Phenotype (MP): growth/size/body region phenotype
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (SDMP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lamin A/C globular tail domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| CPH domain | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| Assembly domain of cartilage oligomeric matrix protein | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Ran-binding domain | 0 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| SMAD4-binding domain of oncoprotein Ski | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| Guanido kinase catalytic domain | 0 | DIRECT |
| Hexokinase | 0 | DIRECT |
| APC10-like | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| Neurotrophin | 0 | DIRECT |
| Creatinase/aminopeptidase | 0 | DIRECT |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Mib/herc2 domain | 0 | DIRECT |
| gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Phenylalanine metabolism regulatory domain | 0 | DIRECT |
| Eps15 homology domain (EH domain) | 0 | DIRECT |
| Homeodomain | 0.000002331 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.00001499 | DIRECT |
| Nuclear receptor | 0.00001914 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.00002685 | DIRECT |
| Bromodomain | 0.0003012 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0003147 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.001804 | INHERITED FROM: postnatal growth retardation |
| T-box | 0.001953 | INHERITED FROM: cleft palate || abnormal secondary palate morphology || abnormal secondary palate development || cleft secondary palate |
| Paired domain | 0.004601 | INHERITED FROM: abnormal body size || decreased body size || abnormal secondary palate morphology || abnormal postnatal growth/weight/body size || decreased birth body size |
| Cell cycle transcription factor e2f-dp | 0.004601 | INHERITED FROM: abnormal prenatal body size |
| Laminin-type module | 0.005387 | INHERITED FROM: abnormal mouth morphology |
| SMAD MH1 domain | 0.008765 | INHERITED FROM: abnormal embryonic growth/weight/body size || decreased embryo size |
| SMAD domain | 0.008765 | INHERITED FROM: abnormal embryonic growth/weight/body size || decreased embryo size |
| Cullin homology domain | 0.01636 | INHERITED FROM: abnormal embryo size || decreased embryo size |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.01636 | INHERITED FROM: abnormal total tissue mass || abnormal embryo size || abnormal body weight || abnormal body composition |
| HMG-box | 0.01852 | INHERITED FROM: abnormal head mesenchyme morphology || abnormal head development || distended abdomen |
| Extracellular domain of cell surface receptors | 0.01852 | INHERITED FROM: abnormal tooth morphology |
| Pyridoxal-dependent decarboxylase | 0.03021 | INHERITED FROM: abnormal palate morphology || cleft palate |
| Transforming growth factor (TGF)-beta | 0.03496 | INHERITED FROM: abnormal incisor morphology || cleft palate |
| Hect, E3 ligase catalytic domain | 0.04456 | INHERITED FROM: decreased lean body mass |
| TB module/8-cys domain | 0.05384 | INHERITED FROM: abnormal incisor morphology |
| Pepsin-like | 0.05551 | INHERITED FROM: cachexia |
| Frizzled cysteine-rich domain | 0.08279 | INHERITED FROM: embryonic growth retardation || prenatal growth retardation |
| Phosphate binding protein-like | 0.08279 | INHERITED FROM: decreased total tissue mass |
| STAT DNA-binding domain | 0.08953 | INHERITED FROM: increased lean body mass || increased total tissue mass || decreased lean body mass || obese || increased body weight |
| Transcription factor STAT-4 N-domain | 0.08953 | INHERITED FROM: increased lean body mass || increased total tissue mass || decreased lean body mass || obese || increased body weight |
| VHS domain | 0.08953 | INHERITED FROM: slow postnatal weight gain || abnormal birth body size || decreased birth weight || abnormal birth weight || decreased birth body size |
| L domain | 0.08953 | INHERITED FROM: postnatal growth retardation || abnormal birth body size || decreased birth weight || abnormal birth weight || abnormal postnatal growth || decreased birth body size |
| STAT | 0.08953 | INHERITED FROM: increased lean body mass || increased total tissue mass || decreased lean body mass || obese || increased body weight |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.08953 | INHERITED FROM: abnormal embryo size |
| YWTD domain | 0.09924 | INHERITED FROM: decreased susceptibility to diet-induced obesity || decreased susceptibility to weight gain |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0.1009 | INHERITED FROM: abnormal embryo size || abnormal prenatal body size || decreased embryo size |
| Macro domain | 0.1009 | INHERITED FROM: abnormal lean body mass || decreased lean body mass || decreased body length || abnormal body length |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0.1009 | INHERITED FROM: abnormal embryo size || abnormal prenatal body size || decreased embryo size |
| GAT domain | 0.1009 | INHERITED FROM: abnormal birth body size || decreased birth weight || abnormal birth weight || decreased birth body size |
| Kinase associated domain 1, KA1 | 0.1009 | INHERITED FROM: decreased susceptibility to diet-induced obesity || decreased susceptibility to weight gain || abnormal susceptibility to weight gain |
| Insulin-like | 0.1132 | INHERITED FROM: decreased fetal size || abnormal birth body size || decreased birth weight || decreased fetal weight || abnormal fetal growth/weight/body size || abnormal birth weight || decreased birth body size |
| Chromo domain | 0.1161 | INHERITED FROM: decreased lean body mass |
| VWC domain | 0.1424 | INHERITED FROM: cleft hard palate || abnormal secondary palate development || cleft secondary palate || abnormal hard palate morphology |
| DIX domain | 0.1452 | INHERITED FROM: abnormal head morphology |
| Hormone receptor domain | 0.1593 | INHERITED FROM: obese |
| Ephrin ectodomain | 0.2564 | INHERITED FROM: abnormal palate morphology || cleft palate |
| DEP domain | 0.2779 | INHERITED FROM: increased body size || increased total tissue mass || increased body weight |
| Transducin (alpha subunit), insertion domain | 0.2842 | INHERITED FROM: abnormal outer ear morphology |
| DEATH domain, DD | 0.3358 | INHERITED FROM: abnormal tooth morphology |
| Intermediate filament protein, coiled coil region | 0.3611 | INHERITED FROM: abnormal tongue morphology || abnormal head morphology |
| FHA domain | 0.4274 | INHERITED FROM: microcephaly |
| SH2 domain | 0.5316 | INHERITED FROM: increased lean body mass |
| Cold shock DNA-binding domain-like | 0.5761 | INHERITED FROM: decreased fetal size |
| I set domains | 0.9233 | INHERITED FROM: midface hypoplasia |
| Rhodopsin-like | 0.9505 | INHERITED FROM: increased body size || increased total tissue mass || abnormal olfactory sensory neuron morphology || increased body weight || abnormal susceptibility to weight gain |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lamin A/C globular tail domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| CPH domain | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| Assembly domain of cartilage oligomeric matrix protein | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| Notch domain | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Ran-binding domain | 0 | Direct |
| NADPH-cytochrome p450 reductase-like | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| SMAD4-binding domain of oncoprotein Ski | 0 | Direct |
| DNA ligase | 0 | Direct |
| RUNT domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| Guanido kinase catalytic domain | 0 | Direct |
| Hexokinase | 0 | Direct |
| APC10-like | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| Neurotrophin | 0 | Direct |
| Creatinase/aminopeptidase | 0 | Direct |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Mib/herc2 domain | 0 | Direct |
| gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Cullin repeat | 0 | Direct |
| SRF-like | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Phenylalanine metabolism regulatory domain | 0 | Direct |
| Eps15 homology domain (EH domain) | 0 | Direct |
| Homeodomain | 0.000002331 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.00001499 | Direct |
| Nuclear receptor | 0.00001914 | Direct |
| Nuclear receptor ligand-binding domain | 0.00002685 | Direct |
| Bromodomain | 0.0003012 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0003147 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.001804 | Inherited |
| T-box | 0.001953 | Inherited |
| Paired domain | 0.004601 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.004601 | Inherited |
| Laminin-type module | 0.005387 | Inherited |
| SMAD MH1 domain | 0.008765 | Inherited |
| SMAD domain | 0.008765 | Inherited |
| Cullin homology domain | 0.01636 | Inherited |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.01636 | Inherited |
| HMG-box | 0.01852 | Inherited |
| Extracellular domain of cell surface receptors | 0.01852 | Inherited |
| Pyridoxal-dependent decarboxylase | 0.03021 | Inherited |
| Transforming growth factor (TGF)-beta | 0.03496 | Inherited |
| Hect, E3 ligase catalytic domain | 0.04456 | Inherited |
| TB module/8-cys domain | 0.05384 | Inherited |
| Pepsin-like | 0.05551 | Inherited |
| Frizzled cysteine-rich domain | 0.08279 | Inherited |
| Phosphate binding protein-like | 0.08279 | Inherited |
| STAT DNA-binding domain | 0.08953 | Inherited |
| Transcription factor STAT-4 N-domain | 0.08953 | Inherited |
| VHS domain | 0.08953 | Inherited |
| L domain | 0.08953 | Inherited |
| STAT | 0.08953 | Inherited |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.08953 | Inherited |
| YWTD domain | 0.09924 | Inherited |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0.1009 | Inherited |
| Macro domain | 0.1009 | Inherited |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0.1009 | Inherited |
| GAT domain | 0.1009 | Inherited |
| Kinase associated domain 1, KA1 | 0.1009 | Inherited |
| Insulin-like | 0.1132 | Inherited |
| Chromo domain | 0.1161 | Inherited |
| VWC domain | 0.1424 | Inherited |
| DIX domain | 0.1452 | Inherited |
| Hormone receptor domain | 0.1593 | Inherited |
| Ephrin ectodomain | 0.2564 | Inherited |
| DEP domain | 0.2779 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.2842 | Inherited |
| DEATH domain, DD | 0.3358 | Inherited |
| Intermediate filament protein, coiled coil region | 0.3611 | Inherited |
| FHA domain | 0.4274 | Inherited |
| SH2 domain | 0.5316 | Inherited |
| Cold shock DNA-binding domain-like | 0.5761 | Inherited |
| I set domains | 0.9233 | Inherited |
| Rhodopsin-like | 0.9505 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this MP term (SPMP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,82895
57184 - Growth factor receptor domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | DIRECT |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | DIRECT |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
100895,48726
100895 - Kazal-type serine protease inhibitors
48726 - Immunoglobulin | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
46955,63763
46955 - Putative DNA-binding domain
63763 - SAND domain-like | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
49265,53300
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.00006213 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0004424 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.009468 | INHERITED FROM: abnormal body size |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.01164 | INHERITED FROM: decreased susceptibility to diet-induced obesity || decreased susceptibility to weight gain |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.01394 | INHERITED FROM: abnormal body weight || abnormal total tissue mass || abnormal body composition || abnormal embryo size |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0.02658 | INHERITED FROM: postnatal growth retardation || decreased birth weight || abnormal postnatal growth || abnormal birth weight || abnormal birth body size || decreased birth body size |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.02727 | INHERITED FROM: decreased susceptibility to diet-induced obesity || decreased susceptibility to weight gain |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.02727 | INHERITED FROM: abnormal body weight || abnormal total tissue mass || abnormal body composition |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0.04977 | INHERITED FROM: embryonic growth retardation |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.07998 | INHERITED FROM: increased lean body mass || increased body weight || increased total tissue mass || decreased lean body mass || obese |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.07998 | INHERITED FROM: postnatal growth retardation || decreased birth weight || abnormal postnatal growth || abnormal birth weight || abnormal birth body size || decreased birth body size |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.07998 | INHERITED FROM: postnatal growth retardation || decreased birth weight || abnormal postnatal growth || abnormal birth weight || abnormal birth body size || decreased birth body size |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.07998 | INHERITED FROM: increased lean body mass || increased body weight || increased total tissue mass || decreased lean body mass || obese |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.07998 | INHERITED FROM: increased lean body mass || increased body weight || increased total tissue mass || decreased lean body mass || obese |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.09225 | INHERITED FROM: abnormal facial morphology || abnormal head morphology |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.1571 | INHERITED FROM: cachexia |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.1819 | INHERITED FROM: abnormal tongue epithelium morphology || abnormal tongue morphology |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0.1882 | INHERITED FROM: abnormal lean body mass || obese |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1882 | INHERITED FROM: abnormal outer ear morphology |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3519 | INHERITED FROM: decreased lean body mass |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,82895
57184 - Growth factor receptor domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | Direct |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | Direct |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
100895,48726
100895 - Kazal-type serine protease inhibitors
48726 - Immunoglobulin | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
46955,63763
46955 - Putative DNA-binding domain
63763 - SAND domain-like | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
49265,53300
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.00006213 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0004424 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.009468 | Inherited |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.01164 | Inherited |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.01394 | Inherited |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0.02658 | Inherited |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.02727 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.02727 | Inherited |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0.04977 | Inherited |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.07998 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.07998 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.07998 | Inherited |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.07998 | Inherited |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.07998 | Inherited |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.09225 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.1571 | Inherited |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.1819 | Inherited |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0.1882 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1882 | Inherited |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3519 | Inherited |
(show details)
Supra-domains annotated to this MP term (SPMP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | DIRECT |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | DIRECT |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
54928,54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0 | DIRECT |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | DIRECT |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.0009571 | DIRECT |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.004671 | INHERITED FROM: decreased susceptibility to diet-induced obesity || abnormal body size || decreased susceptibility to weight gain |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.01394 | INHERITED FROM: abnormal body weight || abnormal total tissue mass || abnormal body composition || abnormal embryo size |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.01394 | INHERITED FROM: abnormal mouth morphology || abnormal facial morphology |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0.02658 | INHERITED FROM: abnormal embryonic growth/weight/body size || abnormal prenatal body size |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.02658 | INHERITED FROM: postnatal growth retardation || abnormal postnatal growth |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.07998 | INHERITED FROM: increased lean body mass || increased body weight || increased total tissue mass || decreased lean body mass || obese |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.07998 | INHERITED FROM: increased lean body mass || increased body weight || increased total tissue mass || decreased lean body mass || obese |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.07998 | INHERITED FROM: postnatal growth retardation || decreased birth weight || abnormal postnatal growth || abnormal birth weight || abnormal birth body size || decreased birth body size |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1999 | INHERITED FROM: abnormal head morphology || abnormal secondary palate development |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3519 | INHERITED FROM: decreased lean body mass |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3519 | INHERITED FROM: decreased lean body mass |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | Direct |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | Direct |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
54928,54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0 | Direct |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | Direct |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.0009571 | Direct |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.004671 | Inherited |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.01394 | Inherited |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.01394 | Inherited |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0.02658 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.02658 | Inherited |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.07998 | Inherited |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.07998 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.07998 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1999 | Inherited |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3519 | Inherited |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3519 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
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