Mammalian Phenotype (MP): cellular phenotype

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ 1: mammalian phenotype [MP:0000001] <29>

0: cellular phenotype [MP:0005384] <6> (95|116) (103|56|31)

- 1: abnormal cell physiology [MP:0005621] <24> (77|96) (84|46|25)

- 1: abnormal cell morphology [MP:0000358] <12> (19|19) (22|9|2)

- 1: genetic imprinting [MP:0003121] <3> (0|0) (0|0|0)

- 1: abnormal extracellular matrix morphology [MP:0013258] <1> (5|5) (5|3|3)

- 1: maternal effect [MP:0003718] (0|0) (0|0|0)

- 1: paternal effect [MP:0010723] (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Restriction endonuclease-like	0	Direct
ATP-dependent DNA ligase DNA-binding domain	0	Direct
The spindle assembly checkpoint protein mad2	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Inhibitor of apoptosis (IAP) repeat	0	Direct
AN1-like Zinc finger	0	Direct
DNA repair protein MutS, domain III	0	Direct
Mss4-like	0	Direct
Polo-box domain	0	Direct
SRF-like	0	Direct
Tubby C-terminal domain-like	0	Direct
Uracil-DNA glycosylase-like	0	Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	Direct
Cullin homology domain	0	Direct
p53 tetramerization domain	0	Direct
DNA ligase/mRNA capping enzyme, catalytic domain	0	Direct
Hedgehog/DD-peptidase	0	Direct
Hedgehog/intein (Hint) domain	0	Direct
Lamin A/C globular tail domain	0	Direct
DNA repair protein MutS, domain II	0	Direct
HMA, heavy metal-associated domain	0	Direct
DNA-glycosylase	0	Direct
Protein kinase-like (PK-like)	0.00000006	Direct
DEATH domain	0.00000167	Direct
Glucocorticoid receptor-like (DNA-binding domain)	0.00002361	Direct
Nuclear receptor ligand-binding domain	0.0000391	Direct
p53-like transcription factors	0.0001991	Direct
Integrin domains	0.0008132	Direct
HLH, helix-loop-helix DNA-binding domain	0.002614	Inherited
Caspase-like	0.003611	Inherited
Homeodomain-like	0.005474	Inherited
SMAD MH1 domain	0.006443	Inherited
Integrin beta tail domain	0.01296	Inherited
HCP-like	0.01296	Inherited
E2F-DP heterodimerization region	0.01296	Inherited
Tudor/PWWP/MBT	0.01361	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.01574	Inherited
Integrin alpha N-terminal domain	0.02296	Inherited
BRCT domain	0.02296	Inherited
Calcium-dependent phosphotriesterase	0.02533	Inherited
Leucine zipper domain	0.02583	Inherited
Plexin repeat	0.02729	Inherited
Nucleic acid-binding proteins	0.02729	Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.02743	Inherited
Ran binding protein zinc finger-like	0.02743	Inherited
Cyclin-like	0.03735	Inherited
PAZ domain	0.04221	Inherited
WD40 repeat-like	0.04876	Inherited
RuvA domain 2-like	0.04893	Inherited
SAND domain-like	0.04893	Inherited
SMAD/FHA domain	0.05139	Inherited
DNA/RNA polymerases	0.06258	Inherited
STAT	0.07361	Inherited
Transcription factor STAT-4 N-domain	0.07361	Inherited
Flavoproteins	0.07361	Inherited
Putative DNA-binding domain	0.07361	Inherited
Bcl-2 inhibitors of programmed cell death	0.08889	Inherited
FnI-like domain	0.1053	Inherited
Galactose-binding domain-like	0.1064	Inherited
Cullin repeat-like	0.1252	Inherited
Growth factor receptor domain	0.128	Inherited
EGF/Laminin	0.1283	Inherited
(Trans)glycosidases	0.1644	Inherited
Sema domain	0.1702	Inherited
SH2 domain	0.1943	Inherited
DNA polymerase beta, N-terminal domain-like	0.2063	Inherited
Alkaline phosphatase-like	0.2068	Inherited
Riboflavin synthase domain-like	0.2207	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.2207	Inherited
DHS-like NAD/FAD-binding domain	0.2218	Inherited
Thioredoxin-like	0.2231	Inherited
Cystine-knot cytokines	0.23	Inherited
RNA-binding domain, RBD	0.2853	Inherited
SAM/Pointed domain	0.287	Inherited
Mitochondrial carrier	0.3134	Inherited
Rhodanese/Cell cycle control phosphatase	0.3445	Inherited
SET domain	0.3734	Inherited
RING/U-box	0.3893	Inherited
Cytokine	0.3951	Inherited
vWA-like	0.4326	Inherited
Toll/Interleukin receptor TIR domain	0.4363	Inherited
Arginase/deacetylase	0.4905	Inherited
Ras GEF	0.5508	Inherited
Fibronectin type III	0.6328	Inherited
PYP-like sensor domain (PAS domain)	0.6396	Inherited
Lipocalins	0.673	Inherited
Cadherin-like	0.7394	Inherited
FAD/NAD(P)-binding domain	0.8672	Inherited
F-box domain	0.8672	Inherited
SNARE fusion complex	0.8686	Inherited
Concanavalin A-like lectins/glucanases	0.8872	Inherited
BAR/IMD domain-like	0.9418	Inherited
C-type lectin-like	1	Inherited
Family A G protein-coupled receptor-like	1	Inherited
Complement control module/SCR domain	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Hedgehog (development protein), N-terminal signaling domain	0	Direct
Lamin A/C globular tail domain	0	Direct
Chromo barrel domain	0	Direct
CPH domain	0	Direct
Transcriptional factor tubby, C-terminal domain	0	Direct
DNA ligase/mRNA capping enzyme postcatalytic domain	0	Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	Direct
p53 DNA-binding domain-like	0	Direct
The spindle assembly checkpoint protein mad2	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
SCF ubiquitin ligase complex WHB domain	0	Direct
SMAD4-binding domain of oncoprotein Ski	0	Direct
RUNT domain	0	Direct
Polo-box duplicated region	0	Direct
Cullin homology domain	0	Direct
Extracellular domain of cell surface receptors	0	Direct
Rel/Dorsal transcription factors, DNA-binding domain	0	Direct
Hedgehog C-terminal (Hog) autoprocessing domain	0	Direct
Other IPT/TIG domains	0	Direct
beta-glycanases	0	Direct
DNA gyrase/MutL, second domain	0	Direct
Inhibitor of apoptosis (IAP) repeat	0	Direct
DNA gyrase/MutL, N-terminal domain	0	Direct
ATP-dependent DNA ligase catalytic domain	0	Direct
p53 tetramerization domain	0	Direct
XPF/Rad1/Mus81 nuclease	0	Direct
Serum paraoxonase/arylesterase 1, PON1	0	Direct
E2F dimerization segment	0	Direct
AN1-like Zinc finger	0	Direct
Retinoblastoma tumor suppressor domains	0	Direct
Cullin repeat	0	Direct
SRF-like	0	Direct
Cytochrome p450 reductase N-terminal domain-like	0	Direct
HMA, heavy metal-associated domain	0	Direct
U-box	0	Direct
DNA repair protein MutS, domain III	0	Direct
Protein kinases, catalytic subunit	0.000001991	Direct
Nuclear receptor	0.00002706	Direct
Nuclear receptor ligand-binding domain	0.000033	Direct
DEATH domain, DD	0.0001007	Direct
Caspase catalytic domain	0.000505	Direct
Integrin domains	0.000621	Direct
Caspase recruitment domain, CARD	0.001261	Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.001349	Inherited
Tandem AAA-ATPase domain	0.00196	Inherited
Cell cycle transcription factor e2f-dp	0.002267	Inherited
HLH, helix-loop-helix DNA-binding domain	0.002655	Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.004487	Inherited
SMAD MH1 domain	0.004735	Inherited
Integrin beta EGF-like domains	0.004735	Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain	0.004735	Inherited
SMAD domain	0.004735	Inherited
Erythroid transcription factor GATA-1	0.004735	Inherited
Glutathione peroxidase-like	0.006303	Inherited
Tudor domain	0.00808	Inherited
Integrin alpha N-terminal domain	0.00967	Inherited
Integrin beta tail domain	0.009722	Inherited
Single strand DNA-binding domain, SSB	0.009722	Inherited
Arylsulfatase	0.0185	Inherited
Insulin-like	0.0185	Inherited
Ran binding protein zinc finger-like	0.02243	Inherited
Leucine zipper domain	0.0235	Inherited
Plexin repeat	0.02398	Inherited
PAZ domain	0.03373	Inherited
UBA domain	0.03627	Inherited
NADPH-cytochrome p450 reductase-like	0.03869	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.03869	Inherited
Transforming growth factor (TGF)-beta	0.04697	Inherited
Homeodomain	0.05571	Inherited
STAT DNA-binding domain	0.06074	Inherited
Transcription factor STAT-4 N-domain	0.06074	Inherited
Sir2 family of transcriptional regulators	0.06074	Inherited
STAT	0.06074	Inherited
Forkhead DNA-binding domain	0.06404	Inherited
Bcl-2 inhibitors of programmed cell death	0.07492	Inherited
C5 cytosine-specific DNA methylase, DCM	0.07592	Inherited
Growth factor receptor domain	0.08641	Inherited
ets domain	0.09583	Inherited
Integrin A (or I) domain	0.1141	Inherited
Laminin-type module	0.1364	Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain	0.1375	Inherited
Sema domain	0.1586	Inherited
WW domain	0.1586	Inherited
Histone lysine methyltransferases	0.1797	Inherited
DNA polymerase beta, N-terminal domain-like	0.1821	Inherited
Laminin G-like module	0.1904	Inherited
VWC domain	0.1981	Inherited
SH2 domain	0.2003	Inherited
C2 set domains	0.2004	Inherited
Cell cycle control phosphatase, catalytic domain	0.2005	Inherited
EGF-type module	0.2533	Inherited
Histone deacetylase, HDAC	0.2872	Inherited
Enabled/VASP homology 1 domain (EVH1 domain)	0.2872	Inherited
RING finger domain, C3HC4	0.2909	Inherited
Mitochondrial carrier	0.2979	Inherited
FHA domain	0.2979	Inherited
Canonical RBD	0.3082	Inherited
Fibroblast growth factors (FGF)	0.36	Inherited
ABC transporter ATPase domain-like	0.4246	Inherited
I set domains	0.442	Inherited
Ephrin receptor ligand binding domain	0.4434	Inherited
Calponin-homology domain, CH-domain	0.4769	Inherited
Toll/Interleukin receptor TIR domain	0.5106	Inherited
Ras GEF	0.5662	Inherited
Tetratricopeptide repeat (TPR)	0.5667	Inherited
Fibronectin type III	0.6641	Inherited
Fatty acid binding protein-like	0.7047	Inherited
DBL homology domain (DH-domain)	0.711	Inherited
Cadherin	0.7608	Inherited
MAM domain	0.8044	Inherited
Long-chain cytokines	0.8044	Inherited
SNARE fusion complex	0.8608	Inherited
SAM (sterile alpha motif) domain	0.8789	Inherited
C-type lectin domain	1	Inherited
Rhodopsin-like	1	Inherited
Complement control module/SCR domain	1	Inherited

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Supra-domain (including individual superfamily)

(show details)

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Cullin homology domain	0	Direct
Tubby C-terminal domain-like	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Hedgehog/intein (Hint) domain	0	Direct
SRF-like	0	Direct
ATP-dependent DNA ligase DNA-binding domain	0	Direct
Polo-box domain	0	Direct
DNA ligase/mRNA capping enzyme, catalytic domain	0	Direct
The spindle assembly checkpoint protein mad2	0	Direct
Restriction endonuclease-like	0	Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	Direct
HMA, heavy metal-associated domain	0	Direct
DNA-glycosylase	0	Direct
Uracil-DNA glycosylase-like	0	Direct
AN1-like Zinc finger	0	Direct
Mss4-like	0	Direct
DNA repair protein MutS, domain II	0	Direct
p53 tetramerization domain	0	Direct
Hedgehog/DD-peptidase	0	Direct
Lamin A/C globular tail domain	0	Direct
Inhibitor of apoptosis (IAP) repeat	0	Direct
DNA repair protein MutS, domain III	0	Direct
Protein kinase-like (PK-like)	0.00000002328	Direct
DEATH domain	0.0000006872	Direct
Glucocorticoid receptor-like (DNA-binding domain)	0.00001073	Direct
Nuclear receptor ligand-binding domain	0.00001813	Direct
p53-like transcription factors	0.0001007	Direct
Integrin domains	0.0004396	Direct
HLH, helix-loop-helix DNA-binding domain	0.001503	Inherited
Caspase-like	0.002118	Inherited
"Winged helix" DNA-binding domain	0.003099	Inherited
Homeodomain-like	0.003292	Inherited
SMAD MH1 domain	0.003924	Inherited
Integrin beta tail domain	0.008239	Inherited
HCP-like	0.008239	Inherited
E2F-DP heterodimerization region	0.008239	Inherited
Tudor/PWWP/MBT	0.008696	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.01014	Inherited
dsRNA-binding domain-like	0.01092	Inherited
BRCT domain	0.01523	Inherited
Integrin alpha N-terminal domain	0.01523	Inherited
Insulin-like	0.0157	Inherited
Acyl-CoA N-acyltransferases (Nat)	0.01616	Inherited
Calcium-dependent phosphotriesterase	0.01694	Inherited
Leucine zipper domain	0.01731	Inherited
Plexin repeat	0.01837	Inherited
Nucleic acid-binding proteins	0.01837	Inherited
Ran binding protein zinc finger-like	0.01848	Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.01848	Inherited
Cyclin-like	0.0258	Inherited
PAZ domain	0.02943	Inherited
WD40 repeat-like	0.03437	Inherited
SAND domain-like	0.0345	Inherited
RuvA domain 2-like	0.0345	Inherited
SMAD/FHA domain	0.03635	Inherited
DNA/RNA polymerases	0.04526	Inherited
STAT	0.05405	Inherited
Flavoproteins	0.05405	Inherited
Putative DNA-binding domain	0.05405	Inherited
Transcription factor STAT-4 N-domain	0.05405	Inherited
Bcl-2 inhibitors of programmed cell death	0.06637	Inherited
FnI-like domain	0.07994	Inherited
Galactose-binding domain-like	0.08097	Inherited
Cullin repeat-like	0.09703	Inherited
Growth factor receptor domain	0.09942	Inherited
EGF/Laminin	0.09967	Inherited
(Trans)glycosidases	0.1313	Inherited
WW domain	0.1363	Inherited
Sema domain	0.1363	Inherited
SH2 domain	0.1581	Inherited
DNA polymerase beta, N-terminal domain-like	0.1689	Inherited
Alkaline phosphatase-like	0.1694	Inherited
Riboflavin synthase domain-like	0.1824	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.1824	Inherited
DHS-like NAD/FAD-binding domain	0.1835	Inherited
Thioredoxin-like	0.1847	Inherited
Cystine-knot cytokines	0.1911	Inherited
RNA-binding domain, RBD	0.2428	Inherited
SAM/Pointed domain	0.2445	Inherited
Mitochondrial carrier	0.2695	Inherited
Rhodanese/Cell cycle control phosphatase	0.2991	Inherited
SET domain	0.3274	Inherited
RING/U-box	0.3428	Inherited
Cytokine	0.3486	Inherited
vWA-like	0.3855	Inherited
Toll/Interleukin receptor TIR domain	0.3889	Inherited
Calponin-homology domain, CH-domain	0.4317	Inherited
Arginase/deacetylase	0.4427	Inherited
Ras GEF	0.504	Inherited
Fibronectin type III	0.5885	Inherited
PYP-like sensor domain (PAS domain)	0.5955	Inherited
Lipocalins	0.6308	Inherited
DBL homology domain (DH-domain)	0.6692	Inherited
Cadherin-like	0.7008	Inherited
FAD/NAD(P)-binding domain	0.8376	Inherited
F-box domain	0.8376	Inherited
SNARE fusion complex	0.8389	Inherited
Concanavalin A-like lectins/glucanases	0.8593	Inherited
BAR/IMD domain-like	0.9194	Inherited
Immunoglobulin	0.9961	Inherited
Complement control module/SCR domain	1	Inherited
Family A G protein-coupled receptor-like	1	Inherited
C-type lectin-like	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0	Direct
55166,51294 55166 - Hedgehog/DD-peptidase 51294 - Hedgehog/intein (Hint) domain	0	Direct
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	Direct
50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins	0	Direct
46579,64593 46579 - Prefoldin 64593 - Intermediate filament protein, coiled coil region	0	Direct
57196,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module	0	Direct
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0	Direct
100934,100934 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain	0	Direct
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	Direct
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain	0	Direct
46955,63763 46955 - Putative DNA-binding domain 63763 - SAND domain-like	0	Direct
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain	0	Direct
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	Direct
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain	0	Direct
53150,48334 53150 - DNA repair protein MutS, domain II 48334 - DNA repair protein MutS, domain III	0	Direct
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0	Direct
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain	0	Direct
48726,82895 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat	0	Direct
55874,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like	0	Direct
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain)	0	Direct
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.000222	Direct
63825,57196 63825 - YWTD domain 57196 - EGF/Laminin	0.001841	Inherited
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.006337	Inherited
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.006337	Inherited
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0.008239	Inherited
53300,69179 53300 - vWA-like 69179 - Integrin domains	0.008239	Inherited
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain	0.008239	Inherited
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like	0.008239	Inherited
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.008239	Inherited
52113,52113 52113 - BRCT domain 52113 - BRCT domain	0.008239	Inherited
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.008638	Inherited
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.01211	Inherited
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0.01694	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.02367	Inherited
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0.05405	Inherited
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0.05405	Inherited
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0.05405	Inherited
48452,81901 48452 - TPR-like 81901 - HCP-like	0.06923	Inherited
50729,55550 50729 - PH domain-like 55550 - SH2 domain	0.09703	Inherited
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain	0.1111	Inherited
101912,103575 101912 - Sema domain 103575 - Plexin repeat	0.1363	Inherited
49785,49899 49785 - Galactose-binding domain-like 49899 - Concanavalin A-like lectins/glucanases	0.1689	Inherited
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain)	0.1694	Inherited
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain	0.1805	Inherited
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0.1805	Inherited
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin	0.1824	Inherited
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain	0.415	Inherited
50729,50729 50729 - PH domain-like 50729 - PH domain-like	0.5382	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.5734	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.587	Inherited
48452,48452 48452 - TPR-like 48452 - TPR-like	0.599	Inherited
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.6242	Inherited
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0.7887	Inherited
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	1	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
101288,50156,50044 101288 - L27 domain 50156 - PDZ domain-like 50044 - SH3-domain	0	Direct
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like	0	Direct
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain	0	Direct
63825,57196,57424 63825 - YWTD domain 57196 - EGF/Laminin 57424 - LDL receptor-like module	0	Direct
57196,57424,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0	Direct
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	Direct
75399,75399,75399 75399 - Plakin repeat 75399 - Plakin repeat 75399 - Plakin repeat	0	Direct
48726,82895,82895 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat	0	Direct
53150,48334,52540 53150 - DNA repair protein MutS, domain II 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	Direct
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0	Direct
48726,48726,82895 48726 - Immunoglobulin 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat	0	Direct
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	Direct
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains	0.004965	Inherited
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.006337	Inherited
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.008239	Inherited
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like	0.008239	Inherited
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.0114	Inherited
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0.05405	Inherited
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0.05405	Inherited
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0.06923	Inherited
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.06923	Inherited
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain	0.09703	Inherited
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.1111	Inherited
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.1117	Inherited
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin	0.1824	Inherited
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0.2765	Inherited
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.3008	Inherited
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.3539	Inherited
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.523	Inherited
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like	0.7104	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Mammalian Phenotype (MP): cellular phenotype

Superfamily

Family

Supra-domain (including individual superfamily)