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Mammalian Phenotype (MP): abnormal cell physiology
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Chromo barrel domain | 0 | DIRECT |
| Transcriptional factor tubby, C-terminal domain | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| The spindle assembly checkpoint protein mad2 | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| SMAD4-binding domain of oncoprotein Ski | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| Other IPT/TIG domains | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| E2F dimerization segment | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| U-box | 0 | DIRECT |
| DEATH domain, DD | 0.00001174 | DIRECT |
| Integrin domains | 0.0001072 | DIRECT |
| Caspase catalytic domain | 0.0001641 | DIRECT |
| Caspase recruitment domain, CARD | 0.0003458 | DIRECT |
| Cell cycle transcription factor e2f-dp | 0.00093 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.001539 | INHERITED FROM: abnormal apoptosis |
| Integrin beta EGF-like domains | 0.002172 | INHERITED FROM: abnormal leukocyte migration |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.002172 | INHERITED FROM: decreased cell proliferation || abnormal chromosome stability || decreased fibroblast proliferation || chromosomal instability || spontaneous chromosome breakage || abnormal fibroblast proliferation |
| Erythroid transcription factor GATA-1 | 0.002172 | INHERITED FROM: abnormal fetal cardiomyocyte proliferation |
| Integrin alpha N-terminal domain | 0.002983 | INHERITED FROM: abnormal cell adhesion || abnormal cellular extravasation |
| Integrin beta tail domain | 0.004988 | INHERITED FROM: abnormal leukocyte migration |
| Single strand DNA-binding domain, SSB | 0.004988 | INHERITED FROM: abnormal chromosome stability || abnormal male germ cell apoptosis || chromosomal instability |
| Plexin repeat | 0.00582 | INHERITED FROM: abnormal cell migration || abnormal neuronal migration |
| Ran binding protein zinc finger-like | 0.009034 | INHERITED FROM: increased apoptosis || increased cell death |
| UBA domain | 0.01616 | INHERITED FROM: chromosomal instability |
| NADPH-cytochrome p450 reductase-like | 0.0246 | INHERITED FROM: abnormal kidney apoptosis || increased kidney apoptosis || increased apoptosis || increased cell death || abnormal apoptosis || increased renal tubule apoptosis |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.0246 | INHERITED FROM: abnormal kidney apoptosis || increased kidney apoptosis || increased apoptosis || increased cell death || abnormal apoptosis || increased renal tubule apoptosis |
| STAT DNA-binding domain | 0.03706 | INHERITED FROM: decreased cell proliferation || increased apoptosis || increased cell death || abnormal apoptosis |
| Transcription factor STAT-4 N-domain | 0.03706 | INHERITED FROM: decreased cell proliferation || increased apoptosis || increased cell death || abnormal apoptosis |
| Sir2 family of transcriptional regulators | 0.03706 | INHERITED FROM: increased sensitivity to induced cell death |
| STAT | 0.03706 | INHERITED FROM: decreased cell proliferation || increased apoptosis || increased cell death || abnormal apoptosis |
| ets domain | 0.04207 | INHERITED FROM: increased B cell apoptosis |
| Bcl-2 inhibitors of programmed cell death | 0.04389 | INHERITED FROM: decreased cell death || abnormal cell death || decreased apoptosis || abnormal T cell apoptosis || abnormal apoptosis |
| C5 cytosine-specific DNA methylase, DCM | 0.05336 | INHERITED FROM: abnormal DNA methylation || abnormal epigenetic regulation of gene expression |
| SH2 domain | 0.06676 | INHERITED FROM: abnormal cell differentiation || increased B cell apoptosis || abnormal B cell apoptosis |
| Sema domain | 0.07177 | INHERITED FROM: abnormal cell migration || abnormal neuronal migration |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.07816 | INHERITED FROM: abnormal vascular regression |
| EGF-type module | 0.07972 | INHERITED FROM: abnormal leukocyte adhesion |
| Leucine zipper domain | 0.09295 | INHERITED FROM: increased hepatocyte apoptosis |
| Histone lysine methyltransferases | 0.0951 | INHERITED FROM: abnormal epigenetic regulation of gene expression |
| HLH, helix-loop-helix DNA-binding domain | 0.1024 | INHERITED FROM: premature neuronal precursor differentiation || abnormal neuron differentiation || abnormal skeletal muscle satellite cell proliferation || abnormal cell differentiation || abnormal retinal apoptosis || abnormal neuronal precursor proliferation |
| RING finger domain, C3HC4 | 0.1193 | INHERITED FROM: chromosomal instability |
| Cell cycle control phosphatase, catalytic domain | 0.1294 | INHERITED FROM: abnormal small intestinal crypt cell proliferation || abnormal enterocyte differentiation || abnormal enterocyte apoptosis || increased enterocyte apoptosis |
| DNA polymerase beta, N-terminal domain-like | 0.1342 | INHERITED FROM: abnormal DNA repair |
| C2 set domains | 0.1349 | INHERITED FROM: abnormal cell chemotaxis |
| Homeodomain | 0.1701 | INHERITED FROM: abnormal neuron differentiation || abnormal cell differentiation |
| Mitochondrial carrier | 0.1779 | INHERITED FROM: abnormal mitochondrial physiology || abnormal cellular respiration |
| FHA domain | 0.1779 | INHERITED FROM: abnormal DNA repair || abnormal chromosome stability || chromosomal instability || increased cellular sensitivity to ionizing radiation |
| Forkhead DNA-binding domain | 0.1848 | INHERITED FROM: abnormal mesenchymal cell proliferation involved in lung development || abnormal pancreatic beta cell differentiation || decreased mesenchymal cell proliferation involved in lung development || abnormal radial glial cell morphology |
| Nuclear receptor | 0.1963 | INHERITED FROM: abnormal cellular cholesterol metabolism |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.2017 | INHERITED FROM: abnormal radial glial cell morphology |
| I set domains | 0.2089 | INHERITED FROM: increased granulosa cell apoptosis || decreased kidney cell proliferation |
| Fibroblast growth factors (FGF) | 0.223 | INHERITED FROM: abnormal cardiac neural crest cell migration |
| WW domain | 0.2826 | INHERITED FROM: increased cardiomyocyte apoptosis |
| Tudor domain | 0.3358 | INHERITED FROM: abnormal male germ cell apoptosis |
| Toll/Interleukin receptor TIR domain | 0.3532 | INHERITED FROM: abnormal splenocyte proliferation || decreased neuron apoptosis |
| Glutathione peroxidase-like | 0.3649 | INHERITED FROM: abnormal redox activity || abnormal mitochondrial physiology || increased cellular sensitivity to hydrogen peroxide || increased cellular sensitivity to oxidative stress || increased sensitivity to induced cell death |
| Calponin-homology domain, CH-domain | 0.3666 | INHERITED FROM: abnormal cell adhesion |
| Nuclear receptor ligand-binding domain | 0.3712 | INHERITED FROM: abnormal cellular cholesterol metabolism |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.3973 | INHERITED FROM: decreased cell proliferation |
| Ras GEF | 0.421 | INHERITED FROM: abnormal cell adhesion |
| Integrin A (or I) domain | 0.5092 | INHERITED FROM: abnormal cell adhesion || abnormal leukocyte migration |
| Tandem AAA-ATPase domain | 0.5328 | INHERITED FROM: chromosome breakage |
| Arylsulfatase | 0.5575 | INHERITED FROM: abnormal lysosome physiology |
| DBL homology domain (DH-domain) | 0.5981 | INHERITED FROM: abnormal vascular endothelial cell migration |
| Ephrin receptor ligand binding domain | 0.6074 | INHERITED FROM: abnormal axon pruning || abnormal axon guidance |
| Histone deacetylase, HDAC | 0.661 | INHERITED FROM: abnormal fibroblast apoptosis || increased fibroblast apoptosis |
| DNA repair protein MutS, domain III | 0.661 | INHERITED FROM: abnormal DNA repair || abnormal mismatch repair |
| Fibronectin type III | 0.6659 | INHERITED FROM: increased granulosa cell apoptosis || abnormal axon guidance |
| ABC transporter ATPase domain-like | 0.6777 | INHERITED FROM: decreased cholesterol efflux || abnormal cellular cholesterol metabolism || abnormal mismatch repair |
| MAM domain | 0.6997 | INHERITED FROM: abnormal neuronal migration |
| Long-chain cytokines | 0.6997 | INHERITED FROM: abnormal osteoclast differentiation |
| SNARE fusion complex | 0.7561 | INHERITED FROM: abnormal axon extension |
| SAM (sterile alpha motif) domain | 0.8241 | INHERITED FROM: abnormal axon pruning || abnormal axon guidance |
| Fatty acid binding protein-like | 0.9412 | INHERITED FROM: abnormal cellular glucose import || abnormal muscle cell glucose uptake |
| Canonical RBD | 0.9519 | INHERITED FROM: premature neuronal precursor differentiation |
| Transforming growth factor (TGF)-beta | 0.9959 | INHERITED FROM: abnormal anterior visceral endoderm cell migration || abnormal interdigital cell death |
| C-type lectin domain | 1 | INHERITED FROM: impaired leukocyte tethering or rolling |
| Rhodopsin-like | 1 | INHERITED FROM: abnormal leukocyte migration |
| Complement control module/SCR domain | 1 | INHERITED FROM: abnormal leukocyte tethering or rolling || impaired leukocyte tethering or rolling |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lamin A/C globular tail domain | 0 | Direct |
| Chromo barrel domain | 0 | Direct |
| Transcriptional factor tubby, C-terminal domain | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| The spindle assembly checkpoint protein mad2 | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| SMAD4-binding domain of oncoprotein Ski | 0 | Direct |
| RUNT domain | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| Other IPT/TIG domains | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| E2F dimerization segment | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| Cullin repeat | 0 | Direct |
| SRF-like | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| U-box | 0 | Direct |
| DEATH domain, DD | 0.00001174 | Direct |
| Integrin domains | 0.0001072 | Direct |
| Caspase catalytic domain | 0.0001641 | Direct |
| Caspase recruitment domain, CARD | 0.0003458 | Direct |
| Cell cycle transcription factor e2f-dp | 0.00093 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.001539 | Inherited |
| Integrin beta EGF-like domains | 0.002172 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.002172 | Inherited |
| Erythroid transcription factor GATA-1 | 0.002172 | Inherited |
| Integrin alpha N-terminal domain | 0.002983 | Inherited |
| Integrin beta tail domain | 0.004988 | Inherited |
| Single strand DNA-binding domain, SSB | 0.004988 | Inherited |
| Plexin repeat | 0.00582 | Inherited |
| Ran binding protein zinc finger-like | 0.009034 | Inherited |
| UBA domain | 0.01616 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.0246 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.0246 | Inherited |
| STAT DNA-binding domain | 0.03706 | Inherited |
| Transcription factor STAT-4 N-domain | 0.03706 | Inherited |
| Sir2 family of transcriptional regulators | 0.03706 | Inherited |
| STAT | 0.03706 | Inherited |
| ets domain | 0.04207 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.04389 | Inherited |
| C5 cytosine-specific DNA methylase, DCM | 0.05336 | Inherited |
| SH2 domain | 0.06676 | Inherited |
| Sema domain | 0.07177 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.07816 | Inherited |
| EGF-type module | 0.07972 | Inherited |
| Leucine zipper domain | 0.09295 | Inherited |
| Histone lysine methyltransferases | 0.0951 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1024 | Inherited |
| RING finger domain, C3HC4 | 0.1193 | Inherited |
| Cell cycle control phosphatase, catalytic domain | 0.1294 | Inherited |
| DNA polymerase beta, N-terminal domain-like | 0.1342 | Inherited |
| C2 set domains | 0.1349 | Inherited |
| Homeodomain | 0.1701 | Inherited |
| Mitochondrial carrier | 0.1779 | Inherited |
| FHA domain | 0.1779 | Inherited |
| Forkhead DNA-binding domain | 0.1848 | Inherited |
| Nuclear receptor | 0.1963 | Inherited |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.2017 | Inherited |
| I set domains | 0.2089 | Inherited |
| Fibroblast growth factors (FGF) | 0.223 | Inherited |
| WW domain | 0.2826 | Inherited |
| Tudor domain | 0.3358 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.3532 | Inherited |
| Glutathione peroxidase-like | 0.3649 | Inherited |
| Calponin-homology domain, CH-domain | 0.3666 | Inherited |
| Nuclear receptor ligand-binding domain | 0.3712 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.3973 | Inherited |
| Ras GEF | 0.421 | Inherited |
| Integrin A (or I) domain | 0.5092 | Inherited |
| Tandem AAA-ATPase domain | 0.5328 | Inherited |
| Arylsulfatase | 0.5575 | Inherited |
| DBL homology domain (DH-domain) | 0.5981 | Inherited |
| Ephrin receptor ligand binding domain | 0.6074 | Inherited |
| Histone deacetylase, HDAC | 0.661 | Inherited |
| DNA repair protein MutS, domain III | 0.661 | Inherited |
| Fibronectin type III | 0.6659 | Inherited |
| ABC transporter ATPase domain-like | 0.6777 | Inherited |
| MAM domain | 0.6997 | Inherited |
| Long-chain cytokines | 0.6997 | Inherited |
| SNARE fusion complex | 0.7561 | Inherited |
| SAM (sterile alpha motif) domain | 0.8241 | Inherited |
| Fatty acid binding protein-like | 0.9412 | Inherited |
| Canonical RBD | 0.9519 | Inherited |
| Transforming growth factor (TGF)-beta | 0.9959 | Inherited |
| C-type lectin domain | 1 | Inherited |
| Rhodopsin-like | 1 | Inherited |
| Complement control module/SCR domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this MP term (SPMP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0 | DIRECT |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
46955,63763
46955 - Putative DNA-binding domain
63763 - SAND domain-like | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
48726,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.00002404 | DIRECT |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.0007288 | DIRECT |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.001911 | INHERITED FROM: abnormal cellular extravasation || abnormal cell adhesion |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.001911 | INHERITED FROM: abnormal cellular extravasation || abnormal cell adhesion |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.004106 | INHERITED FROM: abnormal cell cycle || decreased cell proliferation |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.004106 | INHERITED FROM: abnormal leukocyte migration |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.004106 | INHERITED FROM: abnormal leukocyte migration |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0.004106 | INHERITED FROM: increased cellular sensitivity to ionizing radiation || abnormal chromosome stability || increased sensitivity to induced cell death || abnormal cell cycle || abnormal DNA repair || chromosome breakage || chromosomal instability |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.005024 | INHERITED FROM: decreased neuron apoptosis |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.0095 | INHERITED FROM: abnormal cell death || abnormal apoptosis |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.03222 | INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis || decreased cell proliferation |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.03222 | INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis || decreased cell proliferation |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.03222 | INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis || decreased cell proliferation |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.05787 | INHERITED FROM: abnormal neuronal migration || abnormal cell migration |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.06396 | INHERITED FROM: abnormal cell differentiation |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.06978 | INHERITED FROM: abnormal cell adhesion |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0.1146 | INHERITED FROM: abnormal neuronal migration || abnormal cell migration |
49785,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0.1226 | INHERITED FROM: abnormal neuronal migration || abnormal cell migration |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0.1247 | INHERITED FROM: abnormal axon guidance |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.1323 | INHERITED FROM: abnormal cell adhesion |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.2612 | INHERITED FROM: abnormal cell differentiation || increased granulosa cell apoptosis || decreased kidney cell proliferation || abnormal cell migration |
50729,50729
50729 - PH domain-like
50729 - PH domain-like | 0.3726 | INHERITED FROM: abnormal cellular glucose import |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.451 | INHERITED FROM: abnormal vascular regression |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.4678 | INHERITED FROM: abnormal vascular endothelial cell migration |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.5903 | INHERITED FROM: abnormal neural crest cell migration |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0.5903 | INHERITED FROM: abnormal axon guidance || abnormal axon pruning |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5903 | INHERITED FROM: abnormal neural crest cell migration |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.6452 | INHERITED FROM: abnormal mismatch repair || abnormal DNA repair |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.9687 | INHERITED FROM: increased cellular sensitivity to ionizing radiation |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.9976 | INHERITED FROM: abnormal leukocyte adhesion || impaired leukocyte tethering or rolling || abnormal leukocyte tethering or rolling || abnormal cellular extravasation |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0 | Direct |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
46955,63763
46955 - Putative DNA-binding domain
63763 - SAND domain-like | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
48726,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.00002404 | Direct |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.0007288 | Direct |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.001911 | Inherited |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.001911 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.004106 | Inherited |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.004106 | Inherited |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.004106 | Inherited |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0.004106 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.005024 | Inherited |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.0095 | Inherited |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.03222 | Inherited |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.03222 | Inherited |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.03222 | Inherited |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.05787 | Inherited |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.06396 | Inherited |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.06978 | Inherited |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0.1146 | Inherited |
49785,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0.1226 | Inherited |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0.1247 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.1323 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.2612 | Inherited |
50729,50729
50729 - PH domain-like
50729 - PH domain-like | 0.3726 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.451 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.4678 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.5903 | Inherited |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0.5903 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5903 | Inherited |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.6452 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.9687 | Inherited |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.9976 | Inherited |
(show details)
Supra-domains annotated to this MP term (SPMP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
48726,82895,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
48726,48726,82895
48726 - Immunoglobulin
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.001559 | INHERITED FROM: abnormal cellular extravasation || abnormal cell adhesion |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.001911 | INHERITED FROM: abnormal cellular extravasation || abnormal cell adhesion |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.004106 | INHERITED FROM: abnormal leukocyte migration |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.03222 | INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis || decreased cell proliferation |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.03222 | INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis || decreased cell proliferation |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.04793 | INHERITED FROM: abnormal cell differentiation |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.04793 | INHERITED FROM: abnormal cell differentiation |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.04913 | INHERITED FROM: abnormal neuron differentiation |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.06978 | INHERITED FROM: abnormal cell adhesion |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0.1146 | INHERITED FROM: abnormal neuronal migration || abnormal cell migration |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1511 | INHERITED FROM: abnormal kidney cell proliferation || abnormal cell differentiation || decreased kidney cell proliferation |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.5439 | INHERITED FROM: abnormal neuron proliferation |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5903 | INHERITED FROM: abnormal neural crest cell migration |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.7048 | INHERITED FROM: decreased cell death || decreased apoptosis |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
48726,82895,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
48726,48726,82895
48726 - Immunoglobulin
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.001559 | Inherited |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.001911 | Inherited |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.004106 | Inherited |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.03222 | Inherited |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.03222 | Inherited |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.04793 | Inherited |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.04793 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.04913 | Inherited |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.06978 | Inherited |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0.1146 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1511 | Inherited |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.5439 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5903 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.7048 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
