Mammalian Phenotype (MP): abnormal leukocyte morphology

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + 4: mammalian phenotype [MP:0000001] <29>

+ + + 3: hematopoietic system phenotype [MP:0005397] <2> (72|102) (78|63|30)

+ + + 3: immune system phenotype [MP:0005387] <2> (76|114) (86|66|35)

+ + 2: abnormal hematopoietic system morphology/development [MP:0002396] <5> (58|86) (66|47|21)

+ + 2: abnormal immune system morphology [MP:0000685] <3> (51|76) (60|35|18)

+ 1: abnormal immune system cell morphology [MP:0000716] <5> (38|63) (48|29|16)

+ 1: abnormal hematopoietic cell morphology [MP:0013656] <9> (49|77) (60|43|18)

0: abnormal leukocyte morphology [MP:0008246] <4> (37|62) (47|29|15)

- 1: abnormal leukocyte cell number [MP:0000217] <8> (29|49) (37|25|12)

- 1: abnormal dendritic cell morphology [MP:0005461] <4> (2|4) (2|1|0)

- 1: abnormal mononuclear cell morphology [MP:0008247] <2> (34|57) (41|28|14)

- 1: abnormal myeloid leukocyte morphology [MP:0008250] <2> (11|24) (16|10|2)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
SPOC domain-like	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
PsbU/PolX domain-like	0	Direct
TNF receptor-like	0.000000009813	Direct
p53-like transcription factors	0.0002378	Direct
DEATH domain	0.002106	Inherited
L30e-like	0.002305	Inherited
SH2 domain	0.002424	Inherited
DNA polymerase beta, N-terminal domain-like	0.005761	Inherited
Flavoproteins	0.006722	Inherited
Immunoglobulin	0.007693	Inherited
Toll/Interleukin receptor TIR domain	0.01207	Inherited
Terpenoid cyclases/Protein prenyltransferases	0.0131	Inherited
Triple coiled coil domain of C-type lectins	0.01766	Inherited
Ran binding protein zinc finger-like	0.02047	Inherited
Bcl-2 inhibitors of programmed cell death	0.03057	Inherited
E2F-DP heterodimerization region	0.03935	Inherited
SET domain	0.1148	Inherited
BRCT domain	0.1358	Inherited
Nuclear receptor ligand-binding domain	0.2163	Inherited
TIMP-like	0.2257	Inherited
DNA/RNA polymerases	0.2316	Inherited
Cysteine-rich domain	0.2725	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.3162	Inherited
Riboflavin synthase domain-like	0.3677	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.3677	Inherited
Integrin alpha N-terminal domain	0.4102	Inherited
Integrin domains	0.4208	Inherited
DBL homology domain (DH-domain)	0.4208	Inherited
Nucleotidyltransferase	0.4429	Inherited
Calponin-homology domain, CH-domain	0.4987	Inherited
SMAD/FHA domain	0.5136	Inherited
MHC antigen-recognition domain	0.5136	Inherited
WWE domain	0.5241	Inherited
SH3-domain	0.5706	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Proteasome subunits	0	Direct
STAT DNA-binding domain	0	Direct
RUNT domain	0	Direct
DNA polymerase beta-like	0	Direct
BAFF receptor-like	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
C5 cytosine-specific DNA methylase, DCM	0	Direct
STAT	0	Direct
Interleukin 17F, IL-17F	0	Direct
DNA polymerase beta-like, second domain	0	Direct
TNF receptor-like	0.0000000574	Direct
Rel/Dorsal transcription factors, DNA-binding domain	0.0001491	Direct
Pyrin domain, PYD	0.0003307	Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.001134	Inherited
SH2 domain	0.001475	Inherited
DEATH domain, DD	0.002329	Inherited
ets domain	0.002849	Inherited
Interleukin-1 (IL-1)	0.003958	Inherited
DNA polymerase beta, N-terminal domain-like	0.003958	Inherited
Pointed domain	0.004729	Inherited
Tissue inhibitor of metalloproteinases, TIMP	0.01284	Inherited
Triple coiled coil domain of C-type lectins	0.01284	Inherited
Cytochrome p450 reductase N-terminal domain-like	0.01284	Inherited
E2F dimerization segment	0.01362	Inherited
Ran binding protein zinc finger-like	0.01564	Inherited
Toll/Interleukin receptor TIR domain	0.01796	Inherited
Bcl-2 inhibitors of programmed cell death	0.02335	Inherited
Interferon regulatory factor	0.02335	Inherited
NADPH-cytochrome p450 reductase-like	0.03724	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.03724	Inherited
Nuclear receptor coactivator interlocking domain	0.03724	Inherited
Tetraspanin	0.03724	Inherited
V set domains (antibody variable domain-like)	0.05143	Inherited
DNA polymerase I	0.07288	Inherited
Cell cycle transcription factor e2f-dp	0.0843	Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain	0.1172	Inherited
C1 set domains (antibody constant domain-like)	0.1554	Inherited
MATH domain	0.1611	Inherited
Nuclear receptor ligand-binding domain	0.1823	Inherited
Nuclear receptor	0.1823	Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.1912	Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0.2097	Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases	0.2162	Inherited
Interferons/interleukin-10 (IL-10)	0.2769	Inherited
Long-chain cytokines	0.2769	Inherited
Short-chain cytokines	0.3225	Inherited
CCCH zinc finger	0.334	Inherited
C2 set domains	0.334	Inherited
DBL homology domain (DH-domain)	0.3791	Inherited
Integrin domains	0.3791	Inherited
Phoshoinositide 3-kinase (PI3K) helical domain	0.4014	Inherited
Caspase recruitment domain, CARD	0.4016	Inherited
FHA domain	0.4465	Inherited
MHC antigen-recognition domain	0.4727	Inherited
Calponin-homology domain, CH-domain	0.4805	Inherited
beta-glycanases	0.4831	Inherited
WWE domain	0.4831	Inherited
SH3-domain	0.5297	Inherited
Pleckstrin-homology domain (PH domain)	0.559	Inherited
Myb/SANT domain	0.6912	Inherited
PLC-like (P variant)	0.7006	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
SPOC domain-like	0	Direct
PsbU/PolX domain-like	0	Direct
STAT	0	Direct
Transcription factor STAT-4 N-domain	0	Direct
TNF receptor-like	0.000000003714	Direct
p53-like transcription factors	0.0001207	Direct
DEATH domain	0.0012	Inherited
L30e-like	0.001318	Inherited
SH2 domain	0.001389	Inherited
DNA polymerase beta, N-terminal domain-like	0.003472	Inherited
Flavoproteins	0.004105	Inherited
Immunoglobulin	0.004725	Inherited
Toll/Interleukin receptor TIR domain	0.00764	Inherited
Terpenoid cyclases/Protein prenyltransferases	0.008329	Inherited
Triple coiled coil domain of C-type lectins	0.01149	Inherited
Ran binding protein zinc finger-like	0.01347	Inherited
NAD kinase/diacylglycerol kinase-like	0.01551	Inherited
Bcl-2 inhibitors of programmed cell death	0.02083	Inherited
E2F-DP heterodimerization region	0.02725	Inherited
Nuclear receptor coactivator interlocking domain	0.03416	Inherited
TNF-like	0.04914	Inherited
SET domain	0.08818	Inherited
BRCT domain	0.1064	Inherited
Nuclear receptor ligand-binding domain	0.1784	Inherited
TIMP-like	0.1872	Inherited
DNA/RNA polymerases	0.1926	Inherited
C-type lectin-like	0.1938	Inherited
Cysteine-rich domain	0.2308	Inherited
(Trans)glycosidases	0.2374	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.2721	Inherited
Riboflavin synthase domain-like	0.3219	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.3219	Inherited
CCCH zinc finger	0.328	Inherited
Integrin alpha N-terminal domain	0.3635	Inherited
DBL homology domain (DH-domain)	0.3739	Inherited
Integrin domains	0.3739	Inherited
Protein kinase-like (PK-like)	0.3862	Inherited
Nucleotidyltransferase	0.3953	Inherited
Calponin-homology domain, CH-domain	0.451	Inherited
SMAD/FHA domain	0.4662	Inherited
MHC antigen-recognition domain	0.4662	Inherited
WWE domain	0.4766	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.4795	Inherited
SH3-domain	0.5243	Inherited
Acyl-CoA N-acyltransferases (Nat)	0.7494	Inherited
beta-beta-alpha zinc fingers	0.7828	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0	Direct
47802,81585 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like	0	Direct
81585,81301 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase	0	Direct
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0	Direct
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0	Direct
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain)	0	Direct
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.0000002598	Direct
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.0001209	Direct
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.0006103	Direct
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0.0009977	Direct
50729,55550 50729 - PH domain-like 55550 - SH2 domain	0.0009977	Direct
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0.001318	Inherited
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.003782	Inherited
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain	0.01149	Inherited
57944,56436 57944 - Triple coiled coil domain of C-type lectins 56436 - C-type lectin-like	0.01149	Inherited
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0.02725	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.04769	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.06871	Inherited
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.09515	Inherited
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like	0.1572	Inherited
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.2749	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.3739	Inherited
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain	0.3953	Inherited
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0.3953	Inherited
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.3953	Inherited
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.4167	Inherited
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.4167	Inherited
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.704	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50729,50044,55550 50729 - PH domain-like 50044 - SH3-domain 55550 - SH2 domain	0	Direct
47802,81585,81301 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase	0	Direct
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0	Direct
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0	Direct
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0	Direct
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0	Direct
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain	0	Direct
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	Direct
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.002504	Inherited
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0.01149	Inherited
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.166	Inherited
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.2054	Inherited
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.3953	Inherited
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.3953	Inherited
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.4167	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Mammalian Phenotype (MP): abnormal leukocyte morphology

Superfamily

Family

Supra-domain (including individual superfamily)