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Mammalian Phenotype (MP): preweaning lethality
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Tricorn protease domain 2 | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| Roadblock/LC7 domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Protein prenylyltransferase | 0 | DIRECT |
| DNA clamp | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| E2F-DP heterodimerization region | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| Mob1/phocein | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| Nucleic acid-binding proteins | 0.000002879 | DIRECT |
| Homeodomain-like | 0.0007594 | DIRECT |
| SCOP hierarchy in SUPERFAMILY | 0.01305 | INHERITED FROM: embryonic lethality prior to organogenesis |
| GAT-like domain | 0.03739 | INHERITED FROM: neonatal lethality, incomplete penetrance || postnatal lethality |
| TB module/8-cys domain | 0.06343 | INHERITED FROM: lethality throughout fetal growth and development, incomplete penetrance |
| GroEL apical domain-like | 0.06684 | INHERITED FROM: embryonic lethality between implantation and placentation |
| Growth factor receptor domain | 0.0988 | INHERITED FROM: perinatal lethality |
| HCP-like | 0.1031 | INHERITED FROM: embryonic lethality during organogenesis, incomplete penetrance |
| Terpenoid synthases | 0.1175 | INHERITED FROM: preweaning lethality, complete penetrance |
| "Winged helix" DNA-binding domain | 0.1225 | INHERITED FROM: prenatal lethality |
| ARM repeat | 0.1527 | INHERITED FROM: embryonic lethality |
| BRCT domain | 0.2551 | INHERITED FROM: embryonic lethality prior to tooth bud stage || embryonic lethality prior to organogenesis |
| Flavoproteins | 0.2752 | INHERITED FROM: prenatal lethality, incomplete penetrance |
| L27 domain | 0.2864 | INHERITED FROM: neonatal lethality, complete penetrance |
| p53-like transcription factors | 0.3205 | INHERITED FROM: embryonic lethality during organogenesis, complete penetrance || embryonic lethality, incomplete penetrance || lethality throughout fetal growth and development, complete penetrance |
| HLH, helix-loop-helix DNA-binding domain | 0.3529 | INHERITED FROM: lethality during fetal growth through weaning || postnatal lethality || perinatal lethality |
| dsRNA-binding domain-like | 0.3537 | INHERITED FROM: embryonic lethality prior to organogenesis |
| Protein kinase-like (PK-like) | 0.419 | INHERITED FROM: lethality throughout fetal growth and development |
| EGF/Laminin | 0.5638 | INHERITED FROM: lethality during fetal growth through weaning || perinatal lethality |
| ADC-like | 0.7383 | INHERITED FROM: preweaning lethality, complete penetrance || embryonic lethality prior to tooth bud stage || embryonic lethality prior to organogenesis |
| Subtilisin-like | 0.8867 | INHERITED FROM: embryonic lethality prior to organogenesis |
| Cullin homology domain | 0.8867 | INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and somite formation |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Paired domain | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Chromo barrel domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| L-aspartase/fumarase | 0 | DIRECT |
| Pointed domain | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Ribonuclease PH domain 1-like | 0 | DIRECT |
| SMAD4-binding domain of oncoprotein Ski | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Neurotrophin | 0 | DIRECT |
| Adenosine/AMP deaminase | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| L domain | 0 | DIRECT |
| Mob1/phocein | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| Fumble-like | 0 | DIRECT |
| Roadblock/LC7 domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| Mib/herc2 domain | 0 | DIRECT |
| gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
| E2F dimerization segment | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| SIAH, seven in absentia homolog | 0 | DIRECT |
| U-box | 0 | DIRECT |
| Cell cycle transcription factor e2f-dp | 0 | DIRECT |
| Histone lysine methyltransferases | 0.00001669 | DIRECT |
| T-box | 0.0002477 | DIRECT |
| Homeodomain | 0.0007651 | DIRECT |
| ZZ domain | 0.008342 | INHERITED FROM: postnatal lethality, incomplete penetrance |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.008342 | INHERITED FROM: postnatal lethality, incomplete penetrance || prenatal lethality |
| Erythroid transcription factor GATA-1 | 0.008342 | INHERITED FROM: lethality during fetal growth through weaning || embryonic lethality during organogenesis || embryonic lethality during organogenesis, complete penetrance |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.01603 | INHERITED FROM: embryonic lethality || embryonic lethality prior to organogenesis |
| Growth factor receptor domain | 0.01675 | INHERITED FROM: perinatal lethality |
| RecA protein-like (ATPase-domain) | 0.02655 | INHERITED FROM: embryonic lethality || prenatal lethality |
| Inhibitor of apoptosis (IAP) repeat | 0.0291 | INHERITED FROM: embryonic lethality |
| Tandem AAA-ATPase domain | 0.02927 | INHERITED FROM: preweaning lethality, complete penetrance || embryonic lethality prior to organogenesis |
| TB module/8-cys domain | 0.05178 | INHERITED FROM: lethality throughout fetal growth and development, incomplete penetrance |
| NADPH-cytochrome p450 reductase-like | 0.0539 | INHERITED FROM: prenatal lethality, incomplete penetrance |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.0539 | INHERITED FROM: prenatal lethality, incomplete penetrance |
| Extracellular domain of cell surface receptors | 0.0698 | INHERITED FROM: embryonic lethality between implantation and placentation || embryonic lethality between implantation and somite formation, complete penetrance || lethality throughout fetal growth and development, complete penetrance || embryonic lethality between implantation and somite formation |
| GAT domain | 0.09853 | INHERITED FROM: neonatal lethality, incomplete penetrance |
| C5 cytosine-specific DNA methylase, DCM | 0.09853 | INHERITED FROM: embryonic lethality, complete penetrance |
| HMA, heavy metal-associated domain | 0.09853 | INHERITED FROM: postnatal lethality, incomplete penetrance |
| Laminin G-like module | 0.1345 | INHERITED FROM: perinatal lethality |
| Proprotein convertase P-domain | 0.1416 | INHERITED FROM: embryonic lethality prior to tooth bud stage || embryonic lethality prior to organogenesis |
| Prohormone convertase 1 pro-domain | 0.1416 | INHERITED FROM: embryonic lethality prior to tooth bud stage || embryonic lethality prior to organogenesis |
| DNA polymerase I | 0.1416 | INHERITED FROM: embryonic lethality between implantation and placentation || embryonic lethality prior to tooth bud stage || embryonic lethality prior to organogenesis |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.1675 | INHERITED FROM: preweaning lethality, complete penetrance |
| ets domain | 0.1774 | INHERITED FROM: lethality throughout fetal growth and development, complete penetrance |
| Forkhead DNA-binding domain | 0.2063 | INHERITED FROM: lethality during fetal growth through weaning |
| Adenain-like | 0.2269 | INHERITED FROM: prenatal lethality, complete penetrance |
| Linker histone H1/H5 | 0.2634 | INHERITED FROM: embryonic lethality between implantation and somite formation, incomplete penetrance || prenatal lethality, incomplete penetrance || prenatal lethality, complete penetrance |
| L27 domain | 0.2634 | INHERITED FROM: neonatal lethality, complete penetrance |
| HLH, helix-loop-helix DNA-binding domain | 0.2978 | INHERITED FROM: lethality during fetal growth through weaning || postnatal lethality |
| N-acetyl transferase, NAT | 0.4055 | INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance |
| Protein kinases, catalytic subunit | 0.4876 | INHERITED FROM: lethality throughout fetal growth and development |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.5573 | INHERITED FROM: embryonic lethality between implantation and placentation, complete penetrance |
| Subtilases | 0.5838 | INHERITED FROM: embryonic lethality prior to tooth bud stage || embryonic lethality prior to organogenesis |
| Blood coagulation inhibitor (disintegrin) | 0.589 | INHERITED FROM: perinatal lethality, incomplete penetrance |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.5898 | INHERITED FROM: lethality during fetal growth through weaning, incomplete penetrance |
| SCF ubiquitin ligase complex WHB domain | 0.6399 | INHERITED FROM: embryonic lethality between implantation and placentation || embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and somite formation |
| Extended AAA-ATPase domain | 0.8273 | INHERITED FROM: embryonic lethality prior to tooth bud stage || embryonic lethality before implantation, complete penetrance || embryonic lethality prior to organogenesis |
| Cullin homology domain | 0.8612 | INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and somite formation |
| Armadillo repeat | 0.9112 | INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and somite formation |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Paired domain | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Chromo barrel domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| L-aspartase/fumarase | 0 | Direct |
| Pointed domain | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Ribonuclease PH domain 1-like | 0 | Direct |
| SMAD4-binding domain of oncoprotein Ski | 0 | Direct |
| DNA ligase | 0 | Direct |
| RUNT domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Neurotrophin | 0 | Direct |
| Adenosine/AMP deaminase | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| L domain | 0 | Direct |
| Mob1/phocein | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| Fumble-like | 0 | Direct |
| Roadblock/LC7 domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| SMAD domain | 0 | Direct |
| Mib/herc2 domain | 0 | Direct |
| gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
| E2F dimerization segment | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| SRF-like | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| SIAH, seven in absentia homolog | 0 | Direct |
| U-box | 0 | Direct |
| Cell cycle transcription factor e2f-dp | 0 | Direct |
| Histone lysine methyltransferases | 0.00001669 | Direct |
| T-box | 0.0002477 | Direct |
| Homeodomain | 0.0007651 | Direct |
| ZZ domain | 0.008342 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.008342 | Inherited |
| Erythroid transcription factor GATA-1 | 0.008342 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.01603 | Inherited |
| Growth factor receptor domain | 0.01675 | Inherited |
| RecA protein-like (ATPase-domain) | 0.02655 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.0291 | Inherited |
| Tandem AAA-ATPase domain | 0.02927 | Inherited |
| TB module/8-cys domain | 0.05178 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.0539 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.0539 | Inherited |
| Extracellular domain of cell surface receptors | 0.0698 | Inherited |
| GAT domain | 0.09853 | Inherited |
| C5 cytosine-specific DNA methylase, DCM | 0.09853 | Inherited |
| HMA, heavy metal-associated domain | 0.09853 | Inherited |
| Laminin G-like module | 0.1345 | Inherited |
| Proprotein convertase P-domain | 0.1416 | Inherited |
| Prohormone convertase 1 pro-domain | 0.1416 | Inherited |
| DNA polymerase I | 0.1416 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.1675 | Inherited |
| ets domain | 0.1774 | Inherited |
| Forkhead DNA-binding domain | 0.2063 | Inherited |
| Adenain-like | 0.2269 | Inherited |
| Linker histone H1/H5 | 0.2634 | Inherited |
| L27 domain | 0.2634 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.2978 | Inherited |
| N-acetyl transferase, NAT | 0.4055 | Inherited |
| Protein kinases, catalytic subunit | 0.4876 | Inherited |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.5573 | Inherited |
| Subtilases | 0.5838 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.589 | Inherited |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.5898 | Inherited |
| SCF ubiquitin ligase complex WHB domain | 0.6399 | Inherited |
| Extended AAA-ATPase domain | 0.8273 | Inherited |
| Cullin homology domain | 0.8612 | Inherited |
| Armadillo repeat | 0.9112 | Inherited |
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A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| DNA clamp | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| Roadblock/LC7 domain | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| Protein prenylyltransferase | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Mob1/phocein | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| E2F-DP heterodimerization region | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| Nucleic acid-binding proteins | 0.000001213 | DIRECT |
| Homeodomain-like | 0.0004083 | DIRECT |
| HMG-box | 0.0007285 | DIRECT |
| GAT-like domain | 0.02582 | INHERITED FROM: postnatal lethality || neonatal lethality || neonatal lethality, incomplete penetrance |
| TB module/8-cys domain | 0.04596 | INHERITED FROM: lethality throughout fetal growth and development, incomplete penetrance |
| GroEL apical domain-like | 0.04863 | INHERITED FROM: embryonic lethality between implantation and placentation |
| Growth factor receptor domain | 0.07449 | INHERITED FROM: perinatal lethality || perinatal lethality, complete penetrance |
| Orange domain-like | 0.07802 | INHERITED FROM: postnatal lethality, incomplete penetrance |
| HCP-like | 0.07802 | INHERITED FROM: embryonic lethality during organogenesis, incomplete penetrance |
| Inhibitor of apoptosis (IAP) repeat | 0.07802 | INHERITED FROM: lethality throughout fetal growth and development |
| Terpenoid synthases | 0.09051 | INHERITED FROM: preweaning lethality, complete penetrance |
| HMA, heavy metal-associated domain | 0.09051 | INHERITED FROM: postnatal lethality, incomplete penetrance |
| "Winged helix" DNA-binding domain | 0.0947 | INHERITED FROM: prenatal lethality |
| ARM repeat | 0.1211 | INHERITED FROM: prenatal lethality || embryonic lethality |
| BRCT domain | 0.2144 | INHERITED FROM: embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage |
| Flavoproteins | 0.2335 | INHERITED FROM: prenatal lethality, incomplete penetrance |
| Acyl-CoA N-acyltransferases (Nat) | 0.2345 | INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance |
| L27 domain | 0.244 | INHERITED FROM: neonatal lethality, complete penetrance |
| p53-like transcription factors | 0.2764 | INHERITED FROM: lethality throughout fetal growth and development, complete penetrance || embryonic lethality during organogenesis, complete penetrance || embryonic lethality, incomplete penetrance |
| HLH, helix-loop-helix DNA-binding domain | 0.3075 | INHERITED FROM: postnatal lethality || lethality during fetal growth through weaning || perinatal lethality |
| dsRNA-binding domain-like | 0.3082 | INHERITED FROM: embryonic lethality prior to organogenesis |
| Protein kinase-like (PK-like) | 0.3721 | INHERITED FROM: lethality throughout fetal growth and development |
| EGF/Laminin | 0.5173 | INHERITED FROM: lethality during fetal growth through weaning || perinatal lethality |
| Blood coagulation inhibitor (disintegrin) | 0.5575 | INHERITED FROM: perinatal lethality, incomplete penetrance |
| Riboflavin synthase domain-like | 0.6584 | INHERITED FROM: prenatal lethality, incomplete penetrance |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.6584 | INHERITED FROM: prenatal lethality, incomplete penetrance |
| ADC-like | 0.6996 | INHERITED FROM: preweaning lethality, complete penetrance || embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage |
| Cullin homology domain | 0.8587 | INHERITED FROM: embryonic lethality between implantation and somite formation || embryonic lethality between implantation and somite formation, complete penetrance |
| Subtilisin-like | 0.8587 | INHERITED FROM: embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage |
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57903,63748
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
57184,82895
57184 - Growth factor receptor domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0 | DIRECT |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
63748,82199
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | DIRECT |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
46955,63763
46955 - Putative DNA-binding domain
63763 - SAND domain-like | 0 | DIRECT |
49562,51045
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
51045 - WW domain | 0 | DIRECT |
50729,50156
50729 - PH domain-like
50156 - PDZ domain-like | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
82199,57903
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.007025 | INHERITED FROM: perinatal lethality, incomplete penetrance |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.01347 | INHERITED FROM: perinatal lethality, complete penetrance |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.01347 | INHERITED FROM: perinatal lethality, complete penetrance |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0.02582 | INHERITED FROM: lethality throughout fetal growth and development, incomplete penetrance |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0.02582 | INHERITED FROM: postnatal lethality || neonatal lethality || neonatal lethality, incomplete penetrance |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.02582 | INHERITED FROM: lethality throughout fetal growth and development, incomplete penetrance |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.02582 | INHERITED FROM: perinatal lethality, incomplete penetrance |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.07802 | INHERITED FROM: postnatal lethality, incomplete penetrance |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.09051 | INHERITED FROM: neonatal lethality, complete penetrance |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0.1304 | INHERITED FROM: embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1334 | INHERITED FROM: embryonic lethality prior to organogenesis |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1535 | INHERITED FROM: embryonic lethality, complete penetrance |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.2125 | INHERITED FROM: lethality throughout fetal growth and development, complete penetrance || lethality throughout fetal growth and development |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.2335 | INHERITED FROM: perinatal lethality, incomplete penetrance |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0.2335 | INHERITED FROM: neonatal lethality, complete penetrance |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.3376 | INHERITED FROM: lethality throughout fetal growth and development, incomplete penetrance |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0.5322 | INHERITED FROM: embryonic lethality prior to organogenesis || embryonic lethality between implantation and somite formation || embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality prior to tooth bud stage |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.5575 | INHERITED FROM: perinatal lethality, incomplete penetrance |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0.6391 | INHERITED FROM: prenatal lethality, incomplete penetrance |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0.6391 | INHERITED FROM: embryonic lethality between implantation and somite formation || embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and placentation |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0.6996 | INHERITED FROM: embryonic lethality, complete penetrance |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57903,63748
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT | 0 | Direct |
57184,82895
57184 - Growth factor receptor domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0 | Direct |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | Direct |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
63748,82199
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | Direct |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
46955,63763
46955 - Putative DNA-binding domain
63763 - SAND domain-like | 0 | Direct |
49562,51045
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
51045 - WW domain | 0 | Direct |
50729,50156
50729 - PH domain-like
50156 - PDZ domain-like | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
82199,57903
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | Direct |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.007025 | Inherited |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.01347 | Inherited |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.01347 | Inherited |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0.02582 | Inherited |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0.02582 | Inherited |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.02582 | Inherited |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.02582 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.07802 | Inherited |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.09051 | Inherited |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0.1304 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1334 | Inherited |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1535 | Inherited |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.2125 | Inherited |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.2335 | Inherited |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0.2335 | Inherited |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.3376 | Inherited |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0.5322 | Inherited |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.5575 | Inherited |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0.6391 | Inherited |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0.6391 | Inherited |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0.6996 | Inherited |
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | DIRECT |
63748,63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0 | DIRECT |
49265,48726,49265
49265 - Fibronectin type III
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
57196,57196,63825
57196 - EGF/Laminin
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
50729,50156,50156
50729 - PH domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
57184,49899,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
63748,82199,57903
63748 - Tudor/PWWP/MBT
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
54928,54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0 | DIRECT |
57903,63748,82199
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | DIRECT |
57424,57196,57196
57424 - LDL receptor-like module
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57196,57196,49899
57196 - EGF/Laminin
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.000219 | DIRECT |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.0009017 | DIRECT |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.02582 | INHERITED FROM: neonatal lethality |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.02582 | INHERITED FROM: neonatal lethality |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04863 | INHERITED FROM: lethality throughout fetal growth and development, incomplete penetrance |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.04863 | INHERITED FROM: lethality throughout fetal growth and development, incomplete penetrance |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.07802 | INHERITED FROM: lethality throughout fetal growth and development, incomplete penetrance |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0.1304 | INHERITED FROM: embryonic lethality prior to organogenesis || embryonic lethality prior to tooth bud stage |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1535 | INHERITED FROM: embryonic lethality, complete penetrance |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1535 | INHERITED FROM: embryonic lethality, complete penetrance |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.2125 | INHERITED FROM: lethality throughout fetal growth and development, complete penetrance || lethality throughout fetal growth and development |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.3697 | INHERITED FROM: lethality during fetal growth through weaning |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | Direct |
63748,63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | Direct |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0 | Direct |
49265,48726,49265
49265 - Fibronectin type III
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
57196,57196,63825
57196 - EGF/Laminin
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
50729,50156,50156
50729 - PH domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
57184,49899,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
63748,82199,57903
63748 - Tudor/PWWP/MBT
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | Direct |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
54928,54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0 | Direct |
57903,63748,82199
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | Direct |
57424,57196,57196
57424 - LDL receptor-like module
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57196,57196,49899
57196 - EGF/Laminin
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.000219 | Direct |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.0009017 | Direct |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.02582 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.02582 | Inherited |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04863 | Inherited |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.04863 | Inherited |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.07802 | Inherited |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0.1304 | Inherited |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1535 | Inherited |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1535 | Inherited |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.2125 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.3697 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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