SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from supfam.org. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal exocrine gland morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   endocrine/exocrine gland phenotype [MP:0005379] <2>(51|81) (55|36|12)
+ 1:   abnormal gland morphology [MP:0002163] <8>(44|71) (50|31|11)
0:   abnormal exocrine gland morphology [MP:0013558] <13>(18|22) (19|13|8)
- 1:   abnormal gastric gland morphology [MP:0003892] <11>(0|0) (0|0|0)
- 1:   abnormal lacrimal gland morphology [MP:0001346] <11>(0|0) (0|0|0)
- 1:   abnormal mucous gland morphology [MP:0014032] <9>(1|1) (1|1|0)
- 1:   abnormal exocrine pancreas morphology [MP:0005220] <5>(2|2) (2|0|0)
- 1:   abnormal crypts of Lieberkuhn morphology [MP:0000490] <4>(3|2) (3|0|0)
- 1:   abnormal male accessory sex gland morphology [MP:0013330] <4>(1|0) (1|1|0)
- 1:   abnormal merocrine gland morphology [MP:0013544] <3>(2|2) (2|1|0)
- 1:   abnormal nasal gland morphology [MP:0013580] <2>(0|0) (0|0|0)
- 1:   abnormal serous gland morphology [MP:0008052] <2>(0|0) (0|0|0)
- 1:   abnormal sweat gland morphology [MP:0000674] <2>(0|0) (0|0|0)
- 1:   abnormal apocrine gland morphology [MP:0013554] <1>(11|15) (12|11|5)
- 1:   abnormal holocrine gland morphology [MP:0013543] <1>(2|2) (3|2|3)
- 1:   abnormal olfactory gland morphology [MP:0012067](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
p53 tetramerization domain0Direct
Notch domain0.0001418Direct
Band 7/SPFH domain0.01366Inherited
HLH, helix-loop-helix DNA-binding domain0.01917Inherited
STAT0.02212Inherited
Transcription factor STAT-4 N-domain0.02212Inherited
EGF/Laminin0.03879Inherited
Rhodanese/Cell cycle control phosphatase0.05857Inherited
4-helical cytokines0.06189Inherited
Homeodomain-like0.119Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1329Inherited
Intermediate filament protein, coiled coil region0.1436Inherited
RING/U-box0.1456Inherited
p53-like transcription factors0.1543Inherited
Nuclear receptor ligand-binding domain0.185Inherited
Nuclear receptor coactivator interlocking domain0.192Inherited
Immunoglobulin0.8549Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Retinoblastoma tumor suppressor domains0Direct
Notch domain0.0001048Direct
EGF-type module0.01746Inherited
STAT DNA-binding domain0.01806Inherited
Transcription factor STAT-4 N-domain0.01806Inherited
L domain0.01806Inherited
STAT0.01806Inherited
HLH, helix-loop-helix DNA-binding domain0.01986Inherited
Cell cycle control phosphatase, catalytic domain0.04896Inherited
Long-chain cytokines0.1011Inherited
Nuclear receptor0.1139Inherited
Intermediate filament protein, coiled coil region0.1454Inherited
Homeodomain0.1595Inherited
Nuclear receptor coactivator interlocking domain0.1743Inherited
Nuclear receptor ligand-binding domain0.1869Inherited
FHA domain0.2313Inherited
I set domains0.2423Inherited
Short-chain cytokines0.2835Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Notch domain0.00007062Direct
Band 7/SPFH domain0.008728Inherited
HLH, helix-loop-helix DNA-binding domain0.01253Inherited
STAT0.01463Inherited
Transcription factor STAT-4 N-domain0.01463Inherited
EGF/Laminin0.02685Inherited
Rhodanese/Cell cycle control phosphatase0.04205Inherited
4-helical cytokines0.04472Inherited
Homeodomain-like0.09173Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1037Inherited
Intermediate filament protein, coiled coil region0.1131Inherited
RING/U-box0.1148Inherited
p53-like transcription factors0.1225Inherited
Nuclear receptor ligand-binding domain0.1498Inherited
Nuclear receptor coactivator interlocking domain0.1561Inherited
SH2 domain0.3945Inherited
Immunoglobulin0.824Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.00058Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01463Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.01463Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01463Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01463Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01463Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03063Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03271Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.04472Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.08736Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1404Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2947Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01463Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01463Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01463Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03063Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.06375Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1644Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2543Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)