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Mammalian Phenotype (MP): abnormal hematopoietic cell morphology
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (Not in SDMP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| STAT DNA-binding domain | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| DNA polymerase beta-like | 0 | DIRECT |
| BAFF receptor-like | 0 | DIRECT |
| beta-glycanases | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Interleukin 17F, IL-17F | 0 | DIRECT |
| DNA polymerase beta-like, second domain | 0 | DIRECT |
| TNF receptor-like | 0.000002164 | DIRECT |
| Short-chain cytokines | 0.000002237 | DIRECT |
| Interleukin 8-like chemokines | 0.0001338 | DIRECT |
| ARID domain | 0.0005415 | DIRECT |
| Integrin domains | 0.000609 | DIRECT |
| Integrin beta tail domain | 0.001511 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
| Interferons/interleukin-10 (IL-10) | 0.002569 | INHERITED FROM: decreased erythroid progenitor cell number || abnormal phagocyte morphology |
| Integrin beta EGF-like domains | 0.006358 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.006358 | INHERITED FROM: abnormal reticulocyte cell number || increased myeloid cell number || abnormal erythroid lineage cell morphology || reticulocytosis |
| Pleckstrin-homology domain (PH domain) | 0.009424 | INHERITED FROM: decreased transitional stage B cell number || abnormal B-1 B cell number |
| Notch domain | 0.01104 | INHERITED FROM: extramedullary hematopoiesis || increased hematopoietic cell number |
| Interleukin-1 (IL-1) | 0.01104 | INHERITED FROM: abnormal neutrophil morphology || abnormal neutrophil cell number || increased neutrophil cell number || abnormal granulocyte morphology || increased granulocyte number |
| DNA polymerase beta, N-terminal domain-like | 0.01104 | INHERITED FROM: abnormal lymphocyte cell number || abnormal B cell morphology || abnormal immunoglobulin V(D)J recombination || decreased lymphocyte cell number || decreased leukocyte cell number || abnormal hemopoiesis || abnormal lymphopoiesis || abnormal definitive hematopoiesis || abnormal leukopoiesis || abnormal B cell differentiation |
| Myb/SANT domain | 0.01208 | INHERITED FROM: abnormal common lymphocyte progenitor cell morphology || increased megakaryocyte cell number || abnormal megakaryocyte morphology || arrested B cell differentiation |
| Pointed domain | 0.01515 | INHERITED FROM: abnormal lymphocyte cell number || decreased thymocyte number || decreased lymphocyte cell number || decreased leukocyte cell number || thrombocytopenia || abnormal mature B cell morphology || abnormal B cell differentiation |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.01515 | INHERITED FROM: abnormal CD4-positive, alpha beta T cell number || abnormal neutrophil cell number || abnormal CD8-positive, alpha-beta T cell number || increased neutrophil cell number || abnormal alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell morphology || abnormal CD8-positive, alpha beta T cell morphology || abnormal effector T cell morphology || increased granulocyte number |
| C2 set domains | 0.01629 | INHERITED FROM: abnormal monocyte morphology |
| AraD-like aldolase/epimerase | 0.02831 | INHERITED FROM: abnormal erythrocyte morphology || abnormal mean corpuscular volume || abnormal myeloid cell number || decreased mean corpuscular volume || abnormal reticulocyte morphology || decreased hematocrit || abnormal hematocrit || abnormal reticulocyte cell number || increased myeloid cell number || reticulocytosis || spherocytosis |
| Tissue inhibitor of metalloproteinases, TIMP | 0.02831 | INHERITED FROM: abnormal granulocyte number || abnormal neutrophil morphology || abnormal neutrophil cell number || increased neutrophil cell number || abnormal granulocyte morphology || abnormal phagocyte morphology || increased granulocyte number |
| Triple coiled coil domain of C-type lectins | 0.02831 | INHERITED FROM: abnormal macrophage morphology || abnormal phagocyte morphology || abnormal mononuclear phagocyte morphology || abnormal monocyte cell number || abnormal monocyte morphology |
| Cytochrome p450 reductase N-terminal domain-like | 0.02831 | INHERITED FROM: abnormal macrophage morphology || abnormal macrophage cell number || increased macrophage cell number || abnormal phagocyte morphology || abnormal osteoclast cell number || abnormal osteoclast morphology || abnormal mononuclear phagocyte morphology || increased osteoclast cell number |
| Noncollagenous (NC1) domain of collagen IV | 0.03465 | INHERITED FROM: abnormal erythrocyte morphology || decreased hemoglobin content || abnormal hemoglobin || abnormal hemoglobin content || decreased myeloid cell number || decreased hematocrit || decreased erythrocyte cell number || abnormal erythroid lineage cell morphology |
| WWE domain | 0.03465 | INHERITED FROM: abnormal marginal zone B cell morphology || decreased mature B cell number || decreased marginal zone B cell number || abnormal mature B cell number |
| E2F dimerization segment | 0.03465 | INHERITED FROM: abnormal alpha-beta T cell morphology || abnormal lymphopoiesis || abnormal leukopoiesis || abnormal T cell differentiation || abnormal T cell number || decreased double-positive T cell number |
| Erythroid transcription factor GATA-1 | 0.03473 | INHERITED FROM: abnormal erythrocyte morphology || decreased erythrocyte cell number || abnormal erythroid lineage cell morphology |
| A DNA-binding domain in eukaryotic transcription factors | 0.06138 | INHERITED FROM: abnormal megakaryocyte morphology || thrombocytopenia |
| Ran binding protein zinc finger-like | 0.06138 | INHERITED FROM: abnormal B-1a B cell morphology || abnormal B cell morphology || abnormal B cell number || decreased B-1a cell number || abnormal mature B cell morphology || decreased B cell number || abnormal B-1 B cell number |
| Interferon regulatory factor | 0.06397 | INHERITED FROM: decreased dendritic cell number || decreased T cell number || decreased mature B cell number || increased lymphocyte cell number || decreased plasmacytoid dendritic cell number || abnormal mature B cell number || abnormal plasmacytoid dendritic cell number || abnormal plasmacytoid dendritic cell morphology || abnormal T cell number |
| NADPH-cytochrome p450 reductase-like | 0.07685 | INHERITED FROM: abnormal macrophage morphology || abnormal macrophage cell number || increased macrophage cell number || abnormal osteoclast cell number || abnormal osteoclast morphology || increased osteoclast cell number |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.07685 | INHERITED FROM: abnormal macrophage morphology || abnormal macrophage cell number || increased macrophage cell number || abnormal osteoclast cell number || abnormal osteoclast morphology || increased osteoclast cell number |
| Nuclear receptor coactivator interlocking domain | 0.07685 | INHERITED FROM: increased T cell number |
| Tetraspanin | 0.07685 | INHERITED FROM: abnormal macrophage morphology |
| Toll/Interleukin receptor TIR domain | 0.08159 | INHERITED FROM: increased mature B cell number || decreased mature B cell number || abnormal B-1 B cell number |
| CCCH zinc finger | 0.08623 | INHERITED FROM: increased mature B cell number |
| V set domains (antibody variable domain-like) | 0.08653 | INHERITED FROM: abnormal T-helper 17 cell number || abnormal definitive hematopoiesis || abnormal B-1 B cell number || abnormal T-helper 17 cell morphology |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.102 | INHERITED FROM: abnormal megakaryocyte progenitor cell morphology || abnormal megakaryocyte morphology || abnormal bone marrow hematopoietic cell morphology |
| SH3-domain | 0.115 | INHERITED FROM: decreased single-positive T cell number || abnormal CD8-positive, alpha-beta T cell differentiation |
| Eps15 homology domain (EH domain) | 0.1405 | INHERITED FROM: abnormal hemoglobin || abnormal mean corpuscular hemoglobin |
| Cyclin | 0.1486 | INHERITED FROM: abnormal hematopoietic stem cell morphology || abnormal common myeloid progenitor cell morphology || decreased hematopoietic stem cell number || decreased erythrocyte cell number |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.165 | INHERITED FROM: abnormal hemoglobin content |
| Cell cycle transcription factor e2f-dp | 0.1767 | INHERITED FROM: abnormal T cell differentiation || decreased double-positive T cell number |
| SH2 domain | 0.1899 | INHERITED FROM: decreased thymocyte number || abnormal hemopoiesis || abnormal lymphopoiesis || abnormal pre-B cell morphology || decreased single-positive T cell number || arrested B cell differentiation || abnormal definitive hematopoiesis || increased lymphocyte cell number || decreased immature B cell number || abnormal immature B cell number || abnormal leukopoiesis || abnormal B-1 B cell number |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.2143 | INHERITED FROM: abnormal dendritic cell morphology || decreased dendritic cell number || absent lymphocyte || decreased mature B cell number || increased B cell number || decreased plasmacytoid dendritic cell number || abnormal dendritic cell number || abnormal plasmacytoid dendritic cell number || absent B cells || abnormal plasmacytoid dendritic cell morphology || abnormal B cell differentiation |
| PLC-like (P variant) | 0.2358 | INHERITED FROM: abnormal platelet calcium level || abnormal platelet dense granule morphology || decreased B-2 B cell number || abnormal definitive hematopoiesis || abnormal leukopoiesis || abnormal B-1 B cell number |
| C1 set domains (antibody constant domain-like) | 0.2548 | INHERITED FROM: abnormal mononuclear cell morphology || absent CD8-positive, alpha-beta T cells || abnormal leukocyte cell number |
| DBL homology domain (DH-domain) | 0.2566 | INHERITED FROM: abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number || abnormal transitional stage B cell morphology |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.2974 | INHERITED FROM: decreased thymocyte number || abnormal positive T cell selection |
| MHC antigen-recognition domain | 0.3214 | INHERITED FROM: abnormal mononuclear cell morphology || abnormal T cell morphology || absent CD8-positive, alpha-beta T cells || abnormal T cell number |
| DEATH domain, DD | 0.3214 | INHERITED FROM: abnormal lymphocyte cell number || increased transitional stage B cell number || abnormal mononuclear cell morphology || abnormal B-1 B cell number |
| ets domain | 0.3738 | INHERITED FROM: abnormal hematopoietic stem cell morphology || decreased thymocyte number || decreased pro-B cell number || abnormal definitive hematopoiesis |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.5133 | INHERITED FROM: abnormal B-2 B cell morphology || abnormal follicular B cell morphology || increased mature B cell number || abnormal immature B cell number |
| FHA domain | 0.5293 | INHERITED FROM: abnormal class switch recombination |
| Ankyrin repeat | 0.5477 | INHERITED FROM: extramedullary hematopoiesis |
| Long-chain cytokines | 0.5477 | INHERITED FROM: abnormal osteoclast differentiation |
| Pyrin domain, PYD | 0.592 | INHERITED FROM: abnormal neutrophil morphology || abnormal neutrophil cell number || abnormal leukocyte cell number || abnormal granulocyte morphology || abnormal leukocyte morphology || abnormal hematopoietic cell number |
| Calponin-homology domain, CH-domain | 0.5954 | INHERITED FROM: abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number |
| Bcl-2 inhibitors of programmed cell death | 0.639 | INHERITED FROM: abnormal immature B cell morphology || increased pre-B cell number || decreased mature B cell number || abnormal lymphopoiesis || abnormal pre-B cell morphology || abnormal immature B cell number || abnormal leukopoiesis || abnormal mature B cell number || abnormal T cell differentiation || abnormal T cell number |
| Caspase recruitment domain, CARD | 0.6896 | INHERITED FROM: abnormal follicular B cell morphology |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.7736 | INHERITED FROM: abnormal lymphocyte cell number || abnormal CD4-positive, alpha beta T cell number || abnormal neutrophil cell number || decreased lymphocyte cell number || abnormal T cell morphology || decreased leukocyte cell number || abnormal CD8-positive, alpha-beta T cell number || abnormal phagocyte morphology || abnormal CD4-positive, alpha beta T cell morphology || abnormal CD8-positive, alpha beta T cell morphology || decreased hematopoietic cell number || abnormal lymphocyte morphology || abnormal T cell number |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.7736 | INHERITED FROM: abnormal lymphocyte cell number || abnormal B cell morphology || abnormal macrophage cell number || abnormal dendritic cell morphology || decreased dendritic cell number || abnormal mononuclear cell morphology || abnormal B cell number || decreased lymphocyte cell number || abnormal T cell morphology || decreased leukocyte cell number || decreased T cell number || abnormal blood cell morphology || abnormal leukocyte cell number || abnormal mature B cell morphology || abnormal phagocyte morphology || abnormal definitive hematopoiesis || abnormal osteoclast cell number || decreased CD8-positive, alpha-beta T cell number || abnormal dendritic cell number || abnormal leukopoiesis || decreased hematopoietic cell number || abnormal lymphocyte morphology || increased leukocyte cell number || decreased CD4-positive, alpha beta T cell number || abnormal B-1 B cell number || abnormal T cell number || increased hematopoietic cell number |
| Nuclear receptor ligand-binding domain | 0.8045 | INHERITED FROM: abnormal macrophage cell number || abnormal phagocyte morphology |
| Nuclear receptor | 0.8045 | INHERITED FROM: abnormal macrophage cell number || abnormal phagocyte morphology |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.8057 | INHERITED FROM: abnormal lymphocyte cell number || abnormal B cell morphology || decreased dendritic cell number || abnormal mononuclear cell morphology || abnormal B cell number || decreased lymphocyte cell number || abnormal T cell morphology || decreased leukocyte cell number || decreased T cell number || abnormal blood cell morphology || abnormal leukocyte cell number || abnormal mature B cell morphology || abnormal phagocyte morphology || abnormal definitive hematopoiesis || abnormal osteoclast cell number || abnormal leukocyte morphology || decreased CD8-positive, alpha-beta T cell number || abnormal leukopoiesis || decreased hematopoietic cell number || abnormal lymphocyte morphology || abnormal hematopoietic cell number || increased leukocyte cell number || decreased CD4-positive, alpha beta T cell number || abnormal B-1 B cell number || abnormal T cell number || increased hematopoietic cell number |
| MATH domain | 0.9278 | INHERITED FROM: abnormal immature B cell morphology || abnormal immature B cell number |
| DNA polymerase I | 0.9534 | INHERITED FROM: abnormal B cell differentiation |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| STAT DNA-binding domain | 0 | Direct |
| RUNT domain | 0 | Direct |
| DNA polymerase beta-like | 0 | Direct |
| BAFF receptor-like | 0 | Direct |
| beta-glycanases | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| STAT | 0 | Direct |
| Interleukin 17F, IL-17F | 0 | Direct |
| DNA polymerase beta-like, second domain | 0 | Direct |
| TNF receptor-like | 0.000002164 | Direct |
| Short-chain cytokines | 0.000002237 | Direct |
| Interleukin 8-like chemokines | 0.0001338 | Direct |
| ARID domain | 0.0005415 | Direct |
| Integrin domains | 0.000609 | Direct |
| Integrin beta tail domain | 0.001511 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.002569 | Inherited |
| Integrin beta EGF-like domains | 0.006358 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.006358 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.009424 | Inherited |
| Notch domain | 0.01104 | Inherited |
| Interleukin-1 (IL-1) | 0.01104 | Inherited |
| DNA polymerase beta, N-terminal domain-like | 0.01104 | Inherited |
| Myb/SANT domain | 0.01208 | Inherited |
| Pointed domain | 0.01515 | Inherited |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.01515 | Inherited |
| C2 set domains | 0.01629 | Inherited |
| AraD-like aldolase/epimerase | 0.02831 | Inherited |
| Tissue inhibitor of metalloproteinases, TIMP | 0.02831 | Inherited |
| Triple coiled coil domain of C-type lectins | 0.02831 | Inherited |
| Cytochrome p450 reductase N-terminal domain-like | 0.02831 | Inherited |
| Noncollagenous (NC1) domain of collagen IV | 0.03465 | Inherited |
| WWE domain | 0.03465 | Inherited |
| E2F dimerization segment | 0.03465 | Inherited |
| Erythroid transcription factor GATA-1 | 0.03473 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.06138 | Inherited |
| Ran binding protein zinc finger-like | 0.06138 | Inherited |
| Interferon regulatory factor | 0.06397 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.07685 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.07685 | Inherited |
| Nuclear receptor coactivator interlocking domain | 0.07685 | Inherited |
| Tetraspanin | 0.07685 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.08159 | Inherited |
| CCCH zinc finger | 0.08623 | Inherited |
| V set domains (antibody variable domain-like) | 0.08653 | Inherited |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.102 | Inherited |
| SH3-domain | 0.115 | Inherited |
| Eps15 homology domain (EH domain) | 0.1405 | Inherited |
| Cyclin | 0.1486 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.165 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.1767 | Inherited |
| SH2 domain | 0.1899 | Inherited |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.2143 | Inherited |
| PLC-like (P variant) | 0.2358 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.2548 | Inherited |
| DBL homology domain (DH-domain) | 0.2566 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.2974 | Inherited |
| MHC antigen-recognition domain | 0.3214 | Inherited |
| DEATH domain, DD | 0.3214 | Inherited |
| ets domain | 0.3738 | Inherited |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.5133 | Inherited |
| FHA domain | 0.5293 | Inherited |
| Ankyrin repeat | 0.5477 | Inherited |
| Long-chain cytokines | 0.5477 | Inherited |
| Pyrin domain, PYD | 0.592 | Inherited |
| Calponin-homology domain, CH-domain | 0.5954 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.639 | Inherited |
| Caspase recruitment domain, CARD | 0.6896 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.7736 | Inherited |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.7736 | Inherited |
| Nuclear receptor ligand-binding domain | 0.8045 | Inherited |
| Nuclear receptor | 0.8045 | Inherited |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.8057 | Inherited |
| MATH domain | 0.9278 | Inherited |
| DNA polymerase I | 0.9534 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
 |
Plot tree as:
| |
Download Newick format tree:
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(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47802,81585
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like | 0 | DIRECT |
81585,81301
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
49562,51045
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
51045 - WW domain | 0 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.000000381 | DIRECT |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.0000008753 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.000004963 | DIRECT |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.001274 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.001274 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.003154 | INHERITED FROM: absent mast cells |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.003584 | INHERITED FROM: abnormal myeloid leukocyte morphology || increased hematopoietic cell number || abnormal lymphocyte morphology || abnormal lymphocyte cell number || abnormal definitive hematopoiesis || abnormal blood cell morphology || abnormal leukocyte morphology || abnormal leukocyte cell number || abnormal CD4-positive, alpha beta T cell number || abnormal phagocyte morphology || abnormal macrophage morphology || abnormal myeloid cell morphology || increased leukocyte cell number || abnormal mononuclear cell morphology |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.003584 | INHERITED FROM: abnormal mature B cell morphology || abnormal megakaryocyte morphology || abnormal leukopoiesis || abnormal monocyte morphology || abnormal lymphocyte morphology || abnormal erythroid lineage cell morphology || abnormal neutrophil morphology || abnormal hematopoietic stem cell morphology || abnormal definitive hematopoiesis || abnormal blood cell morphology || abnormal leukocyte morphology || abnormal B cell number || decreased B cell number || abnormal neutrophil cell number || abnormal mononuclear cell morphology || abnormal bone marrow hematopoietic cell morphology || increased neutrophil cell number || abnormal hemopoiesis || increased lymphocyte cell number |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.005466 | INHERITED FROM: decreased leukocyte cell number || decreased T cell number || abnormal T cell number || abnormal leukopoiesis || abnormal lymphocyte morphology || abnormal lymphocyte cell number || abnormal lymphopoiesis || abnormal alpha-beta T cell morphology || decreased lymphocyte cell number || abnormal double-positive T cell morphology || abnormal definitive hematopoiesis || abnormal blood cell morphology || abnormal leukocyte cell number || decreased hematopoietic cell number || abnormal T cell differentiation || abnormal T cell morphology || abnormal mononuclear cell morphology || abnormal hemopoiesis |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.01328 | INHERITED FROM: abnormal CD8-positive, alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell morphology || abnormal neutrophil morphology || abnormal alpha-beta T cell morphology || increased granulocyte number || abnormal CD4-positive, alpha beta T cell number || abnormal alpha-beta T cell number || abnormal CD8-positive, alpha beta T cell morphology || abnormal neutrophil cell number || abnormal effector T cell morphology || increased neutrophil cell number |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.01673 | INHERITED FROM: decreased T cell number |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.01673 | INHERITED FROM: decreased T cell number |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.02582 | INHERITED FROM: extramedullary hematopoiesis |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0.02582 | INHERITED FROM: abnormal leukopoiesis || abnormal lymphopoiesis |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.02582 | INHERITED FROM: abnormal monocyte cell number || abnormal monocyte morphology || abnormal phagocyte morphology || abnormal mononuclear phagocyte morphology || abnormal macrophage morphology |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.03113 | INHERITED FROM: increased alpha-beta T cell number || increased CD8-positive, alpha-beta T cell number || decreased CD4-positive, alpha beta T cell number |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.05429 | INHERITED FROM: abnormal common myeloid progenitor cell morphology || decreased hematopoietic stem cell number || decreased myeloid cell number || abnormal hematopoietic stem cell morphology || abnormal definitive hematopoiesis || decreased erythrocyte cell number || abnormal hemopoiesis |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.0655 | INHERITED FROM: decreased double-positive T cell number || abnormal leukopoiesis || abnormal lymphopoiesis || abnormal alpha-beta T cell morphology || abnormal T cell differentiation |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.07692 | INHERITED FROM: abnormal hemoglobin content || abnormal hemoglobin |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.09271 | INHERITED FROM: thrombocytopenia || abnormal megakaryocyte morphology |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1251 | INHERITED FROM: decreased hemoglobin content || abnormal hemoglobin |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0.1312 | INHERITED FROM: abnormal hemoglobin |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1642 | INHERITED FROM: abnormal hemoglobin content |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.1788 | INHERITED FROM: abnormal transitional stage T2 B cell morphology || decreased transitional stage B cell number || increased transitional stage B cell number || abnormal transitional stage B cell morphology || increased transitional stage T1 B cell number || decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.277 | INHERITED FROM: abnormal immature B cell number || abnormal immature B cell morphology |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.3287 | INHERITED FROM: abnormal T cell number || absent CD8-positive, alpha-beta T cells || abnormal leukocyte cell number || abnormal T cell morphology || abnormal mononuclear cell morphology |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.5488 | INHERITED FROM: decreased DN2 thymocyte number |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.5756 | INHERITED FROM: decreased follicular B cell number || decreased double-negative T cell number || abnormal transitional stage T2 B cell morphology || abnormal immature B cell number || decreased single-positive T cell number || abnormal B-1 B cell number || decreased transitional stage B cell number || increased transitional stage B cell number || increased hematopoietic cell number || abnormal lymphocyte morphology || abnormal transitional stage B cell morphology || decreased mature B cell number || abnormal lymphocyte cell number || abnormal alpha-beta T cell morphology || increased immature B cell number || abnormal follicular B cell morphology || abnormal double-negative T cell morphology || abnormal mature B cell number || decreased immature B cell number || abnormal CD4-positive, alpha beta T cell number || abnormal immature B cell morphology || abnormal effector T cell morphology || increased leukocyte cell number || arrested B cell differentiation || increased lymphocyte cell number |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.6235 | INHERITED FROM: abnormal CD8-positive, alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell morphology || abnormal CD4-positive, alpha beta T cell number || abnormal CD8-positive, alpha beta T cell morphology || increased neutrophil cell number |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.6235 | INHERITED FROM: abnormal common myeloid progenitor cell morphology || abnormal hematopoietic stem cell morphology |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.6814 | INHERITED FROM: abnormal definitive hematopoiesis || increased megakaryocyte cell number |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.7588 | INHERITED FROM: abnormal myeloid leukocyte morphology || abnormal leukocyte morphology || abnormal phagocyte morphology || abnormal macrophage morphology || abnormal macrophage cell number |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.7911 | INHERITED FROM: decreased leukocyte cell number || decreased T cell number || abnormal T cell number || abnormal hematopoietic cell number || abnormal mature B cell morphology || abnormal B-1 B cell number || abnormal leukopoiesis || abnormal dendritic cell number || increased hematopoietic cell number || abnormal lymphocyte morphology || abnormal lymphocyte cell number || decreased lymphocyte cell number || decreased CD8-positive, alpha-beta T cell number || abnormal definitive hematopoiesis || abnormal blood cell morphology || abnormal leukocyte morphology || abnormal leukocyte cell number || abnormal B cell number || abnormal phagocyte morphology || decreased hematopoietic cell number || abnormal B cell morphology || decreased CD4-positive, alpha beta T cell number || abnormal T cell morphology || increased leukocyte cell number || abnormal mononuclear cell morphology || abnormal osteoclast cell number || decreased dendritic cell number |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.837 | INHERITED FROM: decreased erythroid progenitor cell number |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
47802,81585
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like | 0 | Direct |
81585,81301
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
49562,51045
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
51045 - WW domain | 0 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.000000381 | Direct |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.0000008753 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.000004963 | Direct |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.001274 | Inherited |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.001274 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.003154 | Inherited |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.003584 | Inherited |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.003584 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.005466 | Inherited |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.01328 | Inherited |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.01673 | Inherited |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.01673 | Inherited |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.02582 | Inherited |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0.02582 | Inherited |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.02582 | Inherited |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.03113 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.05429 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.0655 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.07692 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.09271 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1251 | Inherited |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0.1312 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1642 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.1788 | Inherited |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.277 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.3287 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.5488 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.5756 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.6235 | Inherited |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.6235 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.6814 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.7588 | Inherited |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.7911 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.837 | Inherited |
(show details)
Supra-domains annotated to this MP term (Not in SPMP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550
50729 - PH domain-like
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
47802,81585,81301
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.00001139 | DIRECT |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.001274 | INHERITED FROM: abnormal hematocrit || abnormal myeloid cell morphology |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.01269 | INHERITED FROM: decreased leukocyte cell number || decreased hematopoietic cell number || abnormal T cell morphology |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.01328 | INHERITED FROM: abnormal CD8-positive, alpha-beta T cell number || abnormal CD4-positive, alpha beta T cell morphology || abnormal neutrophil morphology || abnormal alpha-beta T cell morphology || increased granulocyte number || abnormal CD4-positive, alpha beta T cell number || abnormal alpha-beta T cell number || abnormal CD8-positive, alpha beta T cell morphology || abnormal neutrophil cell number || abnormal effector T cell morphology || increased neutrophil cell number |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.01673 | INHERITED FROM: decreased T cell number |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.02582 | INHERITED FROM: abnormal leukopoiesis || abnormal lymphopoiesis |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.03113 | INHERITED FROM: increased alpha-beta T cell number || increased CD8-positive, alpha-beta T cell number || decreased CD4-positive, alpha beta T cell number |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1106 | INHERITED FROM: abnormal hemoglobin content |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.2032 | INHERITED FROM: absent mast cells |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550
50729 - PH domain-like
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
47802,81585,81301
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.00001139 | Direct |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.001274 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.01269 | Inherited |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.01328 | Inherited |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.01673 | Inherited |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.02582 | Inherited |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.03113 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1106 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.2032 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
