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Mammalian Phenotype (MP): abnormal blood cell morphology
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this MP term (SDMP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| STAT DNA-binding domain | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| DNA polymerase beta-like | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| STAT | 0 | DIRECT |
| DNA polymerase beta-like, second domain | 0 | DIRECT |
| Short-chain cytokines | 0.00000004386 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.00009579 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.0007314 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0.003127 | INHERITED FROM: abnormal definitive hematopoiesis || abnormal B cell differentiation || abnormal hemopoiesis || abnormal leukopoiesis || abnormal lymphopoiesis || abnormal immunoglobulin V(D)J recombination |
| Erythroid transcription factor GATA-1 | 0.009245 | INHERITED FROM: decreased erythrocyte cell number || abnormal erythrocyte morphology |
| AraD-like aldolase/epimerase | 0.01075 | INHERITED FROM: spherocytosis || decreased mean corpuscular volume || decreased hematocrit || abnormal hematocrit || abnormal mean corpuscular volume || abnormal erythrocyte morphology |
| Tissue inhibitor of metalloproteinases, TIMP | 0.01075 | INHERITED FROM: increased granulocyte number || abnormal neutrophil cell number || abnormal neutrophil morphology || abnormal granulocyte number || abnormal granulocyte morphology || increased neutrophil cell number |
| Noncollagenous (NC1) domain of collagen IV | 0.01104 | INHERITED FROM: abnormal hemoglobin content || decreased erythrocyte cell number || decreased hematocrit || abnormal erythrocyte morphology || decreased hemoglobin content || abnormal hemoglobin |
| E2F dimerization segment | 0.01104 | INHERITED FROM: abnormal T cell differentiation || decreased double-positive T cell number || abnormal leukopoiesis || abnormal lymphopoiesis |
| PLC-like (P variant) | 0.01578 | INHERITED FROM: abnormal definitive hematopoiesis || abnormal leukopoiesis || abnormal platelet dense granule morphology || abnormal platelet calcium level |
| Bcl-2 inhibitors of programmed cell death | 0.01845 | INHERITED FROM: abnormal T cell differentiation || abnormal immature B cell number || abnormal leukopoiesis || abnormal immature B cell morphology || abnormal lymphopoiesis |
| SH2 domain | 0.03054 | INHERITED FROM: arrested B cell differentiation || abnormal definitive hematopoiesis || decreased immature B cell number || abnormal hemopoiesis || abnormal immature B cell number || abnormal leukopoiesis || abnormal lymphopoiesis |
| Cyclin | 0.0344 | INHERITED FROM: decreased erythrocyte cell number || abnormal common myeloid progenitor cell morphology |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.05022 | INHERITED FROM: abnormal hemoglobin content |
| DNA polymerase I | 0.06243 | INHERITED FROM: abnormal B cell differentiation |
| Eps15 homology domain (EH domain) | 0.06243 | INHERITED FROM: abnormal mean corpuscular hemoglobin || abnormal hemoglobin |
| Cell cycle transcription factor e2f-dp | 0.07075 | INHERITED FROM: abnormal T cell differentiation || decreased double-positive T cell number |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.1017 | INHERITED FROM: abnormal B cell differentiation |
| Myb/SANT domain | 0.1056 | INHERITED FROM: arrested B cell differentiation |
| A DNA-binding domain in eukaryotic transcription factors | 0.1666 | INHERITED FROM: thrombocytopenia |
| Pleckstrin-homology domain (PH domain) | 0.2218 | INHERITED FROM: decreased transitional stage B cell number |
| ets domain | 0.2252 | INHERITED FROM: abnormal definitive hematopoiesis || decreased pro-B cell number |
| Integrin beta tail domain | 0.2613 | INHERITED FROM: abnormal hematocrit |
| Integrin beta EGF-like domains | 0.2613 | INHERITED FROM: abnormal hematocrit |
| Pointed domain | 0.3281 | INHERITED FROM: abnormal B cell differentiation || thrombocytopenia |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.3281 | INHERITED FROM: increased granulocyte number || abnormal neutrophil cell number || increased neutrophil cell number |
| TNF receptor-like | 0.3463 | INHERITED FROM: abnormal definitive hematopoiesis || abnormal negative T cell selection |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.3768 | INHERITED FROM: abnormal neutrophil cell number |
| FHA domain | 0.395 | INHERITED FROM: abnormal class switch recombination |
| Notch domain | 0.4112 | INHERITED FROM: extramedullary hematopoiesis |
| Interleukin-1 (IL-1) | 0.4112 | INHERITED FROM: increased granulocyte number || abnormal neutrophil cell number || abnormal neutrophil morphology || abnormal granulocyte morphology || increased neutrophil cell number |
| MATH domain | 0.4112 | INHERITED FROM: abnormal immature B cell number || abnormal immature B cell morphology |
| V set domains (antibody variable domain-like) | 0.4876 | INHERITED FROM: abnormal definitive hematopoiesis |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.5102 | INHERITED FROM: abnormal positive T cell selection |
| DEATH domain, DD | 0.5656 | INHERITED FROM: increased transitional stage B cell number |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.5803 | INHERITED FROM: abnormal immature B cell number |
| Pyrin domain, PYD | 0.6015 | INHERITED FROM: abnormal neutrophil cell number || abnormal neutrophil morphology || abnormal granulocyte morphology |
| Ankyrin repeat | 0.6191 | INHERITED FROM: extramedullary hematopoiesis |
| DBL homology domain (DH-domain) | 0.6576 | INHERITED FROM: increased transitional stage B cell number || decreased transitional stage T2 B cell number || decreased transitional stage B cell number || abnormal transitional stage B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage T2 B cell morphology |
| Calponin-homology domain, CH-domain | 0.6836 | INHERITED FROM: increased transitional stage B cell number || decreased transitional stage T2 B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage T2 B cell morphology |
| Interleukin 17F, IL-17F | 0.6907 | INHERITED FROM: abnormal granulocyte morphology |
| SH3-domain | 0.7998 | INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation |
| Integrin domains | 0.8197 | INHERITED FROM: abnormal eosinophil cell number |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| STAT DNA-binding domain | 0 | Direct |
| RUNT domain | 0 | Direct |
| DNA polymerase beta-like | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| STAT | 0 | Direct |
| DNA polymerase beta-like, second domain | 0 | Direct |
| Short-chain cytokines | 0.00000004386 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.00009579 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.0007314 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0.003127 | Inherited |
| Erythroid transcription factor GATA-1 | 0.009245 | Inherited |
| AraD-like aldolase/epimerase | 0.01075 | Inherited |
| Tissue inhibitor of metalloproteinases, TIMP | 0.01075 | Inherited |
| Noncollagenous (NC1) domain of collagen IV | 0.01104 | Inherited |
| E2F dimerization segment | 0.01104 | Inherited |
| PLC-like (P variant) | 0.01578 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.01845 | Inherited |
| SH2 domain | 0.03054 | Inherited |
| Cyclin | 0.0344 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.05022 | Inherited |
| DNA polymerase I | 0.06243 | Inherited |
| Eps15 homology domain (EH domain) | 0.06243 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.07075 | Inherited |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.1017 | Inherited |
| Myb/SANT domain | 0.1056 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.1666 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.2218 | Inherited |
| ets domain | 0.2252 | Inherited |
| Integrin beta tail domain | 0.2613 | Inherited |
| Integrin beta EGF-like domains | 0.2613 | Inherited |
| Pointed domain | 0.3281 | Inherited |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.3281 | Inherited |
| TNF receptor-like | 0.3463 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.3768 | Inherited |
| FHA domain | 0.395 | Inherited |
| Notch domain | 0.4112 | Inherited |
| Interleukin-1 (IL-1) | 0.4112 | Inherited |
| MATH domain | 0.4112 | Inherited |
| V set domains (antibody variable domain-like) | 0.4876 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.5102 | Inherited |
| DEATH domain, DD | 0.5656 | Inherited |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.5803 | Inherited |
| Pyrin domain, PYD | 0.6015 | Inherited |
| Ankyrin repeat | 0.6191 | Inherited |
| DBL homology domain (DH-domain) | 0.6576 | Inherited |
| Calponin-homology domain, CH-domain | 0.6836 | Inherited |
| Interleukin 17F, IL-17F | 0.6907 | Inherited |
| SH3-domain | 0.7998 | Inherited |
| Integrin domains | 0.8197 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
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(show details)
Supra-domains annotated to this MP term (SPMP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47802,81585
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like | 0 | DIRECT |
81585,81301
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.00007163 | DIRECT |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.0007131 | DIRECT |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.0007131 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.0009039 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.009166 | INHERITED FROM: abnormal definitive hematopoiesis || abnormal hemopoiesis || decreased erythrocyte cell number || abnormal common myeloid progenitor cell morphology |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.009377 | INHERITED FROM: extramedullary hematopoiesis |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0.009377 | INHERITED FROM: abnormal leukopoiesis || abnormal lymphopoiesis |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.01406 | INHERITED FROM: abnormal hemoglobin content || abnormal hemoglobin |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.01573 | INHERITED FROM: abnormal common myeloid progenitor cell morphology |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.02158 | INHERITED FROM: decreased double-positive T cell number || abnormal leukopoiesis || abnormal lymphopoiesis || abnormal T cell differentiation |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0.05613 | INHERITED FROM: abnormal hemoglobin |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.06303 | INHERITED FROM: abnormal hemoglobin content |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.1343 | INHERITED FROM: abnormal immature B cell number || abnormal immature B cell morphology |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.1402 | INHERITED FROM: decreased DN2 thymocyte number |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1956 | INHERITED FROM: abnormal hemoglobin || decreased hemoglobin content |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.1956 | INHERITED FROM: thrombocytopenia |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.2466 | INHERITED FROM: abnormal hematocrit |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.2466 | INHERITED FROM: abnormal hematocrit |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.2466 | INHERITED FROM: arrested B cell differentiation || abnormal immature B cell number || increased immature B cell number || abnormal immature B cell morphology || abnormal double-negative T cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number || decreased immature B cell number || abnormal transitional stage T2 B cell morphology || decreased double-negative T cell number || abnormal transitional stage B cell morphology |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.2554 | INHERITED FROM: abnormal definitive hematopoiesis || abnormal leukopoiesis |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.3124 | INHERITED FROM: increased neutrophil cell number || increased granulocyte number || abnormal neutrophil cell number || abnormal neutrophil morphology |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.3124 | INHERITED FROM: increased neutrophil cell number |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.3136 | INHERITED FROM: abnormal definitive hematopoiesis |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.492 | INHERITED FROM: abnormal definitive hematopoiesis || abnormal neutrophil cell number |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.5136 | INHERITED FROM: abnormal immature B cell number || abnormal definitive hematopoiesis || abnormal immature B cell morphology || decreased immature B cell number |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.6326 | INHERITED FROM: decreased transitional stage T2 B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number || abnormal transitional stage T2 B cell morphology || abnormal transitional stage B cell morphology |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9995 | INHERITED FROM: absent mast cells |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
47802,81585
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like | 0 | Direct |
81585,81301
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.00007163 | Direct |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.0007131 | Direct |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.0007131 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.0009039 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.009166 | Inherited |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.009377 | Inherited |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0.009377 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.01406 | Inherited |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.01573 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.02158 | Inherited |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0.05613 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.06303 | Inherited |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.1343 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.1402 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1956 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.1956 | Inherited |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.2466 | Inherited |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.2466 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.2466 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.2554 | Inherited |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.3124 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.3124 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.3136 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.492 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.5136 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.6326 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9995 | Inherited |
(show details)
Supra-domains annotated to this MP term (SPMP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550
50729 - PH domain-like
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
47802,81585,81301
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.009377 | INHERITED FROM: abnormal leukopoiesis || abnormal lymphopoiesis |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.03943 | INHERITED FROM: abnormal hemoglobin content |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.2466 | INHERITED FROM: abnormal hematocrit |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.3124 | INHERITED FROM: increased neutrophil cell number || increased granulocyte number || abnormal neutrophil cell number || abnormal neutrophil morphology |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.4839 | INHERITED FROM: abnormal definitive hematopoiesis |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.6209 | INHERITED FROM: absent mast cells |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,50044,55550
50729 - PH domain-like
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
47802,81585,81301
47802 - DNA polymerase beta, N-terminal domain-like
81585 - PsbU/PolX domain-like
81301 - Nucleotidyltransferase | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.009377 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.03943 | Inherited |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.2466 | Inherited |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.3124 | Inherited |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.4839 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.6209 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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