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Mammalian Phenotype (MP): abnormal IgG2a level

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + + + + 10:   mammalian phenotype [MP:0000001] <29>
+ + + + + + + + + 9:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + + + + 8:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
+ + + + + + + 7:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
+ + + + + + 6:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
+ + + + + + 6:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + + + 6:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
+ + + + + + 6:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
+ + + + + + 6:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
+ + + + + 5:   abnormal lymphocyte physiology [MP:0003945] <4>(21|31) (23|22|13)
+ + + + + 5:   abnormal professional antigen presenting cell physiology [MP:0002452] <3>(25|32) (26|19|12)
+ + + + + 5:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + + + 4:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (32|24|12)
+ + + + 4:   abnormal humoral immune response [MP:0001800] <4>(10|14) (12|10|8)
+ + + + 4:   abnormal B cell physiology [MP:0002459] <9>(19|27) (20|16|10)
+ + + 3:   abnormal immunoglobulin level [MP:0002490] <7>(8|12) (9|9|7)
+ + 2:   abnormal IgG level [MP:0020174] <5>(6|11) (7|7|6)
+ 1:   abnormal IgG2 level [MP:0013802] <5>(4|8) (5|6|2)
0:   abnormal IgG2a level [MP:0020176] <2>(4|8) (4|4|1)
- 1:   decreased IgG2a level [MP:0008496](0|3) (0|1|0)
- 1:   increased IgG2a level [MP:0008500](1|4) (1|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
TNF-like0.000000591Direct
4-helical cytokines0.00001252Direct
TNF receptor-like0.00003614Direct
p53-like transcription factors0.01023Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
TNF-like0.0000002787Direct
Interleukin 17F, IL-17F0.000009997Direct
TNF receptor-like0.00009797Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0002476Direct
Short-chain cytokines0.0006663Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0008689Direct
V set domains (antibody variable domain-like)0.3618Inherited
DEATH domain, DD0.5099Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
TNF-like0.000000238Direct
4-helical cytokines0.000005527Direct
TNF receptor-like0.0000167Direct
p53-like transcription factors0.006404Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000002583Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000234Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0003516Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0004726Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00001224Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)