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Worm Phenotype (WP): cell division variant
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (SDWP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nucleosome core histones | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.00000008248 | DIRECT |
| Extended AAA-ATPase domain | 0.0000002346 | DIRECT |
| RecA protein-like (ATPase-domain) | 0.000005847 | DIRECT |
| Skp1 dimerisation domain-like | 0.00001608 | DIRECT |
| BTB/POZ domain | 0.00002301 | DIRECT |
| Ubiquitin activating enzymes (UBA) | 0.00004846 | DIRECT |
| Frizzled cysteine-rich domain | 0.00004846 | DIRECT |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0.000394 | DIRECT |
| Cdc48 domain 2-like | 0.000394 | DIRECT |
| Anticodon-binding domain | 0.000394 | DIRECT |
| Cdc48 N-terminal domain-like | 0.000394 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0.000394 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0.001067 | INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || diakinesis region organization variant || pachytene region organization variant || chromosome condensation variant |
| DEP domain | 0.001686 | INHERITED FROM: spindle defective early emb || mitotic spindle defective early emb || spindle variant |
| Armadillo repeat | 0.002589 | INHERITED FROM: spindle orientation defective early emb || mitotic spindle defective early emb || spindle variant |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.002657 | INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || pachytene region organization variant || chromosome condensation variant |
| Motor proteins | 0.00477 | INHERITED FROM: X chromosome nondisjunction || cleavage furrow defective || cleavage furrow defective early emb || spindle defective early emb || meiotic spindle defective || passage through meiosis defective early emb || meiosis variant || spindle variant || cytokinesis variant emb |
| CCCH zinc finger | 0.004796 | INHERITED FROM: cell cleavage variant || division axis defective |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.006541 | INHERITED FROM: sister chromatid segregation defective early emb || multiple nuclei early emb || cytokinesis defective early emb || cytokinesis variant || cytokinesis variant emb |
| Actin/HSP70 | 0.007866 | INHERITED FROM: cleavage furrow defective early emb || cytokinesis variant emb |
| G proteins | 0.0139 | INHERITED FROM: mitotic spindle defective early emb || spindle position orientation defective early emb || cytokinesis variant emb |
| Translational machinery components | 0.02807 | INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || pachytene region organization variant || diplotene progression during oogenesis variant |
| F1F0 ATP synthase subunit C | 0.03918 | INHERITED FROM: meiotic chromosome organization variant || meiotic progression prophase variant || mitosis variant || meiosis variant || chromosome condensation variant || diakinesis progression during oogenesis variant |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.04106 | INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || diakinesis region organization variant |
| Pumilio repeat | 0.07009 | INHERITED FROM: multiple nuclei early emb || cytokinesis failure || cytokinesis fails early emb || cytokinesis variant emb |
| Tubulin, GTPase domain | 0.07535 | INHERITED FROM: mitosis variant || mitotic spindle defective early emb || cytokinesis variant emb || spindle assembly defective |
| Cold shock DNA-binding domain-like | 0.07756 | INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || pachytene region organization variant || diplotene progression during oogenesis variant |
| Prefoldin | 0.122 | INHERITED FROM: mitotic spindle defective early emb || spindle variant |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.122 | INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || pachytene region organization variant || diplotene absent during oogenesis || diplotene progression during oogenesis variant |
| L30e/L7ae ribosomal proteins | 0.122 | INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || pachytene region organization variant || meiosis variant || diplotene progression during oogenesis variant || diplotene region organization variant |
| Cyclin | 0.1315 | INHERITED FROM: multiple nuclei early emb || division axis defective || Aba ABp division axis defective early emb |
| Tubulin, C-terminal domain | 0.1315 | INHERITED FROM: mitosis variant || mitotic spindle defective early emb || cytokinesis variant emb || spindle assembly defective |
| Elongation factors | 0.1333 | INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || pachytene region organization variant || diplotene progression during oogenesis variant |
| ABC transporter ATPase domain-like | 0.1989 | INHERITED FROM: anaphase bridging |
| Nitrogenase iron protein-like | 0.2369 | INHERITED FROM: mitosis variant || diplotene progression during oogenesis variant || chromosome condensation variant |
| Clathrin adaptor core protein | 0.3667 | INHERITED FROM: meiotic progression prophase variant || diplotene progression during oogenesis variant || diplotene region organization variant |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.3667 | INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || pachytene region organization variant || diplotene progression during oogenesis variant |
| Calponin-homology domain, CH-domain | 0.4273 | INHERITED FROM: cleavage furrow defective || cleavage furrow defective early emb || cleavage furrow initiation defective early emb || cytokinesis variant emb |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.4468 | INHERITED FROM: pachytene progression during oogenesis variant |
| BCR-homology GTPase activation domain (BH-domain) | 0.4468 | INHERITED FROM: cleavage furrow defective || cleavage furrow defective early emb |
| Protein serine/threonine phosphatase | 0.5821 | INHERITED FROM: meiosis defective early emb |
| Tetratricopeptide repeat (TPR) | 0.6588 | INHERITED FROM: meiosis metaphase to anaphase transition block |
| PDZ domain | 0.6794 | INHERITED FROM: spindle defective early emb || mitotic spindle defective early emb || cell division polarity variant || spindle variant |
| Homeodomain | 0.7898 | INHERITED FROM: sister cell division timing asynchrony reduced |
| Protein kinases, catalytic subunit | 0.829 | INHERITED FROM: synapsis defective || pachytene arrested germline nuclei |
| PX domain | 0.8615 | INHERITED FROM: cell division polarity variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nucleosome core histones | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| LEM domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.00000008248 | Direct |
| Extended AAA-ATPase domain | 0.0000002346 | Direct |
| RecA protein-like (ATPase-domain) | 0.000005847 | Direct |
| Skp1 dimerisation domain-like | 0.00001608 | Direct |
| BTB/POZ domain | 0.00002301 | Direct |
| Ubiquitin activating enzymes (UBA) | 0.00004846 | Direct |
| Frizzled cysteine-rich domain | 0.00004846 | Direct |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0.000394 | Direct |
| Cdc48 domain 2-like | 0.000394 | Direct |
| Anticodon-binding domain | 0.000394 | Direct |
| Cdc48 N-terminal domain-like | 0.000394 | Direct |
| Anticodon-binding domain of Class II aaRS | 0.000394 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0.001067 | Inherited |
| DEP domain | 0.001686 | Inherited |
| Armadillo repeat | 0.002589 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.002657 | Inherited |
| Motor proteins | 0.00477 | Inherited |
| CCCH zinc finger | 0.004796 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.006541 | Inherited |
| Actin/HSP70 | 0.007866 | Inherited |
| G proteins | 0.0139 | Inherited |
| Translational machinery components | 0.02807 | Inherited |
| F1F0 ATP synthase subunit C | 0.03918 | Inherited |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.04106 | Inherited |
| Pumilio repeat | 0.07009 | Inherited |
| Tubulin, GTPase domain | 0.07535 | Inherited |
| Cold shock DNA-binding domain-like | 0.07756 | Inherited |
| Prefoldin | 0.122 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.122 | Inherited |
| L30e/L7ae ribosomal proteins | 0.122 | Inherited |
| Cyclin | 0.1315 | Inherited |
| Tubulin, C-terminal domain | 0.1315 | Inherited |
| Elongation factors | 0.1333 | Inherited |
| ABC transporter ATPase domain-like | 0.1989 | Inherited |
| Nitrogenase iron protein-like | 0.2369 | Inherited |
| Clathrin adaptor core protein | 0.3667 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.3667 | Inherited |
| Calponin-homology domain, CH-domain | 0.4273 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.4468 | Inherited |
| BCR-homology GTPase activation domain (BH-domain) | 0.4468 | Inherited |
| Protein serine/threonine phosphatase | 0.5821 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.6588 | Inherited |
| PDZ domain | 0.6794 | Inherited |
| Homeodomain | 0.7898 | Inherited |
| Protein kinases, catalytic subunit | 0.829 | Inherited |
| PX domain | 0.8615 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0.00003391 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0.0002152 | DIRECT |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0.0002152 | DIRECT |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.0009376 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.00106 | INHERITED FROM: chromosome condensation variant || pachytene progression during oogenesis variant || meiotic progression prophase variant |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.00106 | INHERITED FROM: chromosome condensation variant || pachytene progression during oogenesis variant || meiotic progression prophase variant |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.001438 | INHERITED FROM: division axis defective || cell cleavage variant |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.01471 | INHERITED FROM: cytokinesis variant emb |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.03939 | INHERITED FROM: pachytene region organization variant || pachytene progression during oogenesis variant || meiosis variant || meiotic progression prophase variant |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.04403 | INHERITED FROM: diplotene progression during oogenesis variant |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.07409 | INHERITED FROM: multiple nuclei early emb || division axis defective || Aba ABp division axis defective early emb |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.07409 | INHERITED FROM: spindle assembly defective || mitotic spindle defective early emb || mitosis variant || cytokinesis variant emb |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.07544 | INHERITED FROM: mitotic spindle defective early emb |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.1223 | INHERITED FROM: diplotene absent during oogenesis || diplotene progression during oogenesis variant || pachytene region organization variant || pachytene progression during oogenesis variant || meiotic progression prophase variant |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.1319 | INHERITED FROM: diplotene progression during oogenesis variant || pachytene region organization variant || pachytene progression during oogenesis variant || meiosis variant || meiotic progression prophase variant |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3565 | INHERITED FROM: meiotic spindle defective early emb || meiotic spindle defective |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.9481 | INHERITED FROM: diakinesis progression during oogenesis variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0.00003391 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0.0002152 | Direct |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0.0002152 | Direct |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.0009376 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.00106 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.00106 | Inherited |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.001438 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.01471 | Inherited |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.03939 | Inherited |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.04403 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.07409 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.07409 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.07544 | Inherited |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.1223 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.1319 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3565 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.9481 | Inherited |
(show details)
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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