Worm Phenotype (WP): cell component morphology variant

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Helical domain of Sec23/24	0	Direct
GroEL-intermediate domain like	0	Direct
RBP11-like subunits of RNA polymerase	0	Direct
GroEL equatorial domain-like	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
LEM domain	0	Direct
Sec1/munc18-like (SM) proteins	0	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Heme-dependent catalase-like	0	Direct
Profilin (actin-binding protein)	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Subdomain of clathrin and coatomer appendage domain	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Skp1 dimerisation domain-like	0.000000000351	Direct
Tubulin C-terminal domain-like	0.0000000113	Direct
Tubulin nucleotide-binding domain-like	0.00000005751	Direct
SNARE-like	0.00000006867	Direct
Class II aaRS and biotin synthetases	0.0000323	Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.00009579	Direct
Intermediate filament protein, coiled coil region	0.0001392	Direct
Lamin A/C globular tail domain	0.0001392	Direct
Ribosomal proteins S24e, L23 and L15e	0.0003162	Direct
ValRS/IleRS/LeuRS editing domain	0.0003162	Direct
Translation proteins SH3-like domain	0.0003456	Direct
Calpain large subunit, middle domain (domain III)	0.0009961	Direct
Class II aaRS ABD-related	0.0009961	Direct
Riboflavin synthase domain-like	0.0009961	Direct
Activating enzymes of the ubiquitin-like proteins	0.0009961	Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.0009961	Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.001358	Inherited
ADC-like	0.001803	Inherited
Cdc48 domain 2-like	0.001803	Inherited
beta-sandwich domain of Sec23/24	0.001803	Inherited
Zn-binding ribosomal proteins	0.00429	Inherited
F1F0 ATP synthase subunit C	0.007125	Inherited
CAD & PB1 domains	0.007125	Inherited
L30e-like	0.01719	Inherited
Histone-fold	0.01727	Inherited
Cyclin-like	0.02011	Inherited
Nucleic acid-binding proteins	0.02749	Inherited
EGF/Laminin	0.03268	Inherited
SH2 domain	0.05474	Inherited
Actin-like ATPase domain	0.07696	Inherited
Sm-like ribonucleoproteins	0.15	Inherited
PDZ domain-like	0.1727	Inherited
GTPase activation domain, GAP	0.1968	Inherited
Ribosomal protein S5 domain 2-like	0.2084	Inherited
GroEL apical domain-like	0.2446	Inherited
SNARE fusion complex	0.2446	Inherited
"Winged helix" DNA-binding domain	0.2485	Inherited
ARM repeat	0.2587	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.2728	Inherited
PH domain-like	0.2854	Inherited
Concanavalin A-like lectins/glucanases	0.2856	Inherited
Nucleotidylyl transferase	0.287	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.3293	Inherited
t-snare proteins	0.3364	Inherited
DBL homology domain (DH-domain)	0.3364	Inherited
SH3-domain	0.3883	Inherited
SAM/Pointed domain	0.3936	Inherited
Second domain of FERM	0.4577	Inherited
Prefoldin	0.4577	Inherited
SMAD/FHA domain	0.4577	Inherited
(Phosphotyrosine protein) phosphatases II	0.5057	Inherited
TPR-like	0.535	Inherited
WD40 repeat-like	0.5621	Inherited
Cystine-knot cytokines	0.6167	Inherited
PYP-like sensor domain (PAS domain)	0.6167	Inherited
Integrin domains	0.6167	Inherited
Tropomyosin	0.7348	Inherited
POZ domain	0.7424	Inherited
Immunoglobulin	0.7907	Inherited
dsRNA-binding domain-like	0.7982	Inherited
Spectrin repeat	0.7982	Inherited
Protein kinase-like (PK-like)	0.803	Inherited
Fibronectin type III	0.8141	Inherited
CCCH zinc finger	0.8921	Inherited
Calponin-homology domain, CH-domain	0.9101	Inherited
Voltage-gated potassium channels	0.9147	Inherited
Cysteine-rich domain	0.9177	Inherited
RNA-binding domain, RBD	1	Inherited
EF-hand	1	Inherited
NAD(P)-binding Rossmann-fold domains	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
beta-sandwich domain of Sec23/24	0	Direct
Heme-dependent catalases	0	Direct
Helical domain of Sec23/24	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Sec1/munc18-like (SM) proteins	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Group II chaperonin (CCT, TRIC), intermediate domain	0	Direct
Phoshoinositide 3-kinase (PI3K) helical domain	0	Direct
LEM domain	0	Direct
Trunk domain of Sec23/24	0	Direct
Group II chaperonin (CCT, TRIC), ATPase domain	0	Direct
Integrin domains	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Profilin (actin-binding protein)	0	Direct
Anticodon-binding domain of Class II aaRS	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
Skp1 dimerisation domain-like	0.0000000009924	Direct
Tubulin, C-terminal domain	0.00000008367	Direct
BCR-homology GTPase activation domain (BH-domain)	0.0000001823	Direct
Tubulin, GTPase domain	0.0000003578	Direct
Proteasome subunits	0.0000003712	Direct
Pumilio repeat	0.000006851	Direct
PDZ domain	0.000008036	Direct
Clathrin adaptor core protein	0.0000222	Direct
Clathrin coat assembly domain	0.0000222	Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0.00003231	Direct
Armadillo repeat	0.00009741	Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain	0.0001119	Direct
Laminin-type module	0.0001119	Direct
RecA protein-like (ATPase-domain)	0.0001119	Direct
Intermediate filament protein, coiled coil region	0.0003693	Direct
Extended AAA-ATPase domain	0.0005249	Direct
BAR domain	0.0005556	Direct
Ubiquitin activating enzymes (UBA)	0.0005556	Direct
ValRS/IleRS/LeuRS editing domain	0.0005556	Direct
Smc hinge domain	0.0005556	Direct
Prefoldin	0.0006172	Direct
Calpain large subunit, middle domain (domain III)	0.001968	Inherited
Cdc48 domain 2-like	0.002723	Inherited
Anticodon-binding domain	0.002723	Inherited
Ferredoxin reductase FAD-binding domain-like	0.002723	Inherited
Cdc48 N-terminal domain-like	0.002723	Inherited
Nucleosome core histones	0.004611	Inherited
Transforming growth factor (TGF)-beta	0.0107	Inherited
DEP domain	0.0107	Inherited
F1F0 ATP synthase subunit C	0.0107	Inherited
Translational machinery components	0.01572	Inherited
Laminin G-like module	0.01703	Inherited
Cyclin	0.0223	Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0.0223	Inherited
Cold shock DNA-binding domain-like	0.03601	Inherited
DNA polymerase I	0.04881	Inherited
SH2 domain	0.04968	Inherited
Calpain large subunit, catalytic domain (domain II)	0.06011	Inherited
G proteins	0.06701	Inherited
Elongation factors	0.06814	Inherited
Actin/HSP70	0.09827	Inherited
DnaQ-like 3'-5' exonuclease	0.1077	Inherited
I set domains	0.1167	Inherited
FHA domain	0.1316	Inherited
BTB/POZ domain	0.1852	Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.2289	Inherited
SNARE fusion complex	0.2698	Inherited
Group II chaperonin (CCT, TRIC), apical domain	0.2698	Inherited
t-snare proteins	0.3177	Inherited
DBL homology domain (DH-domain)	0.3177	Inherited
SH3-domain	0.3771	Inherited
Pleckstrin-homology domain (PH domain)	0.3853	Inherited
Second domain of FERM	0.4384	Inherited
Third domain of FERM	0.5117	Inherited
First domain of FERM	0.5956	Inherited
Tropomyosin	0.7171	Inherited
Ubiquitin-related	0.7171	Inherited
LIM domain	0.7171	Inherited
Spectrin repeat	0.7819	Inherited
WD40-repeat	0.8024	Inherited
Fibronectin type III	0.8042	Inherited
Protein kinases, catalytic subunit	0.8154	Inherited
Motor proteins	0.8431	Inherited
CCCH zinc finger	0.8786	Inherited
Calponin-homology domain, CH-domain	0.899	Inherited
Calmodulin-like	1	Inherited
Voltage-gated potassium channels	1	Inherited
Canonical RBD	1	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
GroEL equatorial domain-like	0	Direct
Heme-dependent catalase-like	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
LEM domain	0	Direct
Profilin (actin-binding protein)	0	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
RBP11-like subunits of RNA polymerase	0	Direct
GroEL-intermediate domain like	0	Direct
Subdomain of clathrin and coatomer appendage domain	0	Direct
Helical domain of Sec23/24	0	Direct
Sec1/munc18-like (SM) proteins	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Skp1 dimerisation domain-like	0.0000000002784	Direct
Tubulin C-terminal domain-like	0.00000000901	Direct
Tubulin nucleotide-binding domain-like	0.00000004602	Direct
SNARE-like	0.00000005496	Direct
Class II aaRS and biotin synthetases	0.00002637	Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.00007849	Direct
Lamin A/C globular tail domain	0.0001142	Direct
Intermediate filament protein, coiled coil region	0.0001142	Direct
ValRS/IleRS/LeuRS editing domain	0.0002605	Direct
Ribosomal proteins S24e, L23 and L15e	0.0002605	Direct
Translation proteins SH3-like domain	0.0002849	Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.0008292	Direct
Class II aaRS ABD-related	0.0008292	Direct
Activating enzymes of the ubiquitin-like proteins	0.0008292	Direct
Calpain large subunit, middle domain (domain III)	0.0008292	Direct
Riboflavin synthase domain-like	0.0008292	Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.001133	Inherited
Cdc48 domain 2-like	0.001509	Inherited
beta-sandwich domain of Sec23/24	0.001509	Inherited
ADC-like	0.001509	Inherited
Zn-binding ribosomal proteins	0.003638	Inherited
F1F0 ATP synthase subunit C	0.006082	Inherited
CAD & PB1 domains	0.006082	Inherited
L30e-like	0.01492	Inherited
Histone-fold	0.015	Inherited
Cyclin-like	0.0175	Inherited
Nucleic acid-binding proteins	0.02408	Inherited
EGF/Laminin	0.02874	Inherited
SH2 domain	0.04861	Inherited
Actin-like ATPase domain	0.06896	Inherited
Sm-like ribonucleoproteins	0.1368	Inherited
PDZ domain-like	0.1584	Inherited
GTPase activation domain, GAP	0.1812	Inherited
Ribosomal protein S5 domain 2-like	0.1922	Inherited
SNARE fusion complex	0.227	Inherited
GroEL apical domain-like	0.227	Inherited
"Winged helix" DNA-binding domain	0.2307	Inherited
ARM repeat	0.2407	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.2544	Inherited
PH domain-like	0.2668	Inherited
Concanavalin A-like lectins/glucanases	0.2671	Inherited
Nucleotidylyl transferase	0.2684	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.3097	Inherited
DBL homology domain (DH-domain)	0.3167	Inherited
t-snare proteins	0.3167	Inherited
SH3-domain	0.3678	Inherited
SAM/Pointed domain	0.3731	Inherited
SMAD/FHA domain	0.4367	Inherited
Prefoldin	0.4367	Inherited
Second domain of FERM	0.4367	Inherited
(Phosphotyrosine protein) phosphatases II	0.4839	Inherited
TPR-like	0.5131	Inherited
WD40 repeat-like	0.5403	Inherited
Integrin domains	0.5947	Inherited
PYP-like sensor domain (PAS domain)	0.5947	Inherited
Cystine-knot cytokines	0.5947	Inherited
Tropomyosin	0.7146	Inherited
POZ domain	0.7226	Inherited
Immunoglobulin	0.7723	Inherited
dsRNA-binding domain-like	0.7797	Inherited
Spectrin repeat	0.7797	Inherited
Protein kinase-like (PK-like)	0.7846	Inherited
Fibronectin type III	0.7959	Inherited
CCCH zinc finger	0.8767	Inherited
Calponin-homology domain, CH-domain	0.8949	Inherited
Voltage-gated potassium channels	0.8996	Inherited
Cysteine-rich domain	0.9028	Inherited
RNA-binding domain, RBD	1	Inherited
EF-hand	1	Inherited
NAD(P)-binding Rossmann-fold domains	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	Direct
81383,50978 81383 - F-box domain 50978 - WD40 repeat-like	0	Direct
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	Direct
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	Direct
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	Direct
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	Direct
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain	0	Direct
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0.0000000003324	Direct
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.00000004602	Direct
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.0000247	Direct
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain	0.0002518	Direct
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III)	0.0002518	Direct
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0.0002605	Direct
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0.0006175	Direct
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.0008292	Direct
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.0012	Inherited
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain	0.001267	Inherited
81333,81333 81333 - F1F0 ATP synthase subunit C 81333 - F1F0 ATP synthase subunit C	0.001509	Inherited
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.001509	Inherited
50044,50044 50044 - SH3-domain 50044 - SH3-domain	0.003638	Inherited
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases	0.006082	Inherited
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases	0.01492	Inherited
57625,57625 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins	0.01492	Inherited
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins	0.02279	Inherited
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.02899	Inherited
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.06896	Inherited
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger	0.0738	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.4142	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.4367	Inherited
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like	0.4367	Inherited
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.4489	Inherited
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM	0.5103	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.5103	Inherited
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0.5343	Inherited
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.5887	Inherited
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.8294	Inherited
48452,48452 48452 - TPR-like 48452 - TPR-like	0.9642	Inherited
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	1	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	Direct
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
57625,57625,57625 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins	0.006082	Inherited
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.3028	Inherited
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.3167	Inherited
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.3731	Inherited
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like	0.5103	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Worm Phenotype (WP): cell component morphology variant

Superfamily

Family

Supra-domain (including individual superfamily)