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Worm Phenotype (WP): cell type morphology variant
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Helical domain of Sec23/24 | 0 | DIRECT |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Integrin alpha N-terminal domain | 0 | DIRECT |
Zn-finger domain of Sec23/24 | 0 | DIRECT |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Integrin domains | 0 | DIRECT |
Sm-like ribonucleoproteins | 0.00000001453 | DIRECT |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.00003787 | DIRECT |
Spectrin repeat | 0.00007699 | DIRECT |
Cysteine-rich domain | 0.00007764 | DIRECT |
P-loop containing nucleoside triphosphate hydrolases | 0.0001739 | DIRECT |
Translation proteins SH3-like domain | 0.0001942 | DIRECT |
Ribosomal proteins S24e, L23 and L15e | 0.0002137 | DIRECT |
Calpain large subunit, middle domain (domain III) | 0.0006393 | DIRECT |
Class II aaRS ABD-related | 0.0006393 | DIRECT |
Metal cation-transporting ATPase, ATP-binding domain N | 0.00101 | INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant |
Annexin | 0.001326 | INHERITED FROM: germ cell morphology variant |
ADC-like | 0.001326 | INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell cytoplasmic morphology variant |
Cdc48 domain 2-like | 0.001326 | INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell cytoplasmic morphology variant |
beta-sandwich domain of Sec23/24 | 0.001326 | INHERITED FROM: germ cell morphology variant || germ cell compartment size variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant |
Calcium ATPase, transmembrane domain M | 0.001567 | INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant |
CCCH zinc finger | 0.002507 | INHERITED FROM: P granule abnormal || germ cell cytoplasmic morphology variant |
Zn-binding ribosomal proteins | 0.003001 | INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant |
PLC-like phosphodiesterases | 0.003034 | INHERITED FROM: germ cell morphology variant || oocyte morphology variant || endomitotic oocytes |
Calcium ATPase, transduction domain A | 0.003107 | INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.004894 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || endomitotic oocytes |
Nucleic acid-binding proteins | 0.004894 | INHERITED FROM: cytoplasmic processing body variant || germ cell compartment expansion variant || embryonic cell morphology variant || nuclear appearance number defective early emb || oocyte number decreased |
F1F0 ATP synthase subunit C | 0.005316 | INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocytes lack nucleus || germ cell compartment anucleate || germ cell compartment nuclei number variant |
S15/NS1 RNA-binding domain | 0.005316 | INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant |
PYP-like sensor domain (PAS domain) | 0.00661 | INHERITED FROM: neurite morphology variant |
Myosin rod fragments | 0.01238 | INHERITED FROM: striated muscle morphology variant || body wall muscle thick filament variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant |
L30e-like | 0.01238 | INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased |
Translational machinery components | 0.01305 | INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased |
Calponin-homology domain, CH-domain | 0.01336 | INHERITED FROM: striated muscle morphology variant || body wall muscle myosin organization defective |
SH2 domain | 0.01336 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant |
Second domain of FERM | 0.01726 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant |
ACP-like | 0.02525 | INHERITED FROM: oocyte morphology variant || oocyte number decreased |
Fibronectin type III | 0.04169 | INHERITED FROM: commissure absent || neuron morphology variant || axon morphology variant || body wall muscle sarcomere morphology variant || neurite morphology variant |
SH3-domain | 0.04749 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || endomitotic oocytes || muscle cell morphology variant |
RNA-binding domain, RBD | 0.05736 | INHERITED FROM: P granule localization defective || oocytes disorganized |
SMAD/FHA domain | 0.08285 | INHERITED FROM: axon branching variant |
PH domain-like | 0.09421 | INHERITED FROM: axon morphology variant || endomitotic oocytes || muscle cell morphology variant |
Ribosomal protein S5 domain 2-like | 0.09541 | INHERITED FROM: germ cell compartment expansion variant |
Class II aaRS and biotin synthetases | 0.09541 | INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell compartment expansion variant || germ cell compartment anucleate |
Protein kinase-like (PK-like) | 0.114 | INHERITED FROM: myopodia present || muscle cell morphology variant |
Concanavalin A-like lectins/glucanases | 0.1147 | INHERITED FROM: commissure handedness defective || axon morphology variant || neurite morphology variant |
Actin-like ATPase domain | 0.1147 | INHERITED FROM: germ cell morphology variant || body wall muscle myosin organization defective |
Immunoglobulin | 0.1313 | INHERITED FROM: sperm pseudopod variant || neuron morphology variant || sperm morphology variant || body wall muscle sarcomere morphology variant || neurite morphology variant || muscle cell morphology variant |
GTPase activation domain, GAP | 0.1919 | INHERITED FROM: neuron morphology variant || axon morphology variant || neurite morphology variant || axon branching variant |
DBL homology domain (DH-domain) | 0.1945 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant |
dsRNA-binding domain-like | 0.2446 | INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant |
HAD-like | 0.261 | INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant |
ARM repeat | 0.2964 | INHERITED FROM: P granule localization defective || seam cell morphology variant |
EF-hand | 0.3053 | INHERITED FROM: endomitotic oocytes |
EGF/Laminin | 0.3065 | INHERITED FROM: body wall muscle sarcomere morphology variant || axon trajectory variant || muscle cell morphology variant |
Sec1/munc18-like (SM) proteins | 0.3076 | INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant |
Troponin coil-coiled subunits | 0.3076 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant |
Activating enzymes of the ubiquitin-like proteins | 0.3849 | INHERITED FROM: germ cell morphology variant || germ cell compartment nuclei number variant |
Translation proteins | 0.403 | INHERITED FROM: germ cell morphology variant || germ cell compartment expansion variant |
GroEL apical domain-like | 0.403 | INHERITED FROM: oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate |
GroEL-intermediate domain like | 0.47 | INHERITED FROM: germ cell morphology variant || oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate |
GroEL equatorial domain-like | 0.47 | INHERITED FROM: germ cell morphology variant || oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate |
Cyclin-like | 0.47 | INHERITED FROM: multiple nuclei early emb || pronuclear size defective early emb || excess maternal pronucleus early emb || nuclear morphology variation early emb || excess pronucleus early emb || embryonic cell morphology variant || nuclear appearance number defective early emb |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.4784 | INHERITED FROM: germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased |
RBP11-like subunits of RNA polymerase | 0.4784 | INHERITED FROM: germ cell morphology variant |
TPR-like | 0.4893 | INHERITED FROM: cilia morphology variant || ciliated neuron morphology variant |
Glutathione synthetase ATP-binding domain-like | 0.6246 | INHERITED FROM: body wall muscle myosin organization defective || body wall muscle thick filament variant |
Growth factor receptor domain | 0.6426 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant |
Voltage-gated potassium channels | 0.711 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.7136 | INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased |
Tubulin C-terminal domain-like | 0.7717 | INHERITED FROM: axon morphology variant |
Tubulin nucleotide-binding domain-like | 0.8286 | INHERITED FROM: axon morphology variant |
Tropomyosin | 0.8491 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant |
PDZ domain-like | 0.9162 | INHERITED FROM: endomitotic oocytes |
L domain-like | 1 | INHERITED FROM: myopodia present |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Helical domain of Sec23/24 | 0 | Direct |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Integrin alpha N-terminal domain | 0 | Direct |
Zn-finger domain of Sec23/24 | 0 | Direct |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Integrin domains | 0 | Direct |
Sm-like ribonucleoproteins | 0.00000001453 | Direct |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.00003787 | Direct |
Spectrin repeat | 0.00007699 | Direct |
Cysteine-rich domain | 0.00007764 | Direct |
P-loop containing nucleoside triphosphate hydrolases | 0.0001739 | Direct |
Translation proteins SH3-like domain | 0.0001942 | Direct |
Ribosomal proteins S24e, L23 and L15e | 0.0002137 | Direct |
Calpain large subunit, middle domain (domain III) | 0.0006393 | Direct |
Class II aaRS ABD-related | 0.0006393 | Direct |
Metal cation-transporting ATPase, ATP-binding domain N | 0.00101 | Inherited |
Annexin | 0.001326 | Inherited |
ADC-like | 0.001326 | Inherited |
Cdc48 domain 2-like | 0.001326 | Inherited |
beta-sandwich domain of Sec23/24 | 0.001326 | Inherited |
Calcium ATPase, transmembrane domain M | 0.001567 | Inherited |
CCCH zinc finger | 0.002507 | Inherited |
Zn-binding ribosomal proteins | 0.003001 | Inherited |
PLC-like phosphodiesterases | 0.003034 | Inherited |
Calcium ATPase, transduction domain A | 0.003107 | Inherited |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.004894 | Inherited |
Nucleic acid-binding proteins | 0.004894 | Inherited |
F1F0 ATP synthase subunit C | 0.005316 | Inherited |
S15/NS1 RNA-binding domain | 0.005316 | Inherited |
PYP-like sensor domain (PAS domain) | 0.00661 | Inherited |
Myosin rod fragments | 0.01238 | Inherited |
L30e-like | 0.01238 | Inherited |
Translational machinery components | 0.01305 | Inherited |
Calponin-homology domain, CH-domain | 0.01336 | Inherited |
SH2 domain | 0.01336 | Inherited |
Second domain of FERM | 0.01726 | Inherited |
ACP-like | 0.02525 | Inherited |
Fibronectin type III | 0.04169 | Inherited |
SH3-domain | 0.04749 | Inherited |
RNA-binding domain, RBD | 0.05736 | Inherited |
SMAD/FHA domain | 0.08285 | Inherited |
PH domain-like | 0.09421 | Inherited |
Ribosomal protein S5 domain 2-like | 0.09541 | Inherited |
Class II aaRS and biotin synthetases | 0.09541 | Inherited |
Protein kinase-like (PK-like) | 0.114 | Inherited |
Concanavalin A-like lectins/glucanases | 0.1147 | Inherited |
Actin-like ATPase domain | 0.1147 | Inherited |
Immunoglobulin | 0.1313 | Inherited |
GTPase activation domain, GAP | 0.1919 | Inherited |
DBL homology domain (DH-domain) | 0.1945 | Inherited |
dsRNA-binding domain-like | 0.2446 | Inherited |
HAD-like | 0.261 | Inherited |
ARM repeat | 0.2964 | Inherited |
EF-hand | 0.3053 | Inherited |
EGF/Laminin | 0.3065 | Inherited |
Sec1/munc18-like (SM) proteins | 0.3076 | Inherited |
Troponin coil-coiled subunits | 0.3076 | Inherited |
Activating enzymes of the ubiquitin-like proteins | 0.3849 | Inherited |
Translation proteins | 0.403 | Inherited |
GroEL apical domain-like | 0.403 | Inherited |
GroEL-intermediate domain like | 0.47 | Inherited |
GroEL equatorial domain-like | 0.47 | Inherited |
Cyclin-like | 0.47 | Inherited |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.4784 | Inherited |
RBP11-like subunits of RNA polymerase | 0.4784 | Inherited |
TPR-like | 0.4893 | Inherited |
Glutathione synthetase ATP-binding domain-like | 0.6246 | Inherited |
Growth factor receptor domain | 0.6426 | Inherited |
Voltage-gated potassium channels | 0.711 | Inherited |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.7136 | Inherited |
Tubulin C-terminal domain-like | 0.7717 | Inherited |
Tubulin nucleotide-binding domain-like | 0.8286 | Inherited |
Tropomyosin | 0.8491 | Inherited |
PDZ domain-like | 0.9162 | Inherited |
L domain-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (SDWP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
POU-specific domain | 0 | DIRECT |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
beta-sandwich domain of Sec23/24 | 0 | DIRECT |
Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
Helical domain of Sec23/24 | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Zn-finger domain of Sec23/24 | 0 | DIRECT |
Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
Mammalian PLC | 0 | DIRECT |
Trunk domain of Sec23/24 | 0 | DIRECT |
Integrin domains | 0 | DIRECT |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
Proteasome subunits | 0.000000152 | DIRECT |
Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.0000007276 | DIRECT |
Clathrin coat assembly domain | 0.00001302 | DIRECT |
Spectrin repeat | 0.00007068 | DIRECT |
DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.00007101 | DIRECT |
Laminin-type module | 0.00007101 | DIRECT |
PLC-like (P variant) | 0.0002116 | DIRECT |
EF-hand modules in multidomain proteins | 0.0003817 | DIRECT |
Calpain large subunit, middle domain (domain III) | 0.001294 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant |
First domain of FERM | 0.001833 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant |
Cdc48 domain 2-like | 0.002022 | INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell cytoplasmic morphology variant |
Annexin | 0.002022 | INHERITED FROM: germ cell morphology variant |
Anticodon-binding domain | 0.002022 | INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased |
Troponin I | 0.002022 | INHERITED FROM: muscle cell morphology variant |
Cdc48 N-terminal domain-like | 0.002022 | INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell cytoplasmic morphology variant |
Lamin A/C globular tail domain | 0.003167 | INHERITED FROM: body wall muscle sarcomere morphology variant |
Third domain of FERM | 0.006475 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant |
CCCH zinc finger | 0.008016 | INHERITED FROM: P granule abnormal || germ cell cytoplasmic morphology variant |
L30e/L7ae ribosomal proteins | 0.008074 | INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased |
F1F0 ATP synthase subunit C | 0.008074 | INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocytes lack nucleus || germ cell compartment anucleate || germ cell compartment nuclei number variant |
Calcium ATPase, transduction domain A | 0.008208 | INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant |
Translational machinery components | 0.01133 | INHERITED FROM: germ cell morphology variant || oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01133 | INHERITED FROM: germ cell morphology variant |
Nitrogenase iron protein-like | 0.01173 | INHERITED FROM: oocyte number decreased |
Laminin G-like module | 0.01173 | INHERITED FROM: commissure handedness defective || neuron morphology variant || axon morphology variant || myopodia present || neurite morphology variant |
Calponin-homology domain, CH-domain | 0.01246 | INHERITED FROM: striated muscle morphology variant || body wall muscle myosin organization defective |
Canonical RBD | 0.01465 | INHERITED FROM: P granule localization defective || oocytes disorganized |
Motor proteins | 0.01703 | INHERITED FROM: axon morphology variant || cord commissures variant || neurite morphology variant || axon branching variant || cord commissures fail to reach target |
Myosin rod fragments | 0.02097 | INHERITED FROM: striated muscle morphology variant || body wall muscle thick filament variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant |
Cold shock DNA-binding domain-like | 0.02268 | INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell compartment expansion variant || germ cell cytoplasmic morphology variant || oocyte number decreased |
SH2 domain | 0.0227 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant |
Second domain of FERM | 0.02488 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant |
Actin/HSP70 | 0.03364 | INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || body wall muscle myosin organization defective || body wall muscle sarcomere morphology variant || germ cell compartment nuclei number variant |
BCR-homology GTPase activation domain (BH-domain) | 0.03364 | INHERITED FROM: neuron morphology variant || axon morphology variant || neurite morphology variant || axon branching variant |
Fibronectin type III | 0.03995 | INHERITED FROM: commissure absent || neuron morphology variant || axon morphology variant || body wall muscle sarcomere morphology variant || neurite morphology variant |
G proteins | 0.04044 | INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant || multiple nuclei oocyte |
Calpain large subunit, catalytic domain (domain II) | 0.0433 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant |
SH3-domain | 0.04655 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant |
Pleckstrin-homology domain (PH domain) | 0.0492 | INHERITED FROM: striated muscle morphology variant || axon morphology variant || body wall muscle sarcomere morphology variant || endomitotic oocytes || muscle cell morphology variant |
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.08914 | INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell compartment expansion variant || germ cell compartment anucleate |
FHA domain | 0.1018 | INHERITED FROM: axon morphology variant || neurite morphology variant || axon branching variant |
Protein kinases, catalytic subunit | 0.1404 | INHERITED FROM: myopodia present || muscle cell morphology variant |
Group II chaperonin (CCT, TRIC), apical domain | 0.144 | INHERITED FROM: oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate |
DBL homology domain (DH-domain) | 0.1832 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant |
Group II chaperonin (CCT, TRIC), ATPase domain | 0.1832 | INHERITED FROM: germ cell morphology variant || oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate |
LIM domain | 0.1832 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant |
I set domains | 0.1949 | INHERITED FROM: body wall muscle sarcomere morphology variant || neurite morphology variant || muscle cell morphology variant |
Cyclin | 0.232 | INHERITED FROM: multiple nuclei early emb || pronuclear size defective early emb || excess maternal pronucleus early emb || nuclear morphology variation early emb || excess pronucleus early emb || embryonic cell morphology variant || nuclear appearance number defective early emb |
Synaptotagmin-like (S variant) | 0.232 | INHERITED FROM: body wall muscle sarcomere morphology variant |
Sec1/munc18-like (SM) proteins | 0.2926 | INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant |
Elongation factors | 0.2926 | INHERITED FROM: oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant |
Extended AAA-ATPase domain | 0.2964 | INHERITED FROM: germ cell compartment small || embryonic cell morphology variant || germ cell compartment anucleate |
RecA protein-like (ATPase-domain) | 0.3699 | INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment anucleate |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.4606 | INHERITED FROM: germ cell compartment expansion variant || oocyte number decreased |
Pumilio repeat | 0.5338 | INHERITED FROM: germ cell morphology variant || multiple nuclei early emb || oocytes stacked || nuclear number defective early emb || oocyte morphology variant || embryonic cell morphology variant || nuclear appearance number defective early emb |
Clathrin adaptor core protein | 0.7008 | INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment nuclei number variant |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.7911 | INHERITED FROM: germ cell compartment expansion variant || oocyte number decreased |
Tubulin, GTPase domain | 0.8215 | INHERITED FROM: axon morphology variant |
Tropomyosin | 0.8399 | INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant |
Growth factor receptor domain | 0.9024 | INHERITED FROM: myopodia present |
Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.9024 | INHERITED FROM: oocyte number decreased |
PDZ domain | 0.9241 | INHERITED FROM: endomitotic oocytes |
SCOP term | FDR (all) | Annotation (direct or inherited) |
POU-specific domain | 0 | Direct |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
beta-sandwich domain of Sec23/24 | 0 | Direct |
Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
Helical domain of Sec23/24 | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Zn-finger domain of Sec23/24 | 0 | Direct |
Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
Mammalian PLC | 0 | Direct |
Trunk domain of Sec23/24 | 0 | Direct |
Integrin domains | 0 | Direct |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Anticodon-binding domain of Class II aaRS | 0 | Direct |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
Proteasome subunits | 0.000000152 | Direct |
Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.0000007276 | Direct |
Clathrin coat assembly domain | 0.00001302 | Direct |
Spectrin repeat | 0.00007068 | Direct |
DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.00007101 | Direct |
Laminin-type module | 0.00007101 | Direct |
PLC-like (P variant) | 0.0002116 | Direct |
EF-hand modules in multidomain proteins | 0.0003817 | Direct |
Calpain large subunit, middle domain (domain III) | 0.001294 | Inherited |
First domain of FERM | 0.001833 | Inherited |
Cdc48 domain 2-like | 0.002022 | Inherited |
Annexin | 0.002022 | Inherited |
Anticodon-binding domain | 0.002022 | Inherited |
Troponin I | 0.002022 | Inherited |
Cdc48 N-terminal domain-like | 0.002022 | Inherited |
Lamin A/C globular tail domain | 0.003167 | Inherited |
Third domain of FERM | 0.006475 | Inherited |
CCCH zinc finger | 0.008016 | Inherited |
L30e/L7ae ribosomal proteins | 0.008074 | Inherited |
F1F0 ATP synthase subunit C | 0.008074 | Inherited |
Calcium ATPase, transduction domain A | 0.008208 | Inherited |
Translational machinery components | 0.01133 | Inherited |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01133 | Inherited |
Nitrogenase iron protein-like | 0.01173 | Inherited |
Laminin G-like module | 0.01173 | Inherited |
Calponin-homology domain, CH-domain | 0.01246 | Inherited |
Canonical RBD | 0.01465 | Inherited |
Motor proteins | 0.01703 | Inherited |
Myosin rod fragments | 0.02097 | Inherited |
Cold shock DNA-binding domain-like | 0.02268 | Inherited |
SH2 domain | 0.0227 | Inherited |
Second domain of FERM | 0.02488 | Inherited |
Actin/HSP70 | 0.03364 | Inherited |
BCR-homology GTPase activation domain (BH-domain) | 0.03364 | Inherited |
Fibronectin type III | 0.03995 | Inherited |
G proteins | 0.04044 | Inherited |
Calpain large subunit, catalytic domain (domain II) | 0.0433 | Inherited |
SH3-domain | 0.04655 | Inherited |
Pleckstrin-homology domain (PH domain) | 0.0492 | Inherited |
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.08914 | Inherited |
FHA domain | 0.1018 | Inherited |
Protein kinases, catalytic subunit | 0.1404 | Inherited |
Group II chaperonin (CCT, TRIC), apical domain | 0.144 | Inherited |
DBL homology domain (DH-domain) | 0.1832 | Inherited |
Group II chaperonin (CCT, TRIC), ATPase domain | 0.1832 | Inherited |
LIM domain | 0.1832 | Inherited |
I set domains | 0.1949 | Inherited |
Cyclin | 0.232 | Inherited |
Synaptotagmin-like (S variant) | 0.232 | Inherited |
Sec1/munc18-like (SM) proteins | 0.2926 | Inherited |
Elongation factors | 0.2926 | Inherited |
Extended AAA-ATPase domain | 0.2964 | Inherited |
RecA protein-like (ATPase-domain) | 0.3699 | Inherited |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.4606 | Inherited |
Pumilio repeat | 0.5338 | Inherited |
Clathrin adaptor core protein | 0.7008 | Inherited |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.7911 | Inherited |
Tubulin, GTPase domain | 0.8215 | Inherited |
Tropomyosin | 0.8399 | Inherited |
Growth factor receptor domain | 0.9024 | Inherited |
Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.9024 | Inherited |
PDZ domain | 0.9241 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
Integrin domains | 0 | DIRECT |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Integrin alpha N-terminal domain | 0 | DIRECT |
Helical domain of Sec23/24 | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Zn-finger domain of Sec23/24 | 0 | DIRECT |
Sm-like ribonucleoproteins | 0.00000001159 | DIRECT |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.00003094 | DIRECT |
Spectrin repeat | 0.000063 | DIRECT |
Cysteine-rich domain | 0.00006354 | DIRECT |
P-loop containing nucleoside triphosphate hydrolases | 0.0001427 | DIRECT |
Translation proteins SH3-like domain | 0.0001595 | DIRECT |
Ribosomal proteins S24e, L23 and L15e | 0.0001757 | DIRECT |
Class II aaRS ABD-related | 0.0005298 | DIRECT |
Calpain large subunit, middle domain (domain III) | 0.0005298 | DIRECT |
Metal cation-transporting ATPase, ATP-binding domain N | 0.0008407 | DIRECT |
Actin depolymerizing proteins | 0.0008682 | DIRECT |
Cdc48 domain 2-like | 0.001106 | INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant || germ cell cytoplasmic morphology variant |
Annexin | 0.001106 | INHERITED FROM: germ cell morphology variant |
beta-sandwich domain of Sec23/24 | 0.001106 | INHERITED FROM: germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || germ cell compartment size variant |
ADC-like | 0.001106 | INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant || germ cell cytoplasmic morphology variant |
Calcium ATPase, transmembrane domain M | 0.00131 | INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant |
CCCH zinc finger | 0.00211 | INHERITED FROM: P granule abnormal || germ cell cytoplasmic morphology variant |
Zn-binding ribosomal proteins | 0.002533 | INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant |
PLC-like phosphodiesterases | 0.002561 | INHERITED FROM: germ cell morphology variant || oocyte morphology variant || endomitotic oocytes |
Calcium ATPase, transduction domain A | 0.002623 | INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant |
Nucleic acid-binding proteins | 0.004157 | INHERITED FROM: cytoplasmic processing body variant || oocyte number decreased || germ cell compartment expansion variant || nuclear appearance number defective early emb || embryonic cell morphology variant |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.004157 | INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant || axon morphology variant || endomitotic oocytes |
F1F0 ATP synthase subunit C | 0.00452 | INHERITED FROM: germ cell compartment anucleate || oocytes lack nucleus || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || germ cell compartment nuclei number variant |
S15/NS1 RNA-binding domain | 0.00452 | INHERITED FROM: germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant |
PYP-like sensor domain (PAS domain) | 0.005637 | INHERITED FROM: neurite morphology variant |
L30e-like | 0.01069 | INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01069 | INHERITED FROM: germ cell morphology variant |
Myosin rod fragments | 0.01069 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant || body wall muscle thick filament variant |
Translational machinery components | 0.01127 | INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant || oocyte morphology variant |
Calponin-homology domain, CH-domain | 0.01155 | INHERITED FROM: striated muscle morphology variant || body wall muscle myosin organization defective |
SH2 domain | 0.01155 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant |
Second domain of FERM | 0.01498 | INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant |
ACP-like | 0.02209 | INHERITED FROM: oocyte number decreased || oocyte morphology variant |
Fibronectin type III | 0.03678 | INHERITED FROM: body wall muscle sarcomere morphology variant || neuron morphology variant || neurite morphology variant || commissure absent || axon morphology variant |
SH3-domain | 0.04203 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant || endomitotic oocytes |
RNA-binding domain, RBD | 0.05101 | INHERITED FROM: P granule localization defective || oocytes disorganized |
SMAD/FHA domain | 0.07441 | INHERITED FROM: axon branching variant |
PH domain-like | 0.08492 | INHERITED FROM: muscle cell morphology variant || axon morphology variant || endomitotic oocytes |
Class II aaRS and biotin synthetases | 0.08604 | INHERITED FROM: germ cell compartment anucleate || cytoplasmic processing body variant || germ cell compartment expansion variant || germ cell morphology variant |
Ribosomal protein S5 domain 2-like | 0.08604 | INHERITED FROM: germ cell compartment expansion variant |
Protein kinase-like (PK-like) | 0.1033 | INHERITED FROM: muscle cell morphology variant || myopodia present |
Concanavalin A-like lectins/glucanases | 0.1039 | INHERITED FROM: commissure handedness defective || neurite morphology variant || axon morphology variant |
Actin-like ATPase domain | 0.1039 | INHERITED FROM: germ cell morphology variant || body wall muscle myosin organization defective |
Immunoglobulin | 0.1194 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || myopodia present || sperm morphology variant || sperm pseudopod variant || neuron morphology variant || neurite morphology variant |
GTPase activation domain, GAP | 0.1765 | INHERITED FROM: neuron morphology variant || neurite morphology variant || axon branching variant || axon morphology variant |
DBL homology domain (DH-domain) | 0.1789 | INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant |
dsRNA-binding domain-like | 0.227 | INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant |
HAD-like | 0.243 | INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant |
ARM repeat | 0.2774 | INHERITED FROM: seam cell morphology variant || P granule localization defective |
EF-hand | 0.2861 | INHERITED FROM: endomitotic oocytes |
EGF/Laminin | 0.2873 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || axon trajectory variant |
Troponin coil-coiled subunits | 0.2883 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant |
Sec1/munc18-like (SM) proteins | 0.2883 | INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant |
Activating enzymes of the ubiquitin-like proteins | 0.3644 | INHERITED FROM: germ cell morphology variant || germ cell compartment nuclei number variant |
GroEL apical domain-like | 0.3824 | INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte morphology variant || oocytes small |
Translation proteins | 0.3824 | INHERITED FROM: germ cell compartment expansion variant || germ cell morphology variant |
GroEL equatorial domain-like | 0.4489 | INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || oocytes small |
Cyclin-like | 0.4489 | INHERITED FROM: pronuclear size defective early emb || excess maternal pronucleus early emb || excess pronucleus early emb || nuclear appearance number defective early emb || multiple nuclei early emb || embryonic cell morphology variant || nuclear morphology variation early emb |
GroEL-intermediate domain like | 0.4489 | INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || oocytes small |
RBP11-like subunits of RNA polymerase | 0.457 | INHERITED FROM: germ cell morphology variant |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.457 | INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant |
TPR-like | 0.4677 | INHERITED FROM: cilia morphology variant || ciliated neuron morphology variant |
Glutathione synthetase ATP-binding domain-like | 0.6026 | INHERITED FROM: body wall muscle thick filament variant || body wall muscle myosin organization defective |
Growth factor receptor domain | 0.6208 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant |
Voltage-gated potassium channels | 0.6903 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.693 | INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant || oocyte morphology variant |
Tubulin C-terminal domain-like | 0.7527 | INHERITED FROM: axon morphology variant |
Tubulin nucleotide-binding domain-like | 0.8108 | INHERITED FROM: axon morphology variant |
Tropomyosin | 0.8321 | INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant |
PDZ domain-like | 0.9013 | INHERITED FROM: endomitotic oocytes |
L domain-like | 1 | INHERITED FROM: myopodia present |
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
Integrin domains | 0 | Direct |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Integrin alpha N-terminal domain | 0 | Direct |
Helical domain of Sec23/24 | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Zn-finger domain of Sec23/24 | 0 | Direct |
Sm-like ribonucleoproteins | 0.00000001159 | Direct |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.00003094 | Direct |
Spectrin repeat | 0.000063 | Direct |
Cysteine-rich domain | 0.00006354 | Direct |
P-loop containing nucleoside triphosphate hydrolases | 0.0001427 | Direct |
Translation proteins SH3-like domain | 0.0001595 | Direct |
Ribosomal proteins S24e, L23 and L15e | 0.0001757 | Direct |
Class II aaRS ABD-related | 0.0005298 | Direct |
Calpain large subunit, middle domain (domain III) | 0.0005298 | Direct |
Metal cation-transporting ATPase, ATP-binding domain N | 0.0008407 | Direct |
Actin depolymerizing proteins | 0.0008682 | Direct |
Cdc48 domain 2-like | 0.001106 | Inherited |
Annexin | 0.001106 | Inherited |
beta-sandwich domain of Sec23/24 | 0.001106 | Inherited |
ADC-like | 0.001106 | Inherited |
Calcium ATPase, transmembrane domain M | 0.00131 | Inherited |
CCCH zinc finger | 0.00211 | Inherited |
Zn-binding ribosomal proteins | 0.002533 | Inherited |
PLC-like phosphodiesterases | 0.002561 | Inherited |
Calcium ATPase, transduction domain A | 0.002623 | Inherited |
Nucleic acid-binding proteins | 0.004157 | Inherited |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.004157 | Inherited |
F1F0 ATP synthase subunit C | 0.00452 | Inherited |
S15/NS1 RNA-binding domain | 0.00452 | Inherited |
PYP-like sensor domain (PAS domain) | 0.005637 | Inherited |
L30e-like | 0.01069 | Inherited |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01069 | Inherited |
Myosin rod fragments | 0.01069 | Inherited |
Translational machinery components | 0.01127 | Inherited |
Calponin-homology domain, CH-domain | 0.01155 | Inherited |
SH2 domain | 0.01155 | Inherited |
Second domain of FERM | 0.01498 | Inherited |
ACP-like | 0.02209 | Inherited |
Fibronectin type III | 0.03678 | Inherited |
SH3-domain | 0.04203 | Inherited |
RNA-binding domain, RBD | 0.05101 | Inherited |
SMAD/FHA domain | 0.07441 | Inherited |
PH domain-like | 0.08492 | Inherited |
Class II aaRS and biotin synthetases | 0.08604 | Inherited |
Ribosomal protein S5 domain 2-like | 0.08604 | Inherited |
Protein kinase-like (PK-like) | 0.1033 | Inherited |
Concanavalin A-like lectins/glucanases | 0.1039 | Inherited |
Actin-like ATPase domain | 0.1039 | Inherited |
Immunoglobulin | 0.1194 | Inherited |
GTPase activation domain, GAP | 0.1765 | Inherited |
DBL homology domain (DH-domain) | 0.1789 | Inherited |
dsRNA-binding domain-like | 0.227 | Inherited |
HAD-like | 0.243 | Inherited |
ARM repeat | 0.2774 | Inherited |
EF-hand | 0.2861 | Inherited |
EGF/Laminin | 0.2873 | Inherited |
Troponin coil-coiled subunits | 0.2883 | Inherited |
Sec1/munc18-like (SM) proteins | 0.2883 | Inherited |
Activating enzymes of the ubiquitin-like proteins | 0.3644 | Inherited |
GroEL apical domain-like | 0.3824 | Inherited |
Translation proteins | 0.3824 | Inherited |
GroEL equatorial domain-like | 0.4489 | Inherited |
Cyclin-like | 0.4489 | Inherited |
GroEL-intermediate domain like | 0.4489 | Inherited |
RBP11-like subunits of RNA polymerase | 0.457 | Inherited |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.457 | Inherited |
TPR-like | 0.4677 | Inherited |
Glutathione synthetase ATP-binding domain-like | 0.6026 | Inherited |
Growth factor receptor domain | 0.6208 | Inherited |
Voltage-gated potassium channels | 0.6903 | Inherited |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.693 | Inherited |
Tubulin C-terminal domain-like | 0.7527 | Inherited |
Tubulin nucleotide-binding domain-like | 0.8108 | Inherited |
Tropomyosin | 0.8321 | Inherited |
PDZ domain-like | 0.9013 | Inherited |
L domain-like | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | DIRECT |
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | DIRECT |
50729,47473 50729 - PH domain-like 47473 - EF-hand | 0 | DIRECT |
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat | 0 | DIRECT |
51695,49562 51695 - PLC-like phosphodiesterases 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like | 0 | DIRECT |
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like | 0 | DIRECT |
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.000004215 | DIRECT |
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain | 0.0001589 | DIRECT |
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III) | 0.0001589 | DIRECT |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0.0001589 | DIRECT |
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like | 0.0008407 | DIRECT |
81333,81333 81333 - F1F0 ATP synthase subunit C 81333 - F1F0 ATP synthase subunit C | 0.001106 | INHERITED FROM: germ cell compartment anucleate || oocytes lack nucleus || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || germ cell compartment nuclei number variant |
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related | 0.001106 | INHERITED FROM: germ cell morphology variant |
55550,50044 55550 - SH2 domain 50044 - SH3-domain | 0.001106 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant |
50044,50044 50044 - SH3-domain 50044 - SH3-domain | 0.002533 | INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0.002561 | INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant |
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases | 0.00452 | INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.005637 | INHERITED FROM: germ cell morphology variant |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01069 | INHERITED FROM: germ cell morphology variant |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0.01386 | INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant |
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0.02209 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant || body wall muscle thick filament variant |
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.02209 | INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant || oocyte morphology variant |
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD | 0.04788 | INHERITED FROM: oocytes disorganized |
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger | 0.05311 | INHERITED FROM: P granule abnormal || germ cell cytoplasmic morphology variant |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0.06728 | INHERITED FROM: nuclear appearance number defective early emb || nuclear number defective early emb |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.1039 | INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant || body wall muscle myosin organization defective |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.1101 | INHERITED FROM: body wall muscle sarcomere morphology variant || neuron morphology variant || neurite morphology variant || axon morphology variant |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1765 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || sperm morphology variant || sperm pseudopod variant || muscle birefringence variant || neurite morphology variant || axon morphology variant |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1868 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1868 | INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || myopodia present |
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like | 0.227 | INHERITED FROM: cilia morphology variant || ciliated neuron morphology variant |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0.227 | INHERITED FROM: pronuclear size defective early emb || excess maternal pronucleus early emb || excess pronucleus early emb || nuclear appearance number defective early emb || nuclear number defective early emb || multiple nuclei early emb || embryonic cell morphology variant || nuclear morphology variation early emb |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 0.2883 | INHERITED FROM: germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte morphology variant || oocytes small |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0.2883 | INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant |
48371,48371 48371 - ARM repeat 48371 - ARM repeat | 0.3222 | INHERITED FROM: cytoplasmic processing body variant |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.3644 | INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant || axon morphology variant |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0.4489 | INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || oocytes small |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.4489 | INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || oocytes small |
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.457 | INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0.8108 | INHERITED FROM: axon morphology variant |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | Direct |
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | Direct |
50729,47473 50729 - PH domain-like 47473 - EF-hand | 0 | Direct |
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat | 0 | Direct |
51695,49562 51695 - PLC-like phosphodiesterases 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like | 0 | Direct |
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like | 0 | Direct |
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.000004215 | Direct |
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain | 0.0001589 | Direct |
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III) | 0.0001589 | Direct |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0.0001589 | Direct |
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like | 0.0008407 | Direct |
81333,81333 81333 - F1F0 ATP synthase subunit C 81333 - F1F0 ATP synthase subunit C | 0.001106 | Inherited |
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related | 0.001106 | Inherited |
55550,50044 55550 - SH2 domain 50044 - SH3-domain | 0.001106 | Inherited |
50044,50044 50044 - SH3-domain 50044 - SH3-domain | 0.002533 | Inherited |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0.002561 | Inherited |
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases | 0.00452 | Inherited |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.005637 | Inherited |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01069 | Inherited |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0.01386 | Inherited |
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0.02209 | Inherited |
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.02209 | Inherited |
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD | 0.04788 | Inherited |
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger | 0.05311 | Inherited |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0.06728 | Inherited |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.1039 | Inherited |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.1101 | Inherited |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1765 | Inherited |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1868 | Inherited |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1868 | Inherited |
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like | 0.227 | Inherited |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0.227 | Inherited |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 0.2883 | Inherited |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0.2883 | Inherited |
48371,48371 48371 - ARM repeat 48371 - ARM repeat | 0.3222 | Inherited |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.3644 | Inherited |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0.4489 | Inherited |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.4489 | Inherited |
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.457 | Inherited |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0.8108 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | DIRECT |
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | DIRECT |
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | DIRECT |
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.00000009691 | DIRECT |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.00002036 | DIRECT |
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M | 0.002623 | INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.005637 | INHERITED FROM: germ cell morphology variant |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0.008825 | INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01069 | INHERITED FROM: germ cell morphology variant |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.227 | INHERITED FROM: myopodia present |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.329 | INHERITED FROM: body wall muscle sarcomere morphology variant || sperm morphology variant || sperm pseudopod variant || muscle birefringence variant || axon morphology variant || body wall muscle myosin organization defective |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.4489 | INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || oocytes small |
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.457 | INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | Direct |
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | Direct |
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | Direct |
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.00000009691 | Direct |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.00002036 | Direct |
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M | 0.002623 | Inherited |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.005637 | Inherited |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0.008825 | Inherited |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01069 | Inherited |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.227 | Inherited |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.329 | Inherited |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.4489 | Inherited |
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.457 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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