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Worm Phenotype (WP): organism metabolism processing variant
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| Histone-fold | 0.0000000000002856 | DIRECT |
| RING/U-box | 0.000000000000286 | DIRECT |
| ARM repeat | 0.000000000003181 | DIRECT |
| "Winged helix" DNA-binding domain | 0.000000000003236 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000001687 | DIRECT |
| Cysteine proteinases | 0.00000003358 | DIRECT |
| UBC-like | 0.00000007107 | DIRECT |
| Chromo domain-like | 0.0000000716 | DIRECT |
| RNA-binding domain, RBD | 0.0000001426 | DIRECT |
| HSP20-like chaperones | 0.0000001668 | DIRECT |
| Homeodomain-like | 0.0000002635 | DIRECT |
| WD40 repeat-like | 0.00000063 | DIRECT |
| FYVE/PHD zinc finger | 0.00000204 | DIRECT |
| SET domain | 0.000003172 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.000005652 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0.000005652 | DIRECT |
| Chaperone J-domain | 0.000007062 | DIRECT |
| Class II aaRS and biotin synthetases | 0.00003309 | DIRECT |
| SNARE-like | 0.00005437 | DIRECT |
| Acid proteases | 0.00005718 | DIRECT |
| PH domain-like | 0.0001107 | DIRECT |
| Cysteine-rich domain | 0.0001368 | DIRECT |
| Bromodomain | 0.000256 | DIRECT |
| Actin-like ATPase domain | 0.000267 | DIRECT |
| Hect, E3 ligase catalytic domain | 0.0003199 | DIRECT |
| Translation proteins SH3-like domain | 0.0003349 | DIRECT |
| CoA-dependent acyltransferases | 0.0003892 | DIRECT |
| Nucleotidylyl transferase | 0.0004235 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.000467 | DIRECT |
| Translation proteins | 0.0004984 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0.0005337 | DIRECT |
| beta-beta-alpha zinc fingers | 0.0006987 | DIRECT |
| Nucleotidyltransferase | 0.0008933 | DIRECT |
| Arginase/deacetylase | 0.0009659 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0009659 | DIRECT |
| Cullin repeat-like | 0.0009659 | DIRECT |
| B-box zinc-binding domain | 0.001105 | INHERITED FROM: gene expression variant || protein interaction variant || transgene subcellular localization variant || transgene expression variant || protein aggregation variant || protein protein interaction variant |
| Ubiquitin-like | 0.001275 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| ClpP/crotonase | 0.001755 | INHERITED FROM: lipid metabolism variant || fat content variant || level of transgene expression variant |
| HMG-box | 0.001755 | INHERITED FROM: transgene expression variant |
| Activating enzymes of the ubiquitin-like proteins | 0.00223 | INHERITED FROM: protein subcellular localization variant || protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant |
| PYP-like sensor domain (PAS domain) | 0.00223 | INHERITED FROM: transgene expression reduced || gene expression level reduced || protein aggregation variant || protein protein interaction variant |
| Cyclophilin-like | 0.002293 | INHERITED FROM: gene expression variant || protein interaction variant || transgene subcellular localization variant || transgene expression variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant |
| CCCH zinc finger | 0.002641 | INHERITED FROM: mRNA expression ectopic || gene expression variant || ectopic expression transgene || transgene expression variant |
| Nucleic acid-binding proteins | 0.002737 | INHERITED FROM: nonsense mRNA accumulation || mRNA surveillance defective |
| Galactose-binding domain-like | 0.003072 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| ACP-like | 0.005115 | INHERITED FROM: gene expression variant || mRNA expression variant |
| Sm-like ribonucleoproteins | 0.005205 | INHERITED FROM: protein subcellular localization variant || unfolded protein response variant || transgene expression variant || pattern of transgene expression variant |
| Retrovirus zinc finger-like domains | 0.006463 | INHERITED FROM: gene expression variant |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.00951 | INHERITED FROM: gene expression variant || transgene expression variant || protein aggregation variant || protein protein interaction variant |
| Calpain large subunit, middle domain (domain III) | 0.01068 | INHERITED FROM: protein degradation variant || protein metabolism variant || metabolic pathway variant |
| Riboflavin synthase domain-like | 0.01068 | INHERITED FROM: pattern protein expression variant |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.01068 | INHERITED FROM: pattern protein expression variant |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.01125 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant || protein aggregation variant || protein protein interaction variant |
| L30e-like | 0.01125 | INHERITED FROM: metabolic pathway variant || pattern of transgene expression variant || RNA processing variant || mRNA surveillance defective |
| Lipovitellin-phosvitin complex, superhelical domain | 0.01161 | INHERITED FROM: unfolded protein response variant || metabolic pathway variant |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.01161 | INHERITED FROM: unfolded protein response variant || metabolic pathway variant |
| Translational machinery components | 0.01161 | INHERITED FROM: metabolic pathway variant |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.01161 | INHERITED FROM: level of transgene expression variant |
| Tudor/PWWP/MBT | 0.01208 | INHERITED FROM: pattern of transgene expression variant |
| FKBP-like | 0.01428 | INHERITED FROM: protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant |
| 4Fe-4S ferredoxins | 0.01451 | INHERITED FROM: transgene expression increased |
| Frizzled cysteine-rich domain | 0.01451 | INHERITED FROM: transgene expression reduced || antibody staining variant |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.01702 | INHERITED FROM: transgene expression increased || protein expression reduced || level of transgene expression variant |
| Intermediate filament protein, coiled coil region | 0.01702 | INHERITED FROM: antibody staining variant || protein expression variant |
| UBA-like | 0.01783 | INHERITED FROM: protein aggregation variant || protein protein interaction variant |
| SMAD/FHA domain | 0.02159 | INHERITED FROM: fat content reduced |
| Lipocalins | 0.02308 | INHERITED FROM: lipid metabolism variant || fat content variant || fat content increased |
| Seven-hairpin glycosidases | 0.02416 | INHERITED FROM: protein aggregation variant || protein protein interaction variant |
| PAZ domain | 0.0253 | INHERITED FROM: mRNA levels increased || siRNA expression variant || RNA expression variant || 21U RNA expression variant |
| DHS-like NAD/FAD-binding domain | 0.0299 | INHERITED FROM: protein acetylation variant || metabolic pathway variant |
| Leucine zipper domain | 0.03012 | INHERITED FROM: transgene expression reduced || mRNA levels reduced || level of transgene expression variant || mRNA expression variant |
| GST C-terminal domain-like | 0.0342 | INHERITED FROM: enzyme activity reduced || enzyme activity variant |
| ADC-like | 0.03665 | INHERITED FROM: transgene expression reduced || protein interaction variant || protein metabolism variant || metabolic pathway variant || protein aggregation variant || protein protein interaction variant |
| MIT domain | 0.03665 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| dsRNA-binding domain-like | 0.04552 | INHERITED FROM: RNA expression variant |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.04552 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Zn-binding ribosomal proteins | 0.04594 | INHERITED FROM: nonsense mRNA accumulation || metabolic pathway variant || RNA processing variant || mRNA surveillance defective || level of transgene expression variant || RNA metabolism variant |
| Transducin (alpha subunit), insertion domain | 0.05686 | INHERITED FROM: protein phosphorylation variant || protein phosphorylation reduced || drug induced gene expression variant |
| WWE domain | 0.05826 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| Cdc48 domain 2-like | 0.05826 | INHERITED FROM: transgene expression reduced || protein interaction variant || protein metabolism variant || metabolic pathway variant || protein aggregation variant || protein protein interaction variant |
| Integrin domains | 0.05826 | INHERITED FROM: protein degradation variant || level of protein expression variant || protein metabolism variant || metabolic pathway variant || protein expression reduced || protein expression variant |
| Cyclin-like | 0.05837 | INHERITED FROM: protein phosphorylation variant || protein phosphorylation reduced |
| Acetyl-CoA synthetase-like | 0.05856 | INHERITED FROM: lipid metabolism variant |
| HIT/MYND zinc finger-like | 0.06132 | INHERITED FROM: pattern of transgene expression variant |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.06286 | INHERITED FROM: protein subcellular localization variant || pathogen induced antimicrobial gene expression variant || drug induced gene expression variant || protein expression variant |
| Saposin | 0.06781 | INHERITED FROM: transgene expression reduced || level of transgene expression variant |
| PX domain | 0.06973 | INHERITED FROM: protein subcellular localization variant || protein expression reduced || protein expression variant |
| Spectrin repeat | 0.06973 | INHERITED FROM: protein degradation variant || level of protein expression variant || protein metabolism variant || antibody staining variant |
| Lamin A/C globular tail domain | 0.06973 | INHERITED FROM: antibody staining variant || protein expression variant |
| Single hybrid motif | 0.06973 | INHERITED FROM: transgene expression increased || level of transgene expression variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.08178 | INHERITED FROM: transgene expression reduced || gene expression level reduced || gene expression level high || fat content increased || level of transgene expression variant |
| p53-like transcription factors | 0.08677 | INHERITED FROM: ectopic expression transgene || gene expression level reduced |
| SH3-domain | 0.09964 | INHERITED FROM: protein phosphorylation variant || protein metabolism variant || protein expression reduced || protein expression variant |
| FAD/NAD(P)-binding domain | 0.1026 | INHERITED FROM: ATP levels variant || ATP levels reduced |
| DNA/RNA polymerases | 0.1051 | INHERITED FROM: DNA metabolism variant |
| S15/NS1 RNA-binding domain | 0.1133 | INHERITED FROM: transgene expression increased |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1278 | INHERITED FROM: lipid composition variant |
| Thioredoxin-like | 0.1617 | INHERITED FROM: enzyme activity reduced || enzyme activity variant |
| ARID-like | 0.1688 | INHERITED FROM: protein expression variant |
| Tubby C-terminal domain-like | 0.1688 | INHERITED FROM: transgene expression reduced |
| CAD & PB1 domains | 0.1688 | INHERITED FROM: protein expression variant |
| HSP40/DnaJ peptide-binding domain | 0.1688 | INHERITED FROM: protein aggregation variant |
| Calcium ATPase, transmembrane domain M | 0.1792 | INHERITED FROM: lipid composition variant |
| KA1-like | 0.2195 | INHERITED FROM: RNA expression variant |
| EF-hand | 0.224 | INHERITED FROM: protein interaction variant || protein aggregation variant |
| Eukaryotic type KH-domain (KH-domain type I) | 0.256 | INHERITED FROM: RNA expression variant |
| Quinoprotein alcohol dehydrogenase-like | 0.2573 | INHERITED FROM: protein degradation variant || mRNA levels increased |
| SAM/Pointed domain | 0.307 | INHERITED FROM: gene expression level reduced |
| GTPase activation domain, GAP | 0.3922 | INHERITED FROM: protein expression variant |
| Protein kinase-like (PK-like) | 0.4908 | INHERITED FROM: protein phosphorylation variant || transgene expression reduced || kinase activity reduced || protein subcellular localization variant || protein phosphorylation reduced || lipid synthesis increased || drug induced gene expression variant || second messenger mediated signaling variant || metabolic pathway variant || protein modification variant || protein expression variant |
| PDZ domain-like | 0.4984 | INHERITED FROM: protein expression variant |
| SH2 domain | 0.5325 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
| Skp1 dimerisation domain-like | 0.671 | INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis |
| Clavaminate synthase-like | 0.7331 | INHERITED FROM: histone methylation variant || protein methylation variant |
| Second domain of FERM | 0.7416 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| Periplasmic binding protein-like II | 0.7803 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Ribonuclease H-like | 0.8533 | INHERITED FROM: siRNA expression variant || RNA expression variant || 21U RNA expression variant |
| Snake toxin-like | 0.8826 | INHERITED FROM: fat content reduced |
| Nuclear receptor ligand-binding domain | 0.8829 | INHERITED FROM: transgene expression reduced || gene expression level reduced || gene expression level high || fat content increased || level of transgene expression variant |
| Immunoglobulin | 0.9824 | INHERITED FROM: protein degradation variant |
| PapD-like | 1 | INHERITED FROM: lipid metabolism variant || fat content variant |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: acetylcholinesterase reduced || acetylcholinesterase activity variant |
| POZ domain | 1 | INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis |
| Voltage-gated potassium channels | 1 | INHERITED FROM: protein degradation variant |
| RNI-like | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Cytochrome P450 | 1 | INHERITED FROM: metabolite content decreased |
| Periplasmic binding protein-like I | 1 | INHERITED FROM: second messenger mediated signaling variant |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Nucleotide cyclase | 1 | INHERITED FROM: second messenger mediated signaling variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| FF domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Cytochrome c | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| MIR domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| LEM domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| ISP domain | 0 | Direct |
| Nop domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| Thiolase-like | 0 | Direct |
| Histone-fold | 0.0000000000002856 | Direct |
| RING/U-box | 0.000000000000286 | Direct |
| ARM repeat | 0.000000000003181 | Direct |
| "Winged helix" DNA-binding domain | 0.000000000003236 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000001687 | Direct |
| Cysteine proteinases | 0.00000003358 | Direct |
| UBC-like | 0.00000007107 | Direct |
| Chromo domain-like | 0.0000000716 | Direct |
| RNA-binding domain, RBD | 0.0000001426 | Direct |
| HSP20-like chaperones | 0.0000001668 | Direct |
| Homeodomain-like | 0.0000002635 | Direct |
| WD40 repeat-like | 0.00000063 | Direct |
| FYVE/PHD zinc finger | 0.00000204 | Direct |
| SET domain | 0.000003172 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.000005652 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0.000005652 | Direct |
| Chaperone J-domain | 0.000007062 | Direct |
| Class II aaRS and biotin synthetases | 0.00003309 | Direct |
| SNARE-like | 0.00005437 | Direct |
| Acid proteases | 0.00005718 | Direct |
| PH domain-like | 0.0001107 | Direct |
| Cysteine-rich domain | 0.0001368 | Direct |
| Bromodomain | 0.000256 | Direct |
| Actin-like ATPase domain | 0.000267 | Direct |
| Hect, E3 ligase catalytic domain | 0.0003199 | Direct |
| Translation proteins SH3-like domain | 0.0003349 | Direct |
| CoA-dependent acyltransferases | 0.0003892 | Direct |
| Nucleotidylyl transferase | 0.0004235 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.000467 | Direct |
| Translation proteins | 0.0004984 | Direct |
| PAP/OAS1 substrate-binding domain | 0.0005337 | Direct |
| beta-beta-alpha zinc fingers | 0.0006987 | Direct |
| Nucleotidyltransferase | 0.0008933 | Direct |
| Arginase/deacetylase | 0.0009659 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0009659 | Direct |
| Cullin repeat-like | 0.0009659 | Direct |
| B-box zinc-binding domain | 0.001105 | Inherited |
| Ubiquitin-like | 0.001275 | Inherited |
| ClpP/crotonase | 0.001755 | Inherited |
| HMG-box | 0.001755 | Inherited |
| Activating enzymes of the ubiquitin-like proteins | 0.00223 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.00223 | Inherited |
| Cyclophilin-like | 0.002293 | Inherited |
| CCCH zinc finger | 0.002641 | Inherited |
| Nucleic acid-binding proteins | 0.002737 | Inherited |
| Galactose-binding domain-like | 0.003072 | Inherited |
| ACP-like | 0.005115 | Inherited |
| Sm-like ribonucleoproteins | 0.005205 | Inherited |
| Retrovirus zinc finger-like domains | 0.006463 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.00951 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.01068 | Inherited |
| Riboflavin synthase domain-like | 0.01068 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.01068 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.01125 | Inherited |
| L30e-like | 0.01125 | Inherited |
| Lipovitellin-phosvitin complex, superhelical domain | 0.01161 | Inherited |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.01161 | Inherited |
| Translational machinery components | 0.01161 | Inherited |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.01161 | Inherited |
| Tudor/PWWP/MBT | 0.01208 | Inherited |
| FKBP-like | 0.01428 | Inherited |
| 4Fe-4S ferredoxins | 0.01451 | Inherited |
| Frizzled cysteine-rich domain | 0.01451 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.01702 | Inherited |
| Intermediate filament protein, coiled coil region | 0.01702 | Inherited |
| UBA-like | 0.01783 | Inherited |
| SMAD/FHA domain | 0.02159 | Inherited |
| Lipocalins | 0.02308 | Inherited |
| Seven-hairpin glycosidases | 0.02416 | Inherited |
| PAZ domain | 0.0253 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.0299 | Inherited |
| Leucine zipper domain | 0.03012 | Inherited |
| GST C-terminal domain-like | 0.0342 | Inherited |
| ADC-like | 0.03665 | Inherited |
| MIT domain | 0.03665 | Inherited |
| dsRNA-binding domain-like | 0.04552 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.04552 | Inherited |
| Zn-binding ribosomal proteins | 0.04594 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.05686 | Inherited |
| WWE domain | 0.05826 | Inherited |
| Cdc48 domain 2-like | 0.05826 | Inherited |
| Integrin domains | 0.05826 | Inherited |
| Cyclin-like | 0.05837 | Inherited |
| Acetyl-CoA synthetase-like | 0.05856 | Inherited |
| HIT/MYND zinc finger-like | 0.06132 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.06286 | Inherited |
| Saposin | 0.06781 | Inherited |
| PX domain | 0.06973 | Inherited |
| Spectrin repeat | 0.06973 | Inherited |
| Lamin A/C globular tail domain | 0.06973 | Inherited |
| Single hybrid motif | 0.06973 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.08178 | Inherited |
| p53-like transcription factors | 0.08677 | Inherited |
| SH3-domain | 0.09964 | Inherited |
| FAD/NAD(P)-binding domain | 0.1026 | Inherited |
| DNA/RNA polymerases | 0.1051 | Inherited |
| S15/NS1 RNA-binding domain | 0.1133 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1278 | Inherited |
| Thioredoxin-like | 0.1617 | Inherited |
| ARID-like | 0.1688 | Inherited |
| Tubby C-terminal domain-like | 0.1688 | Inherited |
| CAD & PB1 domains | 0.1688 | Inherited |
| HSP40/DnaJ peptide-binding domain | 0.1688 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1792 | Inherited |
| KA1-like | 0.2195 | Inherited |
| EF-hand | 0.224 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.256 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.2573 | Inherited |
| SAM/Pointed domain | 0.307 | Inherited |
| GTPase activation domain, GAP | 0.3922 | Inherited |
| Protein kinase-like (PK-like) | 0.4908 | Inherited |
| PDZ domain-like | 0.4984 | Inherited |
| SH2 domain | 0.5325 | Inherited |
| Skp1 dimerisation domain-like | 0.671 | Inherited |
| Clavaminate synthase-like | 0.7331 | Inherited |
| Second domain of FERM | 0.7416 | Inherited |
| Periplasmic binding protein-like II | 0.7803 | Inherited |
| Ribonuclease H-like | 0.8533 | Inherited |
| Snake toxin-like | 0.8826 | Inherited |
| Nuclear receptor ligand-binding domain | 0.8829 | Inherited |
| Immunoglobulin | 0.9824 | Inherited |
| PapD-like | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| POZ domain | 1 | Inherited |
| Voltage-gated potassium channels | 1 | Inherited |
| RNI-like | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| Periplasmic binding protein-like I | 1 | Inherited |
| F-box domain | 1 | Inherited |
| Nucleotide cyclase | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| POU-specific domain | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| Thiolase-related | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| PEP carboxykinase C-terminal domain | 0 | DIRECT |
| Sir2 family of transcriptional regulators | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Brix domain | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | DIRECT |
| Tubulin, GTPase domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | DIRECT |
| Acyl-carrier protein (ACP) | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| HSP20 | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Vertebrate phospholipase A2 | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Clathrin coat assembly domain | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| LDH N-terminal domain-like | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Oxysterol-binding protein | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| RecA protein-like (ATPase-domain) | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Nucleosome core histones | 0.000000001793 | DIRECT |
| Homeodomain | 0.000000437 | DIRECT |
| Actin/HSP70 | 0.000001319 | DIRECT |
| UBC-related | 0.000001867 | DIRECT |
| Forkhead DNA-binding domain | 0.000002863 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.00001272 | DIRECT |
| PHD domain | 0.00001587 | DIRECT |
| Pepsin-like | 0.0000279 | DIRECT |
| G proteins | 0.00006721 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0.0001213 | DIRECT |
| Canonical RBD | 0.0001279 | DIRECT |
| Chaperone J-domain | 0.0001322 | DIRECT |
| Dual specificity phosphatase-like | 0.000153 | DIRECT |
| RING finger domain, C3HC4 | 0.0002224 | DIRECT |
| Histone lysine methyltransferases | 0.0002964 | DIRECT |
| Fatty acid binding protein-like | 0.000309 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0.0006031 | DIRECT |
| Papain-like | 0.0006052 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.0006187 | DIRECT |
| PLC-like (P variant) | 0.000632 | DIRECT |
| Tetratricopeptide repeat (TPR) | 0.000659 | DIRECT |
| Hect, E3 ligase catalytic domain | 0.0009747 | DIRECT |
| Bromodomain | 0.001215 | INHERITED FROM: gene expression variant |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0.001215 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Ubiquitin-related | 0.001314 | INHERITED FROM: protein interaction variant || transgene expression variant || protein aggregation variant || hypersensitive to protein aggregation induced paralysis || protein protein interaction variant |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.001318 | INHERITED FROM: gene expression variant || transgene expression increased |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.002063 | INHERITED FROM: pathogen induced gene expression variant || gene expression variant || protein subcellular localization variant || pathogen induced antimicrobial gene expression variant || drug induced gene expression variant || antimicrobial gene expression variant |
| WD40-repeat | 0.00315 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || protein aggregation induced behavior variant |
| Armadillo repeat | 0.003939 | INHERITED FROM: gene expression variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant || transgene subcellular localization variant || pattern protein expression variant || pattern of transgene expression variant |
| HLH, helix-loop-helix DNA-binding domain | 0.004923 | INHERITED FROM: ectopic expression transgene || gene expression level reduced || RNA expression variant |
| B-box zinc-binding domain | 0.005135 | INHERITED FROM: protein interaction variant || transgene subcellular localization variant || transgene expression variant || protein aggregation variant || protein protein interaction variant |
| SMAD domain | 0.005303 | INHERITED FROM: gene expression variant || transgene expression reduced || fat content variant || transgene expression variant || fat content reduced || mRNA expression variant |
| Translational machinery components | 0.005303 | INHERITED FROM: gene expression variant || transgene expression variant || pattern of transgene expression variant |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.005303 | INHERITED FROM: gene expression variant || protein interaction variant || transgene subcellular localization variant || transgene expression variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant |
| Cyclophilin (peptidylprolyl isomerase) | 0.009224 | INHERITED FROM: protein interaction variant || transgene subcellular localization variant || transgene expression variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant |
| acyl-CoA oxidase C-terminal domains | 0.01069 | INHERITED FROM: lipid metabolism variant || fat content variant |
| acyl-CoA oxidase N-terminal domains | 0.01069 | INHERITED FROM: lipid metabolism variant || fat content variant |
| CCCH zinc finger | 0.01449 | INHERITED FROM: mRNA expression ectopic || gene expression variant || ectopic expression transgene || transgene expression variant |
| Cold shock DNA-binding domain-like | 0.01508 | INHERITED FROM: nonsense mRNA accumulation || mRNA surveillance defective || RNA metabolism variant |
| Lipovitellin-phosvitin complex, superhelical domain | 0.02145 | INHERITED FROM: unfolded protein response variant || metabolic pathway variant |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.02145 | INHERITED FROM: unfolded protein response variant || metabolic pathway variant |
| Calpain large subunit, middle domain (domain III) | 0.02293 | INHERITED FROM: protein degradation variant || protein metabolism variant || metabolic pathway variant |
| Gastric lipase | 0.02293 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Crotonase-like | 0.02343 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.02343 | INHERITED FROM: protein subcellular localization variant || pattern protein expression variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant |
| TBP-associated factors, TAFs | 0.02343 | INHERITED FROM: transgene expression variant |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.02506 | INHERITED FROM: transgene subcellular localization variant || protein aggregation variant || protein protein interaction variant |
| Transforming growth factor (TGF)-beta | 0.02517 | INHERITED FROM: transgene expression reduced || level of transgene expression variant |
| Frizzled cysteine-rich domain | 0.02517 | INHERITED FROM: transgene expression reduced || antibody staining variant |
| EF-hand modules in multidomain proteins | 0.02517 | INHERITED FROM: protein expression variant |
| Extended PAW domain | 0.02835 | INHERITED FROM: protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant |
| FKBP immunophilin/proline isomerase | 0.03312 | INHERITED FROM: protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant |
| LIM domain | 0.03312 | INHERITED FROM: protein degradation variant || level of protein expression variant || protein expression reduced |
| Intermediate filament protein, coiled coil region | 0.04012 | INHERITED FROM: antibody staining variant || protein expression variant |
| Ubiquitin activating enzymes (UBA) | 0.04292 | INHERITED FROM: protein interaction variant || transgene subcellular localization variant || protein aggregation variant || protein protein interaction variant |
| Class I alpha-1;2-mannosidase, catalytic domain | 0.04557 | INHERITED FROM: protein aggregation variant || protein protein interaction variant |
| Extended AAA-ATPase domain | 0.04952 | INHERITED FROM: protein expression increased |
| Bacterial lipase | 0.05573 | INHERITED FROM: lipid metabolism variant || fat content variant |
| MIT domain | 0.05573 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| Cdc48 N-terminal domain-like | 0.05573 | INHERITED FROM: transgene expression reduced || protein interaction variant || protein metabolism variant || metabolic pathway variant || protein aggregation variant || protein protein interaction variant |
| Pumilio repeat | 0.06724 | INHERITED FROM: protein subcellular localization variant || protein expression ectopic |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.06724 | INHERITED FROM: transgene expression increased || protein expression reduced || level of transgene expression variant |
| Choline/Carnitine O-acyltransferase | 0.07165 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Cyclin | 0.08045 | INHERITED FROM: level of transgene expression variant |
| Elongation factors | 0.08045 | INHERITED FROM: proteasome core activity variant || protein phosphorylation variant || mRNA levels increased || mRNA levels reduced || protein aggregation variant || protein phosphorylation increased || protein protein interaction variant |
| Cdc48 domain 2-like | 0.08473 | INHERITED FROM: transgene expression reduced || protein interaction variant || protein metabolism variant || metabolic pathway variant || protein aggregation variant || protein protein interaction variant |
| Anticodon-binding domain | 0.08473 | INHERITED FROM: transgene expression increased |
| WWE domain | 0.08473 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| Biotin dependent carboxylase carboxyltransferase domain | 0.08473 | INHERITED FROM: transgene expression increased |
| Leucine zipper domain | 0.09558 | INHERITED FROM: transgene expression reduced || mRNA levels reduced || level of transgene expression variant |
| PAZ domain | 0.09626 | INHERITED FROM: mRNA levels increased || siRNA expression variant || RNA expression variant || 21U RNA expression variant |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.1037 | INHERITED FROM: lipid metabolism variant || fat content variant |
| PDZ domain | 0.1062 | INHERITED FROM: protein expression variant |
| Lamin A/C globular tail domain | 0.1104 | INHERITED FROM: antibody staining variant || protein expression variant |
| Biotinyl/lipoyl-carrier proteins and domains | 0.1345 | INHERITED FROM: transgene expression increased || level of transgene expression variant |
| PX domain | 0.1345 | INHERITED FROM: protein subcellular localization variant || protein expression variant |
| Glutathione S-transferase (GST), N-terminal domain | 0.1379 | INHERITED FROM: enzyme activity reduced || enzyme activity variant |
| Transducin (alpha subunit), insertion domain | 0.1531 | INHERITED FROM: protein phosphorylation variant || protein phosphorylation reduced || drug induced gene expression variant |
| Acetyl-CoA synthetase-like | 0.1771 | INHERITED FROM: lipid metabolism variant |
| Spectrin repeat | 0.2044 | INHERITED FROM: protein degradation variant || level of protein expression variant || protein metabolism variant || antibody staining variant |
| GABA-aminotransferase-like | 0.2044 | INHERITED FROM: fat content reduced |
| DEP domain | 0.2352 | INHERITED FROM: transgene expression reduced |
| Glutathione S-transferase (GST), C-terminal domain | 0.3266 | INHERITED FROM: enzyme activity reduced || enzyme activity variant |
| I set domains | 0.3526 | INHERITED FROM: protein degradation variant |
| SH3-domain | 0.3708 | INHERITED FROM: protein expression reduced || protein expression variant |
| First domain of FERM | 0.4083 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| Calmodulin-like | 0.4362 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| N-acetyl transferase, NAT | 0.5616 | INHERITED FROM: ectopic expression transgene |
| Double-stranded RNA-binding domain (dsRBD) | 0.5625 | INHERITED FROM: miRNA expression variant |
| Calpain large subunit, catalytic domain (domain II) | 0.6591 | INHERITED FROM: protein degradation variant || protein metabolism variant |
| Synaptotagmin-like (S variant) | 0.6802 | INHERITED FROM: protein subcellular localization variant || pattern protein expression variant |
| Third domain of FERM | 0.6893 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| Phosphate binding protein-like | 0.7708 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Second domain of FERM | 0.8305 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| SH2 domain | 0.8739 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
| Thioltransferase | 0.8927 | INHERITED FROM: protein aggregation induced behavior variant |
| Skp1 dimerisation domain-like | 0.9255 | INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis |
| Adenylyl and guanylyl cyclase catalytic domain | 1 | INHERITED FROM: second messenger mediated signaling variant |
| F-box domain | 1 | INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis |
| Nuclear receptor | 1 | INHERITED FROM: transgene expression reduced || gene expression level reduced || gene expression level high || fat content increased |
| BTB/POZ domain | 1 | INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis |
| MSP-like | 1 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Acetylcholinesterase-like | 1 | INHERITED FROM: acetylcholinesterase reduced || acetylcholinesterase activity variant || enzyme activity reduced || enzyme activity variant |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: transgene expression reduced || gene expression level reduced || gene expression level high || fat content increased |
| Voltage-gated potassium channels | 1 | INHERITED FROM: protein degradation variant |
| Protein kinases, catalytic subunit | 1 | INHERITED FROM: protein phosphorylation variant || transgene expression reduced || kinase activity reduced || protein subcellular localization variant || protein phosphorylation reduced || lipid synthesis increased || drug induced gene expression variant || second messenger mediated signaling variant || protein modification variant || protein expression variant |
| Cytochrome P450 | 1 | INHERITED FROM: metabolite content decreased |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| POU-specific domain | 0 | Direct |
| PDI-like | 0 | Direct |
| Thiolase-related | 0 | Direct |
| CAT-like | 0 | Direct |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | Direct |
| MIR domain | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Nop domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| PEP carboxykinase C-terminal domain | 0 | Direct |
| Sir2 family of transcriptional regulators | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Brix domain | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| FF domain | 0 | Direct |
| Cullin repeat | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | Direct |
| Tubulin, GTPase domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | Direct |
| Acyl-carrier protein (ACP) | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| HSP20 | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Vertebrate phospholipase A2 | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Clathrin coat assembly domain | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| Chromo domain | 0 | Direct |
| LEM domain | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Adenain-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Integrin domains | 0 | Direct |
| LDH N-terminal domain-like | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| ets domain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Oxysterol-binding protein | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| RecA protein-like (ATPase-domain) | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Nucleosome core histones | 0.000000001793 | Direct |
| Homeodomain | 0.000000437 | Direct |
| Actin/HSP70 | 0.000001319 | Direct |
| UBC-related | 0.000001867 | Direct |
| Forkhead DNA-binding domain | 0.000002863 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.00001272 | Direct |
| PHD domain | 0.00001587 | Direct |
| Pepsin-like | 0.0000279 | Direct |
| G proteins | 0.00006721 | Direct |
| Pleckstrin-homology domain (PH domain) | 0.0001213 | Direct |
| Canonical RBD | 0.0001279 | Direct |
| Chaperone J-domain | 0.0001322 | Direct |
| Dual specificity phosphatase-like | 0.000153 | Direct |
| RING finger domain, C3HC4 | 0.0002224 | Direct |
| Histone lysine methyltransferases | 0.0002964 | Direct |
| Fatty acid binding protein-like | 0.000309 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0.0006031 | Direct |
| Papain-like | 0.0006052 | Direct |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.0006187 | Direct |
| PLC-like (P variant) | 0.000632 | Direct |
| Tetratricopeptide repeat (TPR) | 0.000659 | Direct |
| Hect, E3 ligase catalytic domain | 0.0009747 | Direct |
| Bromodomain | 0.001215 | Inherited |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0.001215 | Inherited |
| Ubiquitin-related | 0.001314 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.001318 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.002063 | Inherited |
| WD40-repeat | 0.00315 | Inherited |
| Armadillo repeat | 0.003939 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.004923 | Inherited |
| B-box zinc-binding domain | 0.005135 | Inherited |
| SMAD domain | 0.005303 | Inherited |
| Translational machinery components | 0.005303 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.005303 | Inherited |
| Cyclophilin (peptidylprolyl isomerase) | 0.009224 | Inherited |
| acyl-CoA oxidase C-terminal domains | 0.01069 | Inherited |
| acyl-CoA oxidase N-terminal domains | 0.01069 | Inherited |
| CCCH zinc finger | 0.01449 | Inherited |
| Cold shock DNA-binding domain-like | 0.01508 | Inherited |
| Lipovitellin-phosvitin complex, superhelical domain | 0.02145 | Inherited |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.02145 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.02293 | Inherited |
| Gastric lipase | 0.02293 | Inherited |
| Crotonase-like | 0.02343 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.02343 | Inherited |
| TBP-associated factors, TAFs | 0.02343 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.02506 | Inherited |
| Transforming growth factor (TGF)-beta | 0.02517 | Inherited |
| Frizzled cysteine-rich domain | 0.02517 | Inherited |
| EF-hand modules in multidomain proteins | 0.02517 | Inherited |
| Extended PAW domain | 0.02835 | Inherited |
| FKBP immunophilin/proline isomerase | 0.03312 | Inherited |
| LIM domain | 0.03312 | Inherited |
| Intermediate filament protein, coiled coil region | 0.04012 | Inherited |
| Ubiquitin activating enzymes (UBA) | 0.04292 | Inherited |
| Class I alpha-1;2-mannosidase, catalytic domain | 0.04557 | Inherited |
| Extended AAA-ATPase domain | 0.04952 | Inherited |
| Bacterial lipase | 0.05573 | Inherited |
| MIT domain | 0.05573 | Inherited |
| Cdc48 N-terminal domain-like | 0.05573 | Inherited |
| Pumilio repeat | 0.06724 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.06724 | Inherited |
| Choline/Carnitine O-acyltransferase | 0.07165 | Inherited |
| Cyclin | 0.08045 | Inherited |
| Elongation factors | 0.08045 | Inherited |
| Cdc48 domain 2-like | 0.08473 | Inherited |
| Anticodon-binding domain | 0.08473 | Inherited |
| WWE domain | 0.08473 | Inherited |
| Biotin dependent carboxylase carboxyltransferase domain | 0.08473 | Inherited |
| Leucine zipper domain | 0.09558 | Inherited |
| PAZ domain | 0.09626 | Inherited |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.1037 | Inherited |
| PDZ domain | 0.1062 | Inherited |
| Lamin A/C globular tail domain | 0.1104 | Inherited |
| Biotinyl/lipoyl-carrier proteins and domains | 0.1345 | Inherited |
| PX domain | 0.1345 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 0.1379 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.1531 | Inherited |
| Acetyl-CoA synthetase-like | 0.1771 | Inherited |
| Spectrin repeat | 0.2044 | Inherited |
| GABA-aminotransferase-like | 0.2044 | Inherited |
| DEP domain | 0.2352 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.3266 | Inherited |
| I set domains | 0.3526 | Inherited |
| SH3-domain | 0.3708 | Inherited |
| First domain of FERM | 0.4083 | Inherited |
| Calmodulin-like | 0.4362 | Inherited |
| N-acetyl transferase, NAT | 0.5616 | Inherited |
| Double-stranded RNA-binding domain (dsRBD) | 0.5625 | Inherited |
| Calpain large subunit, catalytic domain (domain II) | 0.6591 | Inherited |
| Synaptotagmin-like (S variant) | 0.6802 | Inherited |
| Third domain of FERM | 0.6893 | Inherited |
| Phosphate binding protein-like | 0.7708 | Inherited |
| Second domain of FERM | 0.8305 | Inherited |
| SH2 domain | 0.8739 | Inherited |
| Thioltransferase | 0.8927 | Inherited |
| Skp1 dimerisation domain-like | 0.9255 | Inherited |
| Adenylyl and guanylyl cyclase catalytic domain | 1 | Inherited |
| F-box domain | 1 | Inherited |
| Nuclear receptor | 1 | Inherited |
| BTB/POZ domain | 1 | Inherited |
| MSP-like | 1 | Inherited |
| Acetylcholinesterase-like | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| Voltage-gated potassium channels | 1 | Inherited |
| Protein kinases, catalytic subunit | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein L10-like | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Histone-fold | 0.0000000000002245 | DIRECT |
| RING/U-box | 0.0000000000002249 | DIRECT |
| ARM repeat | 0.000000000002509 | DIRECT |
| "Winged helix" DNA-binding domain | 0.000000000002552 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000001346 | DIRECT |
| Cysteine proteinases | 0.00000002685 | DIRECT |
| UBC-like | 0.00000005689 | DIRECT |
| Chromo domain-like | 0.00000005733 | DIRECT |
| RNA-binding domain, RBD | 0.0000001143 | DIRECT |
| HSP20-like chaperones | 0.0000001339 | DIRECT |
| Homeodomain-like | 0.0000002119 | DIRECT |
| WD40 repeat-like | 0.0000005083 | DIRECT |
| FYVE/PHD zinc finger | 0.000001654 | DIRECT |
| SET domain | 0.000002575 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.000004596 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0.000004596 | DIRECT |
| Chaperone J-domain | 0.000005743 | DIRECT |
| Class II aaRS and biotin synthetases | 0.00002702 | DIRECT |
| SNARE-like | 0.00004451 | DIRECT |
| Acid proteases | 0.00004679 | DIRECT |
| PH domain-like | 0.00009075 | DIRECT |
| Cysteine-rich domain | 0.0001122 | DIRECT |
| Bromodomain | 0.0002106 | DIRECT |
| Actin-like ATPase domain | 0.0002198 | DIRECT |
| Hect, E3 ligase catalytic domain | 0.0002636 | DIRECT |
| Translation proteins SH3-like domain | 0.000276 | DIRECT |
| CoA-dependent acyltransferases | 0.000321 | DIRECT |
| Nucleotidylyl transferase | 0.0003497 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.0003862 | DIRECT |
| Translation proteins | 0.0004126 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0.0004418 | DIRECT |
| beta-beta-alpha zinc fingers | 0.0005797 | DIRECT |
| Nucleotidyltransferase | 0.0007431 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0008038 | DIRECT |
| Cullin repeat-like | 0.0008038 | DIRECT |
| Arginase/deacetylase | 0.0008038 | DIRECT |
| B-box zinc-binding domain | 0.0009203 | DIRECT |
| Ubiquitin-like | 0.001063 | INHERITED FROM: protein protein interaction variant || protein interaction variant || protein aggregation variant |
| HMG-box | 0.001468 | INHERITED FROM: transgene expression variant |
| ClpP/crotonase | 0.001468 | INHERITED FROM: fat content variant || level of transgene expression variant || lipid metabolism variant |
| PYP-like sensor domain (PAS domain) | 0.001873 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || gene expression level reduced || transgene expression reduced |
| Activating enzymes of the ubiquitin-like proteins | 0.001873 | INHERITED FROM: protein subcellular localization variant || protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant |
| Cyclophilin-like | 0.001927 | INHERITED FROM: protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || gene expression variant || protein aggregation variant || transgene expression variant |
| CCCH zinc finger | 0.002225 | INHERITED FROM: gene expression variant || ectopic expression transgene || transgene expression variant || mRNA expression ectopic |
| Nucleic acid-binding proteins | 0.002308 | INHERITED FROM: nonsense mRNA accumulation || mRNA surveillance defective |
| Galactose-binding domain-like | 0.002594 | INHERITED FROM: protein protein interaction variant || protein interaction variant || protein aggregation variant |
| ACP-like | 0.004346 | INHERITED FROM: mRNA expression variant || gene expression variant |
| Sm-like ribonucleoproteins | 0.004423 | INHERITED FROM: protein subcellular localization variant || unfolded protein response variant || pattern of transgene expression variant || transgene expression variant |
| Retrovirus zinc finger-like domains | 0.00551 | INHERITED FROM: gene expression variant |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.008169 | INHERITED FROM: protein protein interaction variant || gene expression variant || protein aggregation variant || transgene expression variant |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.009197 | INHERITED FROM: pattern protein expression variant |
| Calpain large subunit, middle domain (domain III) | 0.009197 | INHERITED FROM: protein degradation variant || metabolic pathway variant || protein metabolism variant |
| Riboflavin synthase domain-like | 0.009197 | INHERITED FROM: pattern protein expression variant |
| L30e-like | 0.009691 | INHERITED FROM: RNA processing variant || metabolic pathway variant || pattern of transgene expression variant || mRNA surveillance defective |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.009691 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant || transgene expression variant |
| Translational machinery components | 0.01 | INHERITED FROM: metabolic pathway variant |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.01 | INHERITED FROM: metabolic pathway variant || unfolded protein response variant |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.01 | INHERITED FROM: level of transgene expression variant || transgene expression variant |
| Lipovitellin-phosvitin complex, superhelical domain | 0.01 | INHERITED FROM: metabolic pathway variant || unfolded protein response variant |
| ENTH/VHS domain | 0.01042 | INHERITED FROM: gene expression variant |
| Tudor/PWWP/MBT | 0.01042 | INHERITED FROM: pattern of transgene expression variant |
| FKBP-like | 0.01236 | INHERITED FROM: protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant |
| 4Fe-4S ferredoxins | 0.01257 | INHERITED FROM: transgene expression increased |
| Frizzled cysteine-rich domain | 0.01257 | INHERITED FROM: antibody staining variant || transgene expression reduced |
| Intermediate filament protein, coiled coil region | 0.01478 | INHERITED FROM: antibody staining variant || protein expression variant |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.01478 | INHERITED FROM: transgene expression increased || protein expression reduced || level of transgene expression variant |
| UBA-like | 0.01549 | INHERITED FROM: protein protein interaction variant || protein aggregation variant |
| SMAD/FHA domain | 0.01881 | INHERITED FROM: fat content reduced |
| Lipocalins | 0.02015 | INHERITED FROM: fat content increased || fat content variant || lipid metabolism variant |
| Seven-hairpin glycosidases | 0.02111 | INHERITED FROM: protein protein interaction variant || protein aggregation variant |
| PAZ domain | 0.02213 | INHERITED FROM: mRNA levels increased || siRNA expression variant || 21U RNA expression variant || RNA expression variant |
| DHS-like NAD/FAD-binding domain | 0.02625 | INHERITED FROM: protein acetylation variant || metabolic pathway variant || protein expression variant |
| Leucine zipper domain | 0.02645 | INHERITED FROM: mRNA levels reduced || mRNA expression variant || level of transgene expression variant || transgene expression reduced |
| GST C-terminal domain-like | 0.0301 | INHERITED FROM: enzyme activity reduced || enzyme activity variant |
| MIT domain | 0.03228 | INHERITED FROM: protein protein interaction variant || protein interaction variant || protein aggregation variant |
| ADC-like | 0.03228 | INHERITED FROM: protein protein interaction variant || metabolic pathway variant || protein interaction variant || protein metabolism variant || protein aggregation variant || transgene expression reduced |
| dsRNA-binding domain-like | 0.04024 | INHERITED FROM: RNA expression variant |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.04024 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Zn-binding ribosomal proteins | 0.04062 | INHERITED FROM: RNA metabolism variant || RNA processing variant || metabolic pathway variant || nonsense mRNA accumulation || mRNA surveillance defective || level of transgene expression variant |
| Transducin (alpha subunit), insertion domain | 0.05054 | INHERITED FROM: protein phosphorylation reduced || drug induced gene expression variant || protein phosphorylation variant |
| Cdc48 domain 2-like | 0.05183 | INHERITED FROM: protein protein interaction variant || metabolic pathway variant || protein interaction variant || protein metabolism variant || protein aggregation variant || transgene expression reduced |
| Integrin domains | 0.05183 | INHERITED FROM: level of protein expression variant || protein degradation variant || metabolic pathway variant || protein expression reduced || protein metabolism variant || protein expression variant |
| WWE domain | 0.05183 | INHERITED FROM: protein protein interaction variant || protein interaction variant || protein aggregation variant |
| Cyclin-like | 0.05192 | INHERITED FROM: protein phosphorylation reduced || protein phosphorylation variant || level of transgene expression variant |
| Acetyl-CoA synthetase-like | 0.0521 | INHERITED FROM: lipid metabolism variant |
| HIT/MYND zinc finger-like | 0.05462 | INHERITED FROM: pattern of transgene expression variant |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.05601 | INHERITED FROM: protein subcellular localization variant || drug induced gene expression variant || pathogen induced antimicrobial gene expression variant || protein expression variant |
| Saposin | 0.06054 | INHERITED FROM: level of transgene expression variant || transgene expression reduced |
| Lamin A/C globular tail domain | 0.06231 | INHERITED FROM: antibody staining variant || protein expression variant |
| Single hybrid motif | 0.06231 | INHERITED FROM: transgene expression increased || level of transgene expression variant |
| Spectrin repeat | 0.06231 | INHERITED FROM: antibody staining variant || level of protein expression variant || protein degradation variant || protein metabolism variant |
| PX domain | 0.06231 | INHERITED FROM: protein subcellular localization variant || protein expression reduced || protein expression variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.07342 | INHERITED FROM: fat content increased || level of transgene expression variant || gene expression level high || gene expression level reduced || transgene expression reduced |
| p53-like transcription factors | 0.078 | INHERITED FROM: level of transgene expression variant || ectopic expression transgene || gene expression level reduced |
| SH3-domain | 0.08996 | INHERITED FROM: protein expression reduced || protein metabolism variant || protein phosphorylation variant || protein expression variant |
| FAD/NAD(P)-binding domain | 0.09267 | INHERITED FROM: ATP levels reduced || ATP levels variant |
| DNA/RNA polymerases | 0.09503 | INHERITED FROM: DNA metabolism variant |
| S15/NS1 RNA-binding domain | 0.1026 | INHERITED FROM: transgene expression increased |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1161 | INHERITED FROM: lipid composition variant |
| Thioredoxin-like | 0.1479 | INHERITED FROM: enzyme activity reduced || enzyme activity variant |
| HSP40/DnaJ peptide-binding domain | 0.1547 | INHERITED FROM: protein protein interaction variant || protein interaction variant || protein aggregation variant |
| Tubby C-terminal domain-like | 0.1547 | INHERITED FROM: transgene expression reduced |
| CAD & PB1 domains | 0.1547 | INHERITED FROM: protein expression variant |
| ARID-like | 0.1547 | INHERITED FROM: protein expression variant |
| Calcium ATPase, transmembrane domain M | 0.1646 | INHERITED FROM: lipid composition variant |
| KA1-like | 0.2029 | INHERITED FROM: RNA expression variant |
| EF-hand | 0.2071 | INHERITED FROM: protein interaction variant || protein aggregation variant |
| DNase I-like | 0.2285 | INHERITED FROM: protein expression variant |
| Eukaryotic type KH-domain (KH-domain type I) | 0.2381 | INHERITED FROM: RNA expression variant |
| Quinoprotein alcohol dehydrogenase-like | 0.2393 | INHERITED FROM: mRNA levels increased || protein degradation variant |
| SAM/Pointed domain | 0.2878 | INHERITED FROM: gene expression level reduced |
| PLC-like phosphodiesterases | 0.3638 | INHERITED FROM: protein expression variant |
| GTPase activation domain, GAP | 0.3717 | INHERITED FROM: protein expression variant |
| Insulin-like | 0.379 | INHERITED FROM: fat content variant |
| Protein kinase-like (PK-like) | 0.4691 | INHERITED FROM: protein modification variant || protein subcellular localization variant || protein phosphorylation reduced || drug induced gene expression variant || metabolic pathway variant || second messenger mediated signaling variant || lipid synthesis increased || protein phosphorylation variant || kinase activity reduced || protein expression variant || transgene expression reduced |
| PDZ domain-like | 0.4767 | INHERITED FROM: protein expression variant |
| SH2 domain | 0.5106 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
| Skp1 dimerisation domain-like | 0.6496 | INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis |
| Clavaminate synthase-like | 0.7128 | INHERITED FROM: protein methylation variant || histone methylation variant |
| Second domain of FERM | 0.7217 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| Periplasmic binding protein-like II | 0.7614 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Ribonuclease H-like | 0.8365 | INHERITED FROM: siRNA expression variant || 21U RNA expression variant || RNA expression variant |
| Snake toxin-like | 0.867 | INHERITED FROM: fat content reduced |
| Nuclear receptor ligand-binding domain | 0.8673 | INHERITED FROM: fat content increased || level of transgene expression variant || gene expression level high || lipid metabolism variant || gene expression level reduced || transgene expression reduced |
| Immunoglobulin | 0.9708 | INHERITED FROM: protein degradation variant |
| POZ domain | 1 | INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis |
| Nucleotide cyclase | 1 | INHERITED FROM: second messenger mediated signaling variant |
| Voltage-gated potassium channels | 1 | INHERITED FROM: protein degradation variant |
| RNI-like | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Cytochrome P450 | 1 | INHERITED FROM: metabolite content decreased |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: acetylcholinesterase reduced || acetylcholinesterase activity variant |
| Periplasmic binding protein-like I | 1 | INHERITED FROM: second messenger mediated signaling variant |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| PapD-like | 1 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein L10-like | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| LEM domain | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Thiolase-like | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| FF domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Nop domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| ISP domain | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Cytochrome c | 0 | Direct |
| MIR domain | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Histone-fold | 0.0000000000002245 | Direct |
| RING/U-box | 0.0000000000002249 | Direct |
| ARM repeat | 0.000000000002509 | Direct |
| "Winged helix" DNA-binding domain | 0.000000000002552 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000001346 | Direct |
| Cysteine proteinases | 0.00000002685 | Direct |
| UBC-like | 0.00000005689 | Direct |
| Chromo domain-like | 0.00000005733 | Direct |
| RNA-binding domain, RBD | 0.0000001143 | Direct |
| HSP20-like chaperones | 0.0000001339 | Direct |
| Homeodomain-like | 0.0000002119 | Direct |
| WD40 repeat-like | 0.0000005083 | Direct |
| FYVE/PHD zinc finger | 0.000001654 | Direct |
| SET domain | 0.000002575 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.000004596 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0.000004596 | Direct |
| Chaperone J-domain | 0.000005743 | Direct |
| Class II aaRS and biotin synthetases | 0.00002702 | Direct |
| SNARE-like | 0.00004451 | Direct |
| Acid proteases | 0.00004679 | Direct |
| PH domain-like | 0.00009075 | Direct |
| Cysteine-rich domain | 0.0001122 | Direct |
| Bromodomain | 0.0002106 | Direct |
| Actin-like ATPase domain | 0.0002198 | Direct |
| Hect, E3 ligase catalytic domain | 0.0002636 | Direct |
| Translation proteins SH3-like domain | 0.000276 | Direct |
| CoA-dependent acyltransferases | 0.000321 | Direct |
| Nucleotidylyl transferase | 0.0003497 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.0003862 | Direct |
| Translation proteins | 0.0004126 | Direct |
| PAP/OAS1 substrate-binding domain | 0.0004418 | Direct |
| beta-beta-alpha zinc fingers | 0.0005797 | Direct |
| Nucleotidyltransferase | 0.0007431 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0008038 | Direct |
| Cullin repeat-like | 0.0008038 | Direct |
| Arginase/deacetylase | 0.0008038 | Direct |
| B-box zinc-binding domain | 0.0009203 | Direct |
| Ubiquitin-like | 0.001063 | Inherited |
| HMG-box | 0.001468 | Inherited |
| ClpP/crotonase | 0.001468 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.001873 | Inherited |
| Activating enzymes of the ubiquitin-like proteins | 0.001873 | Inherited |
| Cyclophilin-like | 0.001927 | Inherited |
| CCCH zinc finger | 0.002225 | Inherited |
| Nucleic acid-binding proteins | 0.002308 | Inherited |
| Galactose-binding domain-like | 0.002594 | Inherited |
| ACP-like | 0.004346 | Inherited |
| Sm-like ribonucleoproteins | 0.004423 | Inherited |
| Retrovirus zinc finger-like domains | 0.00551 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.008169 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.009197 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.009197 | Inherited |
| Riboflavin synthase domain-like | 0.009197 | Inherited |
| L30e-like | 0.009691 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.009691 | Inherited |
| Translational machinery components | 0.01 | Inherited |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.01 | Inherited |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.01 | Inherited |
| Lipovitellin-phosvitin complex, superhelical domain | 0.01 | Inherited |
| ENTH/VHS domain | 0.01042 | Inherited |
| Tudor/PWWP/MBT | 0.01042 | Inherited |
| FKBP-like | 0.01236 | Inherited |
| 4Fe-4S ferredoxins | 0.01257 | Inherited |
| Frizzled cysteine-rich domain | 0.01257 | Inherited |
| Intermediate filament protein, coiled coil region | 0.01478 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.01478 | Inherited |
| UBA-like | 0.01549 | Inherited |
| SMAD/FHA domain | 0.01881 | Inherited |
| Lipocalins | 0.02015 | Inherited |
| Seven-hairpin glycosidases | 0.02111 | Inherited |
| PAZ domain | 0.02213 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.02625 | Inherited |
| Leucine zipper domain | 0.02645 | Inherited |
| GST C-terminal domain-like | 0.0301 | Inherited |
| MIT domain | 0.03228 | Inherited |
| ADC-like | 0.03228 | Inherited |
| dsRNA-binding domain-like | 0.04024 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.04024 | Inherited |
| Zn-binding ribosomal proteins | 0.04062 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.05054 | Inherited |
| Cdc48 domain 2-like | 0.05183 | Inherited |
| Integrin domains | 0.05183 | Inherited |
| WWE domain | 0.05183 | Inherited |
| Cyclin-like | 0.05192 | Inherited |
| Acetyl-CoA synthetase-like | 0.0521 | Inherited |
| HIT/MYND zinc finger-like | 0.05462 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.05601 | Inherited |
| Saposin | 0.06054 | Inherited |
| Lamin A/C globular tail domain | 0.06231 | Inherited |
| Single hybrid motif | 0.06231 | Inherited |
| Spectrin repeat | 0.06231 | Inherited |
| PX domain | 0.06231 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.07342 | Inherited |
| p53-like transcription factors | 0.078 | Inherited |
| SH3-domain | 0.08996 | Inherited |
| FAD/NAD(P)-binding domain | 0.09267 | Inherited |
| DNA/RNA polymerases | 0.09503 | Inherited |
| S15/NS1 RNA-binding domain | 0.1026 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1161 | Inherited |
| Thioredoxin-like | 0.1479 | Inherited |
| HSP40/DnaJ peptide-binding domain | 0.1547 | Inherited |
| Tubby C-terminal domain-like | 0.1547 | Inherited |
| CAD & PB1 domains | 0.1547 | Inherited |
| ARID-like | 0.1547 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1646 | Inherited |
| KA1-like | 0.2029 | Inherited |
| EF-hand | 0.2071 | Inherited |
| DNase I-like | 0.2285 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.2381 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.2393 | Inherited |
| SAM/Pointed domain | 0.2878 | Inherited |
| PLC-like phosphodiesterases | 0.3638 | Inherited |
| GTPase activation domain, GAP | 0.3717 | Inherited |
| Insulin-like | 0.379 | Inherited |
| Protein kinase-like (PK-like) | 0.4691 | Inherited |
| PDZ domain-like | 0.4767 | Inherited |
| SH2 domain | 0.5106 | Inherited |
| Skp1 dimerisation domain-like | 0.6496 | Inherited |
| Clavaminate synthase-like | 0.7128 | Inherited |
| Second domain of FERM | 0.7217 | Inherited |
| Periplasmic binding protein-like II | 0.7614 | Inherited |
| Ribonuclease H-like | 0.8365 | Inherited |
| Snake toxin-like | 0.867 | Inherited |
| Nuclear receptor ligand-binding domain | 0.8673 | Inherited |
| Immunoglobulin | 0.9708 | Inherited |
| POZ domain | 1 | Inherited |
| Nucleotide cyclase | 1 | Inherited |
| Voltage-gated potassium channels | 1 | Inherited |
| RNI-like | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| Periplasmic binding protein-like I | 1 | Inherited |
| F-box domain | 1 | Inherited |
| PapD-like | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | DIRECT |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | DIRECT |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | DIRECT |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | DIRECT |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | DIRECT |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | DIRECT |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.000001766 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.000004596 | DIRECT |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.000006362 | DIRECT |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0.0002099 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.0002099 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.0004418 | DIRECT |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.0005316 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0008038 | DIRECT |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0.001849 | INHERITED FROM: 21U RNA expression variant || gene expression variant || RNA expression variant |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0.004346 | INHERITED FROM: antibody staining variant || protein expression variant |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.004346 | INHERITED FROM: fat content variant || lipid metabolism variant |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0.004346 | INHERITED FROM: protein degradation variant || metabolic pathway variant || protein metabolism variant |
51045,51045
51045 - WW domain
51045 - WW domain | 0.004837 | INHERITED FROM: transgene expression variant |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.005814 | INHERITED FROM: pattern of transgene expression variant || gene expression variant |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.007585 | INHERITED FROM: protein protein interaction variant || protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.009691 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant || transgene expression variant |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.009691 | INHERITED FROM: pathogen induced gene expression variant || protein subcellular localization variant || drug induced gene expression variant || pathogen induced antimicrobial gene expression variant || antimicrobial gene expression variant |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0.01 | INHERITED FROM: metabolic pathway variant || unfolded protein response variant |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.01 | INHERITED FROM: metabolic pathway variant || unfolded protein response variant |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.01299 | INHERITED FROM: mRNA levels increased || mRNA levels reduced || proteasome core activity variant || protein protein interaction variant || protein phosphorylation variant || protein phosphorylation increased || protein aggregation variant || transgene expression variant |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.01443 | INHERITED FROM: fat content variant || lipid metabolism variant |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0.01568 | INHERITED FROM: protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || protein aggregation variant |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.02111 | INHERITED FROM: protein expression reduced |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.02213 | INHERITED FROM: protein expression reduced |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.02287 | INHERITED FROM: pattern protein expression variant || protein subcellular localization variant || protein expression variant |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.03228 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.04024 | INHERITED FROM: fat content variant || lipid metabolism variant |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0.04062 | INHERITED FROM: protein expression reduced |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.04062 | INHERITED FROM: antibody staining variant || level of protein expression variant || protein degradation variant || protein metabolism variant |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.05054 | INHERITED FROM: protein phosphorylation reduced || drug induced gene expression variant || protein phosphorylation variant |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.07155 | INHERITED FROM: enzyme activity reduced || enzyme activity variant |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.07519 | INHERITED FROM: ectopic expression transgene || mRNA expression ectopic |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 0.09503 | INHERITED FROM: protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || protein aggregation variant |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.1026 | INHERITED FROM: transgene expression increased |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1161 | INHERITED FROM: lipid composition variant |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0.1547 | INHERITED FROM: protein protein interaction variant || protein interaction variant || protein aggregation variant |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.1591 | INHERITED FROM: protein protein interaction variant || protein interaction variant || protein aggregation variant |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.1793 | INHERITED FROM: protein metabolism variant |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3495 | INHERITED FROM: protein degradation variant |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.5873 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0.6843 | INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.8048 | INHERITED FROM: level of protein expression variant || protein expression reduced |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9679 | INHERITED FROM: protein degradation variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | Direct |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | Direct |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | Direct |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | Direct |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | Direct |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | Direct |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | Direct |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.000001766 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.000004596 | Direct |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.000006362 | Direct |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0.0002099 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.0002099 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.0004418 | Direct |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.0005316 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0008038 | Direct |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0.001849 | Inherited |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0.004346 | Inherited |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.004346 | Inherited |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0.004346 | Inherited |
51045,51045
51045 - WW domain
51045 - WW domain | 0.004837 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.005814 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.007585 | Inherited |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.009691 | Inherited |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.009691 | Inherited |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0.01 | Inherited |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.01 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.01299 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.01443 | Inherited |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0.01568 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.02111 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.02213 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.02287 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.03228 | Inherited |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.04024 | Inherited |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0.04062 | Inherited |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.04062 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.05054 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.07155 | Inherited |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.07519 | Inherited |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 0.09503 | Inherited |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.1026 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1161 | Inherited |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0.1547 | Inherited |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.1591 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.1793 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3495 | Inherited |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.5873 | Inherited |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0.6843 | Inherited |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.8048 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9679 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.0002636 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0008038 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.004346 | INHERITED FROM: fat content variant || lipid metabolism variant |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.005686 | INHERITED FROM: protein protein interaction variant || protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.009691 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant || transgene expression variant |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.01 | INHERITED FROM: antibody staining variant || level of protein expression variant || protein degradation variant || protein metabolism variant |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.01 | INHERITED FROM: metabolic pathway variant || unfolded protein response variant |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.02625 | INHERITED FROM: protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1692 | INHERITED FROM: lipid composition variant |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1736 | INHERITED FROM: protein degradation variant |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.2767 | INHERITED FROM: protein expression reduced |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.7248 | INHERITED FROM: level of protein expression variant || protein expression reduced |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8594 | INHERITED FROM: protein degradation variant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.0002636 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0008038 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.004346 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.005686 | Inherited |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.009691 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.01 | Inherited |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.01 | Inherited |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.02625 | Inherited |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1692 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1736 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.2767 | Inherited |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.7248 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8594 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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