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Worm Phenotype (WP): growth variant
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Doublecortin (DC) | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Tubby C-terminal domain-like | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| eIF4e-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| ADP-ribosylation | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Hedgehog/intein (Hint) domain | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| CBD9-like | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Cadherin-like | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| MFPT repeat-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| SAND domain-like | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| GAS2 domain-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| PapD-like | 0.01998 | INHERITED FROM: larval arrest || slow growth || larval growth variant || developmental growth variant |
| POZ domain | 0.0399 | INHERITED FROM: L1 arrest || early larval arrest |
| Sm-like ribonucleoproteins | 0.2976 | INHERITED FROM: sick |
| WD40 repeat-like | 0.3529 | INHERITED FROM: late larval arrest || early larval arrest |
| Ribosomal protein S5 domain 2-like | 0.3953 | INHERITED FROM: early larval arrest |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.4146 | INHERITED FROM: growth rate variant |
| UBC-like | 0.45 | INHERITED FROM: late larval arrest || sick |
| Translation proteins SH3-like domain | 0.5485 | INHERITED FROM: early larval arrest |
| RNA-binding domain, RBD | 0.6122 | INHERITED FROM: sick |
| Voltage-gated potassium channels | 0.6518 | INHERITED FROM: growth rate variant |
| Bromodomain | 0.6675 | INHERITED FROM: sick |
| cAMP-binding domain-like | 0.6675 | INHERITED FROM: growth rate variant |
| SNARE-like | 0.6923 | INHERITED FROM: sick |
| Ribonuclease PH domain 2-like | 0.8286 | INHERITED FROM: early larval arrest |
| Quinoprotein alcohol dehydrogenase-like | 0.928 | INHERITED FROM: mid larval arrest || L2 arrest |
| Band 7/SPFH domain | 0.9911 | INHERITED FROM: growth rate variant |
| Nucleic acid-binding proteins | 0.9928 | INHERITED FROM: sick |
| Homeodomain-like | 1 | INHERITED FROM: growth rate variant |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: sick |
| PH domain-like | 1 | INHERITED FROM: growth rate variant |
| Immunoglobulin | 1 | INHERITED FROM: growth rate variant |
| ARM repeat | 1 | INHERITED FROM: sick |
| Protein kinase-like (PK-like) | 1 | INHERITED FROM: mid larval arrest |
| Bet v1-like | 1 | INHERITED FROM: growth rate variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Doublecortin (DC) | 0 | Direct |
| GAT-like domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| FF domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| ARID-like | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Tubby C-terminal domain-like | 0 | Direct |
| Annexin | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Tim10-like | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| eIF4e-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| Pentein | 0 | Direct |
| Elafin-like | 0 | Direct |
| ALDH-like | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| Cytochrome c | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| PIN domain-like | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| MIR domain | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| Ferritin-like | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| LEM domain | 0 | Direct |
| Citrate synthase | 0 | Direct |
| YWTD domain | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| ADP-ribosylation | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| Hedgehog/intein (Hint) domain | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| CBD9-like | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| VPS9 domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| GYF domain | 0 | Direct |
| LysM domain | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Cadherin-like | 0 | Direct |
| PEBP-like | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| MFPT repeat-like | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| SAND domain-like | 0 | Direct |
| PGBD-like | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| TGS-like | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| GAS2 domain-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| HRDC-like | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| L30e-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| YbiA-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| R3H domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| PapD-like | 0.01998 | Inherited |
| POZ domain | 0.0399 | Inherited |
| Sm-like ribonucleoproteins | 0.2976 | Inherited |
| WD40 repeat-like | 0.3529 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.3953 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.4146 | Inherited |
| UBC-like | 0.45 | Inherited |
| Translation proteins SH3-like domain | 0.5485 | Inherited |
| RNA-binding domain, RBD | 0.6122 | Inherited |
| Voltage-gated potassium channels | 0.6518 | Inherited |
| Bromodomain | 0.6675 | Inherited |
| cAMP-binding domain-like | 0.6675 | Inherited |
| SNARE-like | 0.6923 | Inherited |
| Ribonuclease PH domain 2-like | 0.8286 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.928 | Inherited |
| Band 7/SPFH domain | 0.9911 | Inherited |
| Nucleic acid-binding proteins | 0.9928 | Inherited |
| Homeodomain-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| PH domain-like | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| ARM repeat | 1 | Inherited |
| Protein kinase-like (PK-like) | 1 | Inherited |
| Bet v1-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Chitinase insertion domain | 0 | DIRECT |
| Pyk2-associated protein beta ARF-GAP domain | 0 | DIRECT |
| GAPDH-like | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Ras-binding domain, RBD | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| D-aminoacid oxidase-like | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Amylase, catalytic domain | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| Reductases | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| BAR domain | 0 | DIRECT |
| Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| DPP6 catalytic domain-like | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Internalin LRR domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| PEP carboxykinase C-terminal domain | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| La domain | 0 | DIRECT |
| Pancreatic carboxypeptidase, activation domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Type II chitinase | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Brix domain | 0 | DIRECT |
| Anticodon-binding domain | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| Tim10/DDP | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
| RhoGDI-like | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| SWIRM domain | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| First domain of FERM | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| ATP-dependent protease Lon (La), catalytic domain | 0 | DIRECT |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Ribosomal protein L18 and S11 | 0 | DIRECT |
| BC C-terminal domain-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| 28-residue LRR | 0 | DIRECT |
| Glycosyl transferases group 1 | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Ferredoxin reductase FAD-binding domain-like | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Sec63 N-terminal domain | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Carboxypeptidase regulatory domain | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Translation initiation factor eIF4e | 0 | DIRECT |
| Acyl-carrier protein (ACP) | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| Cofilin-like | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| COMT-like | 0 | DIRECT |
| Hexokinase | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Poly(A) polymerase, PAP, middle domain | 0 | DIRECT |
| HSP20 | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| PUA domain | 0 | DIRECT |
| U-box | 0 | DIRECT |
| Tetraspanin | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Adenosine/AMP deaminase | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Methionine aminopeptidase, insert domain | 0 | DIRECT |
| Vertebrate phospholipase A2 | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| GAS2 domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| Glycogenin | 0 | DIRECT |
| D-aminoacid oxidase, N-terminal domain | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| NOL1/NOP2/sun | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| Protein prenyltransferases | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| beta-Lactamase/D-ala carboxypeptidase | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Ngr ectodomain-like | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Epoxide hydrolase | 0 | DIRECT |
| Acireductone dioxygenase | 0 | DIRECT |
| PhzC/PhzF-like | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Cadherin | 0 | DIRECT |
| MFPT repeat | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Acyl-CoA thioesterase | 0 | DIRECT |
| Pancreatic carboxypeptidases | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| Clathrin coat assembly domain | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | DIRECT |
| HEAT repeat | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| DEP domain | 0 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
| L-aminoacid/polyamine oxidase | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Regulator of chromosome condensation RCC1 | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| 1,3-glucuronyltransferase | 0 | DIRECT |
| RNA-polymerase beta-prime | 0 | DIRECT |
| LacY-like proton/sugar symporter | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| YicI catalytic domain-like | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Troponin I | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| Inositol polyphosphate kinase (IPK) | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| Phosphatidylethanolamine binding protein | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | DIRECT |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | DIRECT |
| BC ATP-binding domain-like | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| Sec63 C-terminal domain-like | 0 | DIRECT |
| VHS domain | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| AMPK-beta glycogen binding domain-like | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| LDH N-terminal domain-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | DIRECT |
| Choline kinase | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Glycerol kinase | 0 | DIRECT |
| Glutaminase | 0 | DIRECT |
| Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Oxysterol-binding protein | 0 | DIRECT |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0 | DIRECT |
| Arylsulfatase | 0 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| YihX-like | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| BC N-terminal domain-like | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| SAM (sterile alpha motif) domain | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Gamma-glutamyltranspeptidase-like | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| CoA-binding domain | 0 | DIRECT |
| UBA domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| UDP-glucose pyrophosphorylase | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| Poly(A) polymerase, PAP, C-terminal domain | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| SAND domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| NHL repeat | 0 | DIRECT |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Poly(A) polymerase, PAP, N-terminal domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Arfaptin, Rac-binding fragment | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| Tandem AAA-ATPase domain | 0.0269 | INHERITED FROM: sick |
| BTB/POZ domain | 0.1588 | INHERITED FROM: L1 arrest || early larval arrest |
| Cold shock DNA-binding domain-like | 0.1645 | INHERITED FROM: sick |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.1699 | INHERITED FROM: sick |
| Extended AAA-ATPase domain | 0.1807 | INHERITED FROM: sick |
| UBC-related | 0.2693 | INHERITED FROM: late larval arrest |
| Myb/SANT domain | 0.3599 | INHERITED FROM: growth rate variant |
| Bromodomain | 0.5869 | INHERITED FROM: sick |
| Canonical RBD | 0.6076 | INHERITED FROM: late larval arrest || sick |
| cAMP-binding domain | 0.6146 | INHERITED FROM: growth rate variant |
| Voltage-gated potassium channels | 0.625 | INHERITED FROM: growth rate variant |
| Ribonuclease PH domain 2-like | 0.82 | INHERITED FROM: early larval arrest |
| Ribonuclease PH domain 1-like | 0.82 | INHERITED FROM: early larval arrest |
| Pleckstrin-homology domain (PH domain) | 0.82 | INHERITED FROM: growth rate variant |
| AAT-like | 0.9141 | INHERITED FROM: growth rate variant |
| I set domains | 1 | INHERITED FROM: growth rate variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Chitinase insertion domain | 0 | Direct |
| Pyk2-associated protein beta ARF-GAP domain | 0 | Direct |
| GAPDH-like | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Ras-binding domain, RBD | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Matrix metalloproteases, catalytic domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| PDI-like | 0 | Direct |
| D-aminoacid oxidase-like | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Amylase, catalytic domain | 0 | Direct |
| CAT-like | 0 | Direct |
| Reductases | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| BAR domain | 0 | Direct |
| Ubiquitin activating enzymes (UBA) | 0 | Direct |
| MIR domain | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| DPP6 catalytic domain-like | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Internalin LRR domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| PEP carboxykinase C-terminal domain | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| La domain | 0 | Direct |
| Pancreatic carboxypeptidase, activation domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Type II chitinase | 0 | Direct |
| Annexin | 0 | Direct |
| Brix domain | 0 | Direct |
| Anticodon-binding domain | 0 | Direct |
| Citrate synthase | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| Tim10/DDP | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Hydantoinase (dihydropyrimidinase) | 0 | Direct |
| RhoGDI-like | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| WGR domain | 0 | Direct |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| SWIRM domain | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| First domain of FERM | 0 | Direct |
| FF domain | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| ATP-dependent protease Lon (La), catalytic domain | 0 | Direct |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | Direct |
| ARID domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Ribosomal protein L18 and S11 | 0 | Direct |
| BC C-terminal domain-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| 28-residue LRR | 0 | Direct |
| Glycosyl transferases group 1 | 0 | Direct |
| YWTD domain | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Ferredoxin reductase FAD-binding domain-like | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Sec63 N-terminal domain | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| Carboxypeptidase regulatory domain | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Translation initiation factor eIF4e | 0 | Direct |
| Acyl-carrier protein (ACP) | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| Cofilin-like | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| COMT-like | 0 | Direct |
| Hexokinase | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Poly(A) polymerase, PAP, middle domain | 0 | Direct |
| HSP20 | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| PUA domain | 0 | Direct |
| U-box | 0 | Direct |
| Tetraspanin | 0 | Direct |
| Subtilases | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Adenosine/AMP deaminase | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Methionine aminopeptidase, insert domain | 0 | Direct |
| Vertebrate phospholipase A2 | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| acyl-CoA oxidase C-terminal domains | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| GAS2 domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| Glycogenin | 0 | Direct |
| D-aminoacid oxidase, N-terminal domain | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | Direct |
| NOL1/NOP2/sun | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| Protein prenyltransferases | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| beta-Lactamase/D-ala carboxypeptidase | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Ngr ectodomain-like | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| GYF domain | 0 | Direct |
| Epoxide hydrolase | 0 | Direct |
| Acireductone dioxygenase | 0 | Direct |
| PhzC/PhzF-like | 0 | Direct |
| LysM domain | 0 | Direct |
| Cadherin | 0 | Direct |
| MFPT repeat | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Acyl-CoA thioesterase | 0 | Direct |
| Pancreatic carboxypeptidases | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| Clathrin coat assembly domain | 0 | Direct |
| Paired domain | 0 | Direct |
| Chromo domain | 0 | Direct |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | Direct |
| HEAT repeat | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| LEM domain | 0 | Direct |
| DEP domain | 0 | Direct |
| acyl-CoA oxidase N-terminal domains | 0 | Direct |
| L-aminoacid/polyamine oxidase | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Regulator of chromosome condensation RCC1 | 0 | Direct |
| NTF2-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| 1,3-glucuronyltransferase | 0 | Direct |
| RNA-polymerase beta-prime | 0 | Direct |
| LacY-like proton/sugar symporter | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| YicI catalytic domain-like | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Troponin I | 0 | Direct |
| Adenain-like | 0 | Direct |
| Inositol polyphosphate kinase (IPK) | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| Phosphatidylethanolamine binding protein | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | Direct |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | Direct |
| BC ATP-binding domain-like | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| IF2B-like | 0 | Direct |
| Sec63 C-terminal domain-like | 0 | Direct |
| VHS domain | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| AMPK-beta glycogen binding domain-like | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| YbiA-like | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| Integrin domains | 0 | Direct |
| LDH N-terminal domain-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | Direct |
| Choline kinase | 0 | Direct |
| Elafin-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Glycerol kinase | 0 | Direct |
| Glutaminase | 0 | Direct |
| Bactericidal permeability-increasing protein, BPI | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Oxysterol-binding protein | 0 | Direct |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0 | Direct |
| Arylsulfatase | 0 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
| YihX-like | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| BC N-terminal domain-like | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| SAM (sterile alpha motif) domain | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Gamma-glutamyltranspeptidase-like | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| CoA-binding domain | 0 | Direct |
| UBA domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| UDP-glucose pyrophosphorylase | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| Poly(A) polymerase, PAP, C-terminal domain | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| HD domain | 0 | Direct |
| SAND domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| NHL repeat | 0 | Direct |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Poly(A) polymerase, PAP, N-terminal domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Arfaptin, Rac-binding fragment | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| Tandem AAA-ATPase domain | 0.0269 | Inherited |
| BTB/POZ domain | 0.1588 | Inherited |
| Cold shock DNA-binding domain-like | 0.1645 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.1699 | Inherited |
| Extended AAA-ATPase domain | 0.1807 | Inherited |
| UBC-related | 0.2693 | Inherited |
| Myb/SANT domain | 0.3599 | Inherited |
| Bromodomain | 0.5869 | Inherited |
| Canonical RBD | 0.6076 | Inherited |
| cAMP-binding domain | 0.6146 | Inherited |
| Voltage-gated potassium channels | 0.625 | Inherited |
| Ribonuclease PH domain 2-like | 0.82 | Inherited |
| Ribonuclease PH domain 1-like | 0.82 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.82 | Inherited |
| AAT-like | 0.9141 | Inherited |
| I set domains | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein L10-like | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Tubby C-terminal domain-like | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| ADP-ribosylation | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Hedgehog/intein (Hint) domain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| CBD9-like | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Cadherin-like | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| MFPT repeat-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| GAS2 domain-like | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| eIF4e-like | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| SAND domain-like | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| PapD-like | 0.01738 | INHERITED FROM: larval arrest || slow growth || larval growth variant || developmental growth variant |
| Translation proteins | 0.02366 | INHERITED FROM: sick |
| POZ domain | 0.03518 | INHERITED FROM: early larval arrest || L1 arrest |
| Sm-like ribonucleoproteins | 0.2786 | INHERITED FROM: sick |
| WD40 repeat-like | 0.3328 | INHERITED FROM: late larval arrest || early larval arrest |
| Ribosomal protein S5 domain 2-like | 0.3748 | INHERITED FROM: early larval arrest |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.3938 | INHERITED FROM: growth rate variant |
| UBC-like | 0.4291 | INHERITED FROM: late larval arrest || sick |
| Translation proteins SH3-like domain | 0.5266 | INHERITED FROM: early larval arrest |
| RNA-binding domain, RBD | 0.5901 | INHERITED FROM: sick |
| Voltage-gated potassium channels | 0.6302 | INHERITED FROM: growth rate variant |
| Bromodomain | 0.6459 | INHERITED FROM: sick |
| cAMP-binding domain-like | 0.6459 | INHERITED FROM: growth rate variant |
| SNARE-like | 0.6713 | INHERITED FROM: sick |
| Fibronectin type III | 0.7384 | INHERITED FROM: growth rate variant |
| Ribonuclease PH domain 2-like | 0.8108 | INHERITED FROM: early larval arrest |
| Quinoprotein alcohol dehydrogenase-like | 0.9139 | INHERITED FROM: mid larval arrest || L2 arrest |
| Band 7/SPFH domain | 0.9805 | INHERITED FROM: growth rate variant |
| Nucleic acid-binding proteins | 0.9823 | INHERITED FROM: sick |
| PH domain-like | 1 | INHERITED FROM: growth rate variant |
| Protein kinase-like (PK-like) | 1 | INHERITED FROM: mid larval arrest |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: sick |
| Immunoglobulin | 1 | INHERITED FROM: growth rate variant |
| Homeodomain-like | 1 | INHERITED FROM: growth rate variant |
| Bet v1-like | 1 | INHERITED FROM: growth rate variant |
| ARM repeat | 1 | INHERITED FROM: sick |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein L10-like | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| ALDH-like | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| Elafin-like | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Ferritin-like | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Tubby C-terminal domain-like | 0 | Direct |
| Tim10-like | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| ADP-ribosylation | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Hedgehog/intein (Hint) domain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| ARID-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| PGBD-like | 0 | Direct |
| YWTD domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Integrin domains | 0 | Direct |
| GAT-like domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| PIN domain-like | 0 | Direct |
| Annexin | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| LEM domain | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| R3H domain | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| LysM domain | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| CBD9-like | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| YbiA-like | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| L30e-like | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Cadherin-like | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| VPS9 domain | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| MFPT repeat-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| FF domain | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| GAS2 domain-like | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| eIF4e-like | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| MIR domain | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| SAND domain-like | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| Pentein | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| TGS-like | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| HRDC-like | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| GYF domain | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| Citrate synthase | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| PEBP-like | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| PapD-like | 0.01738 | Inherited |
| Translation proteins | 0.02366 | Inherited |
| POZ domain | 0.03518 | Inherited |
| Sm-like ribonucleoproteins | 0.2786 | Inherited |
| WD40 repeat-like | 0.3328 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.3748 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.3938 | Inherited |
| UBC-like | 0.4291 | Inherited |
| Translation proteins SH3-like domain | 0.5266 | Inherited |
| RNA-binding domain, RBD | 0.5901 | Inherited |
| Voltage-gated potassium channels | 0.6302 | Inherited |
| Bromodomain | 0.6459 | Inherited |
| cAMP-binding domain-like | 0.6459 | Inherited |
| SNARE-like | 0.6713 | Inherited |
| Fibronectin type III | 0.7384 | Inherited |
| Ribonuclease PH domain 2-like | 0.8108 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.9139 | Inherited |
| Band 7/SPFH domain | 0.9805 | Inherited |
| Nucleic acid-binding proteins | 0.9823 | Inherited |
| PH domain-like | 1 | Inherited |
| Protein kinase-like (PK-like) | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| Homeodomain-like | 1 | Inherited |
| Bet v1-like | 1 | Inherited |
| ARM repeat | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81631,55003
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | DIRECT |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | DIRECT |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | DIRECT |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | DIRECT |
51338,51556
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases | 0 | DIRECT |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | DIRECT |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
56601,48403
56601 - beta-lactamase/transpeptidase-like
48403 - Ankyrin repeat | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | DIRECT |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | DIRECT |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | DIRECT |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | DIRECT |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
47576,47576
47576 - Calponin-homology domain, CH-domain
47576 - Calponin-homology domain, CH-domain | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
141739,141739
141739 - MFPT repeat-like
141739 - MFPT repeat-like | 0 | DIRECT |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | DIRECT |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | DIRECT |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | DIRECT |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | DIRECT |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | DIRECT |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | DIRECT |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1866 | INHERITED FROM: sick |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.5345 | INHERITED FROM: late larval arrest |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.8108 | INHERITED FROM: early larval arrest |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.8347 | INHERITED FROM: growth rate variant |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.957 | INHERITED FROM: growth rate variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81631,55003
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | Direct |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | Direct |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | Direct |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | Direct |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | Direct |
51338,51556
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases | 0 | Direct |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | Direct |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
56601,48403
56601 - beta-lactamase/transpeptidase-like
48403 - Ankyrin repeat | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | Direct |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | Direct |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | Direct |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | Direct |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
47576,47576
47576 - Calponin-homology domain, CH-domain
47576 - Calponin-homology domain, CH-domain | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
141739,141739
141739 - MFPT repeat-like
141739 - MFPT repeat-like | 0 | Direct |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | Direct |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | Direct |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | Direct |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | Direct |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | Direct |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | Direct |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | Direct |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | Direct |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1866 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.5345 | Inherited |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.8108 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.8347 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.957 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56436,49854,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
81301,81631,55003
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
57414,57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0 | DIRECT |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
57567,57567,57567
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9984 | INHERITED FROM: growth rate variant |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 1 | INHERITED FROM: growth rate variant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56436,49854,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
81301,81631,55003
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
57414,57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0 | Direct |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
57567,57567,57567
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9984 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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