Worm Phenotype (WP): postembryonic development variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children)	WP term [WP ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + + 4:	Variant [WBPhenotype:0000886] <2>
+ + + 3:	physiology variant [WBPhenotype:0000519] <14>	(510|587)	(510|248|68)
+ + 2:	development variant [WBPhenotype:0000518] <6>	(508|585)	(508|248|68)
+ 1:	organism development variant [WBPhenotype:0000531] <10>	(505|583)	(505|248|68)
0:	postembryonic development variant [WBPhenotype:0000049] <4>	(236|316)	(237|134|34)
- 1:	larval development variant [WBPhenotype:0000750] <8>	(161|217)	(162|96|28)
- 1:	adult development variant [WBPhenotype:0000447] <1>	(0|0)	(0|0|0)
- 1:	developmental delay postembryonic [WBPhenotype:0000045] <1>	(0|0)	(0|0|0)
- 1:	feminization of XX and XO animals [WBPhenotype:0000687] <1>	(1|0)	(1|0|0)

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Superfamily

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Doublecortin (DC)	0	DIRECT
GAT-like domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Trimeric LpxA-like enzymes	0	DIRECT
Ricin B-like lectins	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
FF domain	0	DIRECT
JAB1/MPN domain	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
ARID-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Arginase/deacetylase	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Annexin	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
FtsH protease domain-like	0	DIRECT
HCP-like	0	DIRECT
DEATH domain	0	DIRECT
Cap-Gly domain	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
alpha/beta knot	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
eIF4e-like	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
WWE domain	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Pentein	0	DIRECT
TAZ domain	0	DIRECT
Elafin-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
ALDH-like	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
Cytochrome c	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Aquaporin-like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Nucleotidyltransferase	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Proton glutamate symport protein	0	DIRECT
MIR domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
WGR domain-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Rap/Ran-GAP	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
SMAD/FHA domain	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
LEM domain	0	DIRECT
Citrate synthase	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Cupredoxins	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
ADP-ribosylation	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
SNARE-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
CBD9-like	0	DIRECT
Kringle-like	0	DIRECT
Chaperone J-domain	0	DIRECT
Ammonium transporter	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
PUA domain-like	0	DIRECT
Hormone receptor domain	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
HSP20-like chaperones	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
KA1-like	0	DIRECT
14-3-3 protein	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Radical SAM enzymes	0	DIRECT
VPS9 domain	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Cystatin/monellin	0	DIRECT
PLP-binding barrel	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
LexA/Signal peptidase	0	DIRECT
Small-conductance potassium channel	0	DIRECT
GYF domain	0	DIRECT
LysM domain	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
BAR/IMD domain-like	0	DIRECT
L-aspartase-like	0	DIRECT
Terpenoid synthases	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Cadherin-like	0	DIRECT
PEBP-like	0	DIRECT
BEACH domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
RuvA domain 2-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
SpoIIaa-like	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
ISP domain	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
Nop domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
HIT-like	0	DIRECT
MFPT repeat-like	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Ribokinase-like	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
BolA-like	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
eIF1-like	0	DIRECT
CalX-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
AN1-like Zinc finger	0	DIRECT
SAICAR synthase-like	0	DIRECT
Subtilisin-like	0	DIRECT
SPOC domain-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Flavoproteins	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
SAND domain-like	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
Insulin-like	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
PGBD-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Caspase-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
Nucleoporin domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Mss4-like	0	DIRECT
GroEL apical domain-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Serine protease inhibitors	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	DIRECT
Cyclophilin-like	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
TGS-like	0	DIRECT
Sec7 domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
GAS2 domain-like	0	DIRECT
cAMP-binding domain-like	0	DIRECT
HRDC-like	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
L30e-like	0	DIRECT
Integrin domains	0	DIRECT
PEP carboxykinase-like	0	DIRECT
SCP-like	0	DIRECT
Thiolase-like	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Hemopexin-like domain	0	DIRECT
PHM/PNGase F	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Ribosomal protein S10	0	DIRECT
R3H domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
PapD-like	0.0002618	DIRECT
Mitochondrial carrier	0.03099	INHERITED FROM: larval arrest
Actin-like ATPase domain	0.03433	INHERITED FROM: L1 larval development variant
POZ domain	0.1007	INHERITED FROM: L1 arrest || L1 larval development variant || early larval arrest
UBC-like	0.1782	INHERITED FROM: late larval arrest
Quinoprotein alcohol dehydrogenase-like	0.2034	INHERITED FROM: L2 larval development variant || L2 arrest || mid larval arrest
Growth factor receptor domain	0.3423	INHERITED FROM: molt variant
Ribosomal protein S5 domain 2-like	0.3575	INHERITED FROM: early larval arrest
Intermediate filament protein, coiled coil region	0.4256	INHERITED FROM: molt variant
CoA-dependent acyltransferases	0.599	INHERITED FROM: dauer development variant
TPR-like	0.6805	INHERITED FROM: dauer development variant
WD40 repeat-like	0.741	INHERITED FROM: late larval arrest || early larval arrest
Protein kinase-like (PK-like)	0.7474	INHERITED FROM: dauer development variant || mid larval arrest
Translation proteins SH3-like domain	0.7808	INHERITED FROM: early larval arrest
Lamin A/C globular tail domain	0.8173	INHERITED FROM: molt variant
Ribonuclease PH domain 2-like	0.9577	INHERITED FROM: early larval arrest
F-box domain	1	INHERITED FROM: feminization of XX and XO animals || feminization of germline

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Family

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Chitinase insertion domain	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
GAPDH-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Myeloperoxidase-like	0	DIRECT
POU-specific domain	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
PDI-like	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Thiolase-related	0	DIRECT
Ephrin ectodomain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Amylase, catalytic domain	0	DIRECT
CAT-like	0	DIRECT
Reductases	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
PABC (PABP) domain	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
alpha-mannosidase	0	DIRECT
beta-glycanases	0	DIRECT
BAR domain	0	DIRECT
MIR domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Cap-Gly domain	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
FCH domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Nop domain	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
La domain	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
TAZ domain	0	DIRECT
Type II chitinase	0	DIRECT
Annexin	0	DIRECT
Brix domain	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
Anticodon-binding domain	0	DIRECT
Citrate synthase	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Heme-dependent catalases	0	DIRECT
Third domain of FERM	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
RhoGDI-like	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
WGR domain	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
SWIRM domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
First domain of FERM	0	DIRECT
FF domain	0	DIRECT
Ribokinase-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
SMAD domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Cytochrome b5	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
ARID domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
WWE domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Small-conductance potassium channel	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
28-residue LRR	0	DIRECT
Glycosyl transferases group 1	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Chaperone J-domain	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
ALDH-like	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Cofilin-like	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Insulin-like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
COMT-like	0	DIRECT
Hexokinase	0	DIRECT
E2F dimerization segment	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
HSP20	0	DIRECT
Bacterial lipase	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
PUA domain	0	DIRECT
U-box	0	DIRECT
Tetraspanin	0	DIRECT
Subtilases	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Vertebrate phospholipase A2	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Rap/Ran-GAP	0	DIRECT
GAS2 domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Glycogenin	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
RNA-polymerase beta	0	DIRECT
DNA gyrase/MutL, N-terminal domain	0	DIRECT
Protein prenyltransferases	0	DIRECT
14-3-3 protein	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
STAR domain	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
GYF domain	0	DIRECT
Epoxide hydrolase	0	DIRECT
Acireductone dioxygenase	0	DIRECT
PhzC/PhzF-like	0	DIRECT
LysM domain	0	DIRECT
Ricin B-like	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Cadherin	0	DIRECT
CalX-beta domain	0	DIRECT
MFPT repeat	0	DIRECT
Sec7 domain	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
PhyH-like	0	DIRECT
Linker histone H1/H5	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Ammonium transporter	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Paired domain	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
ATI-like	0	DIRECT
Laminin G-like module	0	DIRECT
LEM domain	0	DIRECT
DEP domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
cAMP-binding domain	0	DIRECT
eIF1-like	0	DIRECT
NTF2-like	0	DIRECT
BolA-like	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
DEATH domain, DD	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Troponin I	0	DIRECT
Adenain-like	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
IF2B-like	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Class I aldolase	0	DIRECT
VHS domain	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Trehalase-like	0	DIRECT
Gelsolin-like	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
FtsH protease domain-like	0	DIRECT
Elongation factors	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Zf-UBP	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Translational machinery components	0	DIRECT
Integrin domains	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
BEACH domain	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
Aquaporin-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
PDEase	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Choline kinase	0	DIRECT
Elafin-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Glycerol kinase	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Glutaminase	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Oxysterol-binding protein	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
Arylsulfatase	0	DIRECT
YihX-like	0	DIRECT
Hemopexin-like domain	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
UBX domain	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
CoA-binding domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
DNA gyrase/MutL, second domain	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
FHA domain	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
4HBT-like	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Mo25 protein	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
Myb/SANT domain	0	DIRECT
TRAPP components	0	DIRECT
HD domain	0	DIRECT
SAND domain	0	DIRECT
Hormone receptor domain	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
NHL repeat	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
ZZ domain	0	DIRECT
Caspase catalytic domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
NagD-like	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Arginine methyltransferase	0	DIRECT
MSP-like	0.0001355	DIRECT
Mitochondrial carrier	0.03245	INHERITED FROM: larval arrest
Pleckstrin-homology domain (PH domain)	0.03589	INHERITED FROM: dauer development variant
Actin/HSP70	0.1183	INHERITED FROM: L1 larval development variant
BTB/POZ domain	0.1384	INHERITED FROM: L1 arrest || L1 larval development variant || early larval arrest
Canonical RBD	0.1998	INHERITED FROM: late larval arrest
Growth factor receptor domain	0.2832	INHERITED FROM: molt variant
UBC-related	0.3118	INHERITED FROM: late larval arrest
Cold shock DNA-binding domain-like	0.4083	INHERITED FROM: molt variant
Intermediate filament protein, coiled coil region	0.4121	INHERITED FROM: molt variant
PLC-like (P variant)	0.4121	INHERITED FROM: dauer formation variant
Proteasome subunits	0.6965	INHERITED FROM: molt variant
Protein kinases, catalytic subunit	0.7156	INHERITED FROM: dauer development variant
Choline/Carnitine O-acyltransferase	0.8069	INHERITED FROM: dauer development variant
WD40-repeat	0.8947	INHERITED FROM: dauer defective
Ribonuclease PH domain 2-like	0.9486	INHERITED FROM: early larval arrest
Ribonuclease PH domain 1-like	0.9486	INHERITED FROM: early larval arrest

---

Supra-domain (including individual superfamily)

Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Mss4-like	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
Ammonium transporter	0	DIRECT
ALDH-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Ribosomal protein S10	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
PEP carboxykinase-like	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
SAICAR synthase-like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
SNARE-like	0	DIRECT
KA1-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Elafin-like	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
PUA domain-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Hemopexin-like domain	0	DIRECT
Cystatin/monellin	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
14-3-3 protein	0	DIRECT
ADP-ribosylation	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	DIRECT
Cap-Gly domain	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Nucleotidyltransferase	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Chaperone J-domain	0	DIRECT
HSP20-like chaperones	0	DIRECT
L-aspartase-like	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Proton glutamate symport protein	0	DIRECT
ARID-like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
PGBD-like	0	DIRECT
TAZ domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Integrin domains	0	DIRECT
GAT-like domain	0	DIRECT
Hormone receptor domain	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
Insulin-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
Annexin	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
LEM domain	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
R3H domain	0	DIRECT
LysM domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
CBD9-like	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Nucleoporin domain	0	DIRECT
Subtilisin-like	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
L30e-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
SMAD MH1 domain	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
alpha/beta knot	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
JAB1/MPN domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Cupredoxins	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
CalX-like	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Cadherin-like	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
HCP-like	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
GroEL apical domain-like	0	DIRECT
VPS9 domain	0	DIRECT
BolA-like	0	DIRECT
Ricin B-like lectins	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Flavoproteins	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
MFPT repeat-like	0	DIRECT
Thiolase-like	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Serine protease inhibitors	0	DIRECT
Ribosomal protein L1	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
PHM/PNGase F	0	DIRECT
BEACH domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
eIF1-like	0	DIRECT
FF domain	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Kringle-like	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Cyclophilin-like	0	DIRECT
PLP-binding barrel	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
SCP-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
GAS2 domain-like	0	DIRECT
Trimeric LpxA-like enzymes	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Nop domain	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Caspase-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
LexA/Signal peptidase	0	DIRECT
ISP domain	0	DIRECT
RuvA domain 2-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
Cytochrome c	0	DIRECT
Restriction endonuclease-like	0	DIRECT
HIT-like	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
DEATH domain	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
eIF4e-like	0	DIRECT
Rap/Ran-GAP	0	DIRECT
FtsH protease domain-like	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
MIR domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
cAMP-binding domain-like	0	DIRECT
TK C-terminal domain-like	0	DIRECT
SAND domain-like	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Pentein	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
TGS-like	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Terpenoid synthases	0	DIRECT
HRDC-like	0	DIRECT
Small-conductance potassium channel	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
GYF domain	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
SPOC domain-like	0	DIRECT
Ribokinase-like	0	DIRECT
Citrate synthase	0	DIRECT
Arginase/deacetylase	0	DIRECT
WGR domain-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
SpoIIaa-like	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
PEBP-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
Sec7 domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
WWE domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Aquaporin-like	0	DIRECT
PapD-like	0.0002155	DIRECT
Mitochondrial carrier	0.02722	INHERITED FROM: larval development variant || larval arrest
Actin-like ATPase domain	0.03021	INHERITED FROM: L1 larval development variant
POZ domain	0.09098	INHERITED FROM: early larval arrest || L1 larval development variant || L1 arrest
UBC-like	0.1636	INHERITED FROM: late larval arrest
Quinoprotein alcohol dehydrogenase-like	0.1874	INHERITED FROM: L2 larval development variant || mid larval arrest || L2 arrest
Growth factor receptor domain	0.3224	INHERITED FROM: molt variant
Ribosomal protein S5 domain 2-like	0.3373	INHERITED FROM: early larval arrest
Intermediate filament protein, coiled coil region	0.4048	INHERITED FROM: molt variant
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.5472	INHERITED FROM: molt variant
CoA-dependent acyltransferases	0.5772	INHERITED FROM: dauer development variant
TPR-like	0.6592	INHERITED FROM: dauer development variant
WD40 repeat-like	0.721	INHERITED FROM: early larval arrest || late larval arrest
Protein kinase-like (PK-like)	0.7276	INHERITED FROM: mid larval arrest || dauer development variant
Translation proteins SH3-like domain	0.7619	INHERITED FROM: early larval arrest
Lamin A/C globular tail domain	0.7993	INHERITED FROM: molt variant
Ribonuclease PH domain 2-like	0.9446	INHERITED FROM: early larval arrest
F-box domain	1	INHERITED FROM: feminization of XX and XO animals || feminization of germline

Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48034,55931 48034 - Guanido kinase N-terminal domain 55931 - Glutamine synthetase/guanido kinase	0	DIRECT
81631,55003 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain	0	DIRECT
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
48425,50729 48425 - Sec7 domain 50729 - PH domain-like	0	DIRECT
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	0	DIRECT
54211,54980 54211 - Ribosomal protein S5 domain 2-like 54980 - EF-G C-terminal domain-like	0	DIRECT
51971,54373 51971 - Nucleotide-binding domain 54373 - FAD-linked reductases, C-terminal domain	0	DIRECT
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0	DIRECT
50044,50044 50044 - SH3-domain 50044 - SH3-domain	0	DIRECT
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like	0	DIRECT
46938,52087 46938 - CRAL/TRIO N-terminal domain 52087 - CRAL/TRIO domain	0	DIRECT
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0	DIRECT
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	DIRECT
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
48464,89009 48464 - ENTH/VHS domain 89009 - GAT-like domain	0	DIRECT
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II	0	DIRECT
47741,56176 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0	DIRECT
54897,53187 54897 - Protease propeptides/inhibitors 53187 - Zn-dependent exopeptidases	0	DIRECT
54368,55931 54368 - Glutamine synthetase, N-terminal domain 55931 - Glutamine synthetase/guanido kinase	0	DIRECT
57889,50729 57889 - Cysteine-rich domain 50729 - PH domain-like	0	DIRECT
81333,81333 81333 - F1F0 ATP synthase subunit C 81333 - F1F0 ATP synthase subunit C	0	DIRECT
55486,49854 55486 - Metalloproteases ("zincins"), catalytic domain 49854 - Spermadhesin, CUB domain	0	DIRECT
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0	DIRECT
81383,52047 81383 - F-box domain 52047 - RNI-like	0	DIRECT
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0	DIRECT
54495,46934 54495 - UBC-like 46934 - UBA-like	0	DIRECT
141072,141072 141072 - CalX-like 141072 - CalX-like	0	DIRECT
54665,56003 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain	0	DIRECT
57362,57362 57362 - BPTI-like 57362 - BPTI-like	0	DIRECT
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	DIRECT
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II	0	DIRECT
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain	0	DIRECT
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like	0	DIRECT
52540,90123 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0	DIRECT
49742,49742 49742 - PHM/PNGase F 49742 - PHM/PNGase F	0	DIRECT
51338,51556 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases	0	DIRECT
54637,54637 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
81383,50978 81383 - F-box domain 50978 - WD40 repeat-like	0	DIRECT
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0	DIRECT
51445,51011 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain	0	DIRECT
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like	0	DIRECT
56601,48403 56601 - beta-lactamase/transpeptidase-like 48403 - Ankyrin repeat	0	DIRECT
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
57414,57414 57414 - Hairpin loop containing domain-like 57414 - Hairpin loop containing domain-like	0	DIRECT
55753,55753 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins	0	DIRECT
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains	0	DIRECT
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins	0	DIRECT
144232,82199 144232 - HIT/MYND zinc finger-like 82199 - SET domain	0	DIRECT
81301,81631 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain	0	DIRECT
68923,53795 68923 - PEP carboxykinase N-terminal domain 53795 - PEP carboxykinase-like	0	DIRECT
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM	0	DIRECT
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
50729,47473 50729 - PH domain-like 47473 - EF-hand	0	DIRECT
81324,81327 81324 - Voltage-gated potassium channels 81327 - Small-conductance potassium channel	0	DIRECT
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	DIRECT
47576,47576 47576 - Calponin-homology domain, CH-domain 47576 - Calponin-homology domain, CH-domain	0	DIRECT
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like	0	DIRECT
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation	0	DIRECT
52283,51735 52283 - Formate/glycerate dehydrogenase catalytic domain-like 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
53187,49464 53187 - Zn-dependent exopeptidases 49464 - Carboxypeptidase regulatory domain-like	0	DIRECT
74650,51445 74650 - Galactose mutarotase-like 51445 - (Trans)glycosidases	0	DIRECT
88713,88688 88713 - Glycoside hydrolase/deacetylase 88688 - Families 57/38 glycoside transferase middle domain	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain	0	DIRECT
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	DIRECT
82171,53474 82171 - DPP6 N-terminal domain-like 53474 - alpha/beta-Hydrolases	0	DIRECT
53187,55031 53187 - Zn-dependent exopeptidases 55031 - Bacterial exopeptidase dimerisation domain	0	DIRECT
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	DIRECT
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
55920,46785 55920 - Creatinase/aminopeptidase 46785 - "Winged helix" DNA-binding domain	0	DIRECT
51206,51206 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like	0	DIRECT
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	DIRECT
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
54534,54534 54534 - FKBP-like 54534 - FKBP-like	0	DIRECT
141739,141739 141739 - MFPT repeat-like 141739 - MFPT repeat-like	0	DIRECT
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier	0	DIRECT
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	DIRECT
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0	DIRECT
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	DIRECT
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0	DIRECT
81698,81698 81698 - FF domain 81698 - FF domain	0	DIRECT
51445,54556 51445 - (Trans)glycosidases 54556 - Chitinase insertion domain	0	DIRECT
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III)	0	DIRECT
56112,56112 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0	DIRECT
57567,57567 57567 - Serine protease inhibitors 57567 - Serine protease inhibitors	0	DIRECT
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
161093,161093 161093 - MgtE membrane domain-like 161093 - MgtE membrane domain-like	0	DIRECT
54631,54631 54631 - CBS-domain pair 54631 - CBS-domain pair	0	DIRECT
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	DIRECT
55394,55394 55394 - Bactericidal permeability-increasing protein, BPI 55394 - Bactericidal permeability-increasing protein, BPI	0	DIRECT
54495,57850 54495 - UBC-like 57850 - RING/U-box	0	DIRECT
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like	0	DIRECT
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0	DIRECT
57903,51197 57903 - FYVE/PHD zinc finger 51197 - Clavaminate synthase-like	0	DIRECT
54980,54211 54980 - EF-G C-terminal domain-like 54211 - Ribosomal protein S5 domain 2-like	0	DIRECT
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0	DIRECT
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat	0	DIRECT
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	DIRECT
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain	0	DIRECT
57903,82199 57903 - FYVE/PHD zinc finger 82199 - SET domain	0	DIRECT
50447,54980 50447 - Translation proteins 54980 - EF-G C-terminal domain-like	0	DIRECT
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain	0	DIRECT
52540,140990 52540 - P-loop containing nucleoside triphosphate hydrolases 140990 - FtsH protease domain-like	0	DIRECT
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
57850,117839 57850 - RING/U-box 117839 - WWE domain	0	DIRECT
48403,52151 48403 - Ankyrin repeat 52151 - FabD/lysophospholipase-like	0	DIRECT
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	DIRECT
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
53448,50370 53448 - Nucleotide-diphospho-sugar transferases 50370 - Ricin B-like lectins	0	DIRECT
141673,50800 141673 - MOSC N-terminal domain-like 50800 - PK beta-barrel domain-like	0	DIRECT
55874,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like	0	DIRECT
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains	0	DIRECT
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like	0	DIRECT
52540,81271 52540 - P-loop containing nucleoside triphosphate hydrolases 81271 - TGS-like	0	DIRECT
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
57863,48403 57863 - ArfGap/RecO-like zinc finger 48403 - Ankyrin repeat	0	DIRECT
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin)	0	DIRECT
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0	DIRECT
54292,47741 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like	0	DIRECT
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.05049	INHERITED FROM: L1 larval development variant
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.4525	INHERITED FROM: late larval arrest
48452,48452 48452 - TPR-like 48452 - TPR-like	0.6854	INHERITED FROM: dauer defective
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases	0.7619	INHERITED FROM: dauer development variant
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.9261	INHERITED FROM: molt variant
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like	0.9446	INHERITED FROM: early larval arrest
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0.9548	INHERITED FROM: dauer formation variant || dauer defective || dauer development variant

Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
56436,49854,49854 56436 - C-type lectin-like 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain	0	DIRECT
51735,48179,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
50447,54980,54211 50447 - Translation proteins 54980 - EF-G C-terminal domain-like 54211 - Ribosomal protein S5 domain 2-like	0	DIRECT
54980,54211,54980 54980 - EF-G C-terminal domain-like 54211 - Ribosomal protein S5 domain 2-like 54980 - EF-G C-terminal domain-like	0	DIRECT
81301,81631,55003 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0	DIRECT
74650,51445,51011 74650 - Galactose mutarotase-like 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain	0	DIRECT
46938,52087,101576 46938 - CRAL/TRIO N-terminal domain 52087 - CRAL/TRIO domain 101576 - Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
90123,52540,90123 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0	DIRECT
57414,57414,57414 57414 - Hairpin loop containing domain-like 57414 - Hairpin loop containing domain-like 57414 - Hairpin loop containing domain-like	0	DIRECT
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
52540,50447,54980 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 54980 - EF-G C-terminal domain-like	0	DIRECT
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
52540,90123,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box	0	DIRECT
50156,50044,52540 50156 - PDZ domain-like 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like	0	DIRECT
57362,57362,57362 57362 - BPTI-like 57362 - BPTI-like 57362 - BPTI-like	0	DIRECT
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	DIRECT
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
55973,55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	DIRECT
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like	0	DIRECT
54292,47741,56176 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0	DIRECT
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	DIRECT
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
57938,49493,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
57567,57567,57567 57567 - Serine protease inhibitors 57567 - Serine protease inhibitors 57567 - Serine protease inhibitors	0	DIRECT
54897,52743,49785 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	DIRECT
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
50044,50044,50044 50044 - SH3-domain 50044 - SH3-domain 50044 - SH3-domain	0	DIRECT